banner
Genes Phenotypes Help, News, Blog

Gene: Lypd6 MGI:2443848

Log in to follow

Gene Summary

Name:
LY6/PLAUR domain containing 6
Synonyms:
E130115E03Rik

Order Alleles

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal skin morphology Lypd6tm1b(KOMP)Wtsi HET Early adult 0.00
abnormal testis morphology Lypd6tm1b(KOMP)Wtsi HET Early adult 0.00
preweaning lethality, incomplete penetrance Lypd6tm1b(KOMP)Wtsi HOM   Early adult 0.00
small superior vagus ganglion Lypd6tm1b(KOMP)Wtsi HET Early adult 0.00
hydrometra Lypd6tm1b(KOMP)Wtsi HET Early adult 0.00
thick skin Lypd6tm1b(KOMP)Wtsi HET Early adult 0.00
scaly skin Lypd6tm1b(KOMP)Wtsi HET Early adult 0.00
small testis Lypd6tm1b(KOMP)Wtsi HET Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Adrenal gland N/A heterozygote 0.0% (0 of 2)
Aorta N/A heterozygote 0.0% (0 of 2)
Blood N/A heterozygote 0.0% (0 of 2)
Bone marrow N/A heterozygote 0.0% (0 of 2)
Brain N/A heterozygote 50% (1 of 2)
Brainstem N/A heterozygote Not available
Brown adipose tissue N/A heterozygote 0.0% (0 of 2)
Cartilage tissue N/A heterozygote Not available
Cecum N/A heterozygote 0.0% (0 of 2)
Cerebellum N/A heterozygote 0.0% (0 of 2)
Cerebral cortex N/A heterozygote Not available
Chest bone N/A heterozygote Not available
Colon N/A heterozygote 0.0% (0 of 2)
Diaphragm N/A heterozygote 0.0% (0 of 2)
Duodenum N/A heterozygote 0.0% (0 of 2)
Epididymis N/A heterozygote 50% (1 of 2)
Esophagus N/A heterozygote 50% (1 of 2)
Eye N/A heterozygote 50% (1 of 2)
Gall bladder N/A heterozygote Not available
Gonadal fat pad N/A heterozygote 0.0% (0 of 2)
Harderian gland N/A heterozygote 0.0% (0 of 2)
Heart N/A heterozygote Not available
Hindlimb N/A heterozygote Not available
Hippocampus N/A heterozygote Not available
Hypothalamus N/A heterozygote Not available
Ileum N/A heterozygote 50% (1 of 2)
Jejunum N/A heterozygote 0.0% (0 of 2)
Kidney N/A heterozygote 100% (2 of 2)
Large intestine N/A heterozygote 0.0% (0 of 2)
Liver N/A heterozygote 0.0% (0 of 2)
Lower urinary tract N/A heterozygote Not available
Lung N/A heterozygote 0.0% (0 of 2)
Lymph node N/A heterozygote Not available
Mammary gland N/A heterozygote 0.0% (0 of 2)
Mesenteric adipose tissue N/A heterozygote 0.0% (0 of 2)
Mesenteric lymph node N/A heterozygote 0.0% (0 of 2)
Midbrain N/A heterozygote 0.0% (0 of 2)
Olfactory lobe N/A heterozygote 0.0% (0 of 2)
Ovary N/A heterozygote 0.0% (0 of 2)
Oviduct N/A heterozygote 0.0% (0 of 2)
Pancreas N/A heterozygote 0.0% (0 of 2)
Parathyroid gland N/A heterozygote 0.0% (0 of 2)
Parotid gland N/A heterozygote 0.0% (0 of 2)
Penis N/A heterozygote 50% (1 of 2)
Peripheral nervous system N/A heterozygote Not available
Peyer's patch N/A heterozygote Not available
Pituitary gland N/A heterozygote 0.0% (0 of 2)
Prostate gland N/A heterozygote 50% (1 of 2)
Quadriceps N/A heterozygote 0.0% (0 of 2)
Sciatic nerve N/A heterozygote 0.0% (0 of 2)
Skeletal muscle N/A heterozygote Not available
Skin N/A heterozygote 0.0% (0 of 2)
Small intestine N/A heterozygote 50% (1 of 2)
Spinal cord N/A heterozygote 0.0% (0 of 2)
Spleen N/A heterozygote 0.0% (0 of 2)
Stomach pyloric region N/A heterozygote Not available
Stomach N/A heterozygote 0.0% (0 of 2)
Striatum N/A heterozygote Not available
Sublingual gland N/A heterozygote 0.0% (0 of 2)
Submandibular gland N/A heterozygote 0.0% (0 of 2)
Testis N/A heterozygote 50% (1 of 2)
Thymus N/A heterozygote 0.0% (0 of 2)
Thyroid gland N/A heterozygote 0.0% (0 of 2)
Tongue N/A heterozygote 100% (2 of 2)
Trachea N/A heterozygote 0.0% (0 of 2)
Trigeminal V nerve N/A heterozygote 0.0% (0 of 2)
Urinary bladder N/A heterozygote 0.0% (0 of 2)
Uterus N/A heterozygote 0.0% (0 of 2)
Vagina N/A heterozygote 0.0% (0 of 2)
Vas deferens N/A heterozygote 50% (1 of 2)
Vascular system N/A heterozygote Not available
Vesicular gland N/A heterozygote 50% (1 of 2)
White adipose tissue N/A heterozygote Not available
No Embryo expression data was found for this gene.

