Gene: Nlrc3 MGI:2444070

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

NLR family, CARD domain containing 3
CLR16.2,  D230007K08Rik,  Caterpiller 16.2

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Nlrc3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Nlrc3 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Neutropenia, Severe Congenital, 1, Autosomal Dominant
Congenital agranulocytosis, Monocytosis, Thrombocytosis, Acute monocytic leukemia, Increased circ... OMIM:202700
Immunodeficiency 14B, Autosomal Recessive
Inflammation of the large intestine, Monocytosis, Thrombocytosis, Leukocytosis, Recurrent sinusit... OMIM:619281
Adult Idiopathic Neutropenia
Monocytosis, Monocytopenia, Increased circulating IgM level, Lymphopenia, Neutropenia, Recurrent ... ORPHA:2688
Ras-Associated Autoimmune Leukoproliferative Disorder
Lymphocytosis, Monocytosis, Hemolytic anemia, Autoimmune thrombocytopenia, Increased circulating ... OMIM:614470
Neutropenia, Severe Congenital, 2, Autosomal Dominant
Monocytosis, B lymphocytopenia, Neutropenia OMIM:613107
Myeloproliferative/Lymphoproliferative Neoplasms, Familial (Multiple Types), Susceptibility To
Monocytosis, Acute myeloid leukemia, Leukopenia, Refractory anemia, Eczema OMIM:616871
Proteasome-Associated Autoinflammatory Syndrome 5
Skin rash, Failure to thrive in infancy, Hypertriglyceridemia, Splenomegaly, Fever OMIM:619175
Hyper-Ige Recurrent Infection Syndrome 5, Autosomal Recessive
Decreased proportion of class-switched memory B cells, Atopic dermatitis, Increased circulating I... OMIM:618944
Autosomal Dominant Severe Congenital Neutropenia
Monocytosis, Periodontitis, Lymphopenia, Leukemia, Pneumonia, Neutropenia, Acute myeloid leukemia... ORPHA:486
Congenital Enterovirus Infection
Skin rash, Leukocytosis, Abnormal macrophage morphology, Neutropenia, Thrombocytopenia, Hepatitis... ORPHA:292
Primary Erythromelalgia
Leukemia, Hypothermia ORPHA:90026
Immunodeficiency 69
Increased circulating ferritin concentration, Skin rash, Thrombocytosis, Leukocytosis, Pancytopen... OMIM:618963
Holoprosencephaly, Recurrent Infections, And Monocytosis
Monocytosis, Recurrent skin infections, Failure to thrive OMIM:610680
Lymphoproliferative Syndrome, X-Linked, 2
Increased circulating ferritin concentration, Folliculitis, Acne, Inflammation of the large intes... OMIM:300635
Combined Oxidative Phosphorylation Deficiency 37
Hypothermia, Failure to thrive, Hyperalaninemia OMIM:618329
Familial Hemophagocytic Lymphohistiocytosis
Increased circulating ferritin concentration, Skin rash, Hemophagocytosis, Increased serum interf... ORPHA:540
Acute Lung Injury
Abnormality of serum cytokine level, Pneumonia, Abnormality of tumor necrosis factor secretion, I... ORPHA:178320
Sweet Syndrome
Inflammation of the large intestine, Pustule, Abnormal serum interleukin level, Leukocytosis, Chr... ORPHA:3243
Spontaneous Periodic Hypothermia
Skin rash, Hypothermia ORPHA:29822
Idiopathic Congenital Hypothyroidism
Neonatal hyperbilirubinemia, Hypothermia ORPHA:95717
Mitochondrial Dna Depletion Syndrome 9 (Encephalomyopathic Type With Methylmalonic Aciduria)
Hypertaurinemia, Failure to thrive, Hypothermia, Hyperglycinemia OMIM:245400
Immunodeficiency 73B With Defective Neutrophil Chemotaxis And Lymphopenia
Partial absence of specific antibody response to Haemophilus influenzae type b (Hib) vaccine, T l... OMIM:618986
Meningococcal Meningitis
Skin rash, Encephalitis, Elevated circulating C-reactive protein concentration, Hypothermia, Fever ORPHA:33475
Mitochondrial Complex Iii Deficiency, Nuclear Type 10
Thrombocytopenia, Normochromic anemia, Small for gestational age, Elevated circulating creatine k... OMIM:618775
Very Long Chain Acyl-Coa Dehydrogenase Deficiency
Hypocalcemia, Hypoproteinemia, Inflammatory abnormality of the skin, Overweight, Pneumonia, Small... ORPHA:26793
Mitochondrial Dna Depletion Syndrome 3 (Hepatocerebral Type)
Hyperbilirubinemia, Thrombocytopenia, Hypoalbuminemia, Failure to thrive, Splenomegaly, Hypothermia OMIM:251880
2-Methylbutyryl-Coa Dehydrogenase Deficiency
Hypothermia OMIM:610006
Neutropenia, Severe Congenital, 4, Autosomal Recessive
Erythroid hypoplasia, Monocytosis, Lymphopenia, Neutropenia, Hypoplasia of the thymus, Thrombocyt... OMIM:612541
Familial Thyroid Dyshormonogenesis
Abnormal circulating thyroglobulin level, Neonatal hyperbilirubinemia, Hypothermia ORPHA:95716
Menkes Disease
Hypothermia OMIM:309400
Immunodeficiency 21
Myeloid leukemia, Monocytopenia, Abnormal natural killer cell morphology, Lymphopenia, Neutropeni... OMIM:614172
