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Gene: Dennd1a MGI:2442794

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Gene Summary

Name:
DENN domain containing 1A
Synonyms:
6030446I19Rik

Order Alleles

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal neural tube closure Dennd1aem1(IMPC)Mbp HET E9.5 0.00
embryonic growth retardation Dennd1aem1(IMPC)Mbp HOM E9.5 0.00
abnormal forebrain development Dennd1aem1(IMPC)Mbp HOM E9.5 0.00
abnormal heart morphology Dennd1aem1(IMPC)Mbp HOM E9.5 0.00
abnormal embryo turning Dennd1aem1(IMPC)Mbp HOM E9.5 0.00
abnormal neural tube morphology Dennd1aem1(IMPC)Mbp HET E9.5 0.00
preweaning lethality, complete penetrance Dennd1aem1(IMPC)Mbp HOM   Early adult 0.00
abnormal neural tube closure Dennd1aem1(IMPC)Mbp HOM E9.5 0.00
prenatal lethality prior to heart atrial septation Dennd1aem1(IMPC)Mbp HOM   E15.5 0.00
abnormal neural tube morphology Dennd1aem1(IMPC)Mbp HOM E9.5 0.00
abnormal hindbrain development Dennd1aem1(IMPC)Mbp HOM E9.5 0.00

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Gross Morphology Embryo E14.5-E15.5

Images

4 Images

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Gross Morphology Embryo E9.5

