Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
enlarged lymph nodes | Alg6em1(IMPC)Tcp | HET | Early adult | 0.00 | ||
abnormal embryo development | Alg6em1(IMPC)Tcp | HOM | E9.5 | 0.00 | ||
abnormal allantois morphology | Alg6em1(IMPC)Tcp | HOM | E9.5 | 0.00 | ||
embryonic growth retardation | Alg6em1(IMPC)Tcp | HOM | E9.5 | 0.00 | ||
abnormal sensory capabilities/reflexes/nociception | Alg6em1(IMPC)Tcp | HET | Early adult | 0.000158 * | ||
preweaning lethality, complete penetrance | Alg6em1(IMPC)Tcp | HOM | Early adult | 0.00 | ||
abnormal skin morphology | Alg6em1(IMPC)Tcp | HET | Early adult | 0.00 | ||
prenatal lethality prior to heart atrial septation | Alg6em1(IMPC)Tcp | HOM | E15.5 | 0.00 | ||
enlarged urinary bladder | Alg6em1(IMPC)Tcp | HET | Early adult | 0.00 | ||
abnormal embryo size | Alg6em1(IMPC)Tcp | HOM | E9.5 | 0.00 |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Alg6 by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Congenital Disorder Of Glycosylation, Type Ic | OMIM:603147 | ||
Alg6-Cdg | ORPHA:79320 |
The table below shows human diseases predicted to be associated to Alg6 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation | Generalized lymphadenopathy, Absent tonsils, Lymph node hypoplasia, Hepatomegaly, Aplasia of the ... | OMIM:602450 | |
T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency | Absent tonsils, Lymph node hypoplasia, Hepatomegaly | ORPHA:276 | |
Meige Disease | Absence of lymph node germinal center, Lymph node hypoplasia | ORPHA:90186 | |
Purine Nucleoside Phosphorylase Deficiency | Lymph node hypoplasia, Splenomegaly | OMIM:613179 | |
Agammaglobulinemia, X-Linked | Lymph node hypoplasia | OMIM:300755 | |
Congenital Disorder Of Glycosylation, Type Ic | OMIM:603147 | ||
Alg6-Cdg | ORPHA:79320 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Alg6em1(IMPC)Tcp | Exon Deletion | Mice |
Alg6tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Alg6tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | ES Cells |
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