Genes Phenotypes

Gene: Nr1d1

Name
nuclear receptor subfamily 1, group D, member 1
MGI ID
MGI:2444210
Synonyms
REV-ERBalpha A530070C09Rik rev-erbA(alpha)
Viability
Homozygous - Viable Homozygous - Subviable
View
3D Imaging
Other links
MGI   Ensembl  
Significant phenotypes (16) Measurements chart (354) All data table (1977)
Expression & images (113) Disease models (0) Histopathology (2) Order (5)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal behavior Nr1d1tm1(KOMP)Vlcg HOM postnatal 1.44×10-05
abnormal eye anterior chamber depth Nr1d1tm1(KOMP)Vlcg HOM postnatal 3.12×10-05
decreased circulating alkaline phosphatase level Nr1d1 HET postnatal 8.55×10-05
abnormal eye morphology Nr1d1tm1(KOMP)Vlcg HOM postnatal 0.00
abnormal eye posterior chamber depth Nr1d1tm1(KOMP)Vlcg HOM postnatal 5.22×10-09
abnormal bone structure Nr1d1tm1(KOMP)Vlcg HOM postnatal 4.97×10-07
short tibia Nr1d1tm1(KOMP)Vlcg HOM postnatal 1.24×10-12
decreased cardiac output Nr1d1tm1(KOMP)Vlcg HOM postnatal 9.27×10-06
decreased vertical activity Nr1d1tm1(KOMP)Vlcg HOM postnatal 1.95×10-05
thin ventricular wall Nr1d1tm1(KOMP)Vlcg HOM postnatal 1.21×10-06
decreased total body fat amount Nr1d1tm1(KOMP)Vlcg HOM postnatal 1.55×10-07
enlarged heart Nr1d1tm1(KOMP)Vlcg HOM postnatal 0.00
increased bone mineral content Nr1d1tm1(KOMP)Vlcg HOM postnatal 4.01×10-08
decreased total retina thickness Nr1d1tm1(KOMP)Vlcg HOM postnatal 5.05×10-06
preweaning lethality, incomplete penetrance Nr1d1tm1.1(KOMP)Vlcg HOM n/a 0.00
hypoactivity Nr1d1tm1(KOMP)Vlcg HOM postnatal 9.03×10-05

