Genes Phenotypes

Gene: Nr1d1

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Name
nuclear receptor subfamily 1, group D, member 1
MGI ID
MGI:2444210
Synonyms
A530070C09Rik REV-ERBalpha rev-erbA(alpha)
Viability
Homozygous - Viable Homozygous - Subviable
Embryo viewer
3D Imaging
Other links
MGI   Ensembl  
Significant phenotypes (25) Measurements chart (307) All data table (1310)
Expression & images (113) Disease models (0) Histopathology (2) Order (5)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
enlarged heart Nr1d1tm1(KOMP)Vlcg HOM Early adult 0.00
thin ventricular wall Nr1d1tm1(KOMP)Vlcg HOM Early adult 1.40×10-10
abnormal adipose tissue amount Nr1d1tm1(KOMP)Vlcg HOM Early adult 1.08×10-12
abnormal tibia morphology Nr1d1tm1(KOMP)Vlcg HOM Early adult 7.21×10-13
abnormal locomotor activation Nr1d1tm1(KOMP)Vlcg HOM Early adult 9.07×10-07
preweaning lethality, incomplete penetrance Nr1d1tm1.1(KOMP)Vlcg HOM Early adult 0.00
abnormal bone mineralization Nr1d1tm1(KOMP)Vlcg HOM Early adult 5.87×10-07
abnormal eye morphology Nr1d1tm1(KOMP)Vlcg HOM Early adult 0.00
abnormal heart left ventricle size Nr1d1tm1(KOMP)Vlcg HOM Early adult 5.57×10-11
decreased cardiac stroke volume Nr1d1tm1(KOMP)Vlcg HOM Early adult 1.98×10-06
increased total body fat amount Nr1d1Nr1d1 HOM Early adult 4.45×10-06
abnormal bone structure Nr1d1tm1(KOMP)Vlcg HOM Early adult 4.20×10-07
increased circulating glucose level Nr1d1Nr1d1 HOM Early adult 8.11×10-07
immune system phenotype Nr1d1tm1(KOMP)Vlcg HOM Early adult 1.37×10-06
abnormal cardiac muscle contractility Nr1d1tm1(KOMP)Vlcg HOM Early adult 8.51×10-06
decreased thigmotaxis Nr1d1tm1(KOMP)Vlcg HOM Early adult 1.00×10-06
decreased circulating alkaline phosphatase level Nr1d1Nr1d1 HET Early adult 1.43×10-06
abnormal cardiac output Nr1d1tm1(KOMP)Vlcg HOM Early adult 5.22×10-10
abnormal lean body mass Nr1d1tm1(KOMP)Vlcg HOM Early adult 3.59×10-06
increased circulating iron level Nr1d1Nr1d1 HOM Early adult 6.63×10-07
abnormal heart left ventricle size Nr1d1tm1.1(KOMP)Vlcg HET Early adult 2.07×10-06
decreased total body fat amount Nr1d1tm1(KOMP)Vlcg HOM Early adult 2.18×10-06
decreased cardiac output Nr1d1tm1(KOMP)Vlcg HOM Early adult 1.37×10-08
abnormal eye anterior chamber depth Nr1d1tm1(KOMP)Vlcg HOM Early adult 1.54×10-05
short tibia Nr1d1tm1(KOMP)Vlcg HOM Early adult 5.17×10-08

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 7 No  (3/589)  (7/7)  Wholemount images
Aorta 7 No  (1/589)  (2/7)  Wholemount images
Bone 7 No  (7/7)  Wholemount images
Brain 7 No  (3/589)  (7/7)  Wholemount images
Brainstem 7 No  (2/589)  (7/7)  Wholemount images
Brown adipose tissue 7 No  (2/7)  Wholemount images
Cartilage tissue 7 No  (7/7)  Wholemount images
Cecum 5 No  (12/379)  (2/5) N/A
Cerebellum 7 No  (3/589)  (7/7)  Wholemount images
Cerebral cortex 7 No  (2/589)  (7/7)  Wholemount images
Esophagus 7 No  (7/415)  (7/7)  Wholemount images
Eye 7 No N/A
Gall bladder 7 No  (2/7)  Wholemount images
Heart 7 No  (1/589)  (7/7)  Wholemount images
Hippocampus 7 No  (3/589)  (7/7)  Wholemount images
Hypothalamus 7 No  (2/589)  (7/7)  Wholemount images
Kidney 7 No  (20/589)  (7/7)  Wholemount images
Large intestine 7 No  (10/589)  (2/7)  Wholemount images
Liver 7 No  (7/7)  Wholemount images
Lower urinary tract 7 No  (1/589)  (7/7)  Wholemount images
Lung 7 No  (1/589)  (7/7) N/A
Lymph node 7 No  (2/7) N/A
Mammary gland 7 No N/A
Mesenteric lymph node 5 No  Wholemount images
Olfactory lobe 7 No  (2/589)  (7/7)  Wholemount images
Oral epithelium 7 No  (2/7)  Wholemount images
Ovary 7 No  (1/589)  (5/7)  Wholemount images
Oviduct 7 No  (1/7)  Wholemount images
Pancreas 7 No  (5/589)  Wholemount images
Parathyroid gland 7 No N/A
Peripheral nervous system 7 No  (1/589)  (2/7)  Wholemount images
Peyer's patch 7 No  (2/7)  Wholemount images
Pituitary gland 7 No  (1/589)  (2/7)  Wholemount images
Prostate gland 7 No  (12/589)  (1/7)  Wholemount images
Skeletal muscle 7 No  (7/7)  Wholemount images
Skin 7 No  (6/7)  Wholemount images
Small intestine 7 No  (9/589)  (7/7)  Wholemount images
Spinal cord 7 No  (2/589)  (7/7)  Wholemount images
Spleen 7 No  (2/589) N/A
Stomach 7 No  (13/589)  (2/7)  Wholemount images
Striatum 7 No  (3/589)  (7/7)  Wholemount images
Testis 7 No  (5/589)  (2/7)  Wholemount images
Thymus 7 No  (2/7)  Wholemount images
Thyroid gland 7 No  (16/589)  (2/7)  Wholemount images
Trachea 7 No  (2/589)  (7/7)  Wholemount images
Trigeminal V nerve 5 No  (2/5)  Wholemount images
Urinary bladder 5 No N/A
Uterus 7 No  (1/7)  Wholemount images
Vas deferens 7 No  (15/388)  Wholemount images
Vascular system 7 No N/A
White adipose tissue 7 No  (2/7)  Wholemount images
LacZ Wholemount Images
Unassigned Top Level MA (57)
adipose tissue (1)
Brown adipose tissue expression
MA:0000057
cardiovascular system (1)
Heart expression
MA:0000072
digestive system (4)
Large Intestine expression
MA:0000333
endocrine system (3)
Adrenal gland expression
MA:0000116
immune system (1)
Thymus expression
MA:0000142
integumental system (2)
Skin expression
MA:0000151
nervous system (3)
Spinal cord expression
MA:0000216
postnatal mouse (18)
Adrenal gland expression
MA:0000116
reproductive system (1)
Ovary expression
MA:0000384
respiratory system (1)
Oral epithelium expression
MA:0000344
set of connective tissues (1)
Brown adipose tissue expression
MA:0000057
trunk (14)
Adrenal gland expression
MA:0000116
urinary system (2)
Kidney expression
MA:0000368
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 2  (1/61) N/A
Axial skeleton 2  (1/65) N/A
Brain 2  (6/506) N/A
Central nervous system ganglion 2  (1/74) N/A
Cranium 2  (1/65) N/A
Dorsal root ganglion 2  (1/61) N/A
Ear 2  (1/506)  (2/2) N/A
Embryo 2  (1/507)  (2/2) N/A
Outer ear 2  (1/70) N/A
Eye 2  (1/506)  (2/2) N/A
Femur pre-cartilage condensation 2  (1/56) N/A
Foot 2  (1/506) N/A
Forearm 2  (1/301)  (2/2) N/A
Forebrain 2  (1/506) N/A
Forelimb 2  (1/506)  (2/2) N/A
Fronto-nasal process 2  (1/62) N/A
Gut 2  (1/60) N/A
Hand 2  (1/505) N/A
Head 2  (5/506)  (2/2) N/A
Head mesenchyme 2  (1/61) N/A
Heart 2  (1/506)  (2/2) N/A
Heart ventricle 2  (1/61)  (2/2) N/A
Hindbrain 2  (6/506) N/A
Hindlimb 2  (1/505) N/A
Humerus pre-cartilage condensation 2  (1/65) N/A
Inner ear 2  (1/65)  (2/2) N/A
Intestine 2  (1/59) N/A
Liver 2  (1/506) N/A
Lower leg 2  (1/301) N/A
Lung 2  (1/502) N/A
Mandibular process 2  (1/506) N/A
Maxillary process 2  (1/506) N/A
Mesonephros of female 2  (1/56) N/A
Mesonephros of male 2  (1/56) N/A
Metanephros 2  (1/56) N/A
Midbrain 2  (1/506) N/A
Nasal septum 2  (1/61) N/A
Nose 2  (1/74) N/A
Notochord 2  (1/61) N/A
Oral cavity 2  (1/506) N/A
Outflow tract 2  (1/61)  (2/2) N/A
Pancreas 2  (1/56) N/A
Pericardium 2  (1/56) N/A
Pharynx 2  (1/56) N/A
Radius-ulna pre-cartilage condensation 2  (1/65)  (2/2) N/A
Rib pre-cartilage condensation 2  (1/58) N/A
Skeleton 2  (1/74) N/A
Skin 2  (1/506) N/A
Spinal cord 2  (1/73) N/A
Stomach 2  (1/56) N/A
Tail 2  (1/506)  (2/2) N/A
Tail somite 2  (1/506) N/A
Thoracic vertebral cartilage condensation 2  (1/56) N/A
Tongue 2  (1/56) N/A
Trachea 2  (1/60) N/A
Trunk mesenchyme 2  (1/61) N/A
Umbilical artery embryonic part 2  (1/61) N/A
Umbilical vein embryonic part 2  (1/61) N/A
Upper arm 2  (1/301) N/A
Upper leg 2  (1/301) N/A
Urinary system 2  (1/60) N/A
Vibrissa 2  (1/70) N/A

 Associated Images

Adult LacZ: LacZ Images Wholemount
75 Images
Embryo LacZ: LacZ images wholemount
4 Images
Histopathology
28 Images
MicroCT E14.5-E15.5: Embryo reconstruction
1 Images
MicroCT E18.5: Embryo reconstruction
1 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Eye with optic nerve - process of degenerative change Nr1d1tm1.1(KOMP)Vlcg HOM Early adult
Mammary gland - metaplasia Nr1d1tm1.1(KOMP)Vlcg HOM Early adult

 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Nr1d1tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice, Tissue
Nr1d1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells, Tissue
Nr1d1tm1(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Nr1d1tm438023(L1L2_Bact_P) Targeting vectors
Nr1d1tm438023(L1L2_GT1_LF2A_LacZ_BetactP_neo) Targeting vectors

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