Gene Summary

Name:
LY6/PLAUR domain containing 6
Synonyms:
E130115E03Rik

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
thick skin Lypd6tm1b(KOMP)Wtsi HET Early adult 0.00
small superior vagus ganglion Lypd6tm1b(KOMP)Wtsi HET Early adult 0.00
scaly skin Lypd6tm1b(KOMP)Wtsi HET Early adult 0.00
abnormal testis morphology Lypd6tm1b(KOMP)Wtsi HET Early adult 0.00
abnormal skin morphology Lypd6tm1b(KOMP)Wtsi HET Early adult 0.00
preweaning lethality, incomplete penetrance Lypd6tm1b(KOMP)Wtsi HOM   Early adult 0.00
hydrometra Lypd6tm1b(KOMP)Wtsi HET Early adult 0.00
small testis Lypd6tm1b(KOMP)Wtsi HET Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Epididymis  Section images heterozygote 50% (1 of 2)
Esophagus  Section images heterozygote 50% (1 of 2)
Eye  Section images heterozygote 50% (1 of 2)
Ileum  Section images heterozygote 50% (1 of 2)
Kidney  Section images heterozygote 100% (2 of 2)
Penis  Section images heterozygote 50% (1 of 2)
Prostate gland  Section images heterozygote 50% (1 of 2)
Testis  Section images heterozygote 50% (1 of 2)
Tongue  Section images heterozygote 100% (2 of 2)
Vas deferens  Section images heterozygote 50% (1 of 2)
Vesicular gland  Section images heterozygote 50% (1 of 2)
Adrenal gland N/A heterozygote 0.0% (0 of 2)
Aorta N/A heterozygote 0.0% (0 of 2)
Blood N/A heterozygote 0.0% (0 of 2)
Bone marrow N/A heterozygote 0.0% (0 of 2)
Brain N/A heterozygote 50% (1 of 2)
Brainstem N/A heterozygote Not available
Brown adipose tissue N/A heterozygote 0.0% (0 of 2)
Cartilage tissue N/A heterozygote Not available
Cecum N/A heterozygote 0.0% (0 of 2)
Cerebellum N/A heterozygote 0.0% (0 of 2)
Cerebral cortex N/A heterozygote Not available
Chest bone N/A heterozygote Not available
Colon N/A heterozygote 0.0% (0 of 2)
Diaphragm N/A heterozygote 0.0% (0 of 2)
Duodenum N/A heterozygote 0.0% (0 of 2)
Gall bladder N/A heterozygote Not available
Gonadal fat pad N/A heterozygote 0.0% (0 of 2)
Harderian gland N/A heterozygote 0.0% (0 of 2)
Heart N/A heterozygote Not available
Hindlimb N/A heterozygote Not available
Hippocampus N/A heterozygote Not available
Hypothalamus N/A heterozygote Not available
Jejunum N/A heterozygote 0.0% (0 of 2)
Large intestine N/A heterozygote 0.0% (0 of 2)
Liver N/A heterozygote 0.0% (0 of 2)
Lower urinary tract N/A heterozygote Not available
Lung N/A heterozygote 0.0% (0 of 2)
Lymph node N/A heterozygote Not available
Mammary gland N/A heterozygote 0.0% (0 of 2)
Mesenteric adipose tissue N/A heterozygote 0.0% (0 of 2)
Mesenteric lymph node N/A heterozygote 0.0% (0 of 2)
Midbrain N/A heterozygote 0.0% (0 of 2)
Olfactory lobe N/A heterozygote 0.0% (0 of 2)
Ovary N/A heterozygote 0.0% (0 of 2)
Oviduct N/A heterozygote 0.0% (0 of 2)
Pancreas N/A heterozygote 0.0% (0 of 2)
Parathyroid gland N/A heterozygote 0.0% (0 of 2)
Parotid gland N/A heterozygote 0.0% (0 of 2)
Peripheral nervous system N/A heterozygote Not available
Peyer's patch N/A heterozygote Not available
Pituitary gland N/A heterozygote 0.0% (0 of 2)
Quadriceps N/A heterozygote 0.0% (0 of 2)
Sciatic nerve N/A heterozygote 0.0% (0 of 2)
Skeletal muscle N/A heterozygote Not available
Skin N/A heterozygote 0.0% (0 of 2)
Small intestine N/A heterozygote 50% (1 of 2)
Spinal cord N/A heterozygote 0.0% (0 of 2)
Spleen N/A heterozygote 0.0% (0 of 2)
Stomach pyloric region N/A heterozygote Not available
Stomach N/A heterozygote 0.0% (0 of 2)
Striatum N/A heterozygote Not available
Sublingual gland N/A heterozygote 0.0% (0 of 2)
Submandibular gland N/A heterozygote 0.0% (0 of 2)
Thymus N/A heterozygote 0.0% (0 of 2)
Thyroid gland N/A heterozygote 0.0% (0 of 2)
Trachea N/A heterozygote 0.0% (0 of 2)
Trigeminal V nerve N/A heterozygote 0.0% (0 of 2)
Urinary bladder N/A heterozygote 0.0% (0 of 2)
Uterus N/A heterozygote 0.0% (0 of 2)
Vagina N/A heterozygote 0.0% (0 of 2)
Vascular system N/A heterozygote Not available
White adipose tissue N/A heterozygote Not available
No Embryo expression data was found for this gene.