Images

31 Images

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MicroCT E9.5

Embryo reconstruction

14 Images

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Human diseases caused by Dennd1a mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Dennd1a by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 10
Neural tube defect OMIM:615041
Spina Bifida-Hypospadias Syndrome
Spina bifida, Spinal dysraphism ORPHA:3176
Anencephaly 1
Spina bifida, Anencephaly OMIM:206500
Myelopathy, Htlv-1-Associated
Myelopathy OMIM:159580
Joubert Syndrome 6
Dilated fourth ventricle, Hepatic fibrosis, Hypoplasia of the brainstem, Molar tooth sign on MRI,... OMIM:610688
Gallbladder Disease 1
Hepatic fibrosis, Cholesterol gallstones, Jaundice, Elevated hepatic transaminase, Portal inflamm... OMIM:600803
Sclerosing Cholangitis, Neonatal
Biliary cirrhosis, Cirrhosis, Hepatic failure, Sclerosing cholangitis, Jaundice, Acholic stools, ... OMIM:617394
Bile Acid Synthesis Defect, Congenital, 3
Elevated circulating alanine aminotransferase concentration, Hepatic failure, Cirrhosis, Hepatiti... OMIM:613812
Biliary Atresia, Extrahepatic
Atretic gallbladder, Cirrhosis, Extrahepatic biliary duct atresia, Jaundice, Elevated hepatic tra... OMIM:210500
Cholestasis, Progressive Familial Intrahepatic, 3
Cirrhosis, Jaundice, Elevated hepatic transaminase, Portal inflammation, Portal fibrosis, Intrahe... OMIM:602347
Cholestasis, Progressive Familial Intrahepatic, 8
Hepatic fibrosis, Elevated circulating alanine aminotransferase concentration, Cirrhosis, Scleros... OMIM:619662
Congenital Bile Acid Synthesis Defect Type 3
Elevated circulating alanine aminotransferase concentration, Hepatic failure, Cirrhosis, Jaundice... ORPHA:79302
Meckel Syndrome, Type 3
Hepatic fibrosis, Hydrocephalus, Malformation of the hepatic ductal plate, Bile duct proliferatio... OMIM:607361
Nephronophthisis 19
Hepatic fibrosis, Malformation of the hepatic ductal plate, Bile duct proliferation, Cholestasis,... OMIM:616217
Renal-Hepatic-Pancreatic Dysplasia 1
Pancreatic cysts, Asplenia, Biliary cirrhosis, Hepatic fibrosis, Cirrhosis, Patent ductus arterio... OMIM:208540
Meckel Syndrome, Type 4
Meningocele, Encephalocele, Molar tooth sign on MRI, Anencephaly, Hydrocephalus, Bile duct prolif... OMIM:611134
Isolated Anencephaly/Exencephaly
Anencephaly ORPHA:1048
Glycogen Storage Disease Ixc
Cirrhosis, Elevated hepatic transaminase, Increased hepatic glycogen content, Bile duct prolifera... OMIM:613027
Meckel Syndrome, Type 7
Pancreatic cysts, Patent ductus arteriosus, Biliary cirrhosis, Hepatosplenomegaly, Bile duct prol... OMIM:267010
Parenteral Nutrition-Associated Cholestasis
Hepatic fibrosis, Biliary hyperplasia, Cirrhosis, Hepatic failure, Jaundice, Elevated hepatic tra... ORPHA:567983
Ichthyosis, Leukocyte Vacuoles, Alopecia, And Sclerosing Cholangitis
Intrahepatic biliary atresia, Hepatic fibrosis, Hepatic failure, Sclerosing cholangitis, Jaundice... OMIM:607626
Isolated Biliary Atresia
Atretic gallbladder, Cirrhosis, Periportal fibrosis, Jaundice, Elevated hepatic transaminase, Ach... ORPHA:30391
Coach Syndrome 2
Hepatic fibrosis, Molar tooth sign on MRI, Hydrocephalus, Elevated hepatic transaminase, Hyperten... OMIM:619111
Caroli Syndrome
Cholangiocarcinoma, Elevated hepatic transaminase, Hepatomegaly, Hematemesis, Abnormality of the ... ORPHA:480520
Combined Oxidative Phosphorylation Deficiency 37
