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Gene: Lrp12 MGI:2443132

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Gene Summary

Name:
low density lipoprotein-related protein 12
Synonyms:
C820005L12Rik

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, incomplete penetrance Lrp12em1(IMPC)Bay HOM   Early adult 0.00
decreased locomotor activity Lrp12em1(IMPC)Bay HET   Early adult 3.00×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Lrp12 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Lrp12 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Amyotrophic Lateral Sclerosis 28
Difficulty walking OMIM:620452
Oculopharyngodistal Myopathy
Difficulty walking, Loss of ambulation ORPHA:98897
Oculopharyngodistal Myopathy 1
Difficulty walking, Ataxia OMIM:164310

The table below shows human diseases predicted to be associated to Lrp12 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Intellectual Developmental Disorder, X-Linked 110
Bradykinesia OMIM:301095
Amyotrophic Lateral Sclerosis 28
Difficulty walking OMIM:620452
Oculopharyngodistal Myopathy
Difficulty walking, Loss of ambulation ORPHA:98897
Oculopharyngodistal Myopathy 1
Difficulty walking, Ataxia OMIM:164310

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Lrp12

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Lrp12.

No publications found that use IMPC mice or data for Lrp12.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Lrp12tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Lrp12tm42509(L1L2_st2) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Lrp12tm42509(L1L2_Pgk_PM) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Lrp12tm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Lrp12em1(IMPC)Bay Exon Deletion Mice

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