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)
adrenal gland 0.55% (3 of 550)
aorta 0.18% (1 of 566)
blood 0.0%
bone marrow 0.0%
brain 0.92% (5 of 543)
brainstem 0.36% (2 of 563)
brown adipose tissue 0.0%
cartilage tissue 0.18% (1 of 563)
cecum 5.6% (20 of 357)
cerebellum 0.36% (2 of 561)
cerebral cortex 0.36% (2 of 558)
chest bone Unavailable
colon 15.15% (20 of 132)
diaphragm 0.0%
duodenum 3.15% (4 of 127)
epididymis 13.77% (19 of 138)
esophagus 1.75% (7 of 400)
eye 0.0%
gall bladder 0.0%
gonadal fat pad 0.0%
harderian gland 0.75% (1 of 133)
heart 0.35% (2 of 564)
hindlimb 0.0%
hippocampus 0.36% (2 of 561)
hypothalamus 0.35% (2 of 572)
ileum 13.97% (19 of 136)
jejunum 8.33% (11 of 132)
kidney 4.84% (27 of 558)
large intestine 5.45% (31 of 569)
liver 0.0%
lower urinary tract 0.18% (1 of 561)
lung 0.36% (2 of 555)
lymph node 0.0%
mammary gland 0.0%
mesenteric adipose tissue 0.0%
mesenteric lymph node 0.33% (1 of 302)
midbrain 0.0%
olfactory lobe 0.36% (2 of 557)
ovary 0.18% (1 of 554)
oviduct 0.0%
pancreas 0.73% (4 of 545)
parathyroid gland 0.19% (1 of 537)
parotid gland 0.0%
penis 0.0%
peripheral nervous system 0.36% (2 of 563)
peyers patch 0.0%
pituitary gland 0.18% (1 of 565)
prostate gland 1.97% (11 of 558)
quadriceps 0.0%
sciatic nerve 0.0%
skeletal muscle 0.0%
skin 0.18% (1 of 561)
small intestine 5.24% (30 of 573)
spinal cord 0.54% (3 of 558)
spleen 0.54% (3 of 553)
stomach 3.76% (21 of 558)
stomach pyloric region 0.0%
striatum 0.54% (3 of 555)
sublingual gland 0.0%
submandibular gland 1.44% (2 of 139)
testis 0.71% (4 of 563)
thymus 0.18% (1 of 564)
thyroid gland 2.84% (16 of 563)
tongue 3.82% (5 of 131)
trachea 0.54% (3 of 558)
trigeminal v nerve 0.0%
urinary bladder 0.0%
uterus 0.18% (1 of 570)
vagina 0.0%
vas deferens 4.84% (18 of 372)
vascular system 0.0%
vesicular gland 0.0%
white adipose tissue 0.0%
No Embryo expression data was found for this gene.

