banner
Genes Phenotypes Help, News, Blog

Gene: Hook3 MGI:2443554

Log in to follow

Gene Summary

Name:
hook microtubule tethering protein 3
Synonyms:
E330005F07Rik,  5830454D03Rik

Order Alleles

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
increased grip strength Hook3tm1b(NCOM)Mfgc HOM Early adult 3.24×10-06
increased basophil cell number Hook3tm1b(NCOM)Mfgc HOM Early adult 2.14×10-05
hyperactivity Hook3tm1b(NCOM)Mfgc HOM   Early adult 3.12×10-05
decreased body length Hook3tm1b(NCOM)Mfgc HOM Early adult 1.37×10-10
decreased total body fat amount Hook3tm1b(NCOM)Mfgc HOM Early adult 2.07×10-08
decreased prepulse inhibition Hook3tm1b(NCOM)Mfgc HOM   Early adult 1.36×10-07
abnormal lung morphology Hook3tm1b(NCOM)Mfgc HOM Early adult 0.00
decreased bone mineral content Hook3tm1b(NCOM)Mfgc HOM Early adult 8.52×10-06
increased circulating alkaline phosphatase level Hook3tm1b(NCOM)Mfgc HOM Early adult 3.42×10-06
decreased bone mineral density Hook3tm1b(NCOM)Mfgc HOM Early adult 4.49×10-08
increased circulating aspartate transaminase level Hook3tm1b(NCOM)Mfgc HOM Early adult 8.20×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Download thumbnail Download
Immunophenotyping

Panel B FCS file(s)

6 Images

View images
X-ray

XRay Images Whole Body Dorso Ventral

11 Images

View images
Download thumbnail Download
Immunophenotyping

Panel A FCS file(s)

6 Images

View images
X-ray

XRay Images Whole Body Lateral Orientation

11 Images

View images
X-ray

XRay Images Skull Dorso Ventral Orientation

11 Images

View images
X-ray

XRay Images Skull Lateral Orientation

11 Images

View images
Histopathology

Images

6 Images

View images
Gross Pathology and Tissue Collection

Images

8 Images

View images
Combined SHIRPA and Dysmorphology

Images

1 Images

View images
X-ray

XRay Images Hind Leg and Hip

1 Images

View images
Eye Morphology

Images Ophthalmoscopy

1 Images

View images

Human diseases caused by Hook3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Hook3 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Immunodeficiency 60 And Autoimmunity
Decreased basophil count, Pancytopenia, Recurrent sinopulmonary infections, Splenomegaly, Pulmona... OMIM:618394
Systemic Mastocytosis With Associated Hematologic Neoplasm
Normocytic anemia, Acute myeloid leukemia, Normochromic anemia, Chronic lymphatic leukemia, Chron... ORPHA:98849
Chronic Myeloid Leukemia
Myeloproliferative disorder, Leukocytosis, Abnormal granulocyte morphology, Thrombocytopenia, Spl... ORPHA:521
Purine Nucleoside Phosphorylase Deficiency
Autoimmune hemolytic anemia, Abnormal T cell morphology, Hypouricemia, Hyperactivity, Decreased p... ORPHA:760

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

Phenotype Allele Zygosity Sex Life Stage
Tibia - MPATH pathological process term fibro-osseous lesion Hook3tm1b(NCOM)Mfgc HOM Early adult
Femur - MPATH pathological process term hypoplasia Hook3tm1b(NCOM)Mfgc HOM Early adult

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Hook3.

No publications found that use IMPC mice or data for Hook3.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Hook3tm1a(NCOM)Mfgc KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Hook3tm1b(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette) Mice, Tissue

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter