Genes Phenotypes

Gene: Nr1d1

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Name
nuclear receptor subfamily 1, group D, member 1
MGI ID
MGI:2444210
Synonyms
REV-ERBalpha A530070C09Rik rev-erbA(alpha)
Viability
Homozygous - Viable Homozygous - Subviable
View
3D Imaging
Other links
MGI   Ensembl  
Significant phenotypes (17) Measurements chart (355) All data table (1979)
Expression & images (113) Disease models (0) Histopathology (2) Order (5)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
decreased total body fat amount Nr1d1tm1(KOMP)Vlcg HOM postnatal 1.55×10-07
decreased cardiac output Nr1d1tm1(KOMP)Vlcg HOM postnatal 9.27×10-06
decreased vertical activity Nr1d1tm1(KOMP)Vlcg HOM postnatal 1.95×10-05
abnormal eye morphology Nr1d1tm1(KOMP)Vlcg HOM postnatal 0.00
increased bone mineral content Nr1d1tm1(KOMP)Vlcg HOM postnatal 4.01×10-08
abnormal eye posterior chamber depth Nr1d1tm1(KOMP)Vlcg HOM postnatal 5.22×10-09
short tibia Nr1d1tm1(KOMP)Vlcg HOM postnatal 1.24×10-12
preweaning lethality, incomplete penetrance Nr1d1tm1.1(KOMP)Vlcg HOM n/a 0.00
decreased circulating alkaline phosphatase level Nr1d1 HET postnatal 8.55×10-05
abnormal bone structure Nr1d1tm1(KOMP)Vlcg HOM postnatal 4.97×10-07
tremors Nr1d1tm1.1(KOMP)Vlcg HOM postnatal 4.03×10-06
enlarged heart Nr1d1tm1(KOMP)Vlcg HOM postnatal 0.00
abnormal eye anterior chamber depth Nr1d1tm1(KOMP)Vlcg HOM postnatal 3.12×10-05
thin ventricular wall Nr1d1tm1(KOMP)Vlcg HOM postnatal 1.21×10-06
hypoactivity Nr1d1tm1(KOMP)Vlcg HOM postnatal 9.03×10-05
decreased total retina thickness Nr1d1tm1(KOMP)Vlcg HOM postnatal 5.05×10-06
abnormal behavior Nr1d1tm1(KOMP)Vlcg HOM postnatal 1.44×10-05