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

Adult LacZ

LacZ Images Section

27 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

1 Images

X-ray

XRay Images Hind Leg and Hip

1 Images

X-ray

XRay Images Forepaw

1 Images

X-ray

XRay Images Skull Lateral Orientation

1 Images

Human diseases caused by Lypd6 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Lypd6 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Amyloidosis, Primary Localized Cutaneous, 1
Abnormal cranial nerve morphology, Scaling skin, Dry skin, Cutis laxa OMIM:105250
Peeling Skin Syndrome 2
Erythema, Scaling skin OMIM:609796
Krt1-Related Diffuse Nonepidermolytic Keratoderma
Scaling skin, Erythema, Dry skin, Palmoplantar scaling skin ORPHA:530838
Psoriasis 2
Epidermal acanthosis, Scaling skin, Psoriasiform dermatitis OMIM:602723
Keratosis Palmoplantaris Striata Ii
Epidermal acanthosis OMIM:612908
Ichthyosis, Congenital, Autosomal Recessive 12
White scaling skin OMIM:617320
Peeling Skin Syndrome 3
White scaling skin OMIM:616265
Dowling-Degos Disease 4
Epidermal acanthosis OMIM:615696
Ichthyosis, Congenital, Autosomal Recessive 14
Erythema, Scaling skin OMIM:617571
Testicular Regression Syndrome
Abnormal male internal genitalia morphology, Absent testis, Hypoplasia of penis, Male pseudoherma... ORPHA:983
Hypogonadism, Male
Hypospadias, Testicular atrophy, Male hypogonadism, Micropenis OMIM:241100
Acral Peeling Skin Syndrome
Erythema, Excessive wrinkling of palmar skin, Scaling skin ORPHA:263534
Epidermolytic Hyperkeratosis
Epidermal acanthosis, Scaling skin OMIM:113800
Ichthyosis-Alopecia-Eclabion-Ectropion-Intellectual Disability Syndrome
Epidermal acanthosis, Scaling skin, Dry skin, Cutis laxa ORPHA:2269
Acral Self-Healing Collodion Baby
Lack of skin elasticity, Erythema, Palmoplantar scaling skin ORPHA:281127
Palmoplantar Keratoderma, Nagashima Type
Epidermal acanthosis OMIM:615598
Leydig Cell Hypoplasia
Abnormal external genitalia, Hypergonadotropic hypogonadism, Primary amenorrhea, Hyoplasia of the... ORPHA:755
Epidermolysis Bullosa Simplex 4, Localized Or Generalized Intermediate, Autosomal Recessive
Epidermal acanthosis OMIM:615028
Peeling Skin Syndrome 5
Epidermal acanthosis OMIM:617115
46,Xy Sex Reversal 11
Urogenital sinus anomaly, Decreased serum testosterone concentration, Gonadal dysgenesis with fem... OMIM:273250
Verrucous Hemangioma
Epidermal acanthosis ORPHA:464318
Acrokeratosis Verruciformis
Epidermal acanthosis OMIM:101900
Idiopathic Localized Lipodystrophy
Erythema, Scaling skin ORPHA:90158
Aicardi-Goutieres Syndrome 5
Scaling skin, Dry skin OMIM:612952
Cole Disease
Epidermal acanthosis OMIM:615522
Oculotrichodysplasia
Scaling skin, Dry skin OMIM:257960
Isolated Follicle Stimulating Hormone Deficiency
Testicular atrophy, Decreased serum testosterone concentration, Azoospermia, Delayed menarche, Hy... ORPHA:52901
Spermatogenic Failure, X-Linked, 2
Azoospermia, Testicular atrophy, Male infertility OMIM:309120
46,Xy Gonadal Dysgenesis-Motor And Sensory Neuropathy Syndrome
Abnormal vagina morphology, Infertility, Hypoplasia of the uterus, Decreased serum testosterone c... ORPHA:168563
Congenital Disorder Of Glycosylation, Type If
Optic atrophy, Scaling skin, Dry skin OMIM:609180
Ichthyosis, Spastic Quadriplegia, And Mental Retardation
Erythema, Dry skin, Scaling skin OMIM:614457
Hypogonadotropic Hypogonadism 8 With Or Without Anosmia
Hypoplasia of the uterus, Micropenis, Hypogonadotropic hypogonadism, Primary amenorrhea, Gonadotr... OMIM:614837
Hypotrichosis Simplex Of The Scalp
Epidermal acanthosis, Scaling skin ORPHA:90368
Peeling Skin With Leukonychia, Acral Punctate Keratoses, Cheilitis, And Knuckle Pads
Epidermal acanthosis, Scaling skin OMIM:616295
Familial Reactive Perforating Collagenosis
Abnormal epidermal morphology ORPHA:79147
Peeling Skin Syndrome 4
Epidermal acanthosis, Scaling skin OMIM:607936
Woodhouse-Sakati Syndrome
Hypoplasia of the uterus, Decreased serum testosterone concentration, Hyperinsulinemia, Decreased... ORPHA:3464
46,Xx Ovotesticular Disorder Of Sex Development
Urogenital sinus anomaly, Abnormal male internal genitalia morphology, Hypoplasia of penis, Bifid... ORPHA:2138
Ovarian Dysgenesis 2
Hypoplasia of the uterus, Streak ovary, Hypergonadotropic hypogonadism, Primary amenorrhea, Secon... OMIM:300510
Hypogonadotropic Hypogonadism 12 With Or Without Anosmia
Hypoplasia of the uterus, Decreased serum testosterone concentration, Hypoplasia of the ovary, Mi... OMIM:614841
Pemphigus Foliaceus
Erythema, Acantholysis, Scaling skin, Skin vesicle, Psoriasiform dermatitis ORPHA:79481
Complete Androgen Insensitivity Syndrome
Increased serum testosterone level, Blind vagina, Increased antimullerian hormone level, Abnormal... ORPHA:99429
Ovarian Dysgenesis 7
Hypoplasia of the uterus, Primary amenorrhea, Delayed puberty OMIM:618117
Erythrokeratodermia Variabilis Et Progressiva 4
Epidermal acanthosis, Erythema OMIM:617526
Cutaneous Mastocytoma
Erythema, Scaling skin ORPHA:79455
Erythrokeratodermia Variabilis Et Progressiva 3
Epidermal acanthosis, Erythema OMIM:617525
Diethylstilbestrol Syndrome
Hypoplasia of the uterus, Cryptorchidism, Micropenis, Hypospadias, Decreased fertility in females... ORPHA:1916
Ifap Syndrome 1, With Or Without Bresheck Syndrome
Dry skin, Cryptorchidism, Scaling skin, Aganglionic megacolon OMIM:308205
Ichthyosis With Confetti
Scaling skin, Hypoplastic nipples OMIM:609165
Mpdu1-Cdg
Optic atrophy, Decreased response to growth hormone stimulation test, Scaling skin, Decreased ser... ORPHA:79323
Ichthyosis, Congenital, Autosomal Recessive 6
Epidermal acanthosis, Scaling skin, Dry skin OMIM:612281
Spinocerebellar Ataxia 32
Infertility, Testicular atrophy, Azoospermia OMIM:613909
Ichthyosis Vulgaris
Absent keratohyalin granules, Dry skin OMIM:146700
Spinocerebellar Ataxia Type 32
Azoospermia, Testicular atrophy, Male infertility ORPHA:276183
Androgen Insensitivity Syndrome
Ambiguous genitalia, male, Male pseudohermaphroditism, Aplasia/hypoplasia of the uterus, Testicul... ORPHA:754
46,Xy Sex Reversal 3
Sex reversal, Hypoplasia of the uterus, Elevated circulating luteinizing hormone level, Gonadal d... OMIM:612965
Partial Androgen Insensitivity Syndrome
Abnormal circulating estrogen level, Blind vagina, Primary amenorrhea, Ambiguous genitalia, Clito... ORPHA:90797
Vulvovaginal Gingival Syndrome
Epidermal acanthosis, Abnormality of female external genitalia, Erythema ORPHA:83453
Bathing Suit Ichthyosis
Epidermal acanthosis, Scaling skin ORPHA:100976
Centrifugal Lipodystrophy
Erythema, Scaling skin ORPHA:90156
Kennedy Disease
Erectile dysfunction, Testicular atrophy, Type II diabetes mellitus, Decreased fertility ORPHA:481
Glycogen Storage Disease Due To Lactate Dehydrogenase M-Subunit Deficiency
Psoriasiform lesion, Scaling skin ORPHA:284426
Premature Ovarian Failure 7
Hypoplasia of the uterus, Elevated circulating luteinizing hormone level, Primary amenorrhea, Gon... OMIM:612964
Peeling Skin Syndrome 1
Scaling skin OMIM:270300
Bone Marrow Failure Syndrome 5
Testicular atrophy, Hypogonadism OMIM:618165
Testicular Agenesis
Urogenital sinus anomaly, Hypoplasia of the uterus, Absent testis, Absent external genitalia, Abn... ORPHA:325124
Perrault Syndrome 6
Hypoplasia of the uterus, Streak ovary, Irregular menstruation, Primary amenorrhea, Secondary ame... OMIM:617565
Congenital Adrenal Hyperplasia Due To 17-Alpha-Hydroxylase Deficiency
Blind vagina, Ovarian cyst, Decreased circulating cortisol level, Primary amenorrhea, Abnormal re... ORPHA:90793
Premature Ovarian Failure 3
Secondary amenorrhea, Hypoplasia of the uterus, Premature ovarian insufficiency OMIM:608996
Atrophoderma Vermiculata
Erythema, Abnormal epidermal morphology ORPHA:79100
Ectodermal Dysplasia/Skin Fragility Syndrome
Scaling skin OMIM:604536
Ovarian Dysgenesis 9
Hypoplasia of the uterus, Hypoplasia of the ovary, Elevated circulating luteinizing hormone level... OMIM:619665
