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Gene: Golm2 MGI:2443129

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Gene Summary

Name:
golgi membrane protein 2
Synonyms:
D130060C09Rik,  Casc4

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Adrenal gland N/A heterozygote 100% (3 of 3)
Adrenal gland N/A homozygote 100% (1 of 1)
Aorta N/A heterozygote 100% (3 of 3)
Aorta N/A homozygote 100% (1 of 1)
Blood vessel N/A heterozygote 0.0% (0 of 3)
Blood vessel N/A homozygote 0.0% (0 of 1)
Bone N/A heterozygote 0.0% (0 of 3)
Bone N/A homozygote 0.0% (0 of 1)
Brain N/A heterozygote 100% (3 of 3)
Brain N/A homozygote 100% (1 of 1)
Brainstem N/A heterozygote 100% (3 of 3)
Brainstem N/A homozygote 100% (1 of 1)
Brown adipose tissue N/A heterozygote 0.0% (0 of 3)
Brown adipose tissue N/A homozygote 0.0% (0 of 1)
Cartilage tissue N/A heterozygote 0.0% (0 of 3)
Cartilage tissue N/A homozygote Ambiguous
Cerebellum N/A heterozygote 100% (3 of 3)
Cerebellum N/A homozygote 100% (1 of 1)
Cerebral cortex N/A heterozygote 100% (3 of 3)
Cerebral cortex N/A homozygote 100% (1 of 1)
Eye N/A heterozygote 0.0% (0 of 3)
Eye N/A homozygote 0.0% (0 of 1)
Gall bladder N/A heterozygote 0.0% (0 of 3)
Gall bladder N/A homozygote 100% (1 of 1)
Heart N/A heterozygote 100% (3 of 3)
Heart N/A homozygote 100% (1 of 1)
Hippocampus N/A heterozygote 100% (3 of 3)
Hippocampus N/A homozygote 100% (1 of 1)
Hypothalamus N/A heterozygote 100% (3 of 3)
Hypothalamus N/A homozygote 100% (1 of 1)
Kidney N/A heterozygote 100% (3 of 3)
Kidney N/A homozygote 100% (1 of 1)
Large intestine N/A heterozygote 0.0% (0 of 3)
Large intestine N/A homozygote 100% (1 of 1)
Liver N/A heterozygote 0.0% (0 of 3)
Liver N/A homozygote 0.0% (0 of 1)
Lower urinary tract N/A heterozygote 33.33% (1 of 3)
Lower urinary tract N/A homozygote 100% (1 of 1)
Lung N/A heterozygote 100% (3 of 3)
Lung N/A homozygote 100% (1 of 1)
Lymph node N/A heterozygote 0.0% (0 of 3)
Lymph node N/A homozygote 0.0% (0 of 1)
Mammary gland N/A heterozygote 0.0% (0 of 3)
Mammary gland N/A homozygote 0.0% (0 of 1)
Esophagus N/A heterozygote 0.0% (0 of 3)
Esophagus N/A homozygote Ambiguous
Olfactory lobe N/A heterozygote 0.0% (0 of 3)
Olfactory lobe N/A homozygote 100% (1 of 1)
Ovary N/A heterozygote 33.33% (1 of 3)
Ovary N/A homozygote Not available
Oviduct N/A heterozygote 66.67% (2 of 3)
Oviduct N/A homozygote Not available
Pancreas N/A heterozygote 0.0% (0 of 3)
Pancreas N/A homozygote 0.0% (0 of 1)
Parathyroid gland N/A heterozygote 100% (3 of 3)
Parathyroid gland N/A homozygote 100% (1 of 1)
Peripheral nervous system N/A heterozygote 100% (3 of 3)
Peripheral nervous system N/A homozygote 100% (1 of 1)
Peyer's patch N/A heterozygote 0.0% (0 of 3)
Peyer's patch N/A homozygote 0.0% (0 of 1)
Pituitary gland N/A heterozygote 100% (3 of 3)
Pituitary gland N/A homozygote 100% (1 of 1)
Prostate gland N/A heterozygote 0.0% (0 of 3)
Prostate gland N/A homozygote Ambiguous
Skeletal muscle tissue N/A heterozygote 0.0% (0 of 3)
Skeletal muscle tissue N/A homozygote 0.0% (0 of 1)
Skin N/A heterozygote 0.0% (0 of 3)
Skin N/A homozygote 0.0% (0 of 1)
Small intestine N/A heterozygote 0.0% (0 of 3)
Small intestine N/A homozygote 100% (1 of 1)
Spinal cord N/A heterozygote 100% (3 of 3)
Spinal cord N/A homozygote 100% (1 of 1)
Spleen N/A heterozygote 0.0% (0 of 3)
Spleen N/A homozygote 0.0% (0 of 1)
Stomach N/A heterozygote Ambiguous
Stomach N/A homozygote 100% (1 of 1)
Striatum N/A heterozygote 100% (3 of 3)
Striatum N/A homozygote 100% (1 of 1)
Testis N/A heterozygote 33.33% (1 of 3)
Testis N/A homozygote 100% (1 of 1)
Thymus N/A heterozygote 0.0% (0 of 3)
Thymus N/A homozygote Ambiguous
Thyroid gland N/A heterozygote 0.0% (0 of 3)
Thyroid gland N/A homozygote 100% (1 of 1)
Trachea N/A heterozygote 66.67% (2 of 3)
Trachea N/A homozygote 100% (1 of 1)
Uterus N/A heterozygote 66.67% (2 of 3)
Uterus N/A homozygote Not available
White adipose tissue N/A heterozygote 0.0% (0 of 3)
White adipose tissue N/A homozygote 0.0% (0 of 1)
No Embryo expression data was found for this gene.

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)
adrenal gland 0.0%
aorta 0.0%
blood vessel
bone 0.0%
brain 0.0%
brainstem 0.0%
brown adipose tissue 0.0%
cartilage tissue 0.0%
cerebellum 0.0%
cerebral cortex 0.0%
eye 0.0%
gall bladder 0.0%
heart 0.0%
hippocampus 0.0%
hypothalamus 0.0%
kidney 0.0%
large intestine 0.0%
liver 0.0%
lower urinary tract 0.0%
lung 0.0%
lymph node 0.0%
mammary gland 0.0%
oesophagus
olfactory lobe 0.0%
ovary 0.0%
oviduct 0.0%
pancreas 0.0%
parathyroid gland 0.0%
peripheral nervous system 0.0%
peyer's patch
pituitary gland 0.0%
prostate gland 0.0%
skeletal muscle tissue
skin 0.0%
small intestine 0.0%
spinal cord 0.0%
spleen 0.0%
stomach 0.0%
striatum 0.0%
testis 0.0%
thymus 0.0%
thyroid gland 0.0%
trachea 0.0%
uterus 0.0%
white adipose tissue 0.0%
No Embryo expression data was found for this gene.

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

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X-ray

XRay Images Forepaw

10 Images

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X-ray

XRay Images Skull Lateral Orientation

10 Images

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Anti-nuclear antibody assay

Images

13 Images

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X-ray

XRay Images Whole Body Dorso Ventral

11 Images

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X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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DSS Histology

Images

7 Images

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Ear epidermis immunophenotyping

Images

12 Images

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Legacy Phenotype Associated Images
Casc4tm2b(EUCOMM)Wtsi
HOM, Male, WTSI
Casc4tm2b(EUCOMM)Wtsi
HOM, Male, WTSI
Casc4tm2b(EUCOMM)Wtsi
HOM, Male, WTSI
Casc4tm2b(EUCOMM)Wtsi
HOM, Male, WTSI
Casc4tm2b(EUCOMM)Wtsi
HOM, Male, WTSI

View all 51 images

Casc4tm2b(EUCOMM)Wtsi
TS20 spinal cord, HET, Male, WTSI
Casc4tm2b(EUCOMM)Wtsi
TS20 chorioallantoic placenta, HET, Female, WTSI
Casc4tm2b(EUCOMM)Wtsi
TS20 lung, HET, Female, WTSI
Casc4tm2b(EUCOMM)Wtsi
TS20 tail somite group, HET, Male, WTSI
Casc4tm2b(EUCOMM)Wtsi
TS20 spinal cord, HET, Male, WTSI

View all 7 images

Human diseases caused by Golm2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.
No human diseases associated to this gene by phenotypic similarity.

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Golm2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Golm2.

No publications found that use IMPC mice or data for Golm2.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Golm2tm2e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Golm2tm2a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Golm2tm2b(EUCOMM)Wtsi Reporter-tagged deletion allele (with selection cassette) Mice
Golm2tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Golm2tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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