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)
adrenal gland 0.0%
aorta 0.0%
blood
bone marrow
brain 0.0%
brainstem 0.0%
brown adipose tissue 0.0%
cartilage tissue 0.0%
cecum 0.0%
cerebellum 0.0%
cerebral cortex 0.0%
chest bone
colon
diaphragm 0.0%
duodenum 0.0%
epididymis Unavailable
esophagus 0.0%
eye 0.0%
gall bladder 0.0%
gonadal fat pad 0.0%
harderian gland
heart 0.0%
hindlimb 0.0%
hippocampus 0.0%
hypothalamus 0.0%
ileum 0.0%
jejunum
kidney 0.0%
large intestine 0.0%
liver 0.0%
lower urinary tract 0.0%
lung 0.0%
lymph node 0.0%
mammary gland 0.0%
mesenteric adipose tissue 0.0%
mesenteric lymph node
midbrain 0.0%
olfactory lobe 0.0%
ovary 0.0%
oviduct 0.0%
pancreas 0.0%
parathyroid gland 0.0%
parotid gland 0.0%
penis 0.0%
peripheral nervous system 0.0%
peyers patch 0.0%
pituitary gland 0.0%
prostate gland 0.0%
quadriceps 0.0%
sciatic nerve 0.0%
skeletal muscle 0.0%
skin 0.0%
small intestine 0.0%
spinal cord 0.0%
spleen 0.0%
stomach 0.0%
stomach pyloric region 0.0%
striatum 0.0%
sublingual gland 0.0%
submandibular gland 0.0%
testis 0.0%
thymus 0.0%
thyroid gland 0.0%
tongue 0.0%
trachea 0.0%
trigeminal v nerve 0.0%
urinary bladder
uterus 0.0%
vagina 0.0%
vas deferens Unavailable
vascular system 0.0%
vesicular gland Unavailable
white adipose tissue 0.0%
No Embryo expression data was found for this gene.

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Adult LacZ

LacZ Images Section

27 Images

View images
X-ray

XRay Images Whole Body Dorso Ventral

10 Images

View images
X-ray

XRay Images Whole Body Lateral Orientation

10 Images

View images
X-ray

XRay Images Forepaw

1 Images

View images
X-ray

XRay Images Hind Leg and Hip

1 Images

View images
X-ray

XRay Images Skull Dorso Ventral Orientation

1 Images

View images
X-ray

XRay Images Skull Lateral Orientation

1 Images

View images

Human diseases caused by Lypd6 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Lypd6 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Peeling Skin Syndrome 5
Epidermal acanthosis, Scaling skin OMIM:617115
Peeling Skin Syndrome 2
Erythema, Scaling skin OMIM:609796
Krt1-Related Diffuse Nonepidermolytic Keratoderma
Erythema, Scaling skin, Palmoplantar scaling skin, Dry skin ORPHA:530838
Peeling Skin Syndrome 3
Erythema, White scaling skin OMIM:616265
Psoriasis 2
Epidermal acanthosis, Psoriasiform dermatitis, Scaling skin OMIM:602723
Amyloidosis, Primary Localized Cutaneous, 1
Dry skin, Scaling skin OMIM:105250
Ichthyosis, Congenital, Autosomal Recessive 12
White scaling skin OMIM:617320
Ichthyosis Hystrix, Curth-Macklin Type
Scaling skin OMIM:146590
Ichthyosis, Congenital, Autosomal Recessive 14
Erythema, Scaling skin OMIM:617571
Testicular Regression Syndrome
Abnormal morphology of female internal genitalia, Decreased testicular size, Decreased fertility,... ORPHA:983
Hypogonadism, Male
Micropenis, Male hypogonadism, Hypospadias, Testicular atrophy OMIM:241100
Acral Peeling Skin Syndrome
Erythema, Excessive wrinkling of palmar skin, Scaling skin ORPHA:263534
Keratosis Palmoplantaris Striata Ii
Epidermal acanthosis OMIM:612908
Epidermolytic Hyperkeratosis 1
Epidermal acanthosis, Scaling skin OMIM:113800
Dowling-Degos Disease 4
Epidermal acanthosis OMIM:615696
Ichthyosis-Alopecia-Eclabion-Ectropion-Intellectual Disability Syndrome
Dry skin, Epidermal acanthosis, Cutis laxa, Scaling skin ORPHA:2269
Acral Self-Healing Collodion Baby
Erythema, Palmoplantar scaling skin, Lack of skin elasticity ORPHA:281127
Leydig Cell Hypoplasia
Cryptorchidism, Male pseudohermaphroditism, Abnormal internal genitalia, Primary amenorrhea, Fema... ORPHA:755
46,Xy Sex Reversal 11
Elevated circulating luteinizing hormone level, Vanishing testis, Decreased serum testosterone co... OMIM:273250
Palmoplantar Keratoderma, Nagashima Type
Epidermal acanthosis OMIM:615598
Epidermolysis Bullosa Simplex 4, Localized Or Generalized Intermediate, Autosomal Recessive
Epidermal acanthosis OMIM:615028
Verrucous Hemangioma
Epidermal acanthosis ORPHA:464318
Idiopathic Localized Lipodystrophy
Erythema, Scaling skin ORPHA:90158
Spermatogenic Failure, X-Linked, 2
Spermatogenesis maturation arrest, Azoospermia, Testicular atrophy, Male infertility OMIM:309120
Aicardi-Goutieres Syndrome 5
Dry skin, Scaling skin OMIM:612952
Isolated Follicle Stimulating Hormone Deficiency
Decreased serum estradiol, Male hypogonadism, Decreased serum testosterone concentration, Decreas... ORPHA:52901
46,Xy Gonadal Dysgenesis-Motor And Sensory Neuropathy Syndrome
Decreased serum estradiol, Male hypogonadism, Abnormal vagina morphology, Gonadal dysgenesis, Abn... ORPHA:168563
Ovarian Dysgenesis 6
Absence of pubertal development, Hypoplasia of the uterus, Hypergonadotropic hypogonadism, Primar... OMIM:618078
Ichthyosis With Erythrokeratoderma
Erythema, Epidermal acanthosis, Scaling skin OMIM:620507
Peeling Skin Syndrome 4
Epidermal acanthosis, Scaling skin OMIM:607936
Familial Reactive Perforating Collagenosis
Abnormal epidermal morphology ORPHA:79147
Hypotrichosis Simplex Of The Scalp
Epidermal acanthosis, Scaling skin ORPHA:90368
Ovarian Dysgenesis 2
Streak ovary, Delayed puberty, Primary amenorrhea, Premature ovarian insufficiency, Hypoplasia of... OMIM:300510
46,Xx Ovotesticular Difference Of Sex Development
Small scrotum, Hypospadias, Bifid scrotum, Abnormal morphology of female internal genitalia, Abno... ORPHA:2138
Pemphigus Foliaceus
Erythema, Psoriasiform dermatitis, Skin vesicle, Scaling skin, Acantholysis ORPHA:79481
Hypogonadotropic Hypogonadism 12 With Or Without Anosmia
Decreased serum estradiol, Decreased circulating gonadotropin concentration, Decreased serum test... OMIM:614841
Peeling Skin Syndrome 6
Dry skin, Scaling skin OMIM:618084
Ichthyosis, Annular Epidermolytic, 2
Erythema, Scaling skin OMIM:620148
Woodhouse-Sakati Syndrome
Decreased serum estradiol, Insulin-resistant diabetes mellitus, Decreased response to growth horm... ORPHA:3464
Diethylstilbestrol Syndrome
Hypoplasia of the uterus, Abnormality of the uterus, Vaginal neoplasm, Cryptorchidism, Testicular... ORPHA:1916
Ichthyosis, Spastic Quadriplegia, And Impaired Intellectual Development
Erythema, Scaling skin, Dry skin OMIM:614457
Complete Androgen Insensitivity Syndrome
Elevated circulating luteinizing hormone level, Abnormal morphology of female internal genitalia,... ORPHA:99429
Cutaneous Mastocytoma
Erythema, Scaling skin ORPHA:79455
Erythrokeratodermia Variabilis Et Progressiva 4
Erythema, Epidermal acanthosis OMIM:617526
Ichthyosis, Congenital, Autosomal Recessive 6
Dry skin, Epidermal acanthosis, Scaling skin OMIM:612281
Ichthyosis Vulgaris
Dry skin, Absent keratohyalin granules OMIM:146700
Spinocerebellar Ataxia 32
Testicular atrophy, Infertility, Azoospermia OMIM:613909
Ichthyosis With Confetti
Hypoplastic nipples, Scaling skin OMIM:609165
Partial Androgen Insensitivity Syndrome
Clitoral hypertrophy, Elevated circulating luteinizing hormone level, Increased serum estradiol, ... ORPHA:90797
Spinocerebellar Ataxia Type 32
Testicular atrophy, Azoospermia, Male infertility ORPHA:276183
46,Xy Sex Reversal 3
Clitoral hypertrophy, Elevated circulating luteinizing hormone level, Gonadal dysgenesis, Ambiguo... OMIM:612965
Hypogonadotropic Hypogonadism 8 With Or Without Anosmia
Absence of pubertal development, Azoospermia, Decreased testicular size, Cryptorchidism, Hypogona... OMIM:614837
Mpdu1-Cdg
Decreased response to growth hormone stimulation test, Optic atrophy, Decreased serum insulin-lik... ORPHA:79323
Vulvovaginal Gingival Syndrome
Abnormal female external genitalia morphology, Erythema, Epidermal acanthosis ORPHA:83453
Peeling Skin With Leukonychia, Acral Punctate Keratoses, Cheilitis, And Knuckle Pads
Dry skin, Acantholysis, Epidermal acanthosis, Scaling skin OMIM:616295
Kennedy Disease
Testicular atrophy, Type II diabetes mellitus, Decreased fertility, Erectile dysfunction ORPHA:481
Premature Ovarian Failure 7
Clitoral hypertrophy, Elevated circulating luteinizing hormone level, Gonadal dysgenesis, Elevate... OMIM:612964
Bathing Suit Ichthyosis
Epidermal acanthosis, Scaling skin ORPHA:100976
Centrifugal Lipodystrophy
Erythema, Scaling skin ORPHA:90156
Ichthyosis, Annular Epidermolytic, 1
Erythema, Scaling skin OMIM:607602
Glycogen Storage Disease Due To Lactate Dehydrogenase M-Subunit Deficiency
Psoriasiform lesion, Scaling skin ORPHA:284426
Congenital Disorder Of Glycosylation, Type If
Optic atrophy, Scaling skin, Dry skin OMIM:609180
Peeling Skin Syndrome 1
Scaling skin OMIM:270300
Cancer, Alopecia, Pigment Dyscrasia, Onychodystrophy, And Keratoderma
Dry skin, Scaling skin, Multinodular goiter OMIM:618373
Congenital Adrenal Hyperplasia Due To 17-Alpha-Hydroxylase Deficiency
Elevated circulating luteinizing hormone level, Absence of pubertal development, Decreased fertil... ORPHA:90793
Perrault Syndrome 6
Irregular menstruation, Streak ovary, Primary amenorrhea, Premature ovarian insufficiency, Hypopl... OMIM:617565
Testicular Agenesis
Absent external genitalia, Hypoplasia of the uterus, Vanishing testis, Decreased serum testostero... ORPHA:325124
Premature Ovarian Failure 3
Premature ovarian insufficiency, Hypoplasia of the uterus, Secondary amenorrhea OMIM:608996
Ovarian Dysgenesis 9
Decreased serum estradiol, Elevated circulating luteinizing hormone level, Hypoplasia of the ovar... OMIM:619665
Atrophoderma Vermiculata
Erythema, Abnormal epidermal morphology ORPHA:79100
Premature Ovarian Failure 6
Elevated circulating luteinizing hormone level, Female infertility, Streak ovary, Elevated circul... OMIM:612310
Recon Progeroid Syndrome
Dry skin, Scaling skin, Thin skin OMIM:620370
Premature Ovarian Failure 18
Irregular menstruation, Elevated circulating luteinizing hormone level, Hypoplasia of the ovary, ... OMIM:619203
Bazex Syndrome
Scaling skin ORPHA:166113
Myoectodermal Gonadal Dysgenesis Syndrome
Elevated circulating luteinizing hormone level, Gonadal dysgenesis, Dry skin, Hypoplastic labia m... OMIM:618419
Immunodeficiency 41 With Lymphoproliferation And Autoimmunity
Type I diabetes mellitus, Psoriasiform dermatitis, Hypothyroidism, Scaling skin, Thyroiditis OMIM:606367
Ectodermal Dysplasia/Skin Fragility Syndrome
Scaling skin OMIM:604536
Ichthyosis, Congenital, Autosomal Recessive 5
Epidermal acanthosis, White scaling skin OMIM:604777
Elastosis Perforans Serpiginosa
Epidermal acanthosis, Cutis laxa ORPHA:79148
Hypogonadotropic Hypogonadism 1 With Or Without Anosmia
Small scrotum, Decreased serum testosterone concentration, Decreased testicular size, Hypothalami... OMIM:308700
Ovarian Dysgenesis 7
Decreased serum estradiol, Elevated circulating luteinizing hormone level, Delayed puberty, Eleva... OMIM:618117
Kallmann Syndrome With Spastic Paraplegia
Hypothalamic gonadotropin-releasing hormone deficiency, Cryptorchidism, Hypogonadotropic hypogona... OMIM:308750
Premature Ovarian Failure 13
Female infertility, Amenorrhea, Oligomenorrhea, Elevated circulating follicle stimulating hormone... OMIM:617442
46,Xy Sex Reversal 7
Sex reversal, Hypoplasia of the fallopian tube, Streak ovary, Abnormal epididymis morphology, Gon... OMIM:233420
Acute Generalized Exanthematous Pustulosis
Skin vesicle, Acantholysis, Purpura, Scaling skin ORPHA:293173
Spinal And Bulbar Muscular Atrophy, X-Linked 1
Testicular atrophy, Decreased fertility OMIM:313200
Mal De Meleda
Erythema, Epidermal acanthosis ORPHA:87503
Perrault Syndrome 3
Elevated circulating luteinizing hormone level, Streak ovary, Elevated circulating follicle stimu... OMIM:614129
Keratoderma Hereditarium Mutilans With Ichthyosis
Epidermal acanthosis, Scaling skin on fingertip ORPHA:79395
46,Xy Partial Gonadal Dysgenesis
Clitoral hypertrophy, Elevated circulating luteinizing hormone level, Abnormal vagina morphology,... ORPHA:251510
Acute Radiation Syndrome
Skin ulcer, Scaling skin ORPHA:454831
Diffuse Cutaneous Mastocytosis
Scaling skin ORPHA:79456
Mullerian Aplasia And Hyperandrogenism
Increased circulating dehydroepiandrosterone-sulfate concentration, Increased circulating androst... OMIM:158330
Normosmic Congenital Hypogonadotropic Hypogonadism
Male hypogonadism, Absence of secondary sex characteristics, Absence of pubertal development, Non... ORPHA:432
Mayer-Rokitansky-Kuster-Hauser Syndrome
Hematocolpos, Abnormal female external genitalia morphology, Aplasia of the vagina, Polycystic ov... OMIM:277000
46,Xy Difference Of Sex Development Due To Isolated 17,20-Lyase Deficiency
Elevated circulating luteinizing hormone level, Decreased fertility, Cryptorchidism, Dysmenorrhea... ORPHA:90796
White Sponge Nevus 2
Epidermal acanthosis OMIM:615785
Ovarian Dysgenesis 5
Decreased serum estradiol, Elevated circulating luteinizing hormone level, Elevated circulating f... OMIM:617690
Hypogonadotropic Hypogonadism 13 With Or Without Anosmia
Decreased serum estradiol, Hypogonadotropic hypogonadism, Decreased circulating luteinizing hormo... OMIM:614842
X-Linked Dominant Chondrodysplasia Punctata
Scaling skin ORPHA:35173
Epidermodysplasia Verruciformis, Susceptibility To, 3
Epidermal acanthosis OMIM:618267
Renal And Mullerian Duct Hypoplasia
Aplasia of the uterus, Anteriorly displaced urethral meatus, Hydrocele testis OMIM:266810
Cardiomyopathy, Dilated, With Woolly Hair And Keratoderma
Acantholysis, Palmoplantar scaling skin, Palmoplantar erythema OMIM:605676
46,Xx Sex Reversal 2
Small scrotum, Elevated circulating luteinizing hormone level, Perineal hypospadias, Bifid scrotu... OMIM:278850
Myotonic Dystrophy 1
Testicular atrophy, Cholelithiasis, Facial diplegia, Hypogonadism OMIM:160900
Inherited Isolated Adrenal Insufficiency Due To Partial Cyp11A1 Deficiency
Midshaft hypospadias, Clitoral hypertrophy, Elevated circulating luteinizing hormone level, Abnor... ORPHA:289548
46,Xy Difference Of Sex Development-Adrenal Insufficiency Due To Cyp11A1 Deficiency
Midshaft hypospadias, Clitoral hypertrophy, Elevated circulating luteinizing hormone level, Abnor... ORPHA:168558
Epidermolytic Palmoplantar Keratoderma
Epidermal acanthosis ORPHA:2199
Neonatal Inflammatory Skin And Bowel Disease
