Gene Summary

Name:
asparagine-linked glycosylation 6 (alpha-1,3,-glucosyltransferase)
Synonyms:
E230028F23Rik

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal allantois morphology Alg6em1(IMPC)Tcp HOM E9.5 0.00
decreased exploration in new environment Alg6em1(IMPC)Tcp HET Early adult 8.11×10-05
embryonic growth retardation Alg6em1(IMPC)Tcp HOM E9.5 0.00
prenatal lethality prior to heart atrial septation Alg6em1(IMPC)Tcp HOM   E15.5 0.00
preweaning lethality, complete penetrance Alg6em1(IMPC)Tcp HOM   Early adult 0.00
enlarged urinary bladder Alg6em1(IMPC)Tcp HET Early adult 0.00
enlarged lymph nodes Alg6em1(IMPC)Tcp HET Early adult 0.00
abnormal embryo size Alg6em1(IMPC)Tcp HOM E9.5 0.00
abnormal skin morphology Alg6em1(IMPC)Tcp HET Early adult 0.00
abnormal embryo development Alg6em1(IMPC)Tcp HOM E9.5 0.00
abnormal sensory capabilities/reflexes/nociception Alg6em1(IMPC)Tcp HET Early adult 0.000158 *

Download data as:  TSV  XLS

* Significant with a threshold of 1x10-3, check the Pain Sensitivity page for more information.
Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes
* Significant with a threshold of 1x10-3, check the Pain Sensitivity page for more information.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Eye Morphology

Images Ophthalmoscopy

81 Images

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

Gross Morphology Embryo E9.5

Images

11 Images

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

X-ray

XRay Images Skull Lateral Orientation

10 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

Gross Pathology and Tissue Collection

Images

8 Images

Human diseases caused by Alg6 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Alg6 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Congenital Disorder Of Glycosylation, Type Ic
OMIM:603147
Alg6-Cdg
ORPHA:79320

The table below shows human diseases predicted to be associated to Alg6 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation
Absent tonsils, Lymph node hypoplasia, Aplasia of the thymus OMIM:602450
T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency
Absent tonsils, Lymph node hypoplasia, Hepatomegaly ORPHA:276
Meige Disease
Absence of lymph node germinal center, Lymph node hypoplasia ORPHA:90186
Purine Nucleoside Phosphorylase Deficiency
Lymph node hypoplasia, Splenomegaly OMIM:613179
Agammaglobulinemia, X-Linked
Lymph node hypoplasia OMIM:300755
Congenital Disorder Of Glycosylation, Type Ic
OMIM:603147
Alg6-Cdg
ORPHA:79320

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Alg6

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Alg6.

No publications found that use IMPC mice or data for Alg6.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Alg6em1(IMPC)Tcp Exon Deletion Mice
Alg6tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Alg6tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells

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