Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

NLR family, CARD domain containing 3
CLR16.2,  Caterpiller 16.2,  D230007K08Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Nlrc3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Nlrc3 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Immunodeficiency 15B
Reduced natural killer cell count, Failure to thrive, Agammaglobulinemia, Monocytosis, Decreased ... OMIM:615592
Neutropenia, Severe Congenital, 1, Autosomal Dominant
Acute monocytic leukemia, Congenital agranulocytosis, Thrombocytosis, Increased circulating antib... OMIM:202700
Immunodeficiency 14B, Autosomal Recessive
Neutrophilia, Decreased circulating IgG level, Inflammation of the large intestine, Recurrent pne... OMIM:619281
Adult Idiopathic Neutropenia
Fever, Lymphopenia, Recurrent aphthous stomatitis, Neutropenia, Monocytosis, Monocytopenia, Incre... ORPHA:2688
Ras-Associated Autoimmune Leukoproliferative Disorder
Pancytopenia, Splenomegaly, Increased circulating antibody level, Lymphocytosis, Neutropenia, Mon... OMIM:614470
Neutropenia, Severe Congenital, 10, Autosomal Recessive
Anorectal abscess, Monocytosis, Thrombocytopenia, Neutropenia, Anemia OMIM:620534
Neutropenia, Severe Congenital, 2, Autosomal Dominant
B lymphocytopenia, Neutropenia, Monocytosis OMIM:613107
Immunodeficiency 32B
Hypoalbuminemia, Pneumonia, Failure to thrive, Fever, Impaired oxidative burst, Abnormal circulat... OMIM:226990
Immunodeficiency 91 And Hyperinflammation
Neutrophilia, Recurrent pneumonia, Hemophagocytosis, Failure to thrive, Recurrent fever, Hepatosp... OMIM:619644
Myeloproliferative/Lymphoproliferative Neoplasms, Familial (Multiple Types), Susceptibility To
Eczematoid dermatitis, Leukopenia, Acute myeloid leukemia, Monocytosis, Refractory anemia OMIM:616871
Macrophage Activation Syndrome
Hypoalbuminemia, Abnormal circulating interleukin concentration, Increased circulating interleuki... ORPHA:158061
Autosomal Dominant Severe Congenital Neutropenia
Pneumonia, Aplastic anemia, Periodontitis, Fever, Lymphopenia, Recurrent aphthous stomatitis, Rec... ORPHA:486
Hyper-Ige Syndrome 5, Autosomal Recessive, With Recurrent Infections
Decreased circulating IgG level, Atopic dermatitis, Cutaneous abscess, Increased circulating IgE ... OMIM:618944
Immunodeficiency 97 With Autoinflammation
Hemophagocytosis, Decreased proportion of CD8-positive T cells, Lymphopenia, Hepatosplenomegaly, ... OMIM:619802
Primary Erythromelalgia
Leukemia, Hypothermia ORPHA:90026
Congenital Enterovirus Infection
Hypoalbuminemia, Hepatitis, Fever, Leukopenia, Leukocytosis, Abnormal macrophage morphology, Hype... ORPHA:292
Immunodeficiency 69
Hemophagocytosis, Failure to thrive, Increased circulating ferritin concentration, Fever, Hepatos... OMIM:618963
Riboflavin Deficiency
Elevated circulating acylcarnitine concentration, Hypothermia OMIM:615026
Immunodeficiency 11A
Monocytopenia, Decreased proportion of CD4+CD25+ regulatory T cells, Agammaglobulinemia, Decrease... OMIM:615206
Acute Lung Injury
Pneumonia, Increased circulating interleukin 6 concentration, Fever, Abnormality of tumor necrosi... ORPHA:178320
Familial Hemophagocytic Lymphohistiocytosis
Hypoalbuminemia, Increased circulating interleukin 6 concentration, Hemophagocytosis, Increased c... ORPHA:540
Sepsis In Premature Infants
Temperature instability, Increased circulating interleukin 6 concentration, Fever, Leukocytosis, ... ORPHA:90051
Immunodeficiency 113 With Autoimmunity And Autoinflammation
Neutrophilia, Minimal change glomerulonephritis, Intraalveolar phospholipid accumulation, Eczemat... OMIM:620565
Sweet Syndrome
Abnormal circulating interleukin concentration, Inflammation of the large intestine, Increased ci... ORPHA:3243
N-Acetylglutamate Synthase Deficiency
Failure to thrive, Hyperammonemia, Hypothermia, Hyperglutamatemia, Hyperglutaminemia, Low plasma ... OMIM:237310
Spontaneous Periodic Hypothermia
Hypothermia, Skin rash ORPHA:29822
Neutropenia, Severe Congenital, X-Linked
Monocytopenia, Decreased CD4:CD8 ratio, Eczematoid dermatitis, Neutropenia OMIM:300299
Idiopathic Congenital Hypothyroidism
Neonatal hyperbilirubinemia, Hypothermia ORPHA:95717
Coenzyme Q10 Deficiency, Primary, 5
Hyperalaninemia, Hypothermia OMIM:614654
Mitochondrial Dna Depletion Syndrome 9 (Encephalomyopathic Type With Methylmalonic Aciduria)
Hypertaurinemia, Hypothermia, Hyperglycinemia, Failure to thrive OMIM:245400
Immunodeficiency 73B With Defective Neutrophil Chemotaxis And Lymphopenia
Abnormally low T cell receptor excision circle level, Decreased circulating IgG level, Recurrent ... OMIM:618986
Very Long Chain Acyl-Coa Dehydrogenase Deficiency
Pneumonia, Increased circulating free fatty acid level, Inflammatory abnormality of the skin, Obe... ORPHA:26793
Meningococcal Meningitis
Fever, Hypothermia, Skin rash, Infectious encephalitis, Elevated circulating C-reactive protein c... ORPHA:33475
2-Methylbutyryl-Coa Dehydrogenase Deficiency
Hypothermia OMIM:610006
Immunodeficiency 21
Reduced natural killer cell count, Aplastic anemia, Lymphopenia, Osteomyelitis, Anemia, Neutropen... OMIM:614172
Mitochondrial Complex Iii Deficiency, Nuclear Type 10
Hypothermia, Elevated circulating creatine kinase concentration, Thrombocytopenia, Small for gest... OMIM:618775
Developmental And Epileptic Encephalopathy 78
Hypothermia OMIM:618557
Familial Thyroid Dyshormonogenesis
Abnormal circulating thyroglobulin concentration, Neonatal hyperbilirubinemia, Hypothermia ORPHA:95716
Timothy Syndrome
Pneumonia, Hypothermia, Hypocalcemia OMIM:601005
3-Hydroxy-3-Methylglutaric Aciduria
Fever, Leukopenia, Leukocytosis, Hyperammonemia, Hyperuricemia, Hypothermia, Weight loss, Thrombo... ORPHA:20
Menkes Disease
Decreased circulating ceruloplasmin concentration, Hypothermia OMIM:309400
Mitochondrial Complex Iv Deficiency, Nuclear Type 13
Hypothermia OMIM:616501
Adult Acute Respiratory Distress Syndrome
Pneumonia, Abnormal circulating interleukin concentration, Abnormality of tumor necrosis factor s... ORPHA:70578
Mitochondrial Dna Depletion Syndrome 3 (Hepatocerebral Type)
Hypoalbuminemia, Failure to thrive, Hyperbilirubinemia, Splenomegaly, Hypothermia, Thrombocytopen... OMIM:251880
Hypotonia, Hypoventilation, Impaired Intellectual Development, Dysautonomia, Epilepsy, And Eye Abnormalities
Recurrent pneumonia, Fever, Obesity, Hypothermia, Abnormality of temperature regulation OMIM:618493
Neutropenia, Severe Congenital, 4, Autosomal Recessive
Failure to thrive, Lymphopenia, Hepatosplenomegaly, Leukopenia, Splenomegaly, Otitis media, Eryth... OMIM:612541
Congenital Hypothyroidism Due To Maternal Intake Of Antithyroid Drugs
Large for gestational age, Hypothermia ORPHA:226313
X-Linked Severe Congenital Neutropenia
Monocytopenia, Neutropenia ORPHA:86788
Sudden Infant Death-Dysgenesis Of The Testes Syndrome
Hypothermia ORPHA:168593
Rigidity And Multifocal Seizure Syndrome, Lethal Neonatal
Hypothermia OMIM:614498
Neuroleptic Malignant Syndrome
Hyperphosphatemia, Fever, Hypomagnesemia, Aspiration pneumonia, Leukocytosis, Hypocalcemia, Hyper... ORPHA:94093
Combined Oxidative Phosphorylation Deficiency 37
Hypoalbuminemia, Hypothermia, Hyperalaninemia, Failure to thrive OMIM:618329
Carnitine-Acylcarnitine Translocase Deficiency
Elevated circulating acylcarnitine concentration, Decreased circulating carnitine concentration, ... ORPHA:159
Marburg Hemorrhagic Fever
Neutrophilia in presence of infection, Lymphopenia, Hypothermia, Increased circulating antibody l... ORPHA:99826
Dopamine Beta-Hydroxylase Deficiency
Elevated circulating creatinine concentration, Hypothermia, Increased blood urea nitrogen, Anemia... ORPHA:230
Vulvovaginal Gingival Syndrome
Abnormality of tumor necrosis factor secretion ORPHA:83453
Genetic Transient Congenital Hypothyroidism
Hypothermia, Increased circulating thyroglobulin concentration ORPHA:226316
Autoinflammatory Syndrome, Familial, X-Linked, Behcet-Like 2
Decreased proportion of memory B cells, Reduced natural killer cell count, Inflammation of the la... OMIM:301074
Isolated Thyroid-Stimulating Hormone Deficiency
Neonatal hyperbilirubinemia, Failure to thrive, Hypothermia, Abnormal circulating thyroglobulin c... ORPHA:90674
Methylmalonic Acidemia With Homocystinuria, Type Cblc
Elevated circulating palmitoleylcarnitine concentration, Failure to thrive, Hyperammonemia, Hypom... ORPHA:79282
Hypothyroidism Due To Tsh Receptor Mutations
Neonatal hyperbilirubinemia, Hypothermia, Increased circulating thyroglobulin concentration ORPHA:90673
Sudden Infant Death With Dysgenesis Of The Testes Syndrome
Hypothermia OMIM:608800
Orthostatic Hypotension 1
Elevated circulating dihydroxyphenylacetic acid concentration, Increased blood urea nitrogen, Int... OMIM:223360
Mitochondrial Dna-Associated Leigh Syndrome
Fever, Failure to thrive, Hypothermia, Low plasma citrulline, Hyperalaninemia ORPHA:255210
Psoriasis-Related Juvenile Idiopathic Arthritis
Uveitis, Abnormality of tumor necrosis factor secretion, Sacroiliac arthritis, Psoriasiform derma... ORPHA:85436
Tbck-Related Intellectual Disability Syndrome
Hypothermia, Eczematoid dermatitis, Abnormal circulating lipid concentration ORPHA:488632
Alexander Disease
Hypothermia, Failure to thrive, Infectious encephalitis ORPHA:58
Ethylene Glycol Poisoning
Hypothermia, Gastritis, Hyperkalemia, Hypocalcemia ORPHA:31826
Bronchiectasis, Fever, Parotitis, Leukopenia, Hypercalcemia, Hypothermia, Increased T cell count,... ORPHA:797
Fatal Infantile Lactic Acidosis With Methylmalonic Aciduria
Hypothermia, Failure to thrive, Methylmalonic acidemia ORPHA:17
Adult-Onset Autosomal Dominant Leukodystrophy
Temperature instability, Hypothermia, Aspiration pneumonia ORPHA:99027
Interstitial Cystitis
Elevated circulating C-reactive protein concentration, Urinary bladder inflammation, Abnormality ... ORPHA:37202
Hypothyroidism, Congenital, Nongoitrous, 2
Hyperbilirubinemia, Hypothermia, Increased circulating thyroglobulin concentration OMIM:218700
Aromatic L-Amino Acid Decarboxylase Deficiency
Intermittent hypothermia, Temperature instability OMIM:608643
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Fever, Obesity, Hyperlipidemia, Hypothermia, Infectious encephalitis, Hyponatremia ORPHA:293987
Hereditary Sensory And Autonomic Neuropathy Type 4
Unexplained fevers, Septic arthritis, Recurrent fever, Fasciitis, Osteomyelitis, Abscess, Hypothe... ORPHA:642
Menkes Disease
Osteomyelitis, Hypothermia ORPHA:565
Hypothyroidism Due To Deficient Transcription Factors Involved In Pituitary Development Or Function
Overweight, Hypothermia ORPHA:226307
Occipital Horn Syndrome
Hypothermia, Esophagitis, Hepatitis ORPHA:198
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome
Anemia, Decreased circulating iron concentration, Hypothermia, Aspiration pneumonia ORPHA:438213


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Nlrc3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Nlrc3.

No publications found that use IMPC mice or data for Nlrc3.

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Nlrc3tm452123(Ifitm2_intron_L1L2_GT0_LF2A_LacZ_BetactP_neo) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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