Cerebellar hypoplasia, Elevated hepatic transaminase, Elevated gamma-glutamyltransferase level, H... OMIM:618329
Congenital Bile Acid Synthesis Defect Type 1
Cirrhosis, Jaundice, Elevated hepatic transaminase, Biliary tract abnormality, Neonatal cholestat... ORPHA:79301
Nphp3-Related Meckel-Like Syndrome
Abnormality of the pancreas, Dandy-Walker malformation, Abnormal biliary tract morphology, Abnorm... ORPHA:3032
Mirizzi Syndrome
Cholesterol gallstones, Jaundice, Elevated hepatic transaminase, Elevated circulating alkaline ph... ORPHA:521219
Meckel Syndrome, Type 6
Absent gallbladder, Hepatic fibrosis, Anencephaly, Hydrocephalus, Bile duct proliferation, Hepati... OMIM:612284
Meckel Syndrome, Type 2
Meningocele, Encephalocele, Anencephaly, Bile duct proliferation, Dandy-Walker malformation OMIM:603194
Fryns Microphthalmia Syndrome
Neural tube defect OMIM:600776
Primary Biliary Cholangitis/Primary Sclerosing Cholangitis And Autoimmune Hepatitis Overlap Syndrome
Cirrhosis, Granulomatous cholangitis, Sclerosing cholangitis, Interface hepatitis, Elevated hepat... ORPHA:562639
Hardikar Syndrome
Elevated hepatic transaminase, Portal inflammation, Hepatosplenomegaly, Hepatomegaly, Decreased l... OMIM:301068
D-Bifunctional Protein Deficiency
Ventriculomegaly, Elevated hepatic transaminase, Hepatic steatosis, Bile duct proliferation, Chol... OMIM:261515
Meckel Syndrome, Type 5
Occipital encephalocele, Anencephaly, Bile duct proliferation OMIM:611561
Protoporphyria, Erythropoietic, X-Linked
Iron deficiency anemia, Elevated hepatic transaminase, Cholelithiasis OMIM:300752
Aminopterin/Methotrexate Embryofetopathy
Meningocele, Spinal dysraphism, Encephalocele, Ventricular septal defect, Short stature, Anenceph... ORPHA:1908
Low Phospholipid-Associated Cholelithiasis
Biliary cirrhosis, Liver abscess, Neoplasm of the liver, Sclerosing cholangitis, Hepatocellular c... ORPHA:69663
Anemia, Congenital Dyserythropoietic, Type Ii
Jaundice, Reticulocytosis, Reduced level of N-acetylglucosaminyltransferase II, Cholelithiasis, A... OMIM:224100
Beta-Thalassemia Intermedia
Hepatocellular carcinoma, Hepatosplenomegaly, Hypoparathyroidism, Hepatomegaly, Decreased liver f... ORPHA:231222
Beta-Thalassemia
Anemia, Hepatitis, Hypertrophic cardiomyopathy, Hepatomegaly, Cholelithiasis, Hypogonadotropic hy... ORPHA:848
Benign Recurrent Intrahepatic Cholestasis
Cholelithiasis, Cirrhosis, Jaundice, Hepatocellular carcinoma, Elevated hepatic transaminase, Ach... ORPHA:65682
Autosomal Recessive Polycystic Kidney Disease
Pancreatic cysts, Hepatic fibrosis, Biliary hyperplasia, Periportal fibrosis, Hypersplenism, Jaun... ORPHA:731
Craniorachischisis
Spinal dysraphism, Myelomeningocele, Anencephaly, Sirenomelia, Cervical spina bifida ORPHA:63260
Alpha-Thalassemia
Anemia, Hemolytic anemia, Hypersplenism, Jaundice, Cholelithiasis, Abnormal hemoglobin, Splenomeg... ORPHA:846
Meckel Syndrome, Type 1
Patent ductus arteriosus, Asplenia, Dilated fourth ventricle, Molar tooth sign on MRI, Ventriculo... OMIM:249000
Mitochondrial Dna Depletion Syndrome 4A (Alpers Type)
Hepatic failure, Microvesicular hepatic steatosis, Jaundice, Elevated hepatic transaminase, Micro... OMIM:203700
Disorder Of Bile Acid Synthesis
Elevated hepatic transaminase, Abnormality of the liver, Cholestasis, Biliary tract abnormality ORPHA:79168
Biliary, Renal, Neurologic, And Skeletal Syndrome
Biliary cirrhosis, Lateral ventricle dilatation, Cardiac arrest, Hepatomegaly, Splenomegaly, Tric... OMIM:619534