Erythema, Psoriasiform dermatitis, Scaling skin ORPHA:294023
Superficial Epidermolytic Ichthyosis
Erythema, Acantholysis, Thin skin ORPHA:455
Perrault Syndrome 4
Decreased serum estradiol, Hypoplasia of the ovary, Oligomenorrhea, Primary amenorrhea, Increased... OMIM:615300
Graft Versus Host Disease
Scaling skin ORPHA:39812
Immunodeficiency 58
Psoriasiform lesion, Scaling skin OMIM:618131
Porphyria Cutanea Tarda
Diabetes mellitus, Scaling skin ORPHA:101330
Bacterial Toxic-Shock Syndrome
Scaling skin, Ecchymosis ORPHA:36234
Kid Syndrome
Epidermal acanthosis, Psoriasiform dermatitis, Scaling skin ORPHA:477
Basan Syndrome
Epidermal acanthosis OMIM:129200
Adrenal Hyperplasia, Congenital, Due To Steroid 11-Beta-Hydroxylase Deficiency
Clitoral hypertrophy, Long penis, Precocious puberty in males, Congenital adrenal hyperplasia, De... OMIM:202010
Infantile Digital Fibromatosis
Epidermal acanthosis ORPHA:199267
Proteus Syndrome
Epidermal acanthosis OMIM:176920
Immunodeficiency, Common Variable, 8, With Autoimmunity
Type I diabetes mellitus, Hypothyroidism, Psoriasiform lesion, Thyroiditis OMIM:614700
T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency
Psoriasiform lesion ORPHA:169154
Hydatidiform Mole
Menometrorrhagia, Hyperthyroidism, Enlarged uterus ORPHA:99927
Singleton-Merten Syndrome 2
Psoriasiform lesion OMIM:616298
Subacute Cutaneous Lupus Erythematosus
Psoriasiform lesion ORPHA:163525
Hemochromatosis, Type 1
Azoospermia, Hypogonadotropic hypogonadism, Amenorrhea, Testicular atrophy, Impotence, Diabetes m... OMIM:235200
Lipoid Proteinosis Of Urbach And Wiethe
Reduced epidermal extracellular matrix protein 1 protein expression OMIM:247100
Diaphragmatic Defects, Limb Deficiencies, And Ossification Defects Of Skull
Testicular atrophy OMIM:601163
Acrokeratosis Verruciformis
Acantholysis, Epidermal acanthosis OMIM:101900
Ichthyosis, Congenital, Autosomal Recessive 7
Epidermal acanthosis OMIM:615022
Vaginal Atresia
Imperforate hymen, Uterus didelphys, Abnormality of the uterus, Vaginal hematocele, Transverse va... ORPHA:65681
Congenital Syphilis
Optic atrophy, Palmoplantar scaling skin, Purpura, Petechiae ORPHA:499009
Autosomal Dominant Palmoplantar Keratoderma And Congenital Alopecia
Dry skin, Facial erythema, Scaling skin ORPHA:1010
Microcephaly-Lymphedema-Chorioretinopathy Syndrome
Optic atrophy, Scaling skin, Skin ulcer, Dry skin ORPHA:2526
Lumbar Syndrome
Bifid scrotum, Cryptorchidism, Hypoplastic labia majora, Ambiguous genitalia, Micropenis, Bifid u... ORPHA:83628
Erythrokeratodermia Variabilis Et Progressiva 1
Epidermal acanthosis OMIM:133200
Estrogen Resistance
Breast aplasia, Hyperinsulinemia, Increased serum estradiol, Polycystic ovaries, Increased circul... OMIM:615363
Inflammatory Skin And Bowel Disease, Neonatal, 2
Epidermal acanthosis OMIM:616069
Focal Facial Dermal Dysplasia Type Iv
Abnormal epidermal morphology ORPHA:398189
Ichthyosis, Congenital, Autosomal Recessive 8
Erythema, Epidermal acanthosis OMIM:613943
Riddle Syndrome
Erythema, Scaling skin ORPHA:420741
Ichthyosis, Congenital, Autosomal Recessive 2
Erythema, External genital hypoplasia, Epidermal acanthosis OMIM:242100
Neurodevelopmental Disorder With Hypotonia And Dysmorphic Facies
Small pituitary gland, Erythema, Decreased response to growth hormone stimulation test, Dry skin,... OMIM:619503
Classic Congenital Adrenal Hyperplasia Due To 21-Hydroxylase Deficiency
Premature adrenarche, Clitoral hypertrophy, Decreased fertility, Abnormal circulating dehydroepia... ORPHA:90794
Restrictive Dermopathy
Webbed neck, Congenital adrenal hypoplasia, Aplasia/Hypoplastia of the eccrine sweat glands, Scal... ORPHA:1662
Wolfram Syndrome 1
Optic atrophy, Hypothyroidism, Testicular atrophy, Diabetes insipidus, Diabetes mellitus OMIM:222300
Rat-Bite Fever
Scaling skin, Parotitis ORPHA:31205
Psoriasis 14, Pustular
Erythema, Epidermal acanthosis, Psoriasiform dermatitis OMIM:614204
Hypoparathyroidism, Sensorineural Deafness, And Renal Dysplasia Syndrome
Uterus didelphys, Septate vagina, Pseudopapilledema, Aplasia of the vagina, Aplasia of the uterus... OMIM:146255
Palmoplantar Keratoderma, Punctate Type Ia
Epidermal acanthosis OMIM:148600
Aarskog-Scott Syndrome