Ichthyosis, Congenital, Autosomal Recessive 5
Epidermal acanthosis, White scaling skin OMIM:604777
Myoectodermal Gonadal Dysgenesis Syndrome
Hypoplasia of the uterus, Elevated circulating luteinizing hormone level, Clitoral hypoplasia, Go... OMIM:618419
Bazex Syndrome
Scaling skin ORPHA:166113
Immunodeficiency 41 With Lymphoproliferation And Autoimmunity
Thyroiditis, Hypothyroidism, Type I diabetes mellitus, Scaling skin, Psoriasiform dermatitis OMIM:606367
Premature Ovarian Failure 6
Hypoplasia of the uterus, Female infertility, Streak ovary, Elevated circulating luteinizing horm... OMIM:612310
Skin Fragility-Woolly Hair Syndrome
Palmoplantar erythema, Acantholysis, Palmoplantar scaling skin OMIM:607655
Elastosis Perforans Serpiginosa
Epidermal acanthosis, Cutis laxa ORPHA:79148
Premature Ovarian Failure 18
Hypoplasia of the uterus, Hypoplasia of the ovary, Elevated circulating luteinizing hormone level... OMIM:619203
Ovarian Dysgenesis 5
Hypoplasia of the uterus, Primary amenorrhea OMIM:617690
Hypogonadotropic Hypogonadism 1 With Or Without Anosmia
Testicular atrophy, Decreased serum testosterone concentration, Leydig cell insensitivity to gona... OMIM:308700
Premature Ovarian Failure 13
Amenorrhea, Hypoplasia of the uterus, Female infertility, Oligomenorrhea, Elevated circulating fo... OMIM:617442
Mal De Meleda
Epidermal acanthosis, Erythema ORPHA:87503
Spinal And Bulbar Muscular Atrophy, X-Linked 1
Testicular atrophy, Decreased fertility OMIM:313200
Kallmann Syndrome With Spastic Paraplegia
Testicular atrophy, Leydig cell insensitivity to gonadotropin, Micropenis, Hypogonadotropic hypog... OMIM:308750
Perrault Syndrome 3
Hypergonadotropic hypogonadism, Hypoplasia of the uterus, Primary amenorrhea OMIM:614129
Diffuse Cutaneous Mastocytosis
Scaling skin ORPHA:79456
46,Xy Sex Reversal 7
Sex reversal, Gonadal dysgenesis, male, Hypoplasia of the uterus, Streak ovary, Primary amenorrhe... OMIM:233420
Keratoderma Hereditarium Mutilans With Ichthyosis
Epidermal acanthosis, Scaling skin on fingertip ORPHA:79395
46,Xy Partial Gonadal Dysgenesis
Streak ovary, Hypergonadotropic hypogonadism, Primary amenorrhea, Ambiguous genitalia, Clitoral h... ORPHA:251510
Epidermodysplasia Verruciformis, Susceptibility To, 3
Epidermal acanthosis OMIM:618267
White Sponge Nevus 2
Epidermal acanthosis OMIM:615785
Mullerian Aplasia And Hyperandrogenism
Amenorrhea, Abnormality of the endocrine system, Aplasia/Hypoplasia of the fallopian tube, Aplasi... OMIM:158330
46,Xy Disorder Of Sex Development Due To Isolated 17,20-Lyase Deficiency
Decreased circulating androgen concentration, Decreased fertility in males, Hypergonadotropic hyp... ORPHA:90796
Normosmic Congenital Hypogonadotropic Hypogonadism
Increased female libido, Hypoplasia of the uterus, Impotence, Decreased serum testosterone concen... ORPHA:432
X-Linked Dominant Chondrodysplasia Punctata
Scaling skin ORPHA:35173
Ovarian Dysgenesis 6
Hypoplasia of the uterus OMIM:618078
46,Xx Sex Reversal 2
Sex reversal, Hypoplasia of the uterus, Decreased serum testosterone concentration, Micropenis, B... OMIM:278850
Hypogonadotropic Hypogonadism 13 With Or Without Anosmia
Hypoplasia of the uterus, Hypogonadotropic hypogonadism, Decreased circulating follicle stimulati... OMIM:614842
Renal And Mullerian Duct Hypoplasia
Hydrocele testis, Anteriorly displaced urethral meatus, Aplasia of the uterus OMIM:266810
Myotonic Dystrophy 1
Cholelithiasis, Testicular atrophy, Facial diplegia, Hypogonadism OMIM:160900
Ectodermal Dysplasia/Short Stature Syndrome
Epidermal acanthosis OMIM:616029
Neonatal Inflammatory Skin And Bowel Disease
Erythema, Scaling skin, Psoriasiform dermatitis ORPHA:294023
Epidermolytic Palmoplantar Keratoderma
Epidermal acanthosis ORPHA:2199
Inflammatory Skin And Bowel Disease, Neonatal, 2
Epidermal acanthosis OMIM:616069
Immunodeficiency 58
Psoriasiform lesion, Scaling skin OMIM:618131
Inherited Isolated Adrenal Insufficiency Due To Partial Cyp11A1 Deficiency
Decreased circulating androgen concentration, Decreased circulating cortisol level, Abnormality o... ORPHA:289548
46,Xy Disorder Of Sex Development-Adrenal Insufficiency Due To Cyp11A1 Deficiency
Decreased circulating androgen concentration, Decreased circulating cortisol level, Abnormality o... ORPHA:168558
Bacterial Toxic-Shock Syndrome
Scaling skin, Ecchymosis ORPHA:36234
Basan Syndrome
Epidermal acanthosis OMIM:129200
Proteus Syndrome
Epidermal acanthosis OMIM:176920
T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency
Psoriasiform lesion ORPHA:169154
Perrault Syndrome 4
Hypoplasia of the uterus, Hypoplasia of the ovary, Bicornuate uterus, Oligomenorrhea, Primary ame... OMIM:615300
Kid Syndrome
Epidermal acanthosis, Scaling skin, Psoriasiform dermatitis ORPHA:477
Graft Versus Host Disease
Scaling skin ORPHA:39812
Superficial Epidermolytic Ichthyosis
Acantholysis, Erythema, Thin skin ORPHA:455
Infantile Digital Fibromatosis
Epidermal acanthosis ORPHA:199267
Porphyria Cutanea Tarda
Scaling skin, Diabetes mellitus ORPHA:101330
Adrenal Hyperplasia, Congenital, Due To Steroid 11-Beta-Hydroxylase Deficiency
Increased serum testosterone level, Decreased circulating aldosterone level, Ambiguous genitalia,... OMIM:202010
Immunodeficiency, Common Variable, 8, With Autoimmunity
Hypothyroidism, Psoriasiform lesion, Type I diabetes mellitus, Thyroiditis OMIM:614700
Hydatidiform Mole
Menometrorrhagia, Hyperthyroidism, Enlarged uterus ORPHA:99927
Hemochromatosis, Type 1
Amenorrhea, Testicular atrophy, Impotence, Hypogonadotropic hypogonadism, Diabetes mellitus, Azoo... OMIM:235200
Mayer-Rokitansky-Kuster-Hauser Syndrome
Amenorrhea, Aplasia of the vagina, Hypoplasia of the uterus OMIM:277000
Rare Cutaneous Lupus Erythematosus
Psoriasiform lesion, Erythema, Scaling skin ORPHA:535
Diaphragmatic Defects, Limb Deficiencies, And Ossification Defects Of Skull
Testicular atrophy OMIM:601163
Ichthyosis, Congenital, Autosomal Recessive 7
Epidermal acanthosis OMIM:615022
Erythrokeratodermia Variabilis Et Progressiva 1
Epidermal acanthosis OMIM:133200
Vaginal Atresia
Bicornuate uterus, Imperforate hymen, Uterus didelphys, Primary amenorrhea, Cervicitis, Transvers... ORPHA:65681
Autosomal Dominant Palmoplantar Keratoderma And Congenital Alopecia
Facial erythema, Scaling skin, Dry skin ORPHA:1010
Focal Facial Dermal Dysplasia Type Iv
Abnormal epidermal morphology ORPHA:398189
Ectodermal Dysplasia-Skin Fragility Syndrome
Anoperineal fistula, Urethral stricture, Scaling skin ORPHA:158668
Lumbar Syndrome
Bifid scrotum, Micropenis, Hypospadias, Bifid uterus, Ambiguous genitalia, Cryptorchidism, Hypopl... ORPHA:83628
Microcephaly-Lymphedema-Chorioretinopathy Syndrome
Optic atrophy, Skin ulcer, Scaling skin, Dry skin ORPHA:2526
Ichthyosis, Congenital, Autosomal Recessive 2
Epidermal acanthosis, Erythema, External genital hypoplasia OMIM:242100
Riddle Syndrome
Erythema, Scaling skin ORPHA:420741
Rat-Bite Fever
Scaling skin, Parotitis ORPHA:31205
Psoriasis 14, Pustular
Epidermal acanthosis, Erythema, Psoriasiform dermatitis OMIM:614204
Ichthyosis, Congenital, Autosomal Recessive 8
Epidermal acanthosis, Erythema OMIM:613943
Restrictive Dermopathy
Hypospadias, Aplasia/Hypoplastia of the eccrine sweat glands, Congenital adrenal hypoplasia, Scal... ORPHA:1662
Classic Congenital Adrenal Hyperplasia Due To 21-Hydroxylase Deficiency
Hyperactive renin-angiotensin system, Ambiguous genitalia, female, Abnormal external genitalia, D... ORPHA:90794
Wolfram Syndrome 1
Testicular atrophy, Hypothyroidism, Optic atrophy, Diabetes mellitus, Diabetes insipidus OMIM:222300
Hypoparathyroidism, Sensorineural Deafness, And Renal Dysplasia Syndrome
Hypoparathyroidism, Uterus didelphys, Primary amenorrhea, Septate vagina, Pseudopapilledema, Apla... OMIM:146255
Restrictive Dermopathy 1
Adrenal hypoplasia, Thin skin, Scaling skin, Hypospadias OMIM:275210
Palmoplantar Keratoderma, Punctate Type Ia
Epidermal acanthosis OMIM:148600
Parkes Weber Syndrome
Skin ulcer, Scaling skin ORPHA:90307
Neurodevelopmental Disorder With Hypotonia And Dysmorphic Facies
Decreased response to growth hormone stimulation test, Small pituitary gland, Micropenis, Cutis l... OMIM:619503
Aarskog-Scott Syndrome
Testicular atrophy, Decreased serum testosterone concentration, Cryptorchidism, Elevated circulat... OMIM:305400
Palmoplantar Keratoderma, Nonepidermolytic, Focal Or Diffuse
Epidermal acanthosis OMIM:615735
Seborrhea-Like Dermatitis With Psoriasiform Elements
Epidermal acanthosis OMIM:610227
Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant 1
Testicular atrophy, Hypergonadotropic hypogonadism, Primary amenorrhea, Secondary amenorrhea, Fac... OMIM:157640
Punctate Palmoplantar Keratoderma Type 1
Epidermal acanthosis, Pancreatic adenocarcinoma, Prostate cancer, Abnormal epidermal morphology ORPHA:79501
Symptomatic Form Of Hemochromatosis Type 1
Amenorrhea, Infertility, Testicular atrophy, Decreased serum testosterone concentration, Hypogona... ORPHA:465508
Hypoparathyroidism-Sensorineural Deafness-Renal Disease Syndrome
Hypoparathyroidism, Uterus didelphys, Septate vagina, Aplasia of the uterus, Diabetes mellitus, V... ORPHA:2237
Dyskeratosis Congenita, Autosomal Recessive 2
Testicular atrophy OMIM:613987
Psoriasis-Related Juvenile Idiopathic Arthritis
Psoriasiform lesion, Psoriasiform dermatitis ORPHA:85436
Acrokeratosis Verruciformis Of Hopf
Epidermal acanthosis ORPHA:79151
Chronic Actinic Dermatitis
Epidermal acanthosis ORPHA:330064
Ichthyotic Keratoderma, Spasticity, Hypomyelination, And Dysmorphic Facial Features
Optic disc pallor, Dry skin, Epidermal acanthosis OMIM:618527
Olmsted Syndrome, X-Linked
Epidermal acanthosis OMIM:300918
Familial Benign Chronic Pemphigus
Skin vesicle, Acantholysis, Erythema ORPHA:2841
Palmoplantar Keratoderma I, Striate, Focal, Or Diffuse
Epidermal acanthosis OMIM:148700
Hypotrichosis And Recurrent Skin Vesicles
Skin vesicle, Epidermal acanthosis OMIM:613102
Ichthyosis Prematurity Syndrome
Epidermal acanthosis OMIM:608649
Woodhouse-Sakati Syndrome
Hypoplasia of the uterus, Decreased serum testosterone concentration, Micropenis, Hypergonadotrop... OMIM:241080
Autoinflammation With Arthritis And Dyskeratosis
Epidermal acanthosis, Dry skin, Thyroiditis OMIM:617388
Huriez Syndrome
Epidermal acanthosis OMIM:181600
Limb-Mammary Syndrome
Absent nipple, Bilateral breast hypoplasia, Primary amenorrhea, Dry skin, Hypoplastic nipples, Br... ORPHA:69085
Townes-Brocks Syndrome 2
Hypospadias, Bifid uterus, Rectovaginal fistula OMIM:617466
Ichthyosis, Congenital, Autosomal Recessive 1
Epidermal acanthosis OMIM:242300
Acrokeratoelastoidosis Of Costa
Epidermal acanthosis ORPHA:38
Pontocerebellar Hypoplasia Type 7
Micropenis, Gonadal dysgenesis, Absent penis, Optic atrophy, Ambiguous genitalia, Abnormal scrota... ORPHA:284339
Popliteal Pterygium Syndrome
Hypoplasia of the uterus, Bifid scrotum, Small scrotum, Hypoplasia of the vagina, Cryptorchidism,... OMIM:119500
Ichthyosis, Leukocyte Vacuoles, Alopecia, And Sclerosing Cholangitis
Epidermal acanthosis, Dry skin OMIM:607626
Oeis Complex
Labial hypoplasia, Ambiguous genitalia, female, Vesicovaginal fistula, Ambiguous genitalia, male,... OMIM:258040
Palmoplantar Carcinoma, Multiple Self-Healing
Epidermal acanthosis OMIM:615225
Ichthyosis, Congenital, Autosomal Recessive 9
Epidermal acanthosis OMIM:615023
Mayer-Rokitansky-K├╝ster-Hauser Syndrome
Aplasia of the uterus, Hypoplasia of the vagina ORPHA:3109
Pseudoxanthoma Elasticum
Civatte bodies, Cutis laxa, Optic disc drusen OMIM:264800
Craniofrontonasal Dysplasia-Poland Anomaly Syndrome
Bifid uterus, Supernumerary nipple, Webbed neck, Abnormal reproductive system morphology ORPHA:1521
Lethal Omphalocele-Cleft Palate Syndrome
Bifid uterus ORPHA:2736
X-Linked Intellectual Disability, Snyder Type
Testicular atrophy, Webbed neck, Hypospadias, Abnormality of the Leydig cells, Cryptorchidism ORPHA:3063
Lesch-Nyhan Syndrome
Testicular atrophy OMIM:300322
