Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
leucine-rich repeats and immunoglobulin-like domains 2
Synonyms:
4632419I10Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Lrig2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Lrig2 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Urofacial Syndrome 2
OMIM:615112
Ochoa Syndrome
ORPHA:2704

The table below shows human diseases predicted to be associated to Lrig2 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Deafness, Autosomal Recessive 9
Sensorineural hearing impairment, Absent brainstem auditory responses OMIM:601071
Auditory Neuropathy, Autosomal Dominant, 1
Sensorineural hearing impairment, Abnormal auditory evoked potentials OMIM:609129
Dystonia 31
Arm dystonia, Writer's cramp, Craniofacial dystonia, Difficulty walking, Generalized dystonia, Ab... OMIM:619565
Methylmalonic Acidemia With Homocystinuria, Type Cbld
Failure to thrive, Gait disturbance, Lethargy ORPHA:79283
Abcd Syndrome
Abnormal auditory evoked potentials, Aganglionic megacolon, Hearing impairment OMIM:600501
Methylmalonic Acidemia With Homocystinuria
Failure to thrive, Gait disturbance, Skin rash, Lethargy ORPHA:26
Charcot-Marie-Tooth Disease, Type 4B1
Decreased motor nerve conduction velocity, Abnormal auditory evoked potentials, Facial palsy OMIM:601382
Homocystinuria Without Methylmalonic Aciduria
Failure to thrive, Ataxia, Lethargy ORPHA:622
Developmental And Epileptic Encephalopathy 92
Dystonia, Ataxia, Inability to walk, Difficulty walking, Lethargy OMIM:617829
Glut1 Deficiency Syndrome 1
Paroxysmal dystonia, Paroxysmal lethargy, Ataxia, Confusion, Lethargy OMIM:606777
Encephalopathy, Acute, Infection-Induced (Herpes-Specific), Susceptibility To, 8
Herpes simplex encephalitis, Confusion, Lethargy OMIM:617900
Optic Atrophy 8
Sensorineural hearing impairment, Optic atrophy, Abnormal auditory evoked potentials, Prolonged s... OMIM:616648
Dihydropyrimidine Dehydrogenase Deficiency
Failure to thrive, Hyperactivity, Lethargy OMIM:274270
N-Acetylglutamate Synthase Deficiency
Failure to thrive, Coma, Confusion, Lethargy OMIM:237310
Mitochondrial Complex I Deficiency, Nuclear Type 3
Dystonia, Ataxia, Lethargy OMIM:618224
Immunodeficiency 83, Susceptibility To Viral Infections
Herpes simplex encephalitis, Confusion, Lethargy OMIM:613002
Hypothyroidism, Congenital, Nongoitrous, 7
Lethargy OMIM:618573
Mitochondrial Complex I Deficiency, Nuclear Type 6
Failure to thrive, Lethargy OMIM:618228
Thiamine Metabolism Dysfunction Syndrome 4 (Bilateral Striatal Degeneration And Progressive Polyneuropathy Type)
Difficulty walking, Lethargy OMIM:613710
Mitochondrial Complex V (Atp Synthase) Deficiency, Nuclear Type 6
Ataxia, Bradykinesia, Lethargy OMIM:618683
Holocarboxylase Synthetase Deficiency
Eczema, Perioral eczema, Weight loss, Alopecia, Ataxia, Coma, Keratoconjunctivitis, Lethargy ORPHA:79242
Classic Pantothenate Kinase-Associated Neurodegeneration
Gait disturbance, Weight loss, Inability to walk, Tip-toe gait, Generalized dystonia, Attention d... ORPHA:216866
Short Chain Acyl-Coa Dehydrogenase Deficiency
Failure to thrive, Dystonia, Lethargy ORPHA:26792
Multiple Mitochondrial Dysfunctions Syndrome 1
Failure to thrive, Lethargy OMIM:605711
Acyl-Coa Dehydrogenase, Short-Chain, Deficiency Of
Failure to thrive, Lethargy OMIM:201470
Pyruvate Dehydrogenase E1-Alpha Deficiency
Dystonia, Episodic ataxia, Small for gestational age, Lethargy OMIM:312170
Vitamin B12-Responsive Methylmalonic Acidemia
Failure to thrive, Coma, Lethargy ORPHA:28
Glycine Encephalopathy
Hyperactivity, Lethargy OMIM:605899
Autosomal Recessive Spastic Paraplegia Type 44
Sensorineural hearing impairment, Abnormal auditory evoked potentials, Abnormality of somatosenso... ORPHA:320401
Hyperammonemia Due To N-Acetylglutamate Synthase Deficiency
Drowsiness, Myelodysplasia, Failure to thrive, Ataxia, Coma, Loss of consciousness, Delirium, Con... ORPHA:927
Autosomal Recessive Dopa-Responsive Dystonia
Bradykinesia, Focal dystonia, Ataxia, Limb dystonia, Generalized dystonia, Oculogyric crisis, Gai... ORPHA:101150
Ravine Syndrome
Abnormal auditory evoked potentials ORPHA:99852
Febrile Infection-Related Epilepsy Syndrome
Sinusitis, Lethargy ORPHA:163703
Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome
Coma, Drowsiness, Increased body weight, Lethargy ORPHA:276608
Classic Glucose Transporter Type 1 Deficiency Syndrome
Confusion, Dystonia, Ataxia, Lethargy ORPHA:71277
Hereditary Central Diabetes Insipidus
Weight loss, Lethargy ORPHA:30925
Developmental And Epileptic Encephalopathy 41
Inability to walk, Lethargy OMIM:617105
Mitochondrial Complex I Deficiency, Nuclear Type 5
Failure to thrive, Dystonia, Ataxia, Lethargy OMIM:618226
Combined Oxidative Phosphorylation Deficiency 2
Small for gestational age, Lethargy OMIM:610498
Hyperinsulinism Due To Hnf1A Deficiency
Drowsiness, Small for gestational age, Large for gestational age, Loss of consciousness, Hypoglyc... ORPHA:324575
Central Diabetes Insipidus
Failure to thrive, Weight loss, Excessive daytime somnolence, Lethargy ORPHA:178029
Citrullinemia Type I
Torticollis, Failure to thrive, Ataxia, Coma, Loss of consciousness, Lethargy ORPHA:247525
Homocystinuria-Megaloblastic Anemia, Cble Complementation Type
Failure to thrive, Gait disturbance, Lethargy OMIM:236270
Glycerol Kinase Deficiency
Coma, Loss of consciousness, Small for gestational age, Lethargy OMIM:307030
Hyperinsulinism Due To Ucp2 Deficiency
Drowsiness, Large for gestational age, Loss of consciousness, Hypoglycemic coma, Lethargy ORPHA:276556
Early Myoclonic Encephalopathy
Lethargy ORPHA:1935
Vitamin B12-Unresponsive Methylmalonic Acidemia Type Mut-
Dystonia, Failure to thrive, Pancreatitis, Coma, Lethargy ORPHA:79312
Dihydrolipoamide Dehydrogenase Deficiency
Dystonia, Ataxia, Lethargy OMIM:246900
Multiple Carboxylase Deficiency
Alopecia, Ataxia, Coma, Skin rash, Lethargy ORPHA:148
Gaba-Transaminase Deficiency
Lethargy OMIM:613163
Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency
Drowsiness, Large for gestational age, Loss of consciousness, Hypoglycemic coma, Lethargy ORPHA:276575
Hyperlysinuria With Hyperammonemia
Coma, Lethargy OMIM:238750
Severe Canavan Disease
Inability to walk, Lethargy ORPHA:314911
Mitochondrial Complex I Deficiency, Nuclear Type 4
Ataxia, Lethargy OMIM:618225
Lethal Infantile Mitochondrial Myopathy
Lethargy ORPHA:254857
Autosomal Dominant Hyperinsulinism Due To Kir6.2 Deficiency
Drowsiness, Large for gestational age, Loss of consciousness, Hypoglycemic coma, Lethargy ORPHA:276580
Carnitine Deficiency, Systemic Primary
Failure to thrive, Excessive daytime somnolence, Coma, Confusion, Lethargy OMIM:212140
Neurodevelopmental Disorder With Hypotonia, Neuropathy, And Deafness
Facial palsy, Sensorineural hearing impairment, Absent brainstem auditory responses, EEG abnormality OMIM:617519
Dopa-Responsive Dystonia
Dystonia, Gait disturbance, Arm dystonia, Inability to walk, Generalized dystonia, Oculogyric cri... ORPHA:255
Insulinoma
Neuroendocrine neoplasm, Zollinger-Ellison syndrome, Neoplasm of the adrenal gland, Coma, Reduced... ORPHA:97279
Acrodermatitis Enteropathica, Zinc-Deficiency Type
Failure to thrive, Ataxia, Alopecia of scalp, Lethargy OMIM:201100
Huntington Disease-Like 1
Gait disturbance, Dysmetria, Weight loss, Bradykinesia, Gait ataxia, Abnormal posturing ORPHA:157941
Mitochondrial Complex Iv Deficiency, Nuclear Type 20
Lethargy, Failure to thrive in infancy, Long eyelashes, Synophrys OMIM:619064
Charcot-Marie-Tooth Disease, Type 4D
Abnormal auditory evoked potentials, Decreased nerve conduction velocity, Hearing impairment OMIM:601455
Mitochondrial Complex Iii Deficiency, Nuclear Type 8
Failure to thrive, Gait disturbance, Ataxia, Lethargy OMIM:615838
Crigler-Najjar Syndrome
Infectious encephalitis, Lethargy ORPHA:205
Ornithine Transcarbamylase Deficiency, Hyperammonemia Due To
Failure to thrive, Ataxia, Coma, Episodic ataxia, Lethargy OMIM:311250
Vitamin B12-Unresponsive Methylmalonic Acidemia Type Mut0
Dystonia, Coma, Pancreatitis, Lethargy ORPHA:289916
Dystonia 1, Torsion, Autosomal Dominant
Writer's cramp, Torticollis, Blepharospasm, Torsion dystonia, Abnormal posturing OMIM:128100
Hyperornithinemia-Hyperammonemia-Homocitrullinuria Syndrome
Failure to thrive, Acute hepatitis, Coma, Confusion, Lethargy OMIM:238970
Mohr-Tranebjaerg Syndrome
Dystonia, Abnormal posturing OMIM:304700
Methylmalonic Aciduria Due To Methylmalonyl-Coa Mutase Deficiency
Tubulointerstitial nephritis, Failure to thrive, Pancreatitis, Coma, Lethargy OMIM:251000
Hemochromatosis, Type 2A
Arthritis, Lethargy OMIM:602390
Optic Atrophy With Or Without Deafness, Ophthalmoplegia, Myopathy, Ataxia, And Neuropathy
Optic atrophy, Abnormal auditory evoked potentials, Progressive sensorineural hearing impairment OMIM:125250
Typhoid
Infectious encephalitis, Ataxia, Coma, Skin rash, Lethargy ORPHA:99745
Cirrhosis, Familial
Lethargy OMIM:215600
Sporadic Infantile Bilateral Striatal Necrosis
Gait disturbance, Dystonia, Bradykinesia, Loss of consciousness, Reduced consciousness/confusion,... ORPHA:225147
Carbamoyl Phosphate Synthetase I Deficiency, Hyperammonemia Due To
Failure to thrive, Ataxia, Coma, Lethargy OMIM:237300
Cyclic Vomiting Syndrome
Ataxia, Attention deficit hyperactivity disorder, Lethargy OMIM:500007
Citrullinemia Type Ii
Drowsiness, Hepatocellular carcinoma, Decreased body mass index, Pancreatitis, Hyperactivity, Com... ORPHA:247585
Hypercalcemia, Infantile, 1
Failure to thrive, Weight loss, Lethargy OMIM:143880
Combined Oxidative Phosphorylation Deficiency 52
Pancreatitis, Lethargy OMIM:619386
Multiple Mitochondrial Dysfunctions Syndrome 2 With Hyperglycinemia
Ataxia, Lethargy OMIM:614299
Galactosemia
Dystonia, Gait disturbance, Gait imbalance, Failure to thrive, Ataxia, Lethargy ORPHA:352
Leukoencephalopathy With Vanishing White Matter
Unsteady gait, Gait disturbance, Lethargy OMIM:603896
Charcot-Marie-Tooth Disease, Type 4C
Decreased motor nerve conduction velocity, Abnormal cranial nerve morphology, Facial palsy, Heari... OMIM:601596
Vitamin B12-Unresponsive Methylmalonic Acidemia
Ataxia, Coma, Pancreatitis, Lethargy ORPHA:27
Scrub Typhus
Myocarditis, Infectious encephalitis, Anterior uveitis, Skin rash, Reduced consciousness/confusio... ORPHA:83317
Central Neurocytoma
Ataxia, Coma, Lethargy ORPHA:73256
Medium Chain Acyl-Coa Dehydrogenase Deficiency
Cachexia, Ataxia, Coma, Loss of consciousness, Lethargy ORPHA:42
Thiamine Metabolism Dysfunction Syndrome 2 (Biotin- Or Thiamine-Responsive Type)
Dystonia, Truncal titubation, Coma, Inability to walk, Craniofacial dystonia, Gait ataxia, Confus... OMIM:607483
Glutaric Acidemia Type 3
Failure to thrive, Lethargy ORPHA:35706
Pyruvate Dehydrogenase E3 Deficiency
Failure to thrive, Ataxia, Lethargy ORPHA:2394
Idiopathic Intracranial Hypertension
Obesity, Lethargy ORPHA:238624
Propionic Acidemia
Dystonia, Eczema, Failure to thrive, Pancreatitis, Coma, Lethargy OMIM:606054
Methylmalonic Aciduria And Homocystinuria, Cblj Type
Abnormal posturing, Lethargy OMIM:614857
3-Methylcrotonyl-Coa Carboxylase 2 Deficiency
Failure to thrive, Seborrheic dermatitis, Alopecia, Coma, Lethargy OMIM:210210
Encephalopathy, Recurrent, Of Childhood
Athetosis, Truncal ataxia, Lethargy OMIM:130950
Maple Syrup Urine Disease
Ataxia, Coma, Pancreatitis, Lethargy OMIM:248600
Pyruvate Dehydrogenase Deficiency
Lethargy, Dystonia, Gait disturbance, Ataxia, Multiple lipomas ORPHA:765
Mitochondrial Complex V (Atp Synthase) Deficiency, Nuclear Type 5
Gait imbalance, Lethargy OMIM:618120
Classic Galactosemia
Dystonia, Gait disturbance, Gait imbalance, Ataxia, Attention deficit hyperactivity disorder, Let... ORPHA:79239
3-Methylcrotonyl-Coa Carboxylase 1 Deficiency
Failure to thrive, Coma, Lethargy OMIM:210200
2-Methylbutyryl-Coa Dehydrogenase Deficiency
Lethargy OMIM:610006
Holocarboxylase Synthetase Deficiency
Coma, Alopecia, Skin rash, Lethargy OMIM:253270
Benign Samaritan Congenital Myopathy
Lethargy ORPHA:324581
Carnitine Palmitoyl Transferase 1A Deficiency
Coma, Loss of consciousness, Lethargy ORPHA:156
Hemochromatosis Type 2
Lethargy ORPHA:79230
Susac Syndrome
Gait ataxia, Confusion, Lethargy ORPHA:838
Glycogen Storage Disease Due To Hepatic Glycogen Synthase Deficiency
Failure to thrive, Lethargy ORPHA:2089
Meningococcal Meningitis
Drowsiness, Infectious encephalitis, Skin rash, Reduced consciousness/confusion, Lethargy ORPHA:33475
Renal Tubular Acidosis, Distal, 4, With Hemolytic Anemia
Failure to thrive, Lethargy OMIM:611590
Thyroid Dyshormonogenesis 1
Lethargy OMIM:274400
Methylcobalamin Deficiency Type Cble
Drowsiness, Failure to thrive, Excessive daytime somnolence, Loss of consciousness, Lethargy ORPHA:2169
Isovaleric Acidemia
Coma, Lethargy OMIM:243500
Dihydropyrimidinase Deficiency
Excessive daytime somnolence, Lethargy OMIM:222748
Idiopathic Congenital Hypothyroidism
Lethargy ORPHA:95717
Hyperinsulinism Due To Hnf4A Deficiency
Drowsiness, Large for gestational age, Coma, Increased body weight, Lethargy ORPHA:263455
Hyperphenylalaninemia, Bh4-Deficient, B
Dystonia, Lethargy OMIM:233910
Spinocerebellar Ataxia, X-Linked 3
Dysmetria, Head titubation, Lethargy OMIM:301790
Ogden Syndrome
Fine hair, Torticollis, Shuffling gait, Excessive daytime somnolence, Aplasia/Hypoplasia of the e... ORPHA:276432
Medulloblastoma
Neuroblastoma, Neoplasm of the lung, Cerebellar ataxia associated with quadrupedal gait, Adenomat... ORPHA:616
Thiamine-Responsive Megaloblastic Anemia Syndrome
Lethargy ORPHA:49827
Encephalopathy, Progressive, Early-Onset, With Brain Edema And/Or Leukoencephalopathy, 2
Dystonia, Ataxia, Skin rash, Lethargy OMIM:618321
Biotinidase Deficiency
Lethargy, Seborrheic dermatitis, Alopecia, Ataxia, Recurrent skin infections, Skin rash, Conjunct... OMIM:253260
Myxedema
Lethargy OMIM:255900
Sandifer Syndrome
Torticollis, Esophagitis, Abnormal posturing ORPHA:71272
Argininosuccinic Aciduria
Dry hair, Failure to thrive, Brittle hair, Trichorrhexis nodosa, Ataxia, Coma, Lethargy OMIM:207900
Methylmalonic Aciduria And Homocystinuria, Cblf Type
Failure to thrive, Stomatitis, Skin rash, Lethargy OMIM:277380
Autosomal Dominant Optic Atrophy Plus Syndrome
Sensorineural hearing impairment, Optic atrophy, Absent brainstem auditory responses, Temporal op... ORPHA:1215
Symptomatic Form Of Hemochromatosis Type 1
Cholangiocarcinoma, Hepatocellular carcinoma, Weight loss, Arthritis, Lethargy ORPHA:465508
Mitochondrial Complex I Deficiency, Nuclear Type 9
Lethargy OMIM:618232
Carnitine Palmitoyltransferase I Deficiency
Coma, Lethargy OMIM:255120
Methylmalonic Acidemia With Homocystinuria Type Cblf
Failure to thrive, Stomatitis, Skin rash, Lethargy ORPHA:79284
Necrotizing Enterocolitis
Peritonitis, Small for gestational age, Lethargy ORPHA:391673
Staphylococcal Necrotizing Pneumonia
Acute infectious pneumonia, Confusion, Pneumonia, Lethargy ORPHA:36238
Mohr-Tranebjaerg Syndrome
Optic atrophy, Abnormality of somatosensory evoked potentials, Absent brainstem auditory response... ORPHA:52368
Very Long Chain Acyl-Coa Dehydrogenase Deficiency
Inflammatory abnormality of the skin, Small for gestational age, Pneumonia, Overweight, Obesity, ... ORPHA:26793
Dengue Fever
Skin rash, Lethargy ORPHA:99828
Mitochondrial Trifunctional Protein Deficiency
Failure to thrive, Small for gestational age, Lethargy OMIM:609015
Methylmalonic Aciduria, Cblb Type
Failure to thrive, Coma, Lethargy OMIM:251110
Multiple Endocrine Neoplasia Type 1
Thyroid carcinoma, Meningioma, Gingival fibromatosis, Insulinoma, Intestinal carcinoid, Pituitary... ORPHA:652
Acyl-Coa Dehydrogenase, Medium-Chain, Deficiency Of
Coma, Lethargy OMIM:201450
Acrocraniofacial Dysostosis
Sensorineural hearing impairment, Conductive hearing impairment, Abnormal auditory evoked potentials OMIM:201050
Transcobalamin Ii Deficiency
Failure to thrive, Ataxia, Lethargy OMIM:275350
Evans Syndrome
Lethargy ORPHA:1959
Carnitine Palmitoyltransferase Ii Deficiency, Infantile
Lethargy OMIM:600649
Methylmalonic Aciduria, Cbla Type
Failure to thrive, Coma, Lethargy OMIM:251100
Vici Syndrome
Failure to thrive, Chronic mucocutaneous candidiasis, Albinism, Hypopigmentation of hair, Abnorma... OMIM:242840
Mitochondrial Trifunctional Protein Deficiency
Coma, Failure to thrive in infancy, Tip-toe gait, Lethargy ORPHA:746
Infantile Liver Failure Syndrome 2
Lethargy OMIM:616483
Axenfeld-Rieger Anomaly With Partially Absent Eye Muscles, Distinctive Face, Hydrocephaly, And Skeletal Abnormalities
Sensorineural hearing impairment, Abnormal auditory evoked potentials OMIM:109120
Citrullinemia, Classic
Failure to thrive, Ataxia, Coma, Lethargy OMIM:215700
Late-Onset Isolated Acth Deficiency
Failure to thrive, Weight loss, Hepatitis, Pituitary adenoma, Hashimoto thyroiditis, Lethargy ORPHA:199299
Familial Thyroid Dyshormonogenesis
Lethargy ORPHA:95716
Methylmalonic Aciduria And Homocystinuria, Cbld Type
Dystonia, Spastic ataxia, Lethargy OMIM:277410
Acyl-Coa Dehydrogenase, Very Long-Chain, Deficiency Of
Necrotizing enterocolitis, Lethargy OMIM:201475
Ebola Hemorrhagic Fever
Hepatitis, Acute pancreatitis, Maculopapular exanthema, Lethargy ORPHA:319218
Biotinidase Deficiency
Lethargy, Eczematoid dermatitis, Alopecia, Ataxia, Skin rash, Conjunctivitis ORPHA:79241
3-Hydroxy-3-Methylglutaric Aciduria
Weight loss, Ataxia, Coma, Acute pancreatitis, Hypoglycemic coma, Lethargy ORPHA:20
Hyperornithinemia-Hyperammonemia-Homocitrullinuria Syndrome
Failure to thrive, Spastic gait, Hepatitis, Progressive cerebellar ataxia, Coma, Confusion, Lethargy ORPHA:415
Sim1-Related Prader-Willi-Like Syndrome
Failure to thrive, Abdominal obesity, Obesity, Hypopigmentation of hair, Lethargy ORPHA:398079
Fructose-1,6-Bisphosphatase Deficiency
Coma, Lethargy OMIM:229700
Resistance To Thyrotropin-Releasing Hormone Syndrome
Overweight, Lethargy ORPHA:99832
Aromatic L-Amino Acid Decarboxylase Deficiency
Athetosis, Torticollis, Limb dystonia, Oculogyric crisis, Blepharospasm, Lethargy OMIM:608643
Pseudo-Torch Syndrome 2
Lethargy OMIM:617397
Hyperinsulinism Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency
Failure to thrive, Confusion, Lethargy ORPHA:71212
Homocystinuria Due To Methylene Tetrahydrofolate Reductase Deficiency
Failure to thrive, Gait disturbance, Ataxia, Lethargy ORPHA:395
Combined Oxidative Phosphorylation Deficiency 11
Lethargy OMIM:614922
Carbonic Anhydrase Va Deficiency, Hyperammonemia Due To
Lethargy OMIM:615751
Methylmalonic Aciduria And Homocystinuria, Cblc Type
Failure to thrive, Delirium, Confusion, Lethargy OMIM:277400
Trichinellosis
Conjunctivitis, Excessive daytime somnolence, Skin rash, Reduced consciousness/confusion, Confusi... ORPHA:863
Amoebiasis Due To Free-Living Amoebae
Sinusitis, Infectious encephalitis, Pustule, Pneumonia, Ataxia, Coma, Loss of consciousness, Conf... ORPHA:68
Familial Hypoaldosteronism
Failure to thrive, Lethargy ORPHA:427
Magel2-Related Prader-Willi-Like Syndrome
Failure to thrive, Abdominal obesity, Hypopigmentation of hair, Increased body weight, Lethargy ORPHA:398069
Carnitine-Acylcarnitine Translocase Deficiency
Coma, Lethargy OMIM:212138
Late-Infantile/Juvenile Krabbe Disease
EEG with persistent abnormal rhythmic activity, Decreased nerve conduction velocity, Prolonged br... ORPHA:206443
Carnitine-Acylcarnitine Translocase Deficiency
Coma, Lethargy ORPHA:159
Cholera
Loss of consciousness, Aspiration pneumonia, Lethargy ORPHA:173
Spondyloepiphyseal Dysplasia, Sensorineural Hearing Loss, Impaired Intellectual Development, And Leber Congenital Amaurosis
Sensorineural hearing impairment, Optic disc pallor, Abnormal auditory evoked potentials OMIM:619260
Autosomal Dominant Progressive External Ophthalmoplegia
Gait disturbance, Failure to thrive, Bradykinesia, Ataxia, Gait ataxia, Lethargy ORPHA:254892
Complete Atrioventricular Septal Defect
Failure to thrive, Recurrent pneumonia, Lethargy ORPHA:1329
Carnitine Palmitoyltransferase Ii Deficiency, Lethal Neonatal
Lethargy OMIM:608836
Isolated Thyroid-Stimulating Hormone Deficiency
Failure to thrive, Attention deficit hyperactivity disorder, Lethargy ORPHA:90674
Encephalitis Lethargica
Coma, Lethargy ORPHA:83600
Isolated Complex I Deficiency
Failure to thrive, Ataxia, Lethargy ORPHA:2609
Methylmalonic Acidemia With Homocystinuria, Type Cblc
Stomatitis, Failure to thrive, Ataxia, Delirium, Lethargy ORPHA:79282
Central Nervous System Calcification-Deafness-Tubular Acidosis-Anemia Syndrome
Absent brainstem auditory responses, Vestibular areflexia ORPHA:3240
Adult Krabbe Disease
EEG abnormality, Prolonged brainstem auditory evoked potentials ORPHA:206448
Chronic Bilirubin Encephalopathy
Sensorineural hearing impairment, Abnormal auditory evoked potentials ORPHA:529808
Acute Bilirubin Encephalopathy
Sensorineural hearing impairment, Abnormal auditory evoked potentials ORPHA:529799
Arthrogryposis, Distal, Type 2A
Abnormal auditory evoked potentials, Hearing impairment OMIM:193700
Posterior Urethral Valve
Pyelonephritis, Lethargy ORPHA:93110
Kufor-Rakeb Syndrome
Confusion, Gait disturbance, Lingual dystonia, Bradykinesia, Oculogyric crisis, Blepharospasm, Di... ORPHA:306674
Pineoblastoma
Lethargy, Pinealoma, Retinoblastoma, Reduced consciousness/confusion ORPHA:251909
Marburg Hemorrhagic Fever
Drowsiness, Pericarditis, Arthritis, Pancreatitis, Coma, Uveitis, Maculopapular exanthema, Skin r... ORPHA:99826
Blackfan-Diamond Anemia
Malignant genitourinary tract tumor, Myelodysplasia, Small for gestational age, Low anterior hair... ORPHA:124
Peripheral Demyelinating Neuropathy, Central Dysmyelination, Waardenburg Syndrome, And Hirschsprung Disease
Absent brainstem auditory responses, Decreased nerve conduction velocity, Sensorineural hearing i... OMIM:609136
Adult-Onset Autosomal Dominant Leukodystrophy
Abnormal auditory evoked potentials, Abnormality of somatosensory evoked potentials, Orthostatic ... ORPHA:99027
Genetic Transient Congenital Hypothyroidism
Lethargy ORPHA:226316
Histiocytoid Cardiomyopathy
Failure to thrive, Drowsiness, Loss of consciousness, Lethargy ORPHA:137675
Charcot-Marie-Tooth Disease Type 1F
Sensorineural hearing impairment, Optic nerve hypoplasia, Absent brainstem auditory responses, De... ORPHA:101085
Mitochondrial Complex I Deficiency, Nuclear Type 1
Failure to thrive, Ataxia, Coma, Lethargy OMIM:252010
Hereditary Fructose Intolerance
Coma, Lethargy ORPHA:469
Hypothyroidism Due To Tsh Receptor Mutations
Lethargy ORPHA:90673
Infantile Krabbe Disease
Prolonged brainstem auditory evoked potentials, Optic atrophy, Decreased nerve conduction velocit... ORPHA:206436
Semilobar Holoprosencephaly
Lethargy, Failure to thrive, Inability to walk, Attention deficit hyperactivity disorder, Aspirat... ORPHA:220386
Alobar Holoprosencephaly
Lethargy, Failure to thrive, Inability to walk, Attention deficit hyperactivity disorder, Aspirat... ORPHA:93925
Midline Interhemispheric Variant Of Holoprosencephaly
Lethargy, Failure to thrive, Inability to walk, Attention deficit hyperactivity disorder, Aspirat... ORPHA:93926
Lobar Holoprosencephaly
Lethargy, Failure to thrive, Inability to walk, Attention deficit hyperactivity disorder, Aspirat... ORPHA:93924
Lysinuric Protein Intolerance
Tubulointerstitial nephritis, Failure to thrive, Membranous nephropathy, Pancreatitis, Coma, Glom... ORPHA:470
Cockayne Syndrome Type 1
Optic atrophy, Macrotia, Absent brainstem auditory responses, Hearing impairment, Abnormality of ... ORPHA:90321
Fructose Intolerance, Hereditary
Failure to thrive, Coma, Lethargy OMIM:229600
Trisomy 10P
Low voltage EEG, Abnormal auditory evoked potentials, Macrotia, Posteriorly rotated ears, EEG wit... ORPHA:171929
Cerebrotendinous Xanthomatosis
Optic atrophy, Optic neuropathy, Abnormal auditory evoked potentials, Optic disc pallor, Abnormal... ORPHA:909
Mogs-Cdg
Sensorineural hearing impairment, Optic atrophy, Absent brainstem auditory responses ORPHA:79330
Glycine Encephalopathy
Lethargy ORPHA:407
Exercise-Induced Malignant Hyperthermia
Ataxia, Delirium, Confusion, Lethargy ORPHA:466650
Visceral Steatosis, Congenital
Coma, Lethargy OMIM:228100
Hypothyroidism Due To Deficient Transcription Factors Involved In Pituitary Development Or Function
Overweight, Lethargy ORPHA:226307
Hydranencephaly
Lethargy ORPHA:2177
Cockayne Syndrome A
Optic atrophy, Abnormal auditory evoked potentials, Abnormality of the pinna, Decreased nerve con... OMIM:216400
Cockayne Syndrome B
Optic atrophy, Abnormal auditory evoked potentials, Abnormality of the pinna, Decreased nerve con... OMIM:133540
Unilateral Polymicrogyria
Abnormal posturing ORPHA:268943
Hypothyroidism, Congenital, Nongoitrous, 2
Lethargy OMIM:218700
Mend Syndrome
Abnormal auditory evoked potentials ORPHA:401973
Eisenmenger Syndrome
Bacterial endocarditis, Lethargy ORPHA:97214
Paroxysmal Nocturnal Hemoglobinuria
Lethargy ORPHA:447
Urofacial Syndrome 2
OMIM:615112
Ochoa Syndrome
ORPHA:2704

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Lrig2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Lrig2.

No publications found that use IMPC mice or data for Lrig2.

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MGI Allele Allele Type Produced
Lrig2tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Lrig2tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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