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 7 No  (2/584)  (7/7)  Wholemount images
Aorta 7 No  (2/7)  Wholemount images
Bone 7 No  (7/7)  Wholemount images
Brain 7 No  (7/7)  Wholemount images
Brainstem 7 No  (7/7)  Wholemount images
Brown adipose tissue 7 No  (2/7)  Wholemount images
Cartilage tissue 7 No  (7/7)  Wholemount images
Cecum 5 No  (12/383)  (2/5) N/A
Cerebellum 7 No  (7/7)  Wholemount images
Cerebral cortex 7 No  (7/7)  Wholemount images
Esophagus 7 No  (7/415)  (7/7)  Wholemount images
Eye 7 No N/A
Gall bladder 7 No  (2/7)  Wholemount images
Heart 7 No  (7/7)  Wholemount images
Hippocampus 7 No  (7/7)  Wholemount images
Hypothalamus 7 No  (7/7)  Wholemount images
Kidney 7 No  (18/584)  (7/7)  Wholemount images
Large intestine 7 No  (10/584)  (2/7)  Wholemount images
Liver 7 No  (7/7)  Wholemount images
Lower urinary tract 7 No  (7/7)  Wholemount images
Lung 7 No  (7/7) N/A
Lymph node 7 No  (2/7) N/A
Mammary gland 7 No N/A
Mesenteric lymph node 5 No N/A
Olfactory lobe 7 No  (7/7)  Wholemount images
Oral epithelium 7 No  (2/7)  Wholemount images
Ovary 7 No  (1/584)  (5/7)  Wholemount images
Oviduct 7 No  (1/7)  Wholemount images
Pancreas 7 No  (5/584)  Wholemount images
Parathyroid gland 7 No N/A
Peripheral nervous system 7 No  (2/7)  Wholemount images
Peyer's patch 7 No  (2/7)  Wholemount images
Pituitary gland 7 No  (2/7)  Wholemount images
Prostate gland 7 No  (12/584)  (1/7)  Wholemount images
Skeletal muscle 7 No  (7/7)  Wholemount images
Skin 7 No  (6/7)  Wholemount images
Small intestine 7 No  (9/584)  (7/7)  Wholemount images
Spinal cord 7 No  (7/7)  Wholemount images
Spleen 7 No  (2/584) N/A
Stomach 7 No  (12/584)  (2/7)  Wholemount images
Striatum 7 No  (7/7)  Wholemount images
Testis 7 No  (2/584)  (2/7)  Wholemount images
Thymus 7 No  (2/7)  Wholemount images
Thyroid gland 7 No  (15/584)  (2/7)  Wholemount images
Trachea 7 No  (7/7)  Wholemount images
Trigeminal V nerve 5 No  (2/5)  Wholemount images
Urinary bladder 5 No N/A
Uterus 7 No  (1/7)  Wholemount images
Vas deferens 7 No  (15/388)  Wholemount images
Vascular system 7 No N/A
White adipose tissue 7 No  (2/7)  Wholemount images
LacZ Wholemount Images
Unassigned Top Level MA (2)
adipose tissue (3)
Brown adipose tissue expression
MA:0000057
cardiovascular system (2)
Heart expression
Aorta expression
MA:0000072
MA:0000062
digestive system (9)
Large Intestine expression
MA:0000333
endocrine system (4)
Adrenal gland expression
MA:0000116
exocrine system (1)
Lower Urinary Tract expression
Prostate gland expression
MA:0002636
MA:0000404
immune system (2)
Peyers Patch expression
Small Intestine expression
MA:0000137
MA:0000337
integumental system (2)
Skin expression
MA:0000151
musculoskeletal system (2)
Cartilage tissue expression
Skeletal Muscle expression
Bone expression
MA:0000104
MA:0003148
MA:0001459
nervous system (7)
Cerebral Cortex expression
Brain expression
Striatum expression
Hippocampus expression
Hypothalamus expression
Cerebellum expression
Brainstem expression
Olfactory Lobe expression
MA:0000185
MA:0000168
MA:0000891
MA:0000191
MA:0000173
MA:0000198
MA:0000169
MA:0002413
postnatal mouse (33)
Adrenal gland expression
MA:0000116
reproductive system (4)
Lower Urinary Tract expression
Prostate gland expression
MA:0002636
MA:0000404
respiratory system (3)
Oral epithelium expression
MA:0000344
set of connective tissues (5)
Brown adipose tissue expression
MA:0000057
trunk (23)
Adrenal gland expression
MA:0000116
urinary system (3)
Kidney expression
MA:0000368
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 2  (1/47) N/A
Axial skeleton 2  (1/51) N/A
Brain 2  (6/485) N/A
Central nervous system ganglion 2  (1/51) N/A
Cranium 2  (1/46) N/A
Dorsal root ganglion 2  (1/47) N/A
Ear 2  (1/485)  (2/2) N/A
Embryo 2  (1/485)  (2/2) N/A
Outer ear 2  (1/47) N/A
Eye 2  (1/485)  (2/2) N/A
Femur pre-cartilage condensation 2  (1/46) N/A
Foot 2  (1/485) N/A
Forearm 2  (1/282)  (2/2) N/A
Forebrain 2  (1/485) N/A
Forelimb 2  (1/485)  (2/2) N/A
Fronto-nasal process 2  (1/48) N/A
Gut 2  (1/50) N/A
Hand 2  (1/485) N/A
Head 2  (5/485)  (2/2) N/A
Head mesenchyme 2  (1/47) N/A
Heart 2  (1/485)  (2/2) N/A
Heart ventricle 2  (1/47)  (2/2) N/A
Hindbrain 2  (6/485) N/A
Hindlimb 2  (1/485) N/A
Humerus pre-cartilage condensation 2  (1/46) N/A
Inner ear 2  (1/46)  (2/2) N/A
Intestine 2  (1/47) N/A
Liver 2  (1/485) N/A
Lower leg 2  (1/282) N/A
Lung 2  (1/485) N/A
Mandibular process 2  (1/485) N/A
Maxillary process 2  (1/485) N/A
Mesonephros of female 2  (1/46) N/A
Mesonephros of male 2  (1/46) N/A
Metanephros 2  (1/46) N/A
Midbrain 2  (1/485) N/A
Nasal septum 2  (1/47) N/A
Nose 2  (1/51) N/A
Notochord 2  (1/47) N/A
Oral cavity 2  (1/485) N/A
Outflow tract 2  (1/47)  (2/2) N/A
Pancreas 2  (1/46) N/A
Pericardium 2  (1/46) N/A
Pharynx 2  (1/46) N/A
Radius-ulna pre-cartilage condensation 2  (1/46)  (2/2) N/A
Rib pre-cartilage condensation 2  (1/46) N/A
Skeleton 2  (1/51) N/A
Skin 2  (1/485) N/A
Spinal cord 2  (1/50) N/A
Stomach 2  (1/46) N/A
Tail 2  (1/485)  (2/2) N/A
Tail somite 2  (1/485) N/A
Thoracic vertebral cartilage condensation 2  (1/46) N/A
Tongue 2  (1/46) N/A
Trachea 2  (1/50) N/A
Trunk mesenchyme 2  (1/47) N/A
Umbilical artery embryonic part 2  (1/47) N/A
Umbilical vein embryonic part 2  (1/47) N/A
Upper arm 2  (1/282) N/A
Upper leg 2  (1/282) N/A
Urinary system 2  (1/50) N/A
Vibrissa 2  (1/47) N/A

 Associated Images

Adult LacZ: LacZ Images Wholemount
35 Images
Embryo LacZ: LacZ images wholemount
4 Images

 Disease Models

No associations by disease annotation and gene orthology found.
Please visit the desktop version to see this section

 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Eye with optic nerve - process of degenerative change Nr1d1tm1.1(KOMP)Vlcg HOM postnatal
Mammary gland - metaplasia Nr1d1tm1.1(KOMP)Vlcg HOM postnatal

 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Nr1d1tm1(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Nr1d1tm438023(L1L2_Bact_P) Targeting vectors
Nr1d1tm438023(L1L2_GT1_LF2A_LacZ_BetactP_neo) Targeting vectors
Nr1d1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells, Tissue
Nr1d1tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice, Tissue

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