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Gene: Ino80c MGI:2443014

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Gene Summary

Name:
INO80 complex subunit C
Synonyms:
D030070L09Rik

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
embryonic growth retardation Ino80cem1(IMPC)J HOM E9.5 0.00
abnormal heart morphology Ino80cem1(IMPC)J HOM E9.5 0.00
prenatal lethality prior to heart atrial septation Ino80cem1(IMPC)J HOM   E15.5 0.00
abnormal hindbrain morphology Ino80cem1(IMPC)J HOM E12.5 0.00
increased vertical activity Ino80cem1(IMPC)J HET Early adult 1.86×10-05
abnormal tail morphology Ino80cem1(IMPC)J HOM E12.5 0.00
abnormal embryo size Ino80cem1(IMPC)J HOM E12.5 0.00
anophthalmia Ino80cem1(IMPC)J HOM E12.5 0.00
preweaning lethality, complete penetrance Ino80cem1(IMPC)J HOM   Early adult 0.00

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Skull Lateral Orientation

9 Images

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Eye Morphology

Images Slit Lamp

2 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

9 Images

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X-ray

XRay Images Whole Body Dorso Ventral

9 Images

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X-ray

XRay Images Whole Body Lateral Orientation

9 Images

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X-ray

XRay Images Forepaw

9 Images

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Combined SHIRPA and Dysmorphology

Images

1 Images

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PDF thumbnail PDF
Electrocardiogram (ECG)

Waveform Image

15 Images

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PDF thumbnail PDF
Auditory Brain Stem Response

Click-evoked + 6 to 30kHz tone waveforms (pdf format)

8 Images

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Human diseases caused by Ino80c mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ino80c by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Attention Deficit-Hyperactivity Disorder 8
Attention deficit hyperactivity disorder OMIM:619957
Attention Deficit-Hyperactivity Disorder
Hyperactivity, Attention deficit hyperactivity disorder OMIM:143465
Schizophrenia 15
Hyperactivity OMIM:613950
22q13 deletion syndrome (Phelan-Mcdermid syndrome)
Hyperactivity DECIPHER:20
Gilles De La Tourette Syndrome
Aggressive behavior, Phonic tics, Attention deficit hyperactivity disorder, Compulsive behaviors,... OMIM:137580
Potocki-Lupski syndrome (17p11.2 duplication syndrome)
Hyperactivity DECIPHER:19
Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome
Microphthalmia, Anophthalmia ORPHA:85275
Microphthalmia, Isolated 1
Microphthalmia, Anophthalmia OMIM:251600
Microphthalmia, Syndromic 12
Anophthalmia, Ventricular septal defect, Hypoplastic left atrium, Neonatal death, Microphthalmia OMIM:615524
Intellectual Developmental Disorder, X-Linked 77
Hyperactivity OMIM:300454
Microphthalmia, Isolated, With Coloboma 10
Microphthalmia, Anophthalmia OMIM:616428
Microphthalmia, Isolated, With Coloboma 5
Microphthalmia, Anophthalmia, Bilateral microphthalmos OMIM:611638
Fryns Microphthalmia Syndrome
Microphthalmia, Anophthalmia, Neural tube defect OMIM:600776
Oculocerebrocutaneous Syndrome
Microphthalmia, Orbital encephalocele, Anophthalmia, Dandy-Walker malformation OMIM:164180
Meckel Syndrome, Type 8
Encephalocele, Occipital encephalocele, Anophthalmia, Pericardial effusion, Microphthalmia OMIM:613885
Anencephaly 2
Anophthalmia, Anencephaly OMIM:619452
Microphthalmia, Syndromic 16
Microphthalmia, Anophthalmia OMIM:611038
Trisomy 13
Anophthalmia, Ventricular septal defect, Aplasia/Hypoplasia of the iris, Chiari malformation, Atr... ORPHA:3378
Early-Onset Epileptic Encephalopathy-Cortical Blindness-Intellectual Disability-Facial Dysmorphism Syndrome
Hypoplasia of the pons, Anophthalmia ORPHA:411986
Microphthalmia, Isolated 8
Microphthalmia, Anophthalmia, Optic nerve hypoplasia, True anophthalmia OMIM:615113
Microphthalmia, Syndromic 9
Atrial septal defect, Anophthalmia, Ventricular septal defect, Short stature, Severe short statur... OMIM:601186
Anophthalmia Plus Syndrome
Anophthalmia, Spina bifida ORPHA:1104
Anophthalmia/Microphthalmia-Esophageal Atresia Syndrome
Growth delay, Microphthalmia, Anophthalmia, Ventricular septal defect ORPHA:77298
Matthew-Wood Syndrome
Microphthalmia, Anophthalmia, Intrauterine growth retardation ORPHA:2470
Microphthalmia With Brain And Digit Anomalies
Microphthalmia, Inferior cerebellar vermis hypoplasia, Anophthalmia ORPHA:139471
Hydrolethalus
Microphthalmia, Anophthalmia, Anencephaly ORPHA:2189
Trisomy 1Q
Anophthalmia, Ventricular septal defect, Cerebellar hypoplasia ORPHA:261344
Cockayne Syndrome Type 2
Intrauterine growth retardation, Anophthalmia ORPHA:90322
Walker-Warburg Syndrome
Anophthalmia, Cerebellar hypoplasia, Microphthalmia, Abnormal cerebellar vermis morphology, Dandy... ORPHA:899
Microphthalmia, Syndromic 5
Microphthalmia, Anophthalmia, Short stature, Optic nerve hypoplasia OMIM:610125
Solitary Median Maxillary Central Incisor
Microphthalmia, Anophthalmia, Short stature OMIM:147250
Microphthalmia With Limb Anomalies
Growth delay, Microphthalmia, Anophthalmia, Postnatal growth retardation OMIM:206920
Cerebrooculonasal Syndrome
Anophthalmia ORPHA:66625
Oculotrichoanal Syndrome
Microphthalmia, Anophthalmia ORPHA:2717
Holoprosencephaly
Encephalocele, Anophthalmia, Ventricular septal defect, Abnormal pulmonary valve morphology, Spin... ORPHA:2162
Microphthalmia, Syndromic 3
Optic nerve aplasia, Anophthalmia, Ventricular septal defect, Optic nerve hypoplasia, Short statu... OMIM:206900
Vacterl With Hydrocephalus
Microphthalmia, Anophthalmia, Spina bifida, Intrauterine growth retardation ORPHA:3412
Cerebrooculonasal Syndrome
Encephalocele, Anophthalmia, Cerebellar vermis hypoplasia, Optic nerve hypoplasia, Postnatal grow... OMIM:605627
Anophthalmia-Megalocornea-Cardiopathy-Skeletal Anomalies Syndrome
Aniridia, Umbilical hernia, Anophthalmia, Tricuspid valve prolapse ORPHA:1101
Fibular Hemimelia
Anophthalmia, Spina bifida, Abnormal heart morphology ORPHA:93323
Manitoba Oculotrichoanal Syndrome
Microphthalmia, Anophthalmia OMIM:248450
Cockayne Syndrome Type 1
Postnatal growth retardation, Anophthalmia ORPHA:90321
Microphthalmia/Coloboma And Skeletal Dysplasia Syndrome
Microphthalmia, Anophthalmia, Rhizomelia OMIM:615877
Charge Syndrome
Anophthalmia, Short stature, Postnatal growth retardation, Abnormal cardiac septum morphology, Ab... ORPHA:138
Meckel Syndrome
Encephalocele, Anophthalmia, Situs inversus totalis, Anencephaly, Aplasia/Hypoplasia of the iris,... ORPHA:564
Joubert Syndrome 21
Encephalocele, Occipital encephalocele, Elongated superior cerebellar peduncle, Anophthalmia OMIM:615636
Microphthalmia, Syndromic 2
Anophthalmia, Ventricular septal defect, Dextrocardia, Short stature, Double outlet right ventric... OMIM:300166
Microgastria-Limb Reduction Defect Syndrome
Anophthalmia, Growth delay, Atrial septal defect, Microphthalmia, Truncus arteriosus ORPHA:2538
Microphthalmia With Linear Skin Defects Syndrome
Anophthalmia, Severe short stature, Dilated cardiomyopathy, Mitral valve prolapse, Growth delay, ... ORPHA:2556
Histidinemia
Hyperactivity ORPHA:2157
Microcephaly-Lymphedema-Chorioretinopathy Syndrome
Atrial septal defect, Microphthalmia, Severe short stature, Anophthalmia ORPHA:2526
14Q22Q23 Microdeletion Syndrome
Optic nerve aplasia, Anophthalmia, Short stature ORPHA:264200
Hyposmia-Nasal And Ocular Hypoplasia-Hypogonadotropic Hypogonadism Syndrome
Microphthalmia, Anophthalmia ORPHA:2250
Holoprosencephaly 9
Microphthalmia, Anophthalmia, Short stature, Optic nerve hypoplasia OMIM:610829
Fraser Syndrome 1
Encephalocele, Anophthalmia, Myelomeningocele, Bilateral microphthalmos, Abnormal heart morphology OMIM:219000
Charge Syndrome
Anophthalmia, Overriding aorta, Ventricular septal defect, Secundum atrial septal defect, Postnat... OMIM:214800
Focal Dermal Hypoplasia
Anophthalmia, Short stature, Myelomeningocele, Umbilical hernia, Chiari malformation, Aniridia, M... OMIM:305600
Proboscis Lateralis
Microphthalmia, Anophthalmia, Ventricular septal defect, Optic nerve hypoplasia ORPHA:141099
Branchiooculofacial Syndrome
Agenesis of cerebellar vermis, Anophthalmia, Postnatal growth retardation, Branchial anomaly, Mic... OMIM:113620
Fraser Syndrome
Encephalocele, Anophthalmia, Myelomeningocele, Umbilical hernia, Microphthalmia ORPHA:2052
Microphthalmia With Limb Anomalies
Microphthalmia, Short stature, True anophthalmia ORPHA:1106
Microphthalmia, Syndromic 6
Microphthalmia, Inferior cerebellar vermis hypoplasia, Anophthalmia, Cerebellar hypoplasia OMIM:607932
Craniofacial Microsomia 1
Occipital encephalocele, Anophthalmia, Ventricular septal defect, Branchial anomaly, Chiari malfo... OMIM:164210
Microphthalmia, Syndromic 1
Growth delay, Microphthalmia, Anophthalmia, Bicuspid aortic valve OMIM:309800

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ino80c

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ino80c.

No publications found that use IMPC mice or data for Ino80c.

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Ino80ctm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Ino80cem1(IMPC)J Exon Deletion Mice

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