Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
enlarged lymph nodes | Alg6em1(IMPC)Tcp | HET | Early adult | 0.00 | ||
abnormal embryo development | Alg6em1(IMPC)Tcp | HOM | E9.5 | 0.00 | ||
embryonic growth retardation | Alg6em1(IMPC)Tcp | HOM | E9.5 | 0.00 | ||
abnormal allantois morphology | Alg6em1(IMPC)Tcp | HOM | E9.5 | 0.00 | ||
prenatal lethality prior to heart atrial septation | Alg6em1(IMPC)Tcp | HOM | E15.5 | 0.00 | ||
enlarged urinary bladder | Alg6em1(IMPC)Tcp | HET | Early adult | 0.00 | ||
decreased exploration in new environment | Alg6em1(IMPC)Tcp | HET | Early adult | 8.30×10-05 | ||
abnormal sensory capabilities/reflexes/nociception | Alg6em1(IMPC)Tcp | HET | Early adult | 0.000158 * | ||
abnormal embryo size | Alg6em1(IMPC)Tcp | HOM | E9.5 | 0.00 | ||
abnormal skin morphology | Alg6em1(IMPC)Tcp | HET | Early adult | 0.00 | ||
preweaning lethality, complete penetrance | Alg6em1(IMPC)Tcp | HOM | Early adult | 0.00 |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Alg6 by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Congenital Disorder Of Glycosylation, Type Ic | OMIM:603147 | ||
Alg6-Cdg | ORPHA:79320 |
The table below shows human diseases predicted to be associated to Alg6 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation | Hepatomegaly, Generalized lymphadenopathy, Aplasia of the thymus, Splenomegaly, Lymph node hypopl... | OMIM:602450 | |
T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency | Lymph node hypoplasia, Absent tonsils, Hepatomegaly | ORPHA:276 | |
Meige Disease | Lymph node hypoplasia, Absence of lymph node germinal center | ORPHA:90186 | |
Purine Nucleoside Phosphorylase Deficiency | Splenomegaly, Lymph node hypoplasia | OMIM:613179 | |
Agammaglobulinemia, X-Linked | Lymph node hypoplasia | OMIM:300755 | |
Congenital Disorder Of Glycosylation, Type Ic | OMIM:603147 | ||
Alg6-Cdg | ORPHA:79320 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Alg6em1(IMPC)Tcp | Exon Deletion | Mice |
Alg6tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Alg6tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | ES Cells |
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