Gene: Hook3

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Name
hook microtubule tethering protein 3
MGI ID
MGI:2443554
Synonyms
5830454D03Rik E330005F07Rik
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
hyperactivity Hook3tm1b(NCOM)Mfgc HOM Early adult 9.65×10-08
abnormal bone structure Hook3tm1b(NCOM)Mfgc HOM Early adult 8.01×10-12
decreased bone mineral density Hook3tm1b(NCOM)Mfgc HOM Early adult 1.77×10-11
abnormal lung morphology Hook3tm1b(NCOM)Mfgc HOM Early adult 0.00
decreased bone mineral content Hook3tm1b(NCOM)Mfgc HOM Early adult 2.27×10-11
decreased circulating triglyceride level Hook3tm1b(NCOM)Mfgc HOM Early adult 1.06×10-05
abnormal behavior Hook3tm1b(NCOM)Mfgc HOM Early adult 1.51×10-06
increased grip strength Hook3tm1b(NCOM)Mfgc HOM Early adult 2.07×10-05
decreased lean body mass Hook3tm1b(NCOM)Mfgc HOM Early adult 5.03×10-11
increased circulating alkaline phosphatase level Hook3tm1b(NCOM)Mfgc HOM Early adult 4.37×10-14
decreased total body fat amount Hook3tm1b(NCOM)Mfgc HOM Early adult 1.01×10-10
decreased body length Hook3tm1b(NCOM)Mfgc HOM Early adult 9.31×10-30
short tibia Hook3tm1b(NCOM)Mfgc HOM Early adult 5.12×10-05

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 Expression

Expression data not available

 Associated Images

Gross Pathology and Tissue Collection
8 Images
Histopathology
6 Images
X-ray: XRay Images Whole Body Dorso Ventral
11 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
11 Images
X-ray: XRay Images Skull Lateral Orientation
11 Images
X-ray: XRay Images Whole Body Lateral Orientation
11 Images
Combined SHIRPA and Dysmorphology
1 Images
Eye Morphology: Images Ophthalmoscopy
1 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Femur - defective growth and differentiation process Hook3tm1b(NCOM)Mfgc HOM Early adult
Tibia - defective growth and differentiation process Hook3tm1b(NCOM)Mfgc HOM Early adult

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MGI Allele Allele Type Produced
Hook3tm1a(NCOM)Mfgc KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Hook3tm1b(NCOM)Mfgc Reporter-tagged deletion allele (post-Cre) Mice, Tissue

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