The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
|Phenotype||System||Allele||Zyg||Sex||Life Stage||P Value|
|abnormal allantois morphology||Alg6em1(IMPC)Tcp||HOM||E9.5||0.00|
|decreased exploration in new environment||Alg6em1(IMPC)Tcp||HET||Early adult||8.11×10-05|
|embryonic growth retardation||Alg6em1(IMPC)Tcp||HOM||E9.5||0.00|
|prenatal lethality prior to heart atrial septation||Alg6em1(IMPC)Tcp||HOM||E15.5||0.00|
|preweaning lethality, complete penetrance||Alg6em1(IMPC)Tcp||HOM||Early adult||0.00|
|enlarged urinary bladder||Alg6em1(IMPC)Tcp||HET||Early adult||0.00|
|enlarged lymph nodes||Alg6em1(IMPC)Tcp||HET||Early adult||0.00|
|abnormal embryo size||Alg6em1(IMPC)Tcp||HOM||E9.5||0.00|
|abnormal skin morphology||Alg6em1(IMPC)Tcp||HET||Early adult||0.00|
|abnormal embryo development||Alg6em1(IMPC)Tcp||HOM||E9.5||0.00|
|abnormal sensory capabilities/reflexes/nociception||Alg6em1(IMPC)Tcp||HET||Early adult||0.000158 *|
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Alg6 by orthology or direct annotation.
The table below shows human diseases predicted to be associated to Alg6 by phenotypic similarity.
|Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation||
||Absent tonsils, Lymph node hypoplasia, Aplasia of the thymus||OMIM:602450|
|T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency||
||Absent tonsils, Lymph node hypoplasia, Hepatomegaly||ORPHA:276|
||Absence of lymph node germinal center, Lymph node hypoplasia||ORPHA:90186|
|Purine Nucleoside Phosphorylase Deficiency||
||Lymph node hypoplasia, Splenomegaly||OMIM:613179|
||Lymph node hypoplasia||OMIM:300755|
|Congenital Disorder Of Glycosylation, Type Ic||
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|MGI Allele||Allele Type||Produced|
|Alg6tm1a(EUCOMM)Hmgu||KO first allele (reporter-tagged insertion with conditional potential)||Targeting vectors, ES Cells|
|Alg6tm1e(EUCOMM)Hmgu||Targeted, non-conditional allele||ES Cells|