Gene Summary

Name:
SID1 transmembrane family, member 1
Synonyms:
B830021E24Rik

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal liver morphology Sidt1tm1.1(KOMP)Vlcg HOM Early adult 0.00
abnormal lymph node morphology Sidt1tm1.1(KOMP)Vlcg HOM Early adult 0.00

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Viewing: all phenotypes

lacZ Expression

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Adrenal gland N/A heterozygote 0.0% (0 of 2)
Aorta N/A heterozygote 0.0% (0 of 2)
Blood N/A heterozygote 0.0% (0 of 2)
Bone marrow N/A heterozygote 0.0% (0 of 2)
Brain N/A heterozygote 0.0% (0 of 2)
Brainstem N/A heterozygote Not available
Brown adipose tissue N/A heterozygote 0.0% (0 of 2)
Cartilage tissue N/A heterozygote Not available
Cecum N/A heterozygote 50% (1 of 2)
Cerebellum N/A heterozygote 0.0% (0 of 2)
Cerebral cortex N/A heterozygote Not available
Chest bone N/A heterozygote Not available
Colon N/A heterozygote 50% (1 of 2)
Diaphragm N/A heterozygote 0.0% (0 of 2)
Duodenum N/A heterozygote 0.0% (0 of 2)
Epididymis N/A heterozygote 50% (1 of 2)
Esophagus N/A heterozygote 0.0% (0 of 2)
Eye N/A heterozygote 0.0% (0 of 2)
Gall bladder N/A heterozygote Not available
Gonadal fat pad N/A heterozygote 0.0% (0 of 2)
Harderian gland N/A heterozygote 0.0% (0 of 2)
Heart N/A heterozygote Not available
Hindlimb N/A heterozygote Not available
Hippocampus N/A heterozygote Not available
Hypothalamus N/A heterozygote Not available
Ileum N/A heterozygote 50% (1 of 2)
Jejunum N/A heterozygote 0.0% (0 of 2)
Kidney N/A heterozygote 0.0% (0 of 2)
Large intestine N/A heterozygote 50% (1 of 2)
Liver N/A heterozygote 0.0% (0 of 2)
Lower urinary tract N/A heterozygote Not available
Lung N/A heterozygote 0.0% (0 of 2)
Lymph node N/A heterozygote Not available
Mammary gland N/A heterozygote 0.0% (0 of 2)
Mesenteric adipose tissue N/A heterozygote 0.0% (0 of 2)
Mesenteric lymph node N/A heterozygote 0.0% (0 of 2)
Midbrain N/A heterozygote 0.0% (0 of 2)
Olfactory lobe N/A heterozygote 0.0% (0 of 2)
Ovary N/A heterozygote 0.0% (0 of 2)
Oviduct N/A heterozygote 0.0% (0 of 2)
Pancreas N/A heterozygote 0.0% (0 of 2)
Parathyroid gland N/A heterozygote 0.0% (0 of 2)
Parotid gland N/A heterozygote 0.0% (0 of 2)
Penis N/A heterozygote 0.0% (0 of 2)
Peripheral nervous system N/A heterozygote Not available
Peyer's patch N/A heterozygote Not available
Pituitary gland N/A heterozygote 0.0% (0 of 2)
Prostate gland N/A heterozygote 50% (1 of 2)
Quadriceps N/A heterozygote 0.0% (0 of 2)
Sciatic nerve N/A heterozygote 0.0% (0 of 2)
Skeletal muscle N/A heterozygote Not available
Skin N/A heterozygote 0.0% (0 of 2)
Small intestine N/A heterozygote 50% (1 of 2)
Spinal cord N/A heterozygote 0.0% (0 of 2)
Spleen N/A heterozygote 0.0% (0 of 2)
Stomach pyloric region N/A heterozygote Not available
Stomach N/A heterozygote 0.0% (0 of 2)
Striatum N/A heterozygote Not available
Sublingual gland N/A heterozygote 0.0% (0 of 2)
Submandibular gland N/A heterozygote 0.0% (0 of 2)
Testis N/A heterozygote 0.0% (0 of 2)
Thymus N/A heterozygote 0.0% (0 of 2)
Thyroid gland N/A heterozygote 0.0% (0 of 2)
Tongue N/A heterozygote 0.0% (0 of 2)
Trachea N/A heterozygote 0.0% (0 of 2)
Trigeminal V nerve N/A heterozygote 0.0% (0 of 2)
Urinary bladder N/A heterozygote 0.0% (0 of 2)
Uterus N/A heterozygote 0.0% (0 of 2)
Vagina N/A heterozygote 0.0% (0 of 2)
Vas deferens N/A heterozygote 50% (1 of 2)
Vascular system N/A heterozygote Not available
Vesicular gland N/A heterozygote 0.0% (0 of 2)
White adipose tissue N/A heterozygote Not available
No Embryo expression data was found for this gene.

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)
adrenal gland 0.0%
aorta 0.0%
blood
bone marrow
brain 0.0%
brainstem 0.0%
brown adipose tissue 0.0%
cartilage tissue 0.0%
cecum 0.0%
cerebellum 0.0%
cerebral cortex 0.0%
chest bone
colon
diaphragm 0.0%
duodenum 0.0%
epididymis Unavailable
esophagus 0.0%
eye 0.0%
gall bladder 0.0%
gonadal fat pad 0.0%
harderian gland
heart 0.0%
hindlimb 0.0%
hippocampus 0.0%
hypothalamus 0.0%
ileum 0.0%
jejunum
kidney 0.0%
large intestine 0.0%
liver 0.0%
lower urinary tract 0.0%
lung 0.0%
lymph node 0.0%
mammary gland 0.0%
mesenteric adipose tissue 0.0%
mesenteric lymph node
midbrain 0.0%
olfactory lobe 0.0%
ovary 0.0%
oviduct 0.0%
pancreas 0.0%
parathyroid gland 0.0%
parotid gland 0.0%
penis 0.0%
peripheral nervous system 0.0%
peyers patch 0.0%
pituitary gland 0.0%
prostate gland 0.0%
quadriceps 0.0%
sciatic nerve 0.0%
skeletal muscle 0.0%
skin 0.0%
small intestine 0.0%
spinal cord 0.0%
spleen 0.0%
stomach 0.0%
stomach pyloric region 0.0%
striatum 0.0%
sublingual gland 0.0%
submandibular gland 0.0%
testis 0.0%
thymus 0.0%
thyroid gland 0.0%
tongue 0.0%
trachea 0.0%
trigeminal v nerve 0.0%
urinary bladder
uterus 0.0%
vagina 0.0%
vas deferens Unavailable
vascular system 0.0%
vesicular gland Unavailable
white adipose tissue 0.0%
No Embryo expression data was found for this gene.