Developmental And Epileptic Encephalopathy 78
Hypothermia OMIM:618557
3-Hydroxy-3-Methylglutaric Aciduria
Thrombocytosis, Leukocytosis, Hyperuricemia, Weight loss, Acute pancreatitis, Leukopenia, Anemia,... ORPHA:20
Congenital Hypothyroidism Due To Maternal Intake Of Antithyroid Drugs
Large for gestational age, Hypothermia ORPHA:226313
Hypotonia, Hypoventilation, Impaired Intellectual Development, Dysautonomia, Epilepsy, And Eye Abnormalities
Recurrent pneumonia, Abnormality of temperature regulation, Hypothermia, Fever, Obesity OMIM:618493
Adult Acute Respiratory Distress Syndrome
Abnormal serum interleukin level, Pneumonia, Abnormality of tumor necrosis factor secretion, Incr... ORPHA:70578
Permanent Congenital Hypothyroidism
Hypothermia ORPHA:226292
X-Linked Severe Congenital Neutropenia
Monocytopenia, Neutropenia ORPHA:86788
Sudden Infant Death-Dysgenesis Of The Testes Syndrome
Hypothermia ORPHA:168593
Neuroleptic Malignant Syndrome
Hypocalcemia, Thrombocytosis, Leukocytosis, Hypernatremia, Hyponatremia, Hyperuricemia, Elevated ... ORPHA:94093
Mitochondrial Complex Iv Deficiency, Nuclear Type 13
Hypothermia OMIM:616501
Carnitine-Acylcarnitine Translocase Deficiency
Decreased plasma carnitine, Elevated creatine kinase after exercise, Elevated circulating acylcar... ORPHA:159
Dopamine Beta-Hydroxylase Deficiency
Increased blood urea nitrogen, Elevated circulating creatinine concentration, Rhinitis, Anemia, H... ORPHA:230
Yellow Fever
Malignant hyperthermia, Hypothermia, Encephalitis, Fever ORPHA:99829
Vulvovaginal Gingival Syndrome
Abnormality of tumor necrosis factor secretion ORPHA:83453
Methylmalonic Acidemia With Homocystinuria, Type Cblc
Megaloblastic anemia, Stomatitis, Neutropenia, Thrombocytopenia, Hypomethioninemia, Methylmalonic... ORPHA:79282
Isolated Thyroid-Stimulating Hormone Deficiency
Hypercholesterolemia, Neonatal hyperbilirubinemia, Failure to thrive, Abnormal circulating thyrog... ORPHA:90674
Genetic Transient Congenital Hypothyroidism
Hypothermia, Increased circulating thyroglobulin level ORPHA:226316
Hypothyroidism Due To Tsh Receptor Mutations
Neonatal hyperbilirubinemia, Hypothermia, Increased circulating thyroglobulin level ORPHA:90673
Congenital Hypothyroidism
Hypothermia, Sinusitis ORPHA:442
Mitochondrial Dna-Associated Leigh Syndrome
Low plasma citrulline, Hyperalaninemia, Failure to thrive, Hypothermia, Fever ORPHA:255210
Tbck-Related Intellectual Disability Syndrome
Eczema, Hypothermia, Abnormal circulating lipid concentration ORPHA:488632
Orthostatic Hypotension 1
Intermittent hypothermia OMIM:223360
Ethylene Glycol Poisoning
Hypocalcemia, Hypothermia, Hyperkalemia, Gastritis ORPHA:31826
Psoriasis-Related Juvenile Idiopathic Arthritis
Skin rash, Iridocyclitis, Iritis, Uveitis, Abnormality of tumor necrosis factor secretion, Sacroi... ORPHA:85436
Alexander Disease
Hypothermia, Encephalitis, Failure to thrive ORPHA:58
Hemolytic anemia, Increased T cell count, Bronchiectasis, Uveitis, Maculopapular exanthema, Weigh... ORPHA:797
Adult-Onset Autosomal Dominant Leukodystrophy
Temperature instability, Hypothermia, Aspiration pneumonia ORPHA:99027
Hereditary Sensory And Autonomic Neuropathy Type 4
Tooth abscess, Septic arthritis, Recurrent fever, Anemia, Fasciitis, Unexplained fevers, Recurren... ORPHA:642
Fatal Infantile Lactic Acidosis With Methylmalonic Aciduria
Hypothermia, Methylmalonic acidemia, Failure to thrive ORPHA:17
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Hyponatremia, Encephalitis, Hypothermia, Hyperlipidemia, Fever, Obesity ORPHA:293987
Aromatic L-Amino Acid Decarboxylase Deficiency
Temperature instability, Intermittent hypothermia OMIM:608643
Menkes Disease
Hypothermia, Osteomyelitis ORPHA:565
Hypothyroidism, Congenital, Nongoitrous, 2
Hyperbilirubinemia, Hypothermia OMIM:218700
Occipital Horn Syndrome
Esophagitis, Hepatitis, Hypothermia ORPHA:198
Hypothyroidism Due To Deficient Transcription Factors Involved In Pituitary Development Or Function
Hypothermia, Overweight ORPHA:226307
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome
Decreased serum iron, Hypothermia, Aspiration pneumonia, Anemia ORPHA:438213


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Nlrc3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Nlrc3.

No publications found that use IMPC mice or data for Nlrc3.

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MGI Allele Allele Type Produced
Nlrc3tm452123(Ifitm2_intron_L1L2_GT0_LF2A_LacZ_BetactP_neo) Targeting vectors

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