Autosomal Erythropoietic Protoporphyria
Decreased liver function, Cirrhosis, Cholelithiasis, Microcytic anemia ORPHA:79278
Short-Rib Thoracic Dysplasia 1 With Or Without Polydactyly
Pancreatic cysts, Hepatic fibrosis, Pulmonary insufficiency, Jaundice, Polycystic liver disease, ... OMIM:208500
Joubert Syndrome 9
Hepatic fibrosis, Encephalocele, Molar tooth sign on MRI, Ventriculomegaly OMIM:612285
Meckel Syndrome, Type 10
Dilated fourth ventricle, Molar tooth sign on MRI, Cerebellar hypoplasia, Anencephaly, Malformati... OMIM:614175
Cranioectodermal Dysplasia 2
Patent ductus arteriosus, Biliary cirrhosis, Polysplenia, Elevated hepatic transaminase, Hyperten... OMIM:613610
Cholestasis, Progressive Familial Intrahepatic, 9
Jaundice, Malformation of the hepatic ductal plate, Intrahepatic cholestasis, Fibro-obliterative ... OMIM:619849
Hemolytic Anemia, Nonspherocytic, Due To Glucose Phosphate Isomerase Deficiency
Splenomegaly, Spontaneous hemolytic crises, Decreased glucosephosphate isomerase level, Jaundice,... OMIM:613470
Congenital Bile Acid Synthesis Defect Type 2
Hepatic failure, Jaundice, Extramedullary hematopoiesis, Elevated hepatic transaminase, Abnormal ... ORPHA:79303
Caroli Disease
Hepatic fibrosis, Biliary cirrhosis, Elevated circulating alanine aminotransferase concentration,... ORPHA:53035
Congenital Disorder Of Glycosylation, Type Iiw
Elevated circulating alanine aminotransferase concentration, Anemia, Increased hepatic echogenici... OMIM:619525
Septopreoptic Holoprosencephaly
Ethmoidal encephalocele, Perisylvian polymicrogyria, Anterior hypopituitarism, Central diabetes i... ORPHA:280195
Hyperbiliverdinemia
Decreased liver function, Cholestasis, Cholelithiasis OMIM:614156
Coach Syndrome 1
Hepatic fibrosis, Cirrhosis, Encephalocele, Molar tooth sign on MRI, Intrahepatic bile duct dilat... OMIM:216360
Cholestasis, Progressive Familial Intrahepatic, 1
Cirrhosis, Jaundice, Epistaxis, Hepatomegaly, Cholelithiasis, Intrahepatic cholestasis with episo... OMIM:211600
Sickle Cell Anemia
Hemolytic anemia, Pigment gallstones, Reticulocytosis, Persistence of hemoglobin F, Iron deficien... ORPHA:232
Liver Disease, Severe Congenital
Systolic heart murmur, Peritonitis, Elevated hepatic transaminase, Portal inflammation, Hepatic s... OMIM:619991
Dehydrated Hereditary Stomatocytosis
Intermittent jaundice, Cholelithiasis, Nonspherocytic hemolytic anemia, Congenital hemolytic anem... ORPHA:3202
Pyruvate Kinase Deficiency Of Red Cells
Splenomegaly, Jaundice, Erythroid hyperplasia, Reticulocytosis, Cholecystitis, Chronic hemolytic ... OMIM:266200
Rajab Interstitial Lung Disease With Brain Calcifications 1
Cirrhosis, Anemia, Elevated hepatic transaminase, Pancytopenia, Hepatic steatosis, Bile duct prol... OMIM:613658
Cholestasis, Benign Recurrent Intrahepatic, 2
Jaundice, Intrahepatic cholestasis, Elevated circulating alkaline phosphatase concentration, Hepa... OMIM:605479
Blepharocheilodontic Syndrome 1
Neural tube defect OMIM:119580
Myotonic Dystrophy 1
Hypogonadism, Testicular atrophy, Atrial flutter, First degree atrioventricular block, Cholelithi... OMIM:160900
Hemolytic Anemia, Nonspherocytic, Due To Hexokinase Deficiency
Normocytic anemia, Jaundice, Reticulocytosis, Cholecystitis, Cholelithiasis, Nonspherocytic hemol... OMIM:235700
Protoporphyria, Erythropoietic, 1
Hemolytic anemia, Hepatic failure, Cholelithiasis OMIM:177000