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Skull Lateral Orientation

10 Images

X-ray

XRay Images Forepaw

10 Images

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

X-ray

XRay Images Hind Leg and Hip

10 Images

Adult LacZ

LacZ Images Section

7 Images

Human diseases caused by Sidt1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Sidt1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Hepatic Venoocclusive Disease With Immunodeficiency
Abnormality of the liver, Absence of lymph node germinal center OMIM:235550
Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Irf8 Deficiency
Lymphadenopathy ORPHA:319600
Reticuloendotheliosis, X-Linked
Jaundice, Hepatosplenomegaly, Lymphadenopathy OMIM:312500
Fragile Site, Distamycin A Type, Rare, Fra(16)(Q22.1)
Abnormal lymph node morphology OMIM:136580
Immunodeficiency 38 With Basal Ganglia Calcification
Axillary lymphadenopathy, Inguinal lymphadenopathy, Lymphadenopathy OMIM:616126
Squamous Cell Carcinoma Of The Esophagus
Lymphadenopathy ORPHA:99977
Pulmonary Nodular Lymphoid Hyperplasia
Mediastinal lymphadenopathy, Follicular hyperplasia ORPHA:60026
Immunodeficiency 75 With Lymphoproliferation
Hepatosplenomegaly, Follicular hyperplasia, Lymphadenopathy OMIM:619126
Mantle Cell Lymphoma
Splenomegaly, Lymphadenopathy ORPHA:52416
Autoinflammation With Episodic Fever And Lymphadenopathy
Hepatomegaly, Recurrent tonsillitis, Splenomegaly, Lymphadenopathy OMIM:618852
Mast Cell Sarcoma
Hepatomegaly, Mediastinal lymphadenopathy, Splenomegaly, Lymphadenopathy ORPHA:66661
Kerion Celsi
Lymphadenopathy ORPHA:499
Immunodeficiency 104
Hepatomegaly, Splenomegaly, Lymphadenopathy OMIM:608971
Kimura Disease
Follicular hyperplasia, Lymphadenopathy ORPHA:482
Adenocarcinoma Of The Esophagus
Lymphadenopathy ORPHA:99976
Burkitt Lymphoma
Abnormality of the spleen, Abnormality of the liver, Abnormality of the pancreas, Abnormal lymph ... ORPHA:543
Nodular Lymphocyte Predominant Hodgkin Lymphoma
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:86893
Follicular Lymphoma
Mediastinal lymphadenopathy, Splenomegaly, Abnormal peritoneum morphology, Lymphadenopathy ORPHA:545
Klatskin Tumor
Lymphadenopathy, Cholangiocarcinoma, Hepatomegaly, Jaundice, Extrahepatic cholestasis ORPHA:99978
Autoimmune Hemolytic Anemia-Autoimmune Thrombocytopenia-Primary Immunodeficiency Syndrome
Splenomegaly, Hepatitis, Lymphadenopathy ORPHA:444463
Immunodeficiency 32A
Lymphadenitis, Lymphadenopathy OMIM:614893
Fish-Eye Disease
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:79292
Lymphoproliferative Syndrome 3
Hepatosplenomegaly, Lymphadenopathy OMIM:618261
Alpha-Heavy Chain Disease
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:100025
Mu-Heavy Chain Disease
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:100024
Deafness, Autosomal Dominant 34, With Or Without Inflammation
Lymphadenopathy OMIM:617772
Hemophagocytic Lymphohistiocytosis, Familial, 4
Hepatomegaly, Jaundice, Splenomegaly, Lymphadenopathy OMIM:603552
Pfapa Syndrome
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:42642
Corticosteroid-Sensitive Aseptic Abscess Syndrome
Elevated circulating hepatic transaminase concentration, Abnormal lymph node morphology, Abnormal... ORPHA:54251
Immunodeficiency 72 With Autoinflammation And Lymphoproliferation
Hepatosplenomegaly, Lymphadenopathy OMIM:618982
Autoimmune Lymphoproliferative Syndrome, Type Iii
Elevated circulating aspartate aminotransferase concentration, Hepatosplenomegaly, Splenomegaly, ... OMIM:615559
Immunodeficiency 14A With Lymphoproliferation, Autosomal Dominant
Splenomegaly, Lymphadenopathy OMIM:615513
Immunodeficiency 76
Splenomegaly, Lymphadenopathy OMIM:619164
Familial Papillary Thyroid Carcinoma With Renal Papillary Neoplasia
Chronic noninfectious lymphadenopathy, Abnormal lymph node morphology ORPHA:97290
Immunodeficiency 78 With Autoimmunity And Developmental Delay
Fluctuating splenomegaly, Lymphadenopathy OMIM:619220
Immunodeficiency, Common Variable, 2
Hepatomegaly, Splenomegaly, Follicular hyperplasia, Lymphadenopathy OMIM:240500
Immunodeficiency With Hyper-Igm, Type 5
Lymphadenopathy OMIM:608106
Familial Papillary Or Follicular Thyroid Carcinoma
Chronic noninfectious lymphadenopathy, Abnormal lymph node morphology ORPHA:319487
Pleural Mesothelioma
Hepatomegaly, Lymphadenopathy ORPHA:50251
Leukocyte Adhesion Deficiency, Type Iii
Hepatomegaly, Hepatosplenomegaly, Splenomegaly, Abnormal lymph node morphology OMIM:612840
Pseudomyxoma Peritonei
Lymphadenopathy, Abnormal peritoneum morphology ORPHA:26790
Granulomatous Slack Skin
Abnormal lymph node morphology ORPHA:33111
Congenital Toxoplasmosis
Hepatomegaly, Jaundice, Elevated circulating hepatic transaminase concentration, Lymphadenopathy ORPHA:858
Immunodeficiency 27B
Generalized lymphadenopathy OMIM:615978
Cold Agglutinin Disease
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:56425
Immunodeficiency 64 With Lymphoproliferation
Cervical lymphadenopathy, Hepatosplenomegaly, Splenomegaly, Lymphadenopathy, Mediastinal lymphade... OMIM:618534
Classic Hodgkin Lymphoma
Hepatomegaly, Bone marrow hypocellularity, Splenomegaly, Lymphadenopathy ORPHA:391
Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia
Mediastinal lymphadenopathy, Splenomegaly, Lymphadenopathy OMIM:300853
Immunodeficiency With Hyper-Igm, Type 2
Lymphadenopathy OMIM:605258
Immunodeficiency 99 With Hypogammaglobulinemia And Autoimmune Cytopenias
Follicular hyperplasia, Lymphadenopathy OMIM:619846
Classic Mycosis Fungoides
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:2584
Immunodeficiency 63 With Lymphoproliferation And Autoimmunity
Hepatomegaly, Splenomegaly, Lymphadenopathy OMIM:618495
Schnitzler Syndrome
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:37748
Hemophagocytic Lymphohistiocytosis, Familial, 5, With Or Without Microvillus Inclusion Disease
Hepatosplenomegaly, Splenomegaly, Lymphadenopathy OMIM:613101
Heme Oxygenase 1 Deficiency
Cervical lymphadenopathy, Elevated circulating aspartate aminotransferase concentration, Elevated... OMIM:614034
Immunodeficiency With Hyper-Igm, Type 3
Absence of lymph node germinal center OMIM:606843
Activated Pi3K-Delta Syndrome
Hepatomegaly, Recurrent tonsillitis, Splenomegaly, Lymphadenopathy ORPHA:397596
Desmoplastic Small Round Cell Tumor
Lymphadenopathy, Abnormal peritoneum morphology, Hepatomegaly, Mediastinal lymphadenopathy, Neopl... ORPHA:83469
Indolent Systemic Mastocytosis
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:98848
Immunodeficiency 27A
Enlarged mesenteric lymph node, Hepatosplenomegaly, Splenomegaly, Lymphadenopathy OMIM:209950
Rosaï-Dorfman Disease
Lymphadenopathy ORPHA:158014
Pancreatoblastoma
Pancreatic calcification, Jaundice, Abnormal lymph node morphology ORPHA:677
Nephroblastoma
Neoplasm of the liver, Lymphadenopathy ORPHA:654
Griscelli Syndrome Type 2
Hepatomegaly, Jaundice, Splenomegaly, Lymphadenopathy ORPHA:79477
Immunodeficiency 54
Hepatomegaly, Splenomegaly, Lymphadenopathy OMIM:609981
Autoinflammatory Syndrome, Familial, With Or Without Immunodeficiency
Hepatomegaly, Splenomegaly, Lymphadenopathy OMIM:619375
Immunodeficiency 7
Hepatomegaly, Splenomegaly, Lymphadenopathy OMIM:615387
Caspase 8 Deficiency
Splenomegaly, Lymphadenopathy OMIM:607271
Immunodeficiency 73C With Defective Neutrophil Chemotaxis And Hypogammaglobulinemia
Cervical lymphadenopathy OMIM:618987
Ras-Associated Autoimmune Leukoproliferative Disorder
Hepatomegaly, Splenomegaly, Follicular hyperplasia OMIM:614470
Immunodeficiency, Common Variable, 1
Hepatomegaly, Splenomegaly, Lymphadenopathy OMIM:607594
Immunodeficiency 109 With Lymphoproliferation
Generalized lymphadenopathy, Splenomegaly OMIM:620282
Squamous Cell Carcinoma Of The Anal Canal
Neoplasm of the liver, Lymphadenopathy ORPHA:424019
Familial Cold Autoinflammatory Syndrome 2
Splenomegaly, Lymphadenopathy OMIM:611762
Immunodeficiency With Hyper-Igm, Type 4
Absence of lymph node germinal center OMIM:608184
Immunodeficiency 52
Splenomegaly, Lymphadenopathy OMIM:617514
Systemic-Onset Juvenile Idiopathic Arthritis
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:85414
Lymphoproliferative Syndrome 2
Hepatomegaly, Hepatosplenomegaly, Splenomegaly, Lymphadenopathy OMIM:615122
Mycosis Fungoides
Lymphadenopathy OMIM:254400
Immunodeficiency 105
Hepatosplenomegaly, Absence of lymph node germinal center OMIM:619924
Proteasome-Associated Autoinflammatory Syndrome 4
Hepatomegaly, Splenomegaly, Lymphadenopathy OMIM:619183
Niemann-Pick Disease, Type A
Elevated circulating aspartate aminotransferase concentration, Splenomegaly, Hepatomegaly, Elevat... OMIM:257200
Immune Dysregulation, Autoimmunity, And Autoinflammation
Cervical lymphadenopathy, Inguinal lymphadenopathy OMIM:620514
Leishmaniasis
Hepatomegaly, Elevated circulating hepatic transaminase concentration, Splenomegaly, Lymphadenopathy ORPHA:507
Immunodeficiency 103, Susceptibility To Fungal Infections
Lymphadenopathy OMIM:212050
Medullary Thyroid Carcinoma
Abnormal liver parenchyma morphology, Lymphadenopathy ORPHA:1332
Tularemia
Cervical lymphadenopathy, Abnormal nasopharyngeal adenoid morphology, Mediastinal lymphadenopathy... ORPHA:3392
Periodic Fever, Immunodeficiency, And Thrombocytopenia Syndrome
Splenomegaly, Lymphadenopathy OMIM:150550
Griscelli Syndrome
Bone marrow hypocellularity, Hepatitis, Splenomegaly, Lymphadenopathy, Hepatomegaly, Jaundice ORPHA:381
Rhabdoid Tumor
Neoplasm of the liver, Lymphadenopathy ORPHA:69077
Familial Pancreatic Carcinoma
Peritoneal abscess, Elevated circulating hepatic transaminase concentration, Pancreatic adenocarc... ORPHA:1333
Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency
Absent tonsils, Absence of lymph node germinal center ORPHA:277
Lymphoproliferative Syndrome, X-Linked, 1
Hepatic failure, Splenomegaly, Lymphadenopathy, Hepatomegaly, Fulminant hepatitis OMIM:308240
Deafness-Lymphedema-Leukemia Syndrome
Hepatomegaly, Bone marrow hypocellularity, Splenomegaly, Lymphadenopathy ORPHA:3226
Kaposi Sarcoma
Abnormality of the spleen, Abnormality of the liver, Generalized lymphadenopathy ORPHA:33276
Autoimmune Lymphoproliferative Syndrome
Hepatomegaly, Chronic noninfectious lymphadenopathy, Splenomegaly, Follicular hyperplasia OMIM:601859
Diffuse Cutaneous Mastocytosis
Hepatomegaly, Abnormality of the spleen, Abnormality of the liver, Lymphadenopathy ORPHA:79456
Roifman Syndrome
Hepatomegaly, Splenomegaly, Lymphadenopathy OMIM:616651
Gallbladder Neuroendocrine Tumor
Biliary tract neoplasm, Chronic noninfectious lymphadenopathy, Cholecystitis, Intermittent jaundi... ORPHA:100086
Autoimmune Lymphoproliferative Syndrome, Type Iia
Chronic noninfectious lymphadenopathy, Splenomegaly, Follicular hyperplasia, Lymphadenopathy, Hep... OMIM:603909
Sézary Syndrome
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:3162
Immunodeficiency 91 And Hyperinflammation
Elevated circulating hepatic transaminase concentration, Acute hepatic failure, Hepatosplenomegal... OMIM:619644
Macrophage Activation Syndrome
Hepatitis, Decreased liver function, Elevated circulating aspartate aminotransferase concentratio... ORPHA:158061
Boutonneuse Fever
Cervical lymphadenopathy, Elevated circulating hepatic transaminase concentration, Lymphadenopathy ORPHA:83313
Primary Myelofibrosis
Hepatosplenomegaly, Portal hypertension, Splenomegaly, Lymphadenopathy, Hepatomegaly ORPHA:824
Immunodeficiency With Hyper-Igm, Type 1
Hepatitis, Absence of lymph node germinal center, Splenomegaly, Sclerosing cholangitis, Enlarged ... OMIM:308230
Granulomatous Disease, Chronic, Autosomal Recessive, 5
Recurrent tonsillitis, Lymphadenitis, Hepatosplenomegaly, Splenomegaly, Lymphadenopathy, Acute pa... OMIM:618935
Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation
Lymph node hypoplasia, Splenomegaly, Aplasia of the thymus, Generalized lymphadenopathy, Hepatome... OMIM:602450
Cinca Syndrome
Hepatosplenomegaly, Lymphadenopathy OMIM:607115
Combined Immunodeficiency Due To Zap70 Deficiency
Hepatosplenomegaly, Lymphadenitis, Lymphadenopathy, Abnormal lymph node morphology ORPHA:911
American Trypanosomiasis
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:3386
Middle Ear Neuroendocrine Tumor
Chronic noninfectious lymphadenopathy ORPHA:100084
Roifman Syndrome
Hepatosplenomegaly, Lymphadenopathy ORPHA:353298
Immune Dysregulation With Autoimmunity, Immunodeficiency, And Lymphoproliferation
Hepatomegaly, Splenomegaly, Lymphadenopathy OMIM:616100
Immunodeficiency 98 With Autoinflammation, X-Linked
Hepatomegaly, Bone marrow hypocellularity, Splenomegaly, Lymphadenopathy OMIM:301078
Polyglucosan Body Myopathy 1 With Or Without Immunodeficiency
Hepatic fibrosis, Elevated circulating hepatic transaminase concentration, Lymphadenitis, Cholest... OMIM:615895
Immunodeficiency 94 With Autoinflammation And Dysmorphic Facies
Hepatosplenomegaly, Lymphadenopathy OMIM:619750
Familial Hemophagocytic Lymphohistiocytosis
Cholestatic liver disease, Elevated circulating hepatic transaminase concentration, Decreased liv... ORPHA:540
Omenn Syndrome
Hepatomegaly, Hypoplasia of the thymus, Splenomegaly, Lymphadenopathy OMIM:603554
Adult-Onset Still Disease
Bone marrow hypocellularity, Elevated circulating hepatic transaminase concentration, Hepatitis, ... ORPHA:829
Carcinoid Syndrome
Hepatic necrosis, Chronic noninfectious lymphadenopathy, Elevated circulating hepatic transaminas... ORPHA:100093
Gamma-Heavy Chain Disease
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:100026
Neurologic, Endocrine, And Pancreatic Disease, Multisystem, Infantile-Onset 2
Accessory spleen, Cholestatic liver disease, Polysplenia, Exocrine pancreatic insufficiency, Hepa... OMIM:619418
Tafro Syndrome
Hepatomegaly, Hepatosplenomegaly, Splenomegaly, Lymphadenopathy ORPHA:457077
Cyclic Neutropenia
Cervical lymphadenopathy, Peritonitis, Recurrent tonsillitis, Lymphadenopathy ORPHA:2686
Aggressive Systemic Mastocytosis
Decreased liver function, Hepatosplenomegaly, Hypersplenism, Portal hypertension, Lymphadenopathy ORPHA:98850
Castleman Disease
Follicular hyperplasia, Generalized lymphadenopathy, Lymphadenopathy, Jaundice, Mediastinal lymph... ORPHA:160
Omenn Syndrome
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:39041
Primary Hepatic Neuroendocrine Carcinoma
Elevated circulating hepatic transaminase concentration, Chronic noninfectious lymphadenopathy, H... ORPHA:100085
Hyperimmunoglobulinemia D With Periodic Fever
Hepatomegaly, Peritonitis, Lymphadenopathy ORPHA:343
Granulomatous Disease, Chronic, Autosomal Recessive, 1
Lymphadenitis, Splenomegaly, Lymphadenopathy, Hepatomegaly, Liver abscess OMIM:233700
Granulomatous Disease, Chronic, Autosomal Recessive, 2
Lymphadenitis, Splenomegaly, Lymphadenopathy, Hepatomegaly, Liver abscess OMIM:233710
Periodic Fever, Familial, Autosomal Dominant
Hepatomegaly, Cervical lymphadenopathy, Hepatic amyloidosis OMIM:142680
Combined Immunodeficiency Due To Crac Channel Dysfunction
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:169090
Lymphoproliferative Syndrome 1
Hepatomegaly, Splenomegaly, Lymphadenopathy OMIM:613011
Hereditary Amyloidosis With Primary Renal Involvement
Decreased liver function, Abnormal lymph node morphology, Hepatosplenomegaly, Lymphadenopathy, He... ORPHA:85450
Legionnaires Disease
Bone marrow hypocellularity, Hepatitis, Splenomegaly, Pancreatitis, Lymphadenopathy, Jaundice ORPHA:549
Immunodeficiency 10
Hepatomegaly, Splenomegaly, Lymphadenopathy OMIM:612783
Acquired Hypertrichosis Lanuginosa
Lymphadenopathy ORPHA:2221
Thyroid Lymphoma
Lymphadenopathy ORPHA:97285
Thymic Neuroendocrine Tumor
Neoplasm of the thymus, Mediastinal lymphadenopathy, Pancreatic islet cell adenoma, Chronic nonin... ORPHA:97289
Granulomatous Disease, Chronic, Autosomal Recessive, 4
Lymphadenitis, Splenomegaly, Lymphadenopathy, Hepatomegaly, Liver abscess OMIM:233690
Cinca Syndrome
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:1451
Papa Syndrome
Lymphadenopathy ORPHA:69126
Felty Syndrome
Hepatomegaly, Bone marrow hypocellularity, Splenomegaly, Lymphadenopathy ORPHA:47612
Scrub Typhus
Splenomegaly, Lymphadenopathy ORPHA:83317
Hypocomplementemic Urticarial Vasculitis
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:36412
Immunodeficiency 97 With Autoinflammation
Hepatosplenomegaly, Mediastinal lymphadenopathy, Splenomegaly, Lymphadenopathy OMIM:619802
Pulmonary Non-Tuberculous Mycobacterial Infection
Lymphadenopathy ORPHA:411703
Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome
Elevated circulating hepatic transaminase concentration, Absence of lymph node germinal center, H... ORPHA:79124
Hemophagocytic Lymphohistiocytosis, Familial, 2
Elevated circulating hepatic transaminase concentration, Hepatosplenomegaly, Splenomegaly, Lympha... OMIM:603553
Proteasome-Associated Autoinflammatory Syndrome 3
Hepatomegaly, Elevated circulating hepatic transaminase concentration, Splenomegaly, Lymphadenopathy OMIM:617591
Drug Reaction With Eosinophilia And Systemic Symptoms
Acute hepatic failure, Elevated circulating hepatic transaminase concentration, Hepatitis, Lympha... ORPHA:139402
Proteasome-Associated Autoinflammatory Syndrome 2
Lymphadenopathy OMIM:618048
Autoimmune Lymphoproliferative Syndrome Due To Ctla4 Haploinsuffiency
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:436159
Hemophagocytic Lymphohistiocytosis, Familial, 1
Hepatomegaly, Jaundice, Splenomegaly, Lymphadenopathy OMIM:267700
Mevalonic Aciduria
Elevated circulating hepatic transaminase concentration, Fluctuating splenomegaly, Hepatosplenome... OMIM:610377
Anaplastic Thyroid Carcinoma
Lymphadenopathy ORPHA:142
Neuroendocrine Tumor Of The Colon
Hepatomegaly, Elevated circulating hepatic transaminase concentration, Chronic noninfectious lymp... ORPHA:100080
Mixed Connective Tissue Disease
Hepatomegaly, Mediastinal lymphadenopathy, Splenomegaly, Lymphadenopathy ORPHA:809
Q Fever
Elevated circulating hepatic transaminase concentration, Hepatitis, Hepatosplenomegaly, Abnormali... ORPHA:781
Lig4 Syndrome
Hepatomegaly, Lymphadenopathy ORPHA:99812
Graft Versus Host Disease
Elevated circulating hepatic transaminase concentration, Hepatosplenomegaly, Lymphadenopathy, Chr... ORPHA:39812
Hypohidrotic Ectodermal Dysplasia With Immunodeficiency
Absent peripheral lymph nodes in presence of infection ORPHA:98813
Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked
Hepatitis, Lymphadenopathy OMIM:304790
Common Variable Immunodeficiency
Abnormality of the liver, Elevated circulating hepatic transaminase concentration, Splenomegaly, ... ORPHA:1572
T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency
Hepatosplenomegaly, Lymphadenopathy ORPHA:169154
Farber Disease
Hepatic fibrosis, Hepatic failure, Elevated circulating hepatic transaminase concentration, Hepat... ORPHA:333
Acute Generalized Exanthematous Pustulosis
Cholestasis, Elevated circulating hepatic transaminase concentration, Lymphadenopathy ORPHA:293173
Melkersson-Rosenthal Syndrome
Lymphadenopathy ORPHA:2483
Immunodeficiency 41 With Lymphoproliferation And Autoimmunity
Enlarged tonsils, Hepatosplenomegaly, Lymphadenopathy OMIM:606367
Respiratory Infections, Recurrent, And Failure To Thrive With Or Without Diarrhea
Cholestasis, Hepatomegaly, Mediastinal lymphadenopathy, Hilar lymph node enlargement OMIM:620233
Immunodeficiency, Common Variable, 8, With Autoimmunity
Generalized lymphadenopathy, Splenomegaly, Lymphadenopathy OMIM:614700
Meige Disease
Lymph node hypoplasia, Absence of lymph node germinal center ORPHA:90186
Granulomatous Disease, Chronic, X-Linked
Lymphadenitis, Splenomegaly, Lymphadenopathy, Hepatomegaly, Liver abscess OMIM:306400
Neuroendocrine Tumor Of The Rectum
Hepatomegaly, Elevated circulating hepatic transaminase concentration, Chronic noninfectious lymp... ORPHA:100081
Neuroendocrine Tumor Of Anal Canal
Hepatomegaly, Elevated circulating hepatic transaminase concentration, Chronic noninfectious lymp... ORPHA:100082
Immunodeficiency 73B With Defective Neutrophil Chemotaxis And Lymphopenia
Hepatosplenomegaly, Generalized lymphadenopathy, Lymphadenitis OMIM:618986
Kikuchi-Fujimoto Disease
Elevated circulating hepatic transaminase concentration, Abnormal lymph node morphology, Cervical... ORPHA:50918
Histiocytosis-Lymphadenopathy Plus Syndrome
Pancreatic hypoplasia, Cervical lymphadenopathy, Hepatosplenomegaly, Splenomegaly, Lymphadenopath... OMIM:602782
Hyper-Igd Syndrome
Hepatosplenomegaly, Lymphadenitis, Splenomegaly, Lymphadenopathy OMIM:260920
Chediak-Higashi Syndrome
Hepatomegaly, Jaundice, Splenomegaly, Lymphadenopathy OMIM:214500
Waldenström Macroglobulinemia
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:33226
Adenocarcinoma Of The Anal Canal
Neoplasm of the liver, Lymphadenopathy ORPHA:424016
Poems Syndrome
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:2905
Acute Interstitial Pneumonia
Lymphadenopathy ORPHA:79126
Pulmonary Capillary Hemangiomatosis
Mediastinal lymphadenopathy, Lymphadenopathy ORPHA:199241
Joint Contractures, Osteochondromas, And B-Cell Lymphoma
Generalized lymphadenopathy OMIM:620232
Aregenerative Anemia
Bone marrow hypocellularity, Lymphadenopathy ORPHA:101096
Vasculitis, Autoinflammation, Immunodeficiency, And Hematologic Defects Syndrome
Bone marrow hypocellularity, Elevated circulating hepatic transaminase concentration, Hepatosplen... OMIM:615688
Systemic Mastocytosis With Associated Hematologic Neoplasm
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:98849
T-Cell Immunodeficiency With Thymic Aplasia
Aplasia of the thymus, Atypical or prolonged hepatitis, Lymphadenopathy ORPHA:83471
Lymphatic Filariasis
Lymphadenitis, Lymphadenopathy, Lymphangiectasis, Abnormality of the lymphatic system ORPHA:2035
Malt Lymphoma
Mediastinal lymphadenopathy, Lymphadenopathy ORPHA:52417
Pediatric Systemic Lupus Erythematosus
Lymphadenopathy ORPHA:93552
Congenital Syphilis
Prolonged neonatal jaundice, Hepatosplenomegaly, Pancreatitis, Lymphadenopathy ORPHA:499009
Ileal Neuroendocrine Tumor
Hepatic failure, Elevated circulating hepatic transaminase concentration, Extrahepatic cholestasi... ORPHA:100078
Acute Promyelocytic Leukemia
Lymphadenopathy ORPHA:520
Autoimmune Lymphoproliferative Syndrome
Bone marrow hypocellularity, Hepatitis, Hypersplenism, Chronic noninfectious lymphadenopathy, Spl... ORPHA:3261
Autoinflammation, Panniculitis, And Dermatosis Syndrome
Lymphadenopathy OMIM:617099
Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome
Splenomegaly, Elevated circulating hepatic transaminase concentration, Hepatitis, Lymphadenopathy ORPHA:37042
Carney Triad
Mediastinal lymphadenopathy, Lymphadenopathy ORPHA:139411
Immunodeficiency 31C
Hepatomegaly, Splenomegaly, Lymphadenopathy OMIM:614162
Coccidioidomycosis
Abnormality of the spleen, Abnormality of the liver, Peritonitis, Pancreatitis, Lymphadenopathy, ... ORPHA:228123
H Syndrome
Hepatosplenomegaly, Lymphadenopathy ORPHA:168569
Igg4-Related Submandibular Gland Disease
Cholangitis, Lymphadenopathy, Abnormal pancreas morphology, Retroperitoneal fibrosis ORPHA:449432
Chédiak-Higashi Syndrome
Elevated circulating hepatic transaminase concentration, Decreased liver function, Hepatosplenome... ORPHA:167
Igg4-Related Kidney Disease
Lymphadenitis, Decreased liver function, Abnormal mesentery morphology, Cholecystitis, Sclerosing... ORPHA:449395
Immunodeficiency 71 With Inflammatory Disease And Congenital Thrombocytopenia
Cervical lymphadenopathy, Lymphadenopathy OMIM:617718
Neuroblastoma
Lymphadenopathy ORPHA:635
Tangier Disease
Hepatosplenomegaly, Orange discolored tonsils, Chronic noninfectious lymphadenopathy ORPHA:31150
Hennekam Syndrome
Lymphadenopathy, Lymphangioma, Splenomegaly, Pulmonary lymphangiectasia ORPHA:2136
Familial Mediterranean Fever
Acute hepatic failure, Splenomegaly, Peritonitis, Pancreatitis, Lymphadenopathy ORPHA:342
Multiple Myeloma
Splenomegaly, Lymphadenopathy ORPHA:29073
Selective Igm Deficiency
Lymphadenitis, Lymphadenopathy ORPHA:331235
Brucellosis
Hypersplenism, Abnormality of the liver, Splenomegaly, Lymphadenopathy, Hepatomegaly, Liver abscess ORPHA:1304
Immunodeficiency 55
Lymphadenopathy OMIM:617827
Rheumatoid Factor-Negative Polyarticular Juvenile Idiopathic Arthritis
Hepatosplenomegaly, Lymphadenopathy ORPHA:85408
Spondyloenchondrodysplasia With Immune Dysregulation
Lymphadenopathy OMIM:607944
Tumor Necrosis Factor Receptor 1 Associated Periodic Syndrome
Peritonitis, Splenomegaly, Lymphadenopathy ORPHA:32960
Sarcoidosis
Hepatic failure, Decreased liver function, Abnormal lymph node morphology, Portal hypertension, A... ORPHA:797
Lymphangioleiomyomatosis
Pulmonary lymphangiomyomatosis, Lymphadenopathy, Abnormality of the lymphatic system ORPHA:538
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Negative
Absent peripheral lymph nodes in presence of infection OMIM:600802
Autosomal Recessive Malignant Osteopetrosis
Hepatomegaly, Splenomegaly, Lymphadenopathy ORPHA:667
Crimean-Congo Hemorrhagic Fever
Hepatic failure, Cholecystitis, Splenomegaly, Lymphadenopathy, Hemoperitoneum, Hepatomegaly, Jaun... ORPHA:99827
Leptospirosis
Hepatitis, Elevated serum transaminases during infections, Lymphadenopathy, Hepatomegaly, Jaundice ORPHA:509
Igg4-Related Ophthalmic Disease
Cholangitis, Pancreatitis, Lymphadenopathy, Retroperitoneal fibrosis ORPHA:449563
Primary Sjögren Syndrome
Biliary cirrhosis, Chronic active hepatitis, Lymphadenopathy, Chronic hepatitis ORPHA:289390
Immunodeficiency 82 With Systemic Inflammation
Splenomegaly, Hepatitis, Follicular hyperplasia, Lymphadenopathy OMIM:619381
Proteasome-Associated Autoinflammatory Syndrome 1
Hepatomegaly, Elevated circulating hepatic transaminase concentration, Splenomegaly, Lymphadenopathy OMIM:256040
Behçet Disease
Pancreatitis, Splenomegaly, Lymphadenopathy ORPHA:117
Blau Syndrome
Abnormality of the liver, Splenomegaly, Lymphadenopathy ORPHA:90340
Chikungunya
Cervical lymphadenopathy, Lymphadenopathy ORPHA:324625
Igg4-Related Dacryoadenitis And Sialadenitis
Lymphadenopathy, Retroperitoneal fibrosis ORPHA:79078
Marburg Hemorrhagic Fever
Jaundice, Elevated circulating hepatic transaminase concentration, Pancreatitis, Lymphadenopathy ORPHA:99826
African Trypanosomiasis
Hepatosplenomegaly, Splenomegaly, Lymphadenopathy, Hepatomegaly, Jaundice ORPHA:3385
Cushing Syndrome Due To Ectopic Acth Secretion
Pancreatic adenocarcinoma, Neoplasm of the thymus, Pancreatoblastoma, Abnormal lymph node morphology ORPHA:99889
Systemic Lupus Erythematosus
Lymphadenopathy ORPHA:536

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Sidt1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Sidt1.

There are 4 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
SIDT1 plays a key role in type I IFN responses to nucleic acids in plasmacytoid dendritic cells and mediates the pathogenesis of an imiquimod-induced psoriasis model. EBioMedicine (January 2022) Sidt1tm1(KOMP)Vlcg PMC8784643
Honeysuckle-derived microRNA2911 inhibits tumor growth by targeting TGF-β1. Chinese medicine (June 2021) Sidt1tm1(KOMP)Vlcg PMC8244210
SIDT1-dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs. Cell research (August 2020) Sidt1tm1(KOMP)Vlcg PMC8026584
SIDT1 Localizes to Endolysosomes and Mediates Double-Stranded RNA Transport into the Cytoplasm. Journal of immunology (Baltimore, Md. : 1950) (May 2019) Sidt1tm1(KOMP)Vlcg 31061008

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Sidt1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, ES Cells
Sidt1tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice, Tissue
Sidt1tm1(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells

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