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 7 No  (2/584)  (7/7)  Wholemount images
Aorta 7 No  (2/7)  Wholemount images
Bone 7 No  (7/7)  Wholemount images
Brain 7 No  (7/7)  Wholemount images
Brainstem 7 No  (7/7)  Wholemount images
Brown adipose tissue 7 No  (2/7)  Wholemount images
Cartilage tissue 7 No  (7/7)  Wholemount images
Cecum 5 No  (12/383)  (2/5) N/A
Cerebellum 7 No  (7/7)  Wholemount images
Cerebral cortex 7 No  (7/7)  Wholemount images
Esophagus 7 No  (7/415)  (7/7)  Wholemount images
Eye 7 No N/A
Gall bladder 7 No  (2/7)  Wholemount images
Heart 7 No  (7/7)  Wholemount images
Hippocampus 7 No  (7/7)  Wholemount images
Hypothalamus 7 No  (7/7)  Wholemount images
Kidney 7 No  (18/584)  (7/7)  Wholemount images
Large intestine 7 No  (10/584)  (2/7)  Wholemount images
Liver 7 No  (7/7)  Wholemount images
Lower urinary tract 7 No  (7/7)  Wholemount images
Lung 7 No  (7/7) N/A
Lymph node 7 No  (2/7) N/A
Mammary gland 7 No N/A
Mesenteric lymph node 5 No N/A
Olfactory lobe 7 No  (7/7)  Wholemount images
Oral epithelium 7 No  (2/7)  Wholemount images
Ovary 7 No  (1/584)  (5/7)  Wholemount images
Oviduct 7 No  (1/7)  Wholemount images
Pancreas 7 No  (5/584)  Wholemount images
Parathyroid gland 7 No N/A
Peripheral nervous system 7 No  (2/7)  Wholemount images
Peyer's patch 7 No  (2/7)  Wholemount images
Pituitary gland 7 No  (2/7)  Wholemount images
Prostate gland 7 No  (12/584)  (1/7)  Wholemount images
Skeletal muscle 7 No  (7/7)  Wholemount images
Skin 7 No  (6/7)  Wholemount images
Small intestine 7 No  (9/584)  (7/7)  Wholemount images
Spinal cord 7 No  (7/7)  Wholemount images
Spleen 7 No  (2/584) N/A
Stomach 7 No  (12/584)  (2/7)  Wholemount images
Striatum 7 No  (7/7)  Wholemount images
Testis 7 No  (2/584)  (2/7)  Wholemount images
Thymus 7 No  (2/7)  Wholemount images
Thyroid gland 7 No  (15/584)  (2/7)  Wholemount images
Trachea 7 No  (7/7)  Wholemount images
Trigeminal V nerve 5 No  (2/5)  Wholemount images
Urinary bladder 5 No N/A
Uterus 7 No  (1/7)  Wholemount images
Vas deferens 7 No  (15/388)  Wholemount images
Vascular system 7 No N/A
White adipose tissue 7 No  (2/7)  Wholemount images
LacZ Wholemount Images
Unassigned Top Level MA (2)
adipose tissue (3)
Brown adipose tissue expression
MA:0000057
cardiovascular system (2)
Heart expression
Aorta expression
MA:0000072
MA:0000062
digestive system (9)
Large Intestine expression
MA:0000333
endocrine system (4)
Adrenal gland expression
MA:0000116
exocrine system (1)
Lower Urinary Tract expression
Prostate gland expression
MA:0002636
MA:0000404
immune system (2)
Peyers Patch expression
Small Intestine expression
MA:0000137
MA:0000337
integumental system (2)
Skin expression
MA:0000151
musculoskeletal system (2)
Cartilage tissue expression
Skeletal Muscle expression
Bone expression
MA:0000104
MA:0003148
MA:0001459
nervous system (7)
Cerebral Cortex expression
Brain expression
Striatum expression
Hippocampus expression
Hypothalamus expression
Cerebellum expression
Brainstem expression
Olfactory Lobe expression
MA:0000185
MA:0000168
MA:0000891
MA:0000191
MA:0000173
MA:0000198
MA:0000169
MA:0002413
postnatal mouse (33)
Adrenal gland expression
MA:0000116
reproductive system (4)
Lower Urinary Tract expression
Prostate gland expression
MA:0002636
MA:0000404
respiratory system (3)
Oral epithelium expression
MA:0000344
set of connective tissues (5)
Brown adipose tissue expression
MA:0000057
trunk (23)
Adrenal gland expression
MA:0000116
urinary system (3)
Kidney expression
MA:0000368
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 2  (1/47) N/A
Axial skeleton 2  (1/51) N/A
Brain 2  (6/485) N/A
Central nervous system ganglion 2  (1/51) N/A
Cranium 2  (1/46) N/A
Dorsal root ganglion 2  (1/47) N/A
Ear 2  (1/485)  (2/2) N/A
Embryo 2  (1/485)  (2/2) N/A
Outer ear 2  (1/47) N/A
Eye 2  (1/485)  (2/2) N/A
Femur pre-cartilage condensation 2  (1/46) N/A
Foot 2  (1/485) N/A
Forearm 2  (1/282)  (2/2) N/A
Forebrain 2  (1/485) N/A
Forelimb 2  (1/485)  (2/2) N/A
Fronto-nasal process 2  (1/48) N/A
Gut 2  (1/50) N/A
Hand 2  (1/485) N/A
Head 2  (5/485)  (2/2) N/A
Head mesenchyme 2  (1/47) N/A
Heart 2  (1/485)  (2/2) N/A
Heart ventricle 2  (1/47)  (2/2) N/A
Hindbrain 2  (6/485) N/A
Hindlimb 2  (1/485) N/A
Humerus pre-cartilage condensation 2  (1/46) N/A
Inner ear 2  (1/46)  (2/2) N/A
Intestine 2  (1/47) N/A
Liver 2  (1/485) N/A
Lower leg 2  (1/282) N/A
Lung 2  (1/485) N/A
Mandibular process 2  (1/485) N/A
Maxillary process 2  (1/485) N/A
Mesonephros of female 2  (1/46) N/A
Mesonephros of male 2  (1/46) N/A
Metanephros 2  (1/46) N/A
Midbrain 2  (1/485) N/A
Nasal septum 2  (1/47) N/A
Nose 2  (1/51) N/A
Notochord 2  (1/47) N/A
Oral cavity 2  (1/485) N/A
Outflow tract 2  (1/47)  (2/2) N/A
Pancreas 2  (1/46) N/A
Pericardium 2  (1/46) N/A
Pharynx 2  (1/46) N/A
Radius-ulna pre-cartilage condensation 2  (1/46)  (2/2) N/A
Rib pre-cartilage condensation 2  (1/46) N/A
Skeleton 2  (1/51) N/A
Skin 2  (1/485) N/A
Spinal cord 2  (1/50) N/A
Stomach 2  (1/46) N/A
Tail 2  (1/485)  (2/2) N/A
Tail somite 2  (1/485) N/A
Thoracic vertebral cartilage condensation 2  (1/46) N/A
Tongue 2  (1/46) N/A
Trachea 2  (1/50) N/A
Trunk mesenchyme 2  (1/47) N/A
Umbilical artery embryonic part 2  (1/47) N/A
Umbilical vein embryonic part 2  (1/47) N/A
Upper arm 2  (1/282) N/A
Upper leg 2  (1/282) N/A
Urinary system 2  (1/50) N/A
Vibrissa 2  (1/47) N/A

 Associated Images

Adult LacZ: LacZ Images Wholemount
35 Images
Embryo LacZ: LacZ images wholemount
4 Images

 Disease Models

No associations by disease annotation and gene orthology found.
Please visit the desktop version to see this section

 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Mammary gland - metaplasia Nr1d1tm1.1(KOMP)Vlcg HOM postnatal
Eye with optic nerve - process of degenerative change Nr1d1tm1.1(KOMP)Vlcg HOM postnatal

 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Nr1d1tm1(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Nr1d1tm438023(L1L2_Bact_P) Targeting vectors
Nr1d1tm438023(L1L2_GT1_LF2A_LacZ_BetactP_neo) Targeting vectors
Nr1d1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells, Tissue
Nr1d1tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice, Tissue

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