Congenital Bile Acid Synthesis Defect Type 4
Hypogonadism, Elevated hepatic transaminase, Abnormal circulating enzyme concentration or activit... ORPHA:79095
Glycogen Storage Disease Vii
Reduced erythrocyte 2,3-diphosphoglycerate concentration, Hemolytic anemia, Jaundice, Reticulocyt... OMIM:232800
Posterior Meningocele
Meningocele, Neural tube defect, Occipital meningocele, Hydrocephalus, Lipomyelomeningocele ORPHA:268810
Cimdag Syndrome
Microvesicular hepatic steatosis, Hypogonadism, Cerebellar hypoplasia, Polymicrogyria, Pontocereb... OMIM:619273
Sickle Cell Disease
Hemolytic anemia, Target cells, Priapism, Splenic infarction, Jaundice, Hypertension, Increased r... OMIM:603903
Alg3-Cdg
Cardiomyopathy, Neural tube defect ORPHA:79321
Hereditary Hemorrhagic Telangiectasia
Pulmonary arterial hypertension, Pulmonary embolism, Hepatic failure, Cirrhosis, Mucosal telangie... ORPHA:774
Cystic Echinococcosis
Peritoneal abscess, Abnormality of the pancreas, Abnormality of the testis size, Jaundice, Spleni... ORPHA:400
Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema
Exercise-induced hemolysis, Increased mean corpuscular hemoglobin concentration, Splenomegaly, He... OMIM:194380
Hereditary Spherocytosis
Increased mean corpuscular hemoglobin concentration, Anemia, Restrictive cardiomyopathy, Spontane... ORPHA:822
Primary Hepatic Neuroendocrine Carcinoma
Intermittent jaundice, Facial telangiectasia, Elevated alkaline phosphatase of hepatic origin, He... ORPHA:100085
Aprosencephaly Syndrome
Anencephaly, Aprosencephaly OMIM:207770
Primary Sclerosing Cholangitis
Spider hemangioma, Elevated alkaline phosphatase of hepatic origin, Cholangiocarcinoma, Elevated ... ORPHA:171
Peroxisome Biogenesis Disorder 12A (Zellweger)
Patent ductus arteriosus, Hepatic failure, Hydrocephalus, Elevated hepatic transaminase, Cholelit... OMIM:614886
Spherocytosis, Type 1
Hemolytic anemia, Jaundice, Reticulocytosis, Cholelithiasis, Splenomegaly, Spherocytosis OMIM:182900
Gcgr-Related Hyperglucagonemia
Neoplasm of the pancreas, Abnormal biliary tract morphology, Cholelithiasis ORPHA:438274
Pancreatic Colipase Deficiency
Exocrine pancreatic insufficiency, Megaloblastic anemia, Cholelithiasis ORPHA:309108
Glycogen Storage Disease Xii
Nonspherocytic hemolytic anemia, Elevated circulating alanine aminotransferase concentration, Ane... OMIM:611881
Agammaglobulinemia-Microcephaly-Craniosynostosis-Severe Dermatitis Syndrome
Pancreatic hypoplasia, Biliary hyperplasia, B lymphocytopenia, Severe B lymphocytopenia, Hepatome... ORPHA:83617
Gallbladder Disease 4
Cholelithiasis OMIM:611465
Combined Immunodeficiency-Enteropathy Spectrum
Peritoneal abscess, Hypoplasia of the thymus, Hepatitis, Autoimmune hemolytic anemia, Abnormality... ORPHA:436252
Arima Syndrome
Dilated fourth ventricle, Hepatic fibrosis, Cirrhosis, Hypoplasia of the brainstem, Molar tooth s... OMIM:243910
Slc35A2-Cdg
Elevated circulating thyroid-stimulating hormone concentration, Lateral ventricle dilatation, Ele... ORPHA:356961
Hereditary Elliptocytosis
Stomatocytosis, Congenital hemolytic anemia, Hemolytic anemia, Elliptocytosis, Jaundice, Reticulo... ORPHA:288
Ketamine-Induced Biliary Dilatation
Abnormal biliary tract morphology ORPHA:293807
Triosephosphate Isomerase Deficiency
Hemolytic anemia, Normocytic anemia, Jaundice, Congestive heart failure, Cholecystitis, Chronic h... OMIM:615512
Mitochondrial Complex Iii Deficiency, Nuclear Type 10
Persistent fetal circulation, Hypertrophic cardiomyopathy, Thrombocytopenia, Bradycardia, Choleli... OMIM:618775
Sialuria
Elevated hepatic transaminase, Cholelithiasis, Hepatomegaly, Hepatosplenomegaly ORPHA:3166
Adult Krabbe Disease
Abnormal circulating enzyme concentration or activity, Erectile dysfunction, Abnormal midbrain mo... ORPHA:206448
Primary Biliary Cholangitis
Hepatic fibrosis, Biliary cirrhosis, Cirrhosis, Hepatic failure, Hepatitis, Jaundice, Hepatocellu... ORPHA:186
Generalized Pseudohypoaldosteronism Type 1
Hypovolemic shock, Cholelithiasis, Arrhythmia ORPHA:171876
Gallbladder Neuroendocrine Tumor
Intermittent jaundice, Extrahepatic cholestasis, Elevated alkaline phosphatase of hepatic origin,... ORPHA:100086
Sacral Defect With Anterior Meningocele
Meningocele, Myelomeningocele, Hydrocephalus, Myeloschisis, Dermal sinus tract OMIM:600145
Hypercholesterolemia Due To Cholesterol 7Alpha-Hydroxylase Deficiency
Hepatitis, Cholesterol gallstones, Hepatic steatosis, Cholestasis, Acute hepatic steatosis, Macro... ORPHA:209902
X-Linked Female Restricted Facial Dysmorphism-Short Stature-Choanal Atresia-Intellectual Disability
Patent ductus arteriosus, Dilated fourth ventricle, Aplasia/Hypoplasia of the cerebellum, Hypopla... ORPHA:480880
Cerebrotendinous Xanthomatosis
Abnormal dentate nucleus morphology, Angina pectoris, Myocardial infarction, Cerebellar atrophy, ... OMIM:213700
Autoimmune Polyendocrine Syndrome, Type I, With Or Without Reversible Metaphyseal Dysplasia
Female hypogonadism, Asplenia, Chronic active hepatitis, Premature ovarian insufficiency, Male hy... OMIM:240300
Ppoma
Intermittent jaundice, Extrahepatic cholestasis, Increased circulating prolactin concentration, P... ORPHA:97278
Mitchell-Riley Syndrome
Pancreatic hypoplasia, Absent gallbladder, Biliary atresia, Acholic stools, Cholestasis, Annular ... OMIM:615710
Trichohepatoneurodevelopmental Syndrome
Patent ductus arteriosus, Recurrent pancreatitis, Decreased liver function, Cerebellar hypoplasia... OMIM:618268
Grfoma
Intermittent jaundice, Extrahepatic cholestasis, Increased circulating prolactin concentration, P... ORPHA:97261
Martinez-Frias Syndrome
Pancreatic hypoplasia, Annular pancreas, Hypoplasia of the gallbladder, Extrahepatic biliary duct... OMIM:601346
Cerebellar-Facial-Dental Syndrome
Abnormal T-wave, Hypoplasia of the brainstem, Ventriculomegaly, Cerebellar hypoplasia, Inferior c... ORPHA:444072
8P Inverted Duplication/Deletion Syndrome
Cerebellar hypoplasia, Cryptorchidism, Dandy-Walker malformation, Aplasia/Hypoplasia of the gallb... ORPHA:96092
Amoebiasis Due To Free-Living Amoebae
Increased red blood cell count, Abnormal cerebellum morphology, Abnormal brainstem MRI signal int... ORPHA:68
Metachromatic Leukodystrophy
Neoplasm of the gallbladder, Abnormal gallbladder morphology, Abnormal circulating enzyme concent... ORPHA:512
Gaucher Disease-Ophthalmoplegia-Cardiovascular Calcification Syndrome
Pulmonary arterial hypertension, Hepatic fibrosis, Anemia, Ventriculomegaly, Spontaneous, recurre... ORPHA:2072
Intellectual Developmental Disorder, X-Linked, Syndromic, Claes-Jensen Type
Decreased testicular size, Cholelithiasis, Cryptorchidism OMIM:300534
Chronic Visceral Acid Sphingomyelinase Deficiency
Cirrhosis, Hepatic failure, Abnormal cerebellum morphology, Hypersplenism, Neoplasm of the liver,... ORPHA:77293
Neurodevelopmental Disorder With Dysmorphic Facies And Thin Corpus Callosum
Patent ductus arteriosus, Cyst of the ductus choledochus, Spina bifida OMIM:619480
Basel-Vanagaite-Smirin-Yosef Syndrome
Pulmonary arterial hypertension, Dilated third ventricle, Cholelithiasis, Lateral ventricle dilat... ORPHA:464738
Steinert Myotonic Dystrophy
Decreased fertility, Supraventricular tachycardia, Decreased response to growth hormone stimulati... ORPHA:273
Porphyria, Congenital Erythropoietic
Hemolytic anemia, Jaundice, Hepatomegaly, Cholelithiasis, Thrombocytopenia, Splenomegaly OMIM:263700
Distal Trisomy 5Q
Cryptorchidism, Aplasia/Hypoplasia of the gallbladder ORPHA:96097
Bohring-Opitz Syndrome
Ventriculomegaly, Annular pancreas, Bradycardia, Cholelithiasis, Dandy-Walker malformation ORPHA:97297
Cerebrotendinous Xanthomatosis
Abnormal dentate nucleus morphology, Abnormal cerebellum morphology, Abnormal circulating enzyme ... ORPHA:909
Intellectual Developmental Disorder, X-Linked, Syndromic, With Pigmentary Mosaicism And Coarse Facies
Hepatosplenomegaly, Cholecystitis, Hepatomegaly, Cholelithiasis, Umbilical hernia OMIM:301066
Trisomy 8P
Heart murmur, Aplasia/Hypoplasia of the gallbladder, Annular pancreas, Hydrocephalus, Cryptorchid... ORPHA:264450
Semilobar Holoprosencephaly
Short stature, Neural tube defect, Hydrocephalus, Growth delay, Abnormal heart morphology ORPHA:220386
Alobar Holoprosencephaly
Short stature, Neural tube defect, Hydrocephalus, Growth delay, Abnormal heart morphology ORPHA:93925
Midline Interhemispheric Variant Of Holoprosencephaly
Short stature, Neural tube defect, Hydrocephalus, Growth delay, Abnormal heart morphology ORPHA:93926
Lobar Holoprosencephaly
Short stature, Neural tube defect, Hydrocephalus, Growth delay, Abnormal heart morphology ORPHA:93924
Pancreatic Hypoplasia-Diabetes-Congenital Heart Disease Syndrome
Pancreatic hypoplasia, Patent ductus arteriosus, Biliary atresia, Aplasia/Hypoplasia of the gallb... ORPHA:2255
Japanese Encephalitis
Abnormal pons morphology, Abnormal midbrain morphology, Abnormal substantia nigra morphology, Neu... ORPHA:79139
22Q11.2 Deletion Syndrome
Patent ductus arteriosus, Meningocele, Hypoplasia of the thymus, Spina bifida, Arrhinencephaly, H... ORPHA:567
Neurofibroma
Abnormal biliary tract morphology, Intestinal bleeding, Enlargement of parotid gland ORPHA:252183
Schinzel-Giedion Syndrome
Abnormal heart morphology, Umbilical hernia, Neural tube defect ORPHA:798
Duplication Of The Pituitary Gland
Abnormality of the pituitary gland, Abnormal midbrain morphology, Encephalocele ORPHA:314621
Williams Syndrome
Sudden cardiac death, Patent ductus arteriosus, Chiari malformation, Cerebral ischemia, Functiona... ORPHA:904
Digeorge Syndrome
Patent ductus arteriosus, Anemia, Hypoplasia of the thymus, Hydrocele testis, Hepatic steatosis, ... OMIM:188400
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Increased circulating prolactin concentration, Gonadotropin deficiency, Decreased response to gro... ORPHA:293987

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Dennd1a

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Dennd1a.

No publications found that use IMPC mice or data for Dennd1a.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Dennd1atm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Dennd1atm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells
Dennd1aem1(IMPC)Mbp Exon Deletion Mice, Tissue

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