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Gene: Lrig2 MGI:2443718

Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:

leucine-rich repeats and immunoglobulin-like domains 2

Synonyms:

4632419I10Rik

Order Alleles

IMPC Data Collections

No Body Weight Data
No Embryo Imaging Data
No Viability Data

IMPC Phenotype Summary

Significant

Not Significant

Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Lrig2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

Human diseases associated with Lrig2 (2 diseases)
Human diseases predicted to be associated with Lrig2 (230 diseases)

The table below shows human diseases associated to Lrig2 by orthology or direct annotation.

Disease	Similarity of phenotypes	Matching phenotypes	Source
Urofacial Syndrome 2			OMIM:615112
Ochoa Syndrome			ORPHA:2704

The table below shows human diseases predicted to be associated to Lrig2 by phenotypic similarity.

Disease	Matching phenotypes	Source
Deafness, Autosomal Recessive 9	Sensorineural hearing impairment, Absent brainstem auditory responses	OMIM:601071
Auditory Neuropathy, Autosomal Dominant, 1	Sensorineural hearing impairment, Abnormal auditory evoked potentials	OMIM:609129
Dystonia 31	Arm dystonia, Writer's cramp, Craniofacial dystonia, Difficulty walking, Generalized dystonia, Ab...	OMIM:619565
Methylmalonic Acidemia With Homocystinuria, Type Cbld	Failure to thrive, Gait disturbance, Lethargy	ORPHA:79283
Abcd Syndrome	Abnormal auditory evoked potentials, Aganglionic megacolon, Hearing impairment	OMIM:600501
Methylmalonic Acidemia With Homocystinuria	Failure to thrive, Gait disturbance, Skin rash, Lethargy	ORPHA:26
Charcot-Marie-Tooth Disease, Type 4B1	Decreased motor nerve conduction velocity, Abnormal auditory evoked potentials, Facial palsy	OMIM:601382
Homocystinuria Without Methylmalonic Aciduria	Failure to thrive, Ataxia, Lethargy	ORPHA:622
Developmental And Epileptic Encephalopathy 92	Dystonia, Ataxia, Inability to walk, Difficulty walking, Lethargy	OMIM:617829
Glut1 Deficiency Syndrome 1	Paroxysmal dystonia, Paroxysmal lethargy, Ataxia, Confusion, Lethargy	OMIM:606777
Encephalopathy, Acute, Infection-Induced (Herpes-Specific), Susceptibility To, 8	Herpes simplex encephalitis, Confusion, Lethargy	OMIM:617900
Optic Atrophy 8	Sensorineural hearing impairment, Optic atrophy, Abnormal auditory evoked potentials, Prolonged s...	OMIM:616648
Dihydropyrimidine Dehydrogenase Deficiency	Failure to thrive, Hyperactivity, Lethargy	OMIM:274270
N-Acetylglutamate Synthase Deficiency	Failure to thrive, Coma, Confusion, Lethargy	OMIM:237310
Mitochondrial Complex I Deficiency, Nuclear Type 3	Dystonia, Ataxia, Lethargy	OMIM:618224
Immunodeficiency 83, Susceptibility To Viral Infections	Herpes simplex encephalitis, Confusion, Lethargy	OMIM:613002
Hypothyroidism, Congenital, Nongoitrous, 7	Lethargy	OMIM:618573
Mitochondrial Complex I Deficiency, Nuclear Type 6	Failure to thrive, Lethargy	OMIM:618228
Thiamine Metabolism Dysfunction Syndrome 4 (Bilateral Striatal Degeneration And Progressive Polyneuropathy Type)	Difficulty walking, Lethargy	OMIM:613710
Mitochondrial Complex V (Atp Synthase) Deficiency, Nuclear Type 6	Ataxia, Bradykinesia, Lethargy	OMIM:618683
Holocarboxylase Synthetase Deficiency	Eczema, Perioral eczema, Weight loss, Alopecia, Ataxia, Coma, Keratoconjunctivitis, Lethargy	ORPHA:79242
Classic Pantothenate Kinase-Associated Neurodegeneration	Gait disturbance, Weight loss, Inability to walk, Tip-toe gait, Generalized dystonia, Attention d...	ORPHA:216866
Short Chain Acyl-Coa Dehydrogenase Deficiency	Failure to thrive, Dystonia, Lethargy	ORPHA:26792
Multiple Mitochondrial Dysfunctions Syndrome 1	Failure to thrive, Lethargy	OMIM:605711
Acyl-Coa Dehydrogenase, Short-Chain, Deficiency Of	Failure to thrive, Lethargy	OMIM:201470
Pyruvate Dehydrogenase E1-Alpha Deficiency	Dystonia, Episodic ataxia, Small for gestational age, Lethargy	OMIM:312170
Vitamin B12-Responsive Methylmalonic Acidemia	Failure to thrive, Coma, Lethargy	ORPHA:28
Glycine Encephalopathy	Hyperactivity, Lethargy	OMIM:605899
Autosomal Recessive Spastic Paraplegia Type 44	Sensorineural hearing impairment, Abnormal auditory evoked potentials, Abnormality of somatosenso...	ORPHA:320401
Hyperammonemia Due To N-Acetylglutamate Synthase Deficiency	Drowsiness, Myelodysplasia, Failure to thrive, Ataxia, Coma, Loss of consciousness, Delirium, Con...	ORPHA:927
Autosomal Recessive Dopa-Responsive Dystonia	Bradykinesia, Focal dystonia, Ataxia, Limb dystonia, Generalized dystonia, Oculogyric crisis, Gai...	ORPHA:101150
Ravine Syndrome	Abnormal auditory evoked potentials	ORPHA:99852
Febrile Infection-Related Epilepsy Syndrome	Sinusitis, Lethargy	ORPHA:163703
Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome	Coma, Drowsiness, Increased body weight, Lethargy	ORPHA:276608
Classic Glucose Transporter Type 1 Deficiency Syndrome	Confusion, Dystonia, Ataxia, Lethargy	ORPHA:71277
Hereditary Central Diabetes Insipidus	Weight loss, Lethargy	ORPHA:30925
Developmental And Epileptic Encephalopathy 41	Inability to walk, Lethargy	OMIM:617105
Mitochondrial Complex I Deficiency, Nuclear Type 5	Failure to thrive, Dystonia, Ataxia, Lethargy	OMIM:618226
Combined Oxidative Phosphorylation Deficiency 2	Small for gestational age, Lethargy	OMIM:610498
Hyperinsulinism Due To Hnf1A Deficiency	Drowsiness, Small for gestational age, Large for gestational age, Loss of consciousness, Hypoglyc...	ORPHA:324575
Central Diabetes Insipidus	Failure to thrive, Weight loss, Excessive daytime somnolence, Lethargy	ORPHA:178029
Citrullinemia Type I	Torticollis, Failure to thrive, Ataxia, Coma, Loss of consciousness, Lethargy	ORPHA:247525
Homocystinuria-Megaloblastic Anemia, Cble Complementation Type	Failure to thrive, Gait disturbance, Lethargy	OMIM:236270
Glycerol Kinase Deficiency	Coma, Loss of consciousness, Small for gestational age, Lethargy	OMIM:307030
Hyperinsulinism Due To Ucp2 Deficiency	Drowsiness, Large for gestational age, Loss of consciousness, Hypoglycemic coma, Lethargy	ORPHA:276556
Early Myoclonic Encephalopathy	Lethargy	ORPHA:1935
Vitamin B12-Unresponsive Methylmalonic Acidemia Type Mut-	Dystonia, Failure to thrive, Pancreatitis, Coma, Lethargy	ORPHA:79312
Dihydrolipoamide Dehydrogenase Deficiency	Dystonia, Ataxia, Lethargy	OMIM:246900
Multiple Carboxylase Deficiency	Alopecia, Ataxia, Coma, Skin rash, Lethargy	ORPHA:148
Gaba-Transaminase Deficiency	Lethargy	OMIM:613163
Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency	Drowsiness, Large for gestational age, Loss of consciousness, Hypoglycemic coma, Lethargy	ORPHA:276575
Hyperlysinuria With Hyperammonemia	Coma, Lethargy	OMIM:238750
Severe Canavan Disease	Inability to walk, Lethargy	ORPHA:314911
Mitochondrial Complex I Deficiency, Nuclear Type 4	Ataxia, Lethargy	OMIM:618225
Lethal Infantile Mitochondrial Myopathy	Lethargy	ORPHA:254857
Autosomal Dominant Hyperinsulinism Due To Kir6.2 Deficiency	Drowsiness, Large for gestational age, Loss of consciousness, Hypoglycemic coma, Lethargy	ORPHA:276580
Carnitine Deficiency, Systemic Primary	Failure to thrive, Excessive daytime somnolence, Coma, Confusion, Lethargy	OMIM:212140
Neurodevelopmental Disorder With Hypotonia, Neuropathy, And Deafness	Facial palsy, Sensorineural hearing impairment, Absent brainstem auditory responses, EEG abnormality	OMIM:617519
Dopa-Responsive Dystonia	Dystonia, Gait disturbance, Arm dystonia, Inability to walk, Generalized dystonia, Oculogyric cri...	ORPHA:255
Insulinoma	Neuroendocrine neoplasm, Zollinger-Ellison syndrome, Neoplasm of the adrenal gland, Coma, Reduced...	ORPHA:97279
Acrodermatitis Enteropathica, Zinc-Deficiency Type	Failure to thrive, Ataxia, Alopecia of scalp, Lethargy	OMIM:201100
Huntington Disease-Like 1	Gait disturbance, Dysmetria, Weight loss, Bradykinesia, Gait ataxia, Abnormal posturing	ORPHA:157941
Mitochondrial Complex Iv Deficiency, Nuclear Type 20	Lethargy, Failure to thrive in infancy, Long eyelashes, Synophrys	OMIM:619064
Charcot-Marie-Tooth Disease, Type 4D	Abnormal auditory evoked potentials, Decreased nerve conduction velocity, Hearing impairment	OMIM:601455
Mitochondrial Complex Iii Deficiency, Nuclear Type 8	Failure to thrive, Gait disturbance, Ataxia, Lethargy	OMIM:615838
Crigler-Najjar Syndrome	Infectious encephalitis, Lethargy	ORPHA:205
Ornithine Transcarbamylase Deficiency, Hyperammonemia Due To	Failure to thrive, Ataxia, Coma, Episodic ataxia, Lethargy	OMIM:311250
Vitamin B12-Unresponsive Methylmalonic Acidemia Type Mut0	Dystonia, Coma, Pancreatitis, Lethargy	ORPHA:289916
Dystonia 1, Torsion, Autosomal Dominant	Writer's cramp, Torticollis, Blepharospasm, Torsion dystonia, Abnormal posturing	OMIM:128100
Hyperornithinemia-Hyperammonemia-Homocitrullinuria Syndrome	Failure to thrive, Acute hepatitis, Coma, Confusion, Lethargy	OMIM:238970
Mohr-Tranebjaerg Syndrome	Dystonia, Abnormal posturing	OMIM:304700
Methylmalonic Aciduria Due To Methylmalonyl-Coa Mutase Deficiency	Tubulointerstitial nephritis, Failure to thrive, Pancreatitis, Coma, Lethargy	OMIM:251000
Hemochromatosis, Type 2A	Arthritis, Lethargy	OMIM:602390
Optic Atrophy With Or Without Deafness, Ophthalmoplegia, Myopathy, Ataxia, And Neuropathy	Optic atrophy, Abnormal auditory evoked potentials, Progressive sensorineural hearing impairment	OMIM:125250
Typhoid	Infectious encephalitis, Ataxia, Coma, Skin rash, Lethargy	ORPHA:99745
Cirrhosis, Familial	Lethargy	OMIM:215600
Sporadic Infantile Bilateral Striatal Necrosis	Gait disturbance, Dystonia, Bradykinesia, Loss of consciousness, Reduced consciousness/confusion,...	ORPHA:225147
Carbamoyl Phosphate Synthetase I Deficiency, Hyperammonemia Due To	Failure to thrive, Ataxia, Coma, Lethargy	OMIM:237300