Olmsted Syndrome 2
Epidermal acanthosis OMIM:619208
Spondylocostal Dysostosis With Anal Atresia And Urogenital Anomalies
Aplasia of the uterus, Aplasia of the vagina, Urethral atresia, Absent external genitalia OMIM:271520
Odontoonychodermal Dysplasia
Epidermal acanthosis, Erythema, Dry skin, Palmoplantar erythema OMIM:257980
Chromosome 17Q12 Deletion Syndrome
Ovarian cyst, Unicornuate uterus, Urethral stenosis, Aplasia of the uterus, Aplasia of the vagina... OMIM:614527
Phocomelia, Schinzel Type
Aplasia of the uterus, Cryptorchidism, Hypoplasia of penis ORPHA:2879
Meckel Syndrome 14
Aplasia of the uterus, Ambiguous genitalia OMIM:619879
Osteomyelitis, Sterile Multifocal, With Periostitis And Pustulosis
Epidermal acanthosis OMIM:612852
Fanconi Anemia, Complementation Group L
Aplasia of the uterus, Webbed neck, Micropenis OMIM:614083
Exstrophy-Epispadias Complex
Female sexual dysfunction, Cystocele, Bifid scrotum, Bifid uterus, Absent penis, Bifid penis, Mal... ORPHA:322
Steinert Myotonic Dystrophy
Cholelithiasis, Secondary hyperparathyroidism, Testicular atrophy, Impotence, Hyperinsulinemia, D... ORPHA:273
Thrombocytopenia-Absent Radius Syndrome
Aplasia of the uterus ORPHA:3320
Microcephaly-Corpus Callosum Hypoplasia-Intellectual Disability-Facial Dysmorphism Syndrome
Aplasia of the uterus, Aplasia of the vagina, Optic nerve hypoplasia ORPHA:457284
Congenital Hemidysplasia With Ichthyosiform Erythroderma And Limb Defects
Adrenal hypoplasia, Erythema, Thyroid hypoplasia, Epidermal acanthosis OMIM:308050
Agammaglobulinemia-Microcephaly-Craniosynostosis-Severe Dermatitis Syndrome
Cholelithiasis, Epidermal acanthosis, Micropenis, Pancreatic hypoplasia, Biliary hyperplasia, Cry... ORPHA:83617
Loeys-Dietz Syndrome
Striae distensae, Thin skin, Uterine rupture ORPHA:60030
Naxos Disease
Epidermal acanthosis, Acantholysis OMIM:601214
Ehlers-Danlos Syndrome, Vascular Type
Uterine prolapse, Uterine rupture, Cystocele, Ecchymosis, Dermal translucency, Cervical insuffici... OMIM:130050
Cardiac-Urogenital Syndrome
Bifid scrotum, Micropenis, Unilateral cryptorchidism, Ambiguous genitalia, Penoscrotal hypospadia... OMIM:618280
Okamoto Syndrome
Bifid uterus, Redundant neck skin, Webbed neck ORPHA:2729
Wolf-Hirschhorn Syndrome
Webbed neck, Precocious puberty, Hypospadias, Aplasia of the uterus, Cryptorchidism OMIM:194190
Townes-Brocks Syndrome 1
Bifid scrotum, Hypospadias, Bifid uterus, Rectoperineal fistula, Hypothyroidism, Urethral valve, ... OMIM:107480
Thrombocytopenia-Absent Radius Syndrome
Aplasia of the uterus, Pancreatic cysts OMIM:274000
Vascular Ehlers-Danlos Syndrome
Uterine prolapse, Cystocele, Uterine rupture, Excessive wrinkled skin, Hypospadias, Redundant ski... ORPHA:286
Ulna And Fibula, Absence Of, With Severe Limb Deficiency
Anteriorly displaced genitalia, Hypospadias, Hypoplastic nipples, Aplasia of the uterus, Cryptorc... OMIM:276820
Hydrolethalus Syndrome 1
Abnormal vagina morphology, Bifid uterus, Hypospadias, Adrenal gland dysgenesis OMIM:236680
Norrie Disease
Uterine rupture, Optic atrophy, Erectile dysfunction, Delayed puberty, Diabetes mellitus, Cryptor... ORPHA:649
Neu-Laxova Syndrome 1
Bifid uterus, Cryptorchidism OMIM:256520
Coffin-Siris Syndrome 1
Aplasia of the uterus, Hypospadias, Cryptorchidism, Clitoral hypertrophy OMIM:135900
Pallister-Killian Syndrome
Labial hypoplasia, Webbed neck, Supernumerary nipple, Hypospadias, Aplasia of the upper vagina, H... OMIM:601803

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Lypd6

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Lypd6.

No publications found that use IMPC mice or data for Lypd6.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

This service may be affected by the Covid-19 pandemic. See how

MGI Allele Allele Type Produced
Lypd6tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Lypd6tm1b(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Mice, Tissue

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter