Gene: Lrch1

Name
leucine-rich repeats and calponin homology (CH) domain containing 1
MGI ID
MGI:2443390
Synonyms
4832412D13Rik Chdc1
Viability
Homozygous - Viable
Other links
View data by physiological system
Significant
Not Significant
Not tested

Filtered by: all phenotypes

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Allele Center Procedure / Parameter Zygosity Mutants Statistical
Method
P Value Status
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Tail - thickness HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Forelimb digit - size HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Clinical Chemistry / Alanine aminotransferase HOM 7f:6m Mixed Model framework, linear mixed-effects model, equation withWeight 0.0193 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Coat - hair distribution - back HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Eye Morphology / Bulging eye HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Forelimb nail - shape HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Electrocardiogram (ECG) / RR HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.0117 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Skin texture - whole body HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Trunk curl HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Eye Morphology / Iris/Pupil HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Hematology / Mean cell hemoglobin concentration HOM 7f:6m Mixed Model framework, generalized least squares, equation withoutWeight 0.0170 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Eye Morphology / Corneal deposits HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Open Field / Percentage center time HOM 5f:6m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.147 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / 6kHz-evoked ABR Threshold HOM 2f:0m 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / 6kHz-evoked ABR Threshold HOM 0f:2m 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Body Composition (DEXA lean/fat) / Body length HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.575 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Vibrissae - presence HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Urinalysis / Magnesium HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.225 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Lower teeth appearance HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Eye Morphology / Lens Opacity HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Skin texture - back paws HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Forelimbs - shape HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Open Field / Periphery distance travelled HOM 5f:6m Mixed Model framework, linear mixed-effects model, equation withWeight 0.960 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Light-Dark Test / Dark side time spent HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.514 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Sleep Wake / Sleep light phase percent HOM 5f:5m Mixed Model framework, linear mixed-effects model, equation withWeight 0.0401 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Eye Morphology / Retina (combined) HOM 8f:8m Not processed Success
Lrch1tm1b(EUCOMM)Hmgu JAX Clinical Chemistry / Calcium HOM 7f:6m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.153 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Contact righting HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Hematology / Hematocrit HOM 7f:6m Mixed Model framework, generalized least squares, equation withoutWeight 0.162 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Skin color - ear HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Grip Strength / Forelimb and hindlimb grip strength normalised against body weight HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.0245 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Hindlimb nail - number HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Coat - hair texture / appearance - head HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Intraperitoneal glucose tolerance test (IPGTT) / Area under glucose response curve HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.00912 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Coat - color - abdomen HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Rotarod / Learning slope HOM 5f:7m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.539 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Eye Morphology / Pupil Dilation HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Body Composition (DEXA lean/fat) / Fat mass HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.00251 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Clinical Chemistry / Potassium HOM 7f:6m Mixed Model framework, linear mixed-effects model, equation withWeight 0.101 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI3 HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.159 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / 30kHz-evoked ABR Threshold HOM 2f:0m 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / 30kHz-evoked ABR Threshold HOM 0f:2m 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Clinical Chemistry / Phosphorus HOM 7f:6m Mixed Model framework, linear mixed-effects model, equation withWeight 0.218 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Hindpaw - shape HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Tremor HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Viability Primary Screen / Outcome HOM 36f:38m Supplied as data Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Genitalia - morphology HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Head morphology HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Sleep Wake / Light sleep bout lengths mean HOM 5f:5m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.151 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Electrocardiogram (ECG) / ST HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.347 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Upper teeth appearance HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Open Field / Center distance travelled HOM 5f:6m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.141 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / 18kHz-evoked ABR Threshold HOM 2f:0m 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / 18kHz-evoked ABR Threshold HOM 0f:2m 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Light-Dark Test / Percent time in dark HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.777 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Eye Morphology / Corneal vascularization HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Eye Morphology / Retinal Blood Vessels Pattern HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Clinical Chemistry / Triglycerides HOM 7f:6m Mixed Model framework, linear mixed-effects model, equation withWeight 0.0142 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Electrocardiogram (ECG) / PQ HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.139 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Sleep Wake / Light sleep bout lengths standard deviation HOM 5f:5m Mixed Model framework, linear mixed-effects model, equation withWeight 0.868 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Hematology / Platelet count HOM 7f:6m Mixed Model framework, generalized least squares, equation withoutWeight 0.189 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Activity (body position) HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Hindlimb digit - size HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Skin texture - snout HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Clinical Chemistry / Total protein HOM 7f:6m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.416 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Eye Morphology / Pupil Position HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Body Composition (DEXA lean/fat) / Fat/Body weight HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.000540 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Hindlimbs - position HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Eye Morphology / Eyelid closure HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Light-Dark Test / Time mobile light side HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.215 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Forelimbs - size HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Sleep Wake / Breath rate during sleep standard deviation HOM 5f:5m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.0235 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Tail - morphology HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Coat - color pattern - abdomen HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Eye Morphology / Iris transilumination HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Clinical Chemistry / Aspartate aminotransferase HOM 7f:6m Mixed Model framework, linear mixed-effects model, equation withWeight 0.564 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Hindlimb nail - length HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Vocalization HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Urinalysis / Albumin to Creatinine ratio HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.0353 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Grip Strength / Forelimb and hindlimb grip strength measurement mean HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.00144 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Hematology / Hemoglobin HOM 7f:6m Mixed Model framework, generalized least squares, equation withoutWeight 0.124 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Open Field / Whole arena resting time HOM 5f:6m Mixed Model framework, linear mixed-effects model, equation withWeight 0.694 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Eye Morphology / Vitreous HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Teeth presence HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Eye Morphology / Lens HOM 8f:8m Fisher Exact Test framework 0.144 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Electrocardiogram (ECG) / QTc HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.555 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Grip Strength / Forelimb grip strength normalised against body weight HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.312 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Head size HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Eye Morphology / Optic Disc HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Coat - color pattern - back HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Open Field / Center average speed HOM 5f:6m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.918 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Eye Morphology / Narrow eye opening HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Clinical Chemistry / Sodium HOM 7f:6m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.136 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Sleep Wake / Sleep dark phase percent HOM 5f:5m Mixed Model framework, linear mixed-effects model, equation withWeight 0.309 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Heart Weight / Heart weight HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.000519 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Forepaw - shape HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Body Composition (DEXA lean/fat) / Bone Mineral Content (excluding skull) HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.889 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Skin color - snout HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Coat - hair texture / appearance - back HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Clinical Chemistry / HDL-cholesterol HOM 7f:6m Mixed Model framework, linear mixed-effects model, equation withWeight 0.449 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Eye Morphology / Persistence of hyaloid vascular system HOM 8f:8m Fisher Exact Test framework 0.448 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI2 HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.539 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Eye Morphology / Pupil Shape HOM 8f:8m Fisher Exact Test framework 0.100 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Acoustic Startle and Pre-pulse Inhibition (PPI) / Response amplitude - S HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.321 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Light-Dark Test / Latency to first transition into dark HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.384 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Electrocardiogram (ECG) / QTc Dispersion HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.692 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Open Field / Periphery average speed HOM 5f:6m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.759 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Fertility of Homozygous Knock-out Mice / Gross Findings Male HOM f:m Supplied as data Success
Lrch1tm1b(EUCOMM)Hmgu JAX Eye Morphology / Eye HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Sleep Wake / Dark sleep bout lengths standard deviation HOM 5f:5m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.952 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Mouth morphology HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Head bobbing HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Light-Dark Test / Percent time in light HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.777 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Body Composition (DEXA lean/fat) / Lean/Body weight HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.0495 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Electrocardiogram (ECG) / rMSSD HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.421 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Skin texture - ear HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Open Field / Distance travelled - total HOM 5f:6m Mixed Model framework, linear mixed-effects model, equation withWeight 0.667 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Snout size HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Electrocardiogram (ECG) / PR HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.122 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Sleep Wake / Dark sleep bout lengths mean HOM 5f:5m Mixed Model framework, linear mixed-effects model, equation withWeight 0.222 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Eye Morphology / Synechia HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Clinical Chemistry / Iron HOM 7f:6m Mixed Model framework, linear mixed-effects model, equation withWeight 0.235 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / 24kHz-evoked ABR Threshold HOM 2f:0m 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / 24kHz-evoked ABR Threshold HOM 0f:2m 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Clinical Chemistry / Total cholesterol HOM 7f:6m Mixed Model framework, linear mixed-effects model, equation withWeight 0.709 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Light-Dark Test / Light side time spent HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.514 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Genitalia - size HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Open Field / Periphery permanence time HOM 5f:6m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.148 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Clinical Chemistry / Albumin HOM 7f:6m Mixed Model framework, linear mixed-effects model, equation withWeight 0.830 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Forelimb nail - length HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Intraperitoneal glucose tolerance test (IPGTT) / Initial response to glucose challenge HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.000121 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Electrocardiogram (ECG) / HR HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.00224 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Aggression HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Grip Strength / Forelimb grip strength measurement mean HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.0128 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Hindlimbs - shape HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Startle response HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Eye Morphology / Eyelid morphology HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Hematology / Mean cell volume HOM 7f:6m Mixed Model framework, generalized least squares, equation withoutWeight 0.0937 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Coat - color - back HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Sleep Wake / Sleep daily percent HOM 5f:5m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.152 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Forelimb digit - shape HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Clinical Chemistry / Free fatty acids HOM 7f:6m Mixed Model framework, linear mixed-effects model, equation withWeight 0.0597 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Eye Morphology / Cornea HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Open Field / Center permanence time HOM 5f:6m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.147 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / 12kHz-evoked ABR Threshold HOM 2f:0m 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Auditory Brain Stem Response / 12kHz-evoked ABR Threshold HOM 0f:2m 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Hindpaw - size HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Body Composition (DEXA lean/fat) / Bone Mineral Density (excluding skull) HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.721 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Upper lip morphology HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Hematology / Red blood cell count HOM 7f:6m Mixed Model framework, generalized least squares, equation withoutWeight 0.127 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Locomotor activity HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.582 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Urinalysis / Creatinine HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.0351 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Light-Dark Test / Fecal boli HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.535 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Skin texture - tail HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Eye Morphology / Iris Pigmentation HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Vibrissae - appearance HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Sleep Wake / Breath rate during sleep mean HOM 5f:5m Mixed Model framework, linear mixed-effects model, equation withWeight 0.0207 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Electrocardiogram (ECG) / HRV HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.404 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Acoustic Startle and Pre-pulse Inhibition (PPI) / % Pre-pulse inhibition - PPI1 HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.348 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Eye Morphology / Retinal Blood Vessels HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Sleep Wake / Sleep bout lengths mean HOM 5f:5m Mixed Model framework, linear mixed-effects model, equation withWeight 0.347 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Skin color - back paws HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Limb grasp HOM 8f:8m Fisher Exact Test framework 0.0590 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Skin color - whole body HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Coat - hair distribution - abdomen HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Rotarod / Average duration HOM 5f:7m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.552 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Clinical Chemistry / Urea (Blood Urea Nitrogen - BUN) HOM 7f:6m Mixed Model framework, linear mixed-effects model, equation withWeight 0.162 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Coat - color pattern - head HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Genitalia - presence HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Coat - hair distribution - head HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Urinalysis / Glucose HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.232 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Light-Dark Test / Side changes HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.206 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Eye Morphology / Corneal Sclerization HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Hindlimb digit - number HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Clinical Chemistry / Alkaline phosphatase HOM 7f:6m Mixed Model framework, linear mixed-effects model, equation withWeight 0.00286 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Hole-board Exploration / Total holepokes HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.102 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Tail - length HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Eye Morphology / Eye Hemorrhage or Blood Presence HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Hindlimb nail - shape HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Open Field / Number of rears - total HOM 5f:6m Mixed Model framework, linear mixed-effects model, equation withWeight 0.107 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Unexpected behaviors HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Hindlimbs - size HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Skin texture - front paws HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Body Composition (DEXA lean/fat) / Bone Area HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.541 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Eye Morphology / Fusion between cornea and lens HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Coat - color - head HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Hematology / Mean corpuscular hemoglobin HOM 7f:6m Mixed Model framework, generalized least squares, equation withoutWeight 0.0961 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Hindlimb digit - shape HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Intraperitoneal glucose tolerance test (IPGTT) / Fasted blood glucose concentration HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.147 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Clinical Chemistry / Total bilirubin HOM 7f:6m Mixed Model framework, linear mixed-effects model, equation withWeight 0.251 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Electrocardiogram (ECG) / CV HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.556 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Forelimbs - position HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Forepaw - size HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Body Composition (DEXA lean/fat) / BMC/Body weight HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.237 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Lower lip morphology HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Skin color - front paws HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Coat - hair texture / appearance - abdomen HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Sleep Wake / Peak wake with respect to dark onset median HOM 5f:5m Mixed Model framework, linear mixed-effects model, equation withWeight 0.349 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Clinical Chemistry / Glucose HOM 7f:6m Mixed Model framework, linear mixed-effects model, equation withWeight 0.00619 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Light-Dark Test / Time mobile dark side HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.516 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Eye Morphology / Retinal Blood Vessels Structure HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Fertility of Homozygous Knock-out Mice / Gross Findings Female HOM f:m Supplied as data Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Forelimb nail - number HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Urinalysis / microAlbumin (calculated) HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.374 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Gait HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Electrocardiogram (ECG) / QRS HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withWeight 0.413 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Ears HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Tail - presence HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Clinical Chemistry / Chloride HOM 7f:6m Mixed Model framework, linear mixed-effects model, equation withWeight 0.854 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Rotarod / Learning difference HOM 5f:7m Mixed Model framework, generalized least squares, equation withoutWeight 0.273 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Body Composition (DEXA lean/fat) / Lean mass HOM 8f:8m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.926 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Eye Morphology / Pupil Light Response HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Open Field / Whole arena average speed HOM 5f:6m Mixed Model framework, linear mixed-effects model, equation withWeight 0.666 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Eye Morphology / Corneal opacity HOM 8f:8m Fisher Exact Test framework 1.00 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Sleep Wake / Sleep bout lengths standard deviation HOM 5f:5m Mixed Model framework, linear mixed-effects model, equation withWeight 0.951 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Forelimb digit - number HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK
Lrch1tm1b(EUCOMM)Hmgu JAX Hematology / White blood cell count HOM 7f:6m Mixed Model framework, linear mixed-effects model, equation withoutWeight 0.203 Success
Lrch1tm1b(EUCOMM)Hmgu JAX Combined SHIRPA and Dysmorphology / Skin color - tail HOM 8f:8m Fisher Exact Test framework 1.00 Not tested (No variation) - OK

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No  (2/2)  Section images
Brain 2 No  Section images
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No  (2/2)  Section images
Cerebral cortex 2 No N/A
Epididymis 2 No  (18/134)  (1/2)  Section images
Esophagus 2 No  (7/415)  (2/2)  Section images
Eye 2 No  (2/2)  Section images
Heart 2 No  (2/2)  Section images
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (2/2)  Section images
Large intestine 2 No  (10/584)  (2/2)  Section images
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No  (2/2)  Section images
Lymph node 2 No N/A
Mammary gland 2 No N/A
Midbrain 2 No N/A
Olfactory lobe 2 No N/A
Ovary 2 No  (1/584)  (1/2)  Section images
Oviduct 2 No  (1/2)  Section images
Pancreas 2 No  (5/584) N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (2/2)  Section images
Small intestine 2 No  (9/584)  (2/2)  Section images
Spinal cord 2 No  (2/2)  Section images
Spleen 2 No  (2/584)  (2/2)  Section images
Stomach 2 No  (12/584)  (2/2)  Section images
Striatum 2 No N/A
Submandibular gland 2 No  (2/132) N/A
Testis 2 No  (2/584)  (1/2)  Section images
Thalamus 2 No N/A
Thymus 2 No  (2/2)  Section images
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No N/A
Urinary bladder 2 No  (2/2)  Section images
Uterus 2 No  (1/2)  Section images
Vascular system 2 No  (2/2)  Section images
Vesicular gland 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/485)  (1/3) N/A
Dorsal root ganglion 1  (1/47) Image Only N/A
Ear 2  (1/485) N/A
Embryo 2  (1/485)  (2/3)  Wholemount images
Eye 2  (1/485) N/A
Foot 2  (1/485)  (1/3) N/A
Forebrain 2  (1/485) N/A
Forelimb 2  (1/485)  (1/3) N/A
Fronto-nasal process 1  (1/48) N/A
Hand 2  (1/485)  (1/3) N/A
Head 2  (5/485)  (1/3) N/A
Heart 2  (1/485) N/A
Hindbrain 2  (6/485)  (1/3) N/A
Hindlimb 2  (1/485)  (1/3) N/A
Liver 2  (1/485) N/A
Lung 2  (1/485) N/A
Mandibular process 2  (1/485) N/A
Maxillary process 2  (1/485) N/A
Midbrain 2  (1/485)  (1/3) N/A
Nose 1  (1/51) N/A
Oral cavity 2  (1/485) N/A
Skin 2  (1/485) N/A
Spinal cord 1  (1/50) N/A
Tail 2  (1/485)  (2/3) N/A
Tail somite 2  (1/485) N/A

 Associated Images

X-ray: XRay Images Forepaw
10 Images
Original Image
Adult LacZ: LacZ Images Section
22 Images
X-ray: XRay Images Lateral Orientation
10 Images
X-ray: XRay Images Skull Lateral Orientation
10 Images
X-ray: XRay Images Dorso Ventral
10 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
Sleep Wake: Wake state (bmp file)
10 Images
Embryo LacZ: LacZ images wholemount
8 Images

 Disease Models

No associations by disease annotation and gene orthology found.
Please visit the desktop version to see this section

 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Lrch1tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice
Lrch1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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