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Gene: Dna2 MGI:2443732

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
DNA replication helicase/nuclease 2
Synonyms:
E130315B21Rik,  Dna2l

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Dna2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Dna2 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Dna2-Related Mitochondrial Dna Deletion Syndrome
Decreased mitochondrial number ORPHA:352470
Seckel Syndrome
ORPHA:808
Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant 6
OMIM:615156
Seckel Syndrome 8
OMIM:615807

The table below shows human diseases predicted to be associated to Dna2 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Tumor Predisposition Syndrome 1
Cutaneous melanoma, Meningioma, Malignant mesothelioma, Lung adenocarcinoma, Uveal melanoma, Rena... OMIM:614327
Lung Cancer
Non-small cell lung carcinoma, Lung adenocarcinoma, Alveolar cell carcinoma OMIM:211980
Li-Fraumeni Syndrome
Choriocarcinoma, Acute leukemia, Osteosarcoma, Prostate cancer, Nephroblastoma, Lung adenocarcino... OMIM:151623
N Syndrome
Leukemia, Abnormality of chromosome stability, Neoplasm OMIM:310465
Fanconi Anemia, Complementation Group G
Leukemia, Abnormality of chromosome stability, Myelodysplasia OMIM:614082
Asbestos Intoxication
Abnormal pulmonary interstitial morphology, Atelectasis, Interlobular septal thickening, Malignan... ORPHA:2302
Bazex Syndrome
Liposarcoma, Lung adenocarcinoma, Neoplasm ORPHA:166113
Fanconi Renotubular Syndrome 5
Emphysema, Pulmonary fibrosis, Lung adenocarcinoma OMIM:618913
Fanconi Anemia, Complementation Group D1
Acute myeloid leukemia, T-cell acute lymphoblastic leukemias, Chromosomal breakage induced by cro... OMIM:605724
Mosaic Variegated Aneuploidy Syndrome 4
Abnormality of chromosome stability OMIM:620153
Fanconi Anemia, Complementation Group T
Acute myeloid leukemia, Chromosomal breakage induced by crosslinking agents OMIM:616435
Intrauterine Growth Retardation With Increased Mitomycin C Sensitivity
Abnormality of chromosome stability OMIM:600546
Immunodeficiency 54
Hepatomegaly, Chromosome breakage, Lymphoproliferative disorder, Recurrent respiratory infections OMIM:609981
Fraxf Syndrome
Folate-dependent fragile site at Xq28 ORPHA:100974
Ataxia-Telangiectasia
Recurrent respiratory infections, Abnormality of chromosome stability, Elevated circulating hepat... ORPHA:100
Microcephaly, Growth Restriction, And Increased Sister Chromatid Exchange 2
Increased susceptibility to spontaneous sister chromatid exchange OMIM:618097
Fanconi Anemia, Complementation Group S
Chromosome breakage, Ovarian neoplasm, Ovarian carcinoma, Breast carcinoma OMIM:617883
Nijmegen Breakage Syndrome-Like Disorder
Chromosomal breakage induced by ionizing radiation OMIM:613078
Legius Syndrome
Acute monocytic leukemia, Vestibular schwannoma, Nephroblastoma, Multiple lipomas, Non-small cell... ORPHA:137605
Adrenocortical Carcinoma
Adrenocortical carcinoma, Lung adenocarcinoma ORPHA:1501
Transcobalamin Deficiency
Abnormality of chromosome stability ORPHA:859
Bloom Syndrome
Chromosome breakage, Recurrent upper respiratory tract infections, Abnormality of chromosome stab... OMIM:210900
Scleroderma, Familial Progressive
Chromosome breakage, Abnormality of chromosome stability OMIM:181750
Lig4 Syndrome
Hepatomegaly, Acute leukemia, Abnormality of chromosome stability, Lymphoma ORPHA:99812
Fanconi Anemia, Complementation Group J
Chromosomal breakage induced by crosslinking agents OMIM:609054
Opsoclonus-Myoclonus Syndrome
Small cell lung carcinoma, Ovarian teratoma, Neoplasm, Melanoma, Neuroblastoma, Neoplasm of the l... ORPHA:1183
Mitochondrial Complex Iv Deficiency, Nuclear Type 16
Chromosomal breakage induced by crosslinking agents OMIM:619060
Fragile X Syndrome
Folate-dependent fragile site at Xq28 OMIM:300624
Cancer-Associated Retinopathy
Small cell lung carcinoma, Thymoma, Uterine neoplasm, Cutaneous melanoma, Pancreatic adenocarcino... ORPHA:71505
Radial-Renal Syndrome
Chromosome breakage OMIM:179280
Fanconi Anemia, Complementation Group O
Chromosome breakage OMIM:613390
Fanconi Anemia, Complementation Group E
Leukemia, Prolonged G2 phase of cell cycle, Deficient excision of UV-induced pyrimidine dimers in... OMIM:600901
Fanconi Anemia, Complementation Group A
Leukemia, Prolonged G2 phase of cell cycle, Deficient excision of UV-induced pyrimidine dimers in... OMIM:227650
Dermatomyositis
Elevated circulating hepatic transaminase concentration, Lymphoma, Neoplasm, Lung adenocarcinoma,... ORPHA:221
Fanconi Anemia, Complementation Group N
Medulloblastoma, Nephroblastoma, Acute myeloid leukemia, Chromosomal breakage induced by crosslin... OMIM:610832
Fanconi Anemia, Complementation Group P
Squamous cell carcinoma, Chromosomal breakage induced by crosslinking agents OMIM:613951
Fanconi Anemia, Complementation Group Q
Chromosome breakage, Biliary atresia OMIM:615272
Fragile X Syndrome
Folate-dependent fragile site at Xq28 ORPHA:908
Nijmegen Breakage Syndrome
Acute leukemia, Abnormality of chromosome stability, Glioma, Recurrent pneumonia, Lymphoma, Neopl... ORPHA:647
Fanconi Anemia, Complementation Group C
Leukemia, Prolonged G2 phase of cell cycle, Deficient excision of UV-induced pyrimidine dimers in... OMIM:227645
Bone Marrow Failure Syndrome 3
Chromosome breakage, Acute myeloid leukemia OMIM:617052
Icf Syndrome
Recurrent respiratory infections, Abnormality of chromosome stability ORPHA:2268
Fanconi Anemia, Complementation Group V
Chromosomal breakage induced by crosslinking agents OMIM:617243
Fanconi Anemia, Complementation Group B
Abnormality of chromosome stability, Abnormal lung lobation OMIM:300514
Fanconi Anemia, Complementation Group D2
Leukemia, Prolonged G2 phase of cell cycle, Deficient excision of UV-induced pyrimidine dimers in... OMIM:227646
Fanconi Anemia, Complementation Group I
Chromosomal breakage induced by crosslinking agents OMIM:609053
Lambert-Eaton Myasthenic Syndrome
Small cell lung carcinoma ORPHA:43393
Fanconi Anemia, Complementation Group U
Chromosome breakage OMIM:617247
Fanconi Anemia, Complementation Group R
Chromosomal breakage induced by crosslinking agents OMIM:617244
Riddle Syndrome
Pneumonia, Recurrent pneumonia, Bronchitis, Recurrent sinusitis, Chromosomal breakage induced by ... ORPHA:420741
Dyskeratosis Congenita, Autosomal Recessive 8
Chromosomal breakage induced by crosslinking agents OMIM:620133
Cartilage-Hair Hypoplasia
Hepatomegaly, Abnormality of chromosome stability ORPHA:175
Fanconi Anemia, Complementation Group L
Chromosome breakage, Chromosomal breakage induced by crosslinking agents OMIM:614083
Fanconi Anemia, Complementation Group F
Pneumonia, Chromosomal breakage induced by crosslinking agents OMIM:603467
Fanconi Anemia
Abnormality of chromosome stability, Azoospermia, Abnormality of the liver, Neoplasm, Myelodysplasia ORPHA:84
Cushing Syndrome Due To Ectopic Acth Secretion
Small cell lung carcinoma, Malignant gastrointestinal tract tumors, Pulmonary carcinoid tumor, Ne... ORPHA:99889
Meningioma
Neoplasm of the skin, Neurofibroma, Neoplasm of the anterior pituitary, Spinal meningioma, Chromo... ORPHA:2495
Sotos Syndrome
Small cell lung carcinoma, Neoplasm, Cholesteatoma, Astrocytoma, Hemangioma, Neuroblastoma, Prolo... ORPHA:821
Dna2-Related Mitochondrial Dna Deletion Syndrome
Decreased mitochondrial number ORPHA:352470
Seckel Syndrome 8
OMIM:615807
Seckel Syndrome
ORPHA:808
Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant 6
OMIM:615156

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Dna2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Dna2.

No publications found that use IMPC mice or data for Dna2.

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MGI Allele Allele Type Produced
Dna2tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Dna2tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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