Cyclic Vomiting Syndrome	Ataxia, Attention deficit hyperactivity disorder, Lethargy	OMIM:500007
Citrullinemia Type Ii	Drowsiness, Hepatocellular carcinoma, Decreased body mass index, Pancreatitis, Hyperactivity, Com...	ORPHA:247585
Hypercalcemia, Infantile, 1	Failure to thrive, Weight loss, Lethargy	OMIM:143880
Combined Oxidative Phosphorylation Deficiency 52	Pancreatitis, Lethargy	OMIM:619386
Multiple Mitochondrial Dysfunctions Syndrome 2 With Hyperglycinemia	Ataxia, Lethargy	OMIM:614299
Galactosemia	Dystonia, Gait disturbance, Gait imbalance, Failure to thrive, Ataxia, Lethargy	ORPHA:352
Leukoencephalopathy With Vanishing White Matter	Unsteady gait, Gait disturbance, Lethargy	OMIM:603896
Charcot-Marie-Tooth Disease, Type 4C	Decreased motor nerve conduction velocity, Abnormal cranial nerve morphology, Facial palsy, Heari...	OMIM:601596
Vitamin B12-Unresponsive Methylmalonic Acidemia	Ataxia, Coma, Pancreatitis, Lethargy	ORPHA:27
Scrub Typhus	Myocarditis, Infectious encephalitis, Anterior uveitis, Skin rash, Reduced consciousness/confusio...	ORPHA:83317
Central Neurocytoma	Ataxia, Coma, Lethargy	ORPHA:73256
Medium Chain Acyl-Coa Dehydrogenase Deficiency	Cachexia, Ataxia, Coma, Loss of consciousness, Lethargy	ORPHA:42
Thiamine Metabolism Dysfunction Syndrome 2 (Biotin- Or Thiamine-Responsive Type)	Dystonia, Truncal titubation, Coma, Inability to walk, Craniofacial dystonia, Gait ataxia, Confus...	OMIM:607483
Glutaric Acidemia Type 3	Failure to thrive, Lethargy	ORPHA:35706
Pyruvate Dehydrogenase E3 Deficiency	Failure to thrive, Ataxia, Lethargy	ORPHA:2394
Idiopathic Intracranial Hypertension	Obesity, Lethargy	ORPHA:238624
Propionic Acidemia	Dystonia, Eczema, Failure to thrive, Pancreatitis, Coma, Lethargy	OMIM:606054
Methylmalonic Aciduria And Homocystinuria, Cblj Type	Abnormal posturing, Lethargy	OMIM:614857
3-Methylcrotonyl-Coa Carboxylase 2 Deficiency	Failure to thrive, Seborrheic dermatitis, Alopecia, Coma, Lethargy	OMIM:210210
Encephalopathy, Recurrent, Of Childhood	Athetosis, Truncal ataxia, Lethargy	OMIM:130950
Maple Syrup Urine Disease	Ataxia, Coma, Pancreatitis, Lethargy	OMIM:248600
Pyruvate Dehydrogenase Deficiency	Lethargy, Dystonia, Gait disturbance, Ataxia, Multiple lipomas	ORPHA:765
Mitochondrial Complex V (Atp Synthase) Deficiency, Nuclear Type 5	Gait imbalance, Lethargy	OMIM:618120
Classic Galactosemia	Dystonia, Gait disturbance, Gait imbalance, Ataxia, Attention deficit hyperactivity disorder, Let...	ORPHA:79239
3-Methylcrotonyl-Coa Carboxylase 1 Deficiency	Failure to thrive, Coma, Lethargy	OMIM:210200
2-Methylbutyryl-Coa Dehydrogenase Deficiency	Lethargy	OMIM:610006
Holocarboxylase Synthetase Deficiency	Coma, Alopecia, Skin rash, Lethargy	OMIM:253270
Benign Samaritan Congenital Myopathy	Lethargy	ORPHA:324581
Carnitine Palmitoyl Transferase 1A Deficiency	Coma, Loss of consciousness, Lethargy	ORPHA:156
Hemochromatosis Type 2	Lethargy	ORPHA:79230
Susac Syndrome	Gait ataxia, Confusion, Lethargy	ORPHA:838
Glycogen Storage Disease Due To Hepatic Glycogen Synthase Deficiency	Failure to thrive, Lethargy	ORPHA:2089
Meningococcal Meningitis	Drowsiness, Infectious encephalitis, Skin rash, Reduced consciousness/confusion, Lethargy	ORPHA:33475
Renal Tubular Acidosis, Distal, 4, With Hemolytic Anemia	Failure to thrive, Lethargy	OMIM:611590
Thyroid Dyshormonogenesis 1	Lethargy	OMIM:274400
Methylcobalamin Deficiency Type Cble	Drowsiness, Failure to thrive, Excessive daytime somnolence, Loss of consciousness, Lethargy	ORPHA:2169
Isovaleric Acidemia	Coma, Lethargy	OMIM:243500
Dihydropyrimidinase Deficiency	Excessive daytime somnolence, Lethargy	OMIM:222748
Idiopathic Congenital Hypothyroidism	Lethargy	ORPHA:95717
Hyperinsulinism Due To Hnf4A Deficiency	Drowsiness, Large for gestational age, Coma, Increased body weight, Lethargy	ORPHA:263455
Hyperphenylalaninemia, Bh4-Deficient, B	Dystonia, Lethargy	OMIM:233910
Spinocerebellar Ataxia, X-Linked 3	Dysmetria, Head titubation, Lethargy	OMIM:301790
Ogden Syndrome	Fine hair, Torticollis, Shuffling gait, Excessive daytime somnolence, Aplasia/Hypoplasia of the e...	ORPHA:276432
Medulloblastoma	Neuroblastoma, Neoplasm of the lung, Cerebellar ataxia associated with quadrupedal gait, Adenomat...	ORPHA:616
Thiamine-Responsive Megaloblastic Anemia Syndrome	Lethargy	ORPHA:49827
Encephalopathy, Progressive, Early-Onset, With Brain Edema And/Or Leukoencephalopathy, 2	Dystonia, Ataxia, Skin rash, Lethargy	OMIM:618321
Biotinidase Deficiency	Lethargy, Seborrheic dermatitis, Alopecia, Ataxia, Recurrent skin infections, Skin rash, Conjunct...	OMIM:253260
Myxedema	Lethargy	OMIM:255900
Sandifer Syndrome	Torticollis, Esophagitis, Abnormal posturing	ORPHA:71272
Argininosuccinic Aciduria	Dry hair, Failure to thrive, Brittle hair, Trichorrhexis nodosa, Ataxia, Coma, Lethargy	OMIM:207900
Methylmalonic Aciduria And Homocystinuria, Cblf Type	Failure to thrive, Stomatitis, Skin rash, Lethargy	OMIM:277380
Autosomal Dominant Optic Atrophy Plus Syndrome	Sensorineural hearing impairment, Optic atrophy, Absent brainstem auditory responses, Temporal op...	ORPHA:1215
Symptomatic Form Of Hemochromatosis Type 1	Cholangiocarcinoma, Hepatocellular carcinoma, Weight loss, Arthritis, Lethargy	ORPHA:465508
Mitochondrial Complex I Deficiency, Nuclear Type 9	Lethargy	OMIM:618232
Carnitine Palmitoyltransferase I Deficiency	Coma, Lethargy	OMIM:255120
Methylmalonic Acidemia With Homocystinuria Type Cblf	Failure to thrive, Stomatitis, Skin rash, Lethargy	ORPHA:79284
Necrotizing Enterocolitis	Peritonitis, Small for gestational age, Lethargy	ORPHA:391673
Staphylococcal Necrotizing Pneumonia	Acute infectious pneumonia, Confusion, Pneumonia, Lethargy	ORPHA:36238
Mohr-Tranebjaerg Syndrome	Optic atrophy, Abnormality of somatosensory evoked potentials, Absent brainstem auditory response...	ORPHA:52368
Very Long Chain Acyl-Coa Dehydrogenase Deficiency	Inflammatory abnormality of the skin, Small for gestational age, Pneumonia, Overweight, Obesity, ...	ORPHA:26793
Dengue Fever	Skin rash, Lethargy	ORPHA:99828
Mitochondrial Trifunctional Protein Deficiency	Failure to thrive, Small for gestational age, Lethargy	OMIM:609015
Methylmalonic Aciduria, Cblb Type	Failure to thrive, Coma, Lethargy	OMIM:251110
Multiple Endocrine Neoplasia Type 1	Thyroid carcinoma, Meningioma, Gingival fibromatosis, Insulinoma, Intestinal carcinoid, Pituitary...	ORPHA:652
Acyl-Coa Dehydrogenase, Medium-Chain, Deficiency Of	Coma, Lethargy	OMIM:201450
Acrocraniofacial Dysostosis	Sensorineural hearing impairment, Conductive hearing impairment, Abnormal auditory evoked potentials	OMIM:201050
Transcobalamin Ii Deficiency	Failure to thrive, Ataxia, Lethargy	OMIM:275350
Evans Syndrome	Lethargy	ORPHA:1959
Carnitine Palmitoyltransferase Ii Deficiency, Infantile	Lethargy	OMIM:600649
Methylmalonic Aciduria, Cbla Type	Failure to thrive, Coma, Lethargy	OMIM:251100
Vici Syndrome	Failure to thrive, Chronic mucocutaneous candidiasis, Albinism, Hypopigmentation of hair, Abnorma...	OMIM:242840
Mitochondrial Trifunctional Protein Deficiency	Coma, Failure to thrive in infancy, Tip-toe gait, Lethargy	ORPHA:746
Infantile Liver Failure Syndrome 2	Lethargy	OMIM:616483
Axenfeld-Rieger Anomaly With Partially Absent Eye Muscles, Distinctive Face, Hydrocephaly, And Skeletal Abnormalities	Sensorineural hearing impairment, Abnormal auditory evoked potentials	OMIM:109120
Citrullinemia, Classic	Failure to thrive, Ataxia, Coma, Lethargy	OMIM:215700
Late-Onset Isolated Acth Deficiency	Failure to thrive, Weight loss, Hepatitis, Pituitary adenoma, Hashimoto thyroiditis, Lethargy	ORPHA:199299
Familial Thyroid Dyshormonogenesis	Lethargy	ORPHA:95716
Methylmalonic Aciduria And Homocystinuria, Cbld Type	Dystonia, Spastic ataxia, Lethargy	OMIM:277410
Acyl-Coa Dehydrogenase, Very Long-Chain, Deficiency Of	Necrotizing enterocolitis, Lethargy	OMIM:201475
Ebola Hemorrhagic Fever	Hepatitis, Acute pancreatitis, Maculopapular exanthema, Lethargy	ORPHA:319218
Biotinidase Deficiency	Lethargy, Eczematoid dermatitis, Alopecia, Ataxia, Skin rash, Conjunctivitis	ORPHA:79241
3-Hydroxy-3-Methylglutaric Aciduria	Weight loss, Ataxia, Coma, Acute pancreatitis, Hypoglycemic coma, Lethargy	ORPHA:20
Hyperornithinemia-Hyperammonemia-Homocitrullinuria Syndrome	Failure to thrive, Spastic gait, Hepatitis, Progressive cerebellar ataxia, Coma, Confusion, Lethargy	ORPHA:415
Sim1-Related Prader-Willi-Like Syndrome	Failure to thrive, Abdominal obesity, Obesity, Hypopigmentation of hair, Lethargy	ORPHA:398079
Fructose-1,6-Bisphosphatase Deficiency	Coma, Lethargy	OMIM:229700
Resistance To Thyrotropin-Releasing Hormone Syndrome	Overweight, Lethargy	ORPHA:99832
Aromatic L-Amino Acid Decarboxylase Deficiency	Athetosis, Torticollis, Limb dystonia, Oculogyric crisis, Blepharospasm, Lethargy	OMIM:608643
Pseudo-Torch Syndrome 2	Lethargy	OMIM:617397
Hyperinsulinism Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency	Failure to thrive, Confusion, Lethargy	ORPHA:71212
Homocystinuria Due To Methylene Tetrahydrofolate Reductase Deficiency	Failure to thrive, Gait disturbance, Ataxia, Lethargy	ORPHA:395
Combined Oxidative Phosphorylation Deficiency 11	Lethargy	OMIM:614922
Carbonic Anhydrase Va Deficiency, Hyperammonemia Due To	Lethargy	OMIM:615751
Methylmalonic Aciduria And Homocystinuria, Cblc Type	Failure to thrive, Delirium, Confusion, Lethargy	OMIM:277400
Trichinellosis	Conjunctivitis, Excessive daytime somnolence, Skin rash, Reduced consciousness/confusion, Confusi...	ORPHA:863
Amoebiasis Due To Free-Living Amoebae	Sinusitis, Infectious encephalitis, Pustule, Pneumonia, Ataxia, Coma, Loss of consciousness, Conf...	ORPHA:68
Familial Hypoaldosteronism	Failure to thrive, Lethargy	ORPHA:427
Magel2-Related Prader-Willi-Like Syndrome	Failure to thrive, Abdominal obesity, Hypopigmentation of hair, Increased body weight, Lethargy	ORPHA:398069
Carnitine-Acylcarnitine Translocase Deficiency	Coma, Lethargy	OMIM:212138
Late-Infantile/Juvenile Krabbe Disease	EEG with persistent abnormal rhythmic activity, Decreased nerve conduction velocity, Prolonged br...	ORPHA:206443
Carnitine-Acylcarnitine Translocase Deficiency	Coma, Lethargy	ORPHA:159
Cholera	Loss of consciousness, Aspiration pneumonia, Lethargy	ORPHA:173
Spondyloepiphyseal Dysplasia, Sensorineural Hearing Loss, Impaired Intellectual Development, And Leber Congenital Amaurosis	Sensorineural hearing impairment, Optic disc pallor, Abnormal auditory evoked potentials	OMIM:619260
Autosomal Dominant Progressive External Ophthalmoplegia	Gait disturbance, Failure to thrive, Bradykinesia, Ataxia, Gait ataxia, Lethargy	ORPHA:254892
Complete Atrioventricular Septal Defect	Failure to thrive, Recurrent pneumonia, Lethargy	ORPHA:1329
Carnitine Palmitoyltransferase Ii Deficiency, Lethal Neonatal	Lethargy	OMIM:608836
Isolated Thyroid-Stimulating Hormone Deficiency	Failure to thrive, Attention deficit hyperactivity disorder, Lethargy	ORPHA:90674
Encephalitis Lethargica	Coma, Lethargy	ORPHA:83600
Isolated Complex I Deficiency	Failure to thrive, Ataxia, Lethargy	ORPHA:2609
Methylmalonic Acidemia With Homocystinuria, Type Cblc	Stomatitis, Failure to thrive, Ataxia, Delirium, Lethargy	ORPHA:79282
Central Nervous System Calcification-Deafness-Tubular Acidosis-Anemia Syndrome	Absent brainstem auditory responses, Vestibular areflexia	ORPHA:3240
Adult Krabbe Disease	EEG abnormality, Prolonged brainstem auditory evoked potentials	ORPHA:206448
Chronic Bilirubin Encephalopathy	Sensorineural hearing impairment, Abnormal auditory evoked potentials	ORPHA:529808
Acute Bilirubin Encephalopathy	Sensorineural hearing impairment, Abnormal auditory evoked potentials	ORPHA:529799
Arthrogryposis, Distal, Type 2A	Abnormal auditory evoked potentials, Hearing impairment	OMIM:193700
Posterior Urethral Valve	Pyelonephritis, Lethargy	ORPHA:93110
Kufor-Rakeb Syndrome	Confusion, Gait disturbance, Lingual dystonia, Bradykinesia, Oculogyric crisis, Blepharospasm, Di...	ORPHA:306674
Pineoblastoma	Lethargy, Pinealoma, Retinoblastoma, Reduced consciousness/confusion	ORPHA:251909
Marburg Hemorrhagic Fever	Drowsiness, Pericarditis, Arthritis, Pancreatitis, Coma, Uveitis, Maculopapular exanthema, Skin r...	ORPHA:99826
Blackfan-Diamond Anemia	Malignant genitourinary tract tumor, Myelodysplasia, Small for gestational age, Low anterior hair...	ORPHA:124
Peripheral Demyelinating Neuropathy, Central Dysmyelination, Waardenburg Syndrome, And Hirschsprung Disease	Absent brainstem auditory responses, Decreased nerve conduction velocity, Sensorineural hearing i...	OMIM:609136
Adult-Onset Autosomal Dominant Leukodystrophy	Abnormal auditory evoked potentials, Abnormality of somatosensory evoked potentials, Orthostatic ...	ORPHA:99027
Genetic Transient Congenital Hypothyroidism	Lethargy	ORPHA:226316
Histiocytoid Cardiomyopathy	Failure to thrive, Drowsiness, Loss of consciousness, Lethargy	ORPHA:137675
Charcot-Marie-Tooth Disease Type 1F	Sensorineural hearing impairment, Optic nerve hypoplasia, Absent brainstem auditory responses, De...	ORPHA:101085
Mitochondrial Complex I Deficiency, Nuclear Type 1	Failure to thrive, Ataxia, Coma, Lethargy	OMIM:252010
Hereditary Fructose Intolerance	Coma, Lethargy	ORPHA:469
Hypothyroidism Due To Tsh Receptor Mutations	Lethargy	ORPHA:90673
Infantile Krabbe Disease	Prolonged brainstem auditory evoked potentials, Optic atrophy, Decreased nerve conduction velocit...	ORPHA:206436
Semilobar Holoprosencephaly	Lethargy, Failure to thrive, Inability to walk, Attention deficit hyperactivity disorder, Aspirat...	ORPHA:220386
Alobar Holoprosencephaly	Lethargy, Failure to thrive, Inability to walk, Attention deficit hyperactivity disorder, Aspirat...	ORPHA:93925
Midline Interhemispheric Variant Of Holoprosencephaly	Lethargy, Failure to thrive, Inability to walk, Attention deficit hyperactivity disorder, Aspirat...	ORPHA:93926
Lobar Holoprosencephaly	Lethargy, Failure to thrive, Inability to walk, Attention deficit hyperactivity disorder, Aspirat...	ORPHA:93924
Lysinuric Protein Intolerance	Tubulointerstitial nephritis, Failure to thrive, Membranous nephropathy, Pancreatitis, Coma, Glom...	ORPHA:470
Cockayne Syndrome Type 1	Optic atrophy, Macrotia, Absent brainstem auditory responses, Hearing impairment, Abnormality of ...	ORPHA:90321
Fructose Intolerance, Hereditary	Failure to thrive, Coma, Lethargy	OMIM:229600
Trisomy 10P	Low voltage EEG, Abnormal auditory evoked potentials, Macrotia, Posteriorly rotated ears, EEG wit...	ORPHA:171929
Cerebrotendinous Xanthomatosis	Optic atrophy, Optic neuropathy, Abnormal auditory evoked potentials, Optic disc pallor, Abnormal...	ORPHA:909
Mogs-Cdg	Sensorineural hearing impairment, Optic atrophy, Absent brainstem auditory responses	ORPHA:79330
Glycine Encephalopathy	Lethargy	ORPHA:407
Exercise-Induced Malignant Hyperthermia	Ataxia, Delirium, Confusion, Lethargy	ORPHA:466650
Visceral Steatosis, Congenital	Coma, Lethargy	OMIM:228100
Hypothyroidism Due To Deficient Transcription Factors Involved In Pituitary Development Or Function	Overweight, Lethargy	ORPHA:226307
Hydranencephaly	Lethargy	ORPHA:2177
Cockayne Syndrome A	Optic atrophy, Abnormal auditory evoked potentials, Abnormality of the pinna, Decreased nerve con...	OMIM:216400
Cockayne Syndrome B	Optic atrophy, Abnormal auditory evoked potentials, Abnormality of the pinna, Decreased nerve con...	OMIM:133540
Unilateral Polymicrogyria	Abnormal posturing	ORPHA:268943
Hypothyroidism, Congenital, Nongoitrous, 2	Lethargy	OMIM:218700
Mend Syndrome	Abnormal auditory evoked potentials	ORPHA:401973
Eisenmenger Syndrome	Bacterial endocarditis, Lethargy	ORPHA:97214
Paroxysmal Nocturnal Hemoglobinuria	Lethargy	ORPHA:447
Urofacial Syndrome 2		OMIM:615112
Ochoa Syndrome		ORPHA:2704

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Lrig2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Lrig2.

No publications found that use IMPC mice or data for Lrig2.

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MGI Allele	Allele Type	Produced
Lrig2^{tm1e(EUCOMM)Hmgu}	Targeted, non-conditional allele	ES Cells
Lrig2^{tm1a(EUCOMM)Hmgu}	KO first allele (reporter-tagged insertion with conditional potential)	Targeting vectors, ES Cells

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