Elevated circulating luteinizing hormone level, Bilateral cryptorchidism, Decreased serum testost... OMIM:305400
Bone Marrow Failure Syndrome 5
Testicular atrophy, Hypogonadism OMIM:618165
Restrictive Dermopathy 1
Hypospadias, Adrenal hypoplasia, Scaling skin, Thin skin OMIM:275210
Erythrokeratodermia Variabilis Et Progressiva 3
Erythema, Epidermal acanthosis OMIM:617525
Palmoplantar Keratoderma, Nonepidermolytic, Focal Or Diffuse
Epidermal acanthosis OMIM:615735
Parkes Weber Syndrome
Skin ulcer, Scaling skin ORPHA:90307
Mayer-Rokitansky-Küster-Hauser Syndrome
Ectopic ovary, Aplasia of the ovary, Endometriosis, Aplasia of the uterus, Dyspareunia, Primary a... ORPHA:3109
Ectodermal Dysplasia-Skin Fragility Syndrome
Anoperineal fistula, Scaling skin ORPHA:158668
Punctate Palmoplantar Keratoderma Type 1
Pancreatic adenocarcinoma, Abnormal epidermal morphology, Epidermal acanthosis, Prostate cancer ORPHA:79501
Dyskeratosis Congenita, Autosomal Recessive 2
Testicular atrophy OMIM:613987
Symptomatic Form Of Hfe-Related Hemochromatosis
Decreased serum testosterone concentration, Decreased libido, Hypogonadotropic hypogonadism, Amen... ORPHA:465508
Seborrhea-Like Dermatitis With Psoriasiform Elements
Epidermal acanthosis OMIM:610227
Hypoparathyroidism-Sensorineural Deafness-Renal Disease Syndrome
Parathyroid hypoplasia, Uterus didelphys, Septate vagina, Psoriasiform dermatitis, Aplasia of the... ORPHA:2237
Familial Benign Chronic Pemphigus
Erythema, Acantholysis, Skin vesicle ORPHA:2841
Acrokeratosis Verruciformis Of Hopf
Epidermal acanthosis ORPHA:79151
Ifap Syndrome 1, With Or Without Bresheck Syndrome
Dry skin, Cryptorchidism, Aganglionic megacolon, Scaling skin, Hypospadias, Perianal erythema OMIM:308205
Chronic Actinic Dermatitis
Epidermal acanthosis ORPHA:330064
Olmsted Syndrome, X-Linked
Epidermal acanthosis OMIM:300918
Ichthyotic Keratoderma, Spasticity, Hypomyelination, And Dysmorphic Facial Features
Optic disc pallor, Epidermal acanthosis, Dry skin OMIM:618527
Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant 1
Primary amenorrhea, Testicular atrophy, Premature ovarian insufficiency, Facial palsy, Secondary ... OMIM:157640
Palmoplantar Keratoderma I, Striate, Focal, Or Diffuse
Epidermal acanthosis OMIM:148700
Psoriasis-Related Juvenile Idiopathic Arthritis
Psoriasiform dermatitis, Psoriasiform lesion ORPHA:85436
Ichthyosis Prematurity Syndrome
Epidermal acanthosis OMIM:608649
Hypotrichosis And Recurrent Skin Vesicles
Skin vesicle, Epidermal acanthosis OMIM:613102
Limb-Mammary Syndrome
Absent nipple, Breast aplasia, Dry skin, Psoriasiform dermatitis, Aplasia of the ovary, Aplasia o... ORPHA:69085
Autoinflammation With Arthritis And Dyskeratosis
Dry skin, Epidermal acanthosis, Thyroiditis OMIM:617388
Woodhouse-Sakati Syndrome
Elevated circulating thyroid-stimulating hormone concentration, Decreased serum testosterone conc... OMIM:241080
Acrokeratoelastoidosis Of Costa
Epidermal acanthosis ORPHA:38
Huriez Syndrome
Epidermal acanthosis OMIM:181600
Ectodermal Dysplasia/Short Stature Syndrome
Epidermal acanthosis OMIM:616029
Ichthyosis, Congenital, Autosomal Recessive 1
Epidermal acanthosis OMIM:242300
Pontocerebellar Hypoplasia Type 7
Optic atrophy, Clitoral hypertrophy, Microphallus, Gonadal dysgenesis, Cryptorchidism, Aplasia of... ORPHA:284339
Popliteal Pterygium Syndrome
Small scrotum, Bifid scrotum, Cryptorchidism, Hypoplastic labia majora, Hypoplasia of the uterus,... OMIM:119500
Oeis Complex
Ambiguous genitalia, female, Absent scrotum, Cryptorchidism, Ambiguous genitalia, male, Bifid ute... OMIM:258040
Townes-Brocks Syndrome 2
Bifid uterus, Rectovaginal fistula, Hypospadias OMIM:617466
Ichthyosis, Leukocyte Vacuoles, Alopecia, And Sclerosing Cholangitis
Dry skin, Epidermal acanthosis, Bile duct proliferation OMIM:607626
Ichthyosis, Congenital, Autosomal Recessive 9
Epidermal acanthosis OMIM:615023
Cole Disease
Epidermal acanthosis OMIM:615522
Pseudoxanthoma Elasticum
Optic disc drusen, Cutis laxa, Civatte bodies OMIM:264800
Palmoplantar Carcinoma, Multiple Self-Healing
Epidermal acanthosis OMIM:615225
Kawasaki Disease
Palmoplantar erythema, Scaling skin on fingertip ORPHA:2331
Craniofrontonasal Dysplasia-Poland Anomaly Syndrome
Abnormal reproductive system morphology, Webbed neck, Bifid uterus, Supernumerary nipple ORPHA:1521
Lethal Omphalocele-Cleft Palate Syndrome
Bifid uterus ORPHA:2736
X-Linked Intellectual Disability, Snyder Type
Webbed neck, Abnormality of the Leydig cells, Cryptorchidism, Testicular atrophy, Hypospadias ORPHA:3063
Olmsted Syndrome 2
Epidermal acanthosis OMIM:619208
Lesch-Nyhan Syndrome
Testicular atrophy OMIM:300322
Odontoonychodermal Dysplasia
Erythema, Epidermal acanthosis, Palmoplantar erythema, Dry skin OMIM:257980
Fanconi Anemia, Complementation Group L
Micropenis, Aplasia of the uterus, Webbed neck OMIM:614083
Meckel Syndrome 14
Aplasia of the uterus, Ambiguous genitalia OMIM:619879
Spondylocostal Dysostosis With Anal Atresia And Urogenital Anomalies
Aplasia of the uterus, Absent external genitalia, Aplasia of the vagina OMIM:271520
Phocomelia, Schinzel Type
Aplasia of the uterus, Hypoplasia of penis, Cryptorchidism ORPHA:2879
Exstrophy-Epispadias Complex
Penoscrotal transposition, Male sexual dysfunction, Bifid scrotum, Female sexual dysfunction, Cys... ORPHA:322
Chronic Recurrent Multifocal Osteomyelitis 2, With Periostitis And Pustulosis
Epidermal acanthosis OMIM:612852
Thrombocytopenia-Absent Radius Syndrome
Aplasia of the uterus ORPHA:3320
Steinert Myotonic Dystrophy
Male hypogonadism, Cholelithiasis, Impotence, Decreased response to growth hormone stimulation te... ORPHA:273
Chromosome 17Q12 Deletion Syndrome
Cryptorchidism, Ovarian cyst, Aplasia of the vagina, Aplasia of the uterus, Unicornuate uterus OMIM:614527
Naxos Disease
Acantholysis, Epidermal acanthosis OMIM:601214
Microcephaly-Corpus Callosum Hypoplasia-Intellectual Disability-Facial Dysmorphism Syndrome
Aplasia of the uterus, Aplasia of the vagina, Optic nerve hypoplasia ORPHA:457284
Cardiac-Urogenital Syndrome
Bifid scrotum, Cryptorchidism, Aplasia of the uterus, Ambiguous genitalia, Penoscrotal hypospadia... OMIM:618280
Congenital Hemidysplasia With Ichthyosiform Erythroderma And Limb Defects
Erythema, Epidermal acanthosis, Thyroid hypoplasia, Adrenal hypoplasia OMIM:308050
Loeys-Dietz Syndrome
Striae distensae, Uterine rupture, Thin skin ORPHA:60030
Agammaglobulinemia-Microcephaly-Craniosynostosis-Severe Dermatitis Syndrome
Cholelithiasis, Pancreatic hypoplasia, Cryptorchidism, Biliary hyperplasia, Micropenis, Epidermal... ORPHA:83617
Ehlers-Danlos Syndrome, Vascular Type
Uterine rupture, Cystocele, Cryptorchidism, Uterine prolapse, Ecchymosis, Dermal translucency, Ce... OMIM:130050
Wolf-Hirschhorn Syndrome
Precocious puberty, Webbed neck, Cryptorchidism, Aplasia of the uterus, Hypospadias OMIM:194190
Okamoto Syndrome
Bifid uterus, Webbed neck, Redundant neck skin ORPHA:2729
Thrombocytopenia-Absent Radius Syndrome
Aplasia of the uterus, Pancreatic cysts OMIM:274000
Vascular Ehlers-Danlos Syndrome
Uterine rupture, Cystocele, Redundant skin, Cryptorchidism, Uterine prolapse, Excessive wrinkled ... ORPHA:286
Norrie Disease
Optic atrophy, Uterine rupture, Cryptorchidism, Delayed puberty, Erectile dysfunction, Diabetes m... ORPHA:649
Ulna And Fibula, Absence Of, With Severe Limb Deficiency
Small scrotum, Cryptorchidism, Anteriorly displaced genitalia, Hypoplastic nipples, Aplasia of th... OMIM:276820
Townes-Brocks Syndrome 1
Bifid scrotum, Cryptorchidism, Hypothyroidism, Rectoperineal fistula, Bifid uterus, Rectovaginal ... OMIM:107480
Coffin-Siris Syndrome 1
Aplasia of the uterus, Clitoral hypertrophy, Hypospadias, Cryptorchidism OMIM:135900
Hydrolethalus Syndrome 1
Bifid uterus, Adrenal gland dysgenesis, Hypospadias, Abnormal vagina morphology OMIM:236680
Neu-Laxova Syndrome 1
Bifid uterus, Cryptorchidism OMIM:256520
Pallister-Killian Syndrome
Small scrotum, Webbed neck, Supernumerary nipple, Cryptorchidism, Aplasia of the uterus, Hypoplas... OMIM:601803

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Lypd6

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Lypd6.

No publications found that use IMPC mice or data for Lypd6.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Lypd6tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Lypd6tm1b(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Mice, Tissue

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter