Setx | senataxin

GeneMGI:2443480Synonyms: A930037J23Rik, Als4

Physiological systems

20 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Homeostasis/metabolism Reproductive system Immune system Endocrine/exocrine gland Vision/eye Hematopoietic system

14 No significant impact

4 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:10Significant phenotypes
4Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased monocyte cell number1 supporting datasetSetxtm1b(EUCOMM)WtsihomozygoteEarly adult7.84x10-10 
decreased lymphocyte cell number2 supporting datasetsSetxtm1b(EUCOMM)WtsihomozygoteEarly adult6.23x10-6 
male infertility1 supporting datasetSetxtm1b(EUCOMM)WtsihomozygoteEarly adultN/A * 
decreased leukocyte cell number1 supporting datasetSetxtm1b(EUCOMM)WtsihomozygoteEarly adult9.29x10-5 
increased neutrophil cell number1 supporting datasetSetxtm1b(EUCOMM)WtsihomozygoteEarly adult5.49x10-6 
small testis1 supporting datasetSetxtm1b(EUCOMM)WtsihomozygoteEarly adultN/A * 
increased NK cell number2 supporting datasetsSetxtm1b(EUCOMM)WtsihomozygoteEarly adult2.36x10-5 
improved glucose tolerance1 supporting datasetSetxtm1b(EUCOMM)WtsihomozygoteEarly adult1.85x10-5 
increased eosinophil cell number1 supporting datasetSetxtm1b(EUCOMM)WtsihomozygoteEarly adult2.09x10-7 
decreased total retina thickness1 supporting datasetSetxtm1b(EUCOMM)WtsihomozygoteEarly adult9.68x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Setxtm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Setxtm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse

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