Gene Summary

Name:
exocyst complex component 3
Synonyms:
E430013E20Rik,  Sec6l1,  2810050O03Rik

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
increased lean body mass Exoc3tm2b(EUCOMM)Hmgu HET Early adult 5.35×10-07
decreased fasting circulating glucose level Exoc3tm2b(EUCOMM)Hmgu HET Early adult 3.82×10-05
decreased total body fat amount Exoc3tm2b(EUCOMM)Hmgu HET Early adult 3.44×10-06

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Legacy Phenotype Associated Images

Human diseases caused by Exoc3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Exoc3 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Hyperinsulinemic Hypoglycemia, Familial, 2
Hyperinsulinemic hypoglycemia, Hypoglycemia, Large for gestational age OMIM:601820
Hyperinsulinemic Hypoglycemia, Familial, 7
Hyperinsulinemic hypoglycemia, Hypoglycemic seizures, Hypoglycemia, Hyperinsulinemia OMIM:610021

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Exoc3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Exoc3.

There are 7 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Loss of the exocyst complex component EXOC3 promotes hemostasis and accelerates arterial thrombosis. Blood advances (February 2021) Exoc3tm2a(EUCOMM)Hmgu PMC7876885
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Exoc3tm2b(EUCOMM)Hmgu Exoc3l2tm1a(KOMP)Wtsi Exoc3l2tm1b(KOMP)Wtsi PMC7263671
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation. Nature immunology (December 2019) Exoc3l2tm1b(KOMP)Wtsi PMC7338221
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Exoc3tm2b(EUCOMM)Hmgu Exoc3tm2b(EUCOMM)Hmgu Exoc3l2tm1a(KOMP)Wtsi Exoc3l2tm1b(KOMP)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Exoc3l2tm1a(KOMP)Wtsi Exoc3l2tm1b(KOMP)Wtsi PMC6459510
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Exoc3l2tm1b(KOMP)Wtsi Exoc3l2tm1a(KOMP)Wtsi PMC5827107
Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice. Wellcome open research (January 2016) Exoc3l2tm1b(KOMP)Wtsi PMC5159622

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MGI Allele Allele Type Produced
Exoc3tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Exoc3tm2a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Exoc3tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Exoc3tm2b(EUCOMM)Hmgu Reporter-tagged deletion allele (with selection cassette) Mice
Exoc3tm2e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Exoc3tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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