Fa2h | fatty acid 2-hydroxylase
Physiological systems
20 / 24 physiological systems tested
10 Significantly impacted by the knock-out
Homeostasis/metabolism Reproductive system Immune system Integument Endocrine/exocrine gland Growth/size/body region Vision/eye Hematopoietic system Behavior/neurological Renal/urinary system
10 No significant impact
4 Not tested
Data collections
Gene metrics:17Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues
| abnormal skin morphology | 2 supporting datasets | Fa2hem1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal kidney morphology | 1 supporting dataset | Fa2hem1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| enlarged kidney | 1 supporting dataset | Fa2hem1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| abnormal spleen morphology | 1 supporting dataset | Fa2hem1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| decreased circulating HDL cholesterol level | 1 supporting dataset | Fa2hem1(IMPC)Mbp | homozygote | Early adult | 9.09x10-5 | ||
| abnormal coat/ hair morphology | 3 supporting datasets | Fa2hem1(IMPC)Mbp | homozygote | Early adult | 6.83x10-18 | ||
| abnormal vitreous body morphology | 1 supporting dataset | Fa2hem1(IMPC)Mbp | homozygote | Early adult | 6.27x10-8 | ||
| decreased circulating cholesterol level | 1 supporting dataset | Fa2hem1(IMPC)Mbp | homozygote | Early adult | 1.59x10-6 | ||
| abnormal testis morphology | 1 supporting dataset | Fa2hem1(IMPC)Mbp | homozygote | Early adult | N/A * | ||
| increased freezing behavior | 1 supporting dataset | Fa2hem1(IMPC)Mbp | homozygote | Early adult | 4.27x10-23 |
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Human diseases caused by Fa2h mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
This gene doesn't have any significant Histopathology hits. Click here to see the raw data
External links
No external links available for Fa2h.
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| Fa2hem1(IMPC)Mbp | Exon Deletion | | mouse |
| Fa2htm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Fa2htm1e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |
| Fa2htm2a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
| Fa2htm2e(KOMP)Wtsi | Targeted, non-conditional allele | | ES Cell |