Genes Phenotypes

Gene: Sgms1

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Name
sphingomyelin synthase 1
MGI ID
MGI:2444110
Synonyms
Tmem23 9530058O11Rik SMS1gamma SMS1 SMS1beta SMS1alpha2 SMS1alpha1
Viability
Homozygous - Viable
View
N/A
Other links
MGI   Ensembl  
Significant phenotypes (18) Measurements chart (406) All data table (533)
Expression & images (0) Disease models (0) Order (3)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
decreased mean corpuscular hemoglobin Sgms1tm1a(EUCOMM)Wtsi HOM postnatal 8.20×10-07
decreased CD8-positive, alpha-beta T cell number Sgms1tm1a(EUCOMM)Wtsi HOM postnatal 2.32×10-10
increased circulating magnesium level Sgms1tm1a(EUCOMM)Wtsi HOM postnatal 3.89×10-06
increased lean body mass Sgms1tm1a(EUCOMM)Wtsi HOM postnatal 4.01×10-06
decreased total body fat amount Sgms1tm1a(EUCOMM)Wtsi HOM postnatal 1.58×10-09
decreased circulating alanine transaminase level Sgms1tm1a(EUCOMM)Wtsi HOM postnatal 6.97×10-05
increased mean platelet volume Sgms1tm1a(EUCOMM)Wtsi HOM postnatal 4.30×10-14
decreased NK cell number Sgms1tm1a(EUCOMM)Wtsi HOM postnatal 4.22×10-07
tremors Sgms1tm1a(EUCOMM)Wtsi HOM postnatal 3.06×10-06
increased effector memory CD8-positive, alpha-beta T cell number Sgms1tm1a(EUCOMM)Wtsi HOM postnatal 5.82×10-24
increased bone mineral content Sgms1tm1a(EUCOMM)Wtsi HOM postnatal 6.86×10-06
male infertility Sgms1tm1a(EUCOMM)Wtsi HOM postpartum stage 0.00
increased circulating amylase level Sgms1tm1a(EUCOMM)Wtsi HOM postnatal 9.10×10-06
increased circulating alkaline phosphatase level Sgms1tm1a(EUCOMM)Wtsi HOM postnatal 1.29×10-07
decreased T cell number Sgms1tm1a(EUCOMM)Wtsi HOM postnatal 2.08×10-06
increased grip strength Sgms1tm1a(EUCOMM)Wtsi HOM postnatal 5.06×10-07
thrombocytopenia Sgms1tm1a(EUCOMM)Wtsi HOM postnatal 6.38×10-09
decreased NK T cell number Sgms1tm1a(EUCOMM)Wtsi HOM postnatal 3.16×10-11

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Viewing: all phenotypes

 Expression

Expression data not available

 Associated Images

Anti-nuclear antibody assay
6 Images
DSS Histology
8 Images
X-ray: XRay Images Lateral Orientation
28 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
14 Images
X-ray: XRay Images Dorso Ventral
42 Images
X-ray: XRay Images Forepaw
14 Images
X-ray: XRay Images Skull Lateral Orientation
14 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Sgms1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Sgms1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Sgms1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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