Gene Summary

Name:
DENN domain containing 1A
Synonyms:
6030446I19Rik

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal hindbrain development Dennd1aem1(IMPC)Mbp HOM E9.5 0.00
abnormal heart morphology Dennd1aem1(IMPC)Mbp HOM E9.5 0.00
abnormal embryo turning Dennd1aem1(IMPC)Mbp HOM E9.5 0.00
abnormal neural tube closure Dennd1aem1(IMPC)Mbp HET E9.5 0.00
abnormal neural tube morphology Dennd1aem1(IMPC)Mbp HET E9.5 0.00
abnormal neural tube closure Dennd1aem1(IMPC)Mbp HOM E9.5 0.00
preweaning lethality, complete penetrance Dennd1aem1(IMPC)Mbp HOM   Early adult 0.00
abnormal forebrain development Dennd1aem1(IMPC)Mbp HOM E9.5 0.00
embryonic growth retardation Dennd1aem1(IMPC)Mbp HOM E9.5 0.00
prenatal lethality prior to heart atrial septation Dennd1aem1(IMPC)Mbp HOM   E15.5 0.00
decreased thigmotaxis Dennd1aem1(IMPC)Mbp HET   Early adult 5.22×10-05
abnormal neural tube morphology Dennd1aem1(IMPC)Mbp HOM E9.5 0.00

Download data as:  TSV  XLS

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

28 Images

MicroCT E9.5

Embryo reconstruction

32 Images

Gross Morphology Embryo E9.5

Images

31 Images

X-ray

XRay Images Whole Body Dorso Ventral

56 Images

Gross Morphology Embryo E14.5-E15.5

Images

4 Images

Human diseases caused by Dennd1a mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Dennd1a by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Major Depressive Disorder
Depression OMIM:608516
Major Affective Disorder 1
Depression, Mania OMIM:125480
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 10
Neural tube defect OMIM:615041
Spina Bifida-Hypospadias Syndrome
Spinal dysraphism, Spina bifida ORPHA:3176
Myelopathy, Htlv-1-Associated
Myelopathy OMIM:159580
Anencephaly 1
Anencephaly, Spina bifida OMIM:206500
Joubert Syndrome 6
Hepatic fibrosis, Cerebellar vermis hypoplasia, Enlarged fossa interpeduncularis, Hypoplasia of t... OMIM:610688
Gallbladder Disease 1
Hepatic fibrosis, Cholelithiasis, Elevated circulating hepatic transaminase concentration, Portal... OMIM:600803
Sclerosing Cholangitis, Neonatal
Hepatic bridging fibrosis, Elevated gamma-glutamyltransferase level, Hepatic failure, Portal fibr... OMIM:617394
Pandas
Depression, Abnormal fear-induced behavior, Oppositional defiant disorder, Obsessive-compulsive t... ORPHA:66624
Bile Acid Synthesis Defect, Congenital, 3
Hepatic bridging fibrosis, Intrahepatic cholestasis, Hepatic failure, Hematochezia, Hepatitis, El... OMIM:613812
Cholestasis, Progressive Familial Intrahepatic, 3
Intrahepatic cholestasis, Elevated gamma-glutamyltransferase level, Elevated circulating hepatic ... OMIM:602347
Biliary Atresia, Extrahepatic
Portal fibrosis, Elevated circulating hepatic transaminase concentration, Atretic gallbladder, Ci... OMIM:210500
Cholestasis, Progressive Familial Intrahepatic, 8
Hepatic bridging fibrosis, Hepatic fibrosis, Elevated gamma-glutamyltransferase level, Cholestasi... OMIM:619662
Congenital Bile Acid Synthesis Defect Type 3
Hepatic failure, Cholestasis, Elevated circulating aspartate aminotransferase concentration, Hepa... ORPHA:79302
Meckel Syndrome, Type 3
Malformation of the hepatic ductal plate, Hepatic fibrosis, Occipital encephalocele, Hydrocephalu... OMIM:607361
Nephronophthisis 19
Malformation of the hepatic ductal plate, Hepatic fibrosis, Cholestasis, Splenomegaly, Hepatomega... OMIM:616217
Renal-Hepatic-Pancreatic Dysplasia 1
Malformation of the hepatic ductal plate, Hepatic fibrosis, Aortic valve stenosis, Biliary cirrho... OMIM:208540
Meckel Syndrome, Type 4
Agenesis of cerebellar vermis, Encephalocele, Hydrocephalus, Molar tooth sign on MRI, Meningocele... OMIM:611134
Glycogen Storage Disease Ixc
Elevated circulating hepatic transaminase concentration, Splenomegaly, Increased hepatic glycogen... OMIM:613027
Meckel Syndrome, Type 7
Aortic valve stenosis, Biliary cirrhosis, Cholestasis, Hepatosplenomegaly, Portal hypertension, B... OMIM:267010
Ichthyosis, Leukocyte Vacuoles, Alopecia, And Sclerosing Cholangitis
Hepatic fibrosis, Hepatic failure, Cholestasis, Portal hypertension, Splenomegaly, Sclerosing cho... OMIM:607626
Isolated Biliary Atresia
Elevated gamma-glutamyltransferase level, Periportal fibrosis, Elevated circulating hepatic trans... ORPHA:30391
Isolated Anencephaly/Exencephaly
Anencephaly ORPHA:1048
Parenteral Nutrition-Associated Cholestasis
Hepatic fibrosis, Cholelithiasis, Hepatic failure, Elevated circulating hepatic transaminase conc... ORPHA:567983
Coach Syndrome 2
Hepatic fibrosis, Cerebellar vermis hypoplasia, Elevated circulating hepatic transaminase concent... OMIM:619111
Caroli Syndrome
Hypersplenism, Congenital hepatic fibrosis, Elevated circulating alkaline phosphatase concentrati... ORPHA:480520
Combined Oxidative Phosphorylation Deficiency 37
Elevated gamma-glutamyltransferase level, Elevated circulating hepatic transaminase concentration... OMIM:618329
Congenital Bile Acid Synthesis Defect Type 1
Gastrointestinal hemorrhage, Elevated circulating hepatic transaminase concentration, Neonatal ch... ORPHA:79301
Mirizzi Syndrome
Cholelithiasis, Elevated circulating hepatic transaminase concentration, Elevated circulating alk... ORPHA:521219
Nphp3-Related Meckel-Like Syndrome
Abnormal liver parenchyma morphology, Dandy-Walker malformation, Abnormality of the pancreas, Abn... ORPHA:3032
Meckel Syndrome, Type 6
Hepatic fibrosis, Occipital encephalocele, Absent gallbladder, Hepatic cysts, Hydrocephalus, Anen... OMIM:612284
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome
Hypoplastic left heart, Anencephaly, Spina bifida, Ventricular septal defect ORPHA:2476
Meckel Syndrome, Type 2
Encephalocele, Meningocele, Anencephaly, Bile duct proliferation, Dandy-Walker malformation OMIM:603194
Primary Biliary Cholangitis/Primary Sclerosing Cholangitis And Autoimmune Hepatitis Overlap Syndrome
Cholestatic liver disease, Elevated gamma-glutamyltransferase level, Elevated circulating hepatic... ORPHA:562639
Hardikar Syndrome
Portal inflammation, Cholestasis, Hepatosplenomegaly, Hypersplenism, Cirrhosis, Hepatomegaly, Jau... OMIM:301068
D-Bifunctional Protein Deficiency
Ventriculomegaly, Elevated circulating hepatic transaminase concentration, Cerebellar atrophy, Po... OMIM:261515
Meckel Syndrome, Type 5
Occipital encephalocele, Bile duct proliferation, Anencephaly OMIM:611561
Fryns Microphthalmia Syndrome
Neural tube defect OMIM:600776
Aminopterin/Methotrexate Embryofetopathy
Spinal dysraphism, Tetralogy of Fallot, Intrauterine growth retardation, Situs inversus totalis, ... ORPHA:1908
Protoporphyria, Erythropoietic, X-Linked
Cholelithiasis, Elevated circulating hepatic transaminase concentration, Iron deficiency anemia OMIM:300752
Anemia, Congenital Dyserythropoietic, Type Ii
Cholelithiasis, Splenomegaly, Reticulocytosis, Anemia of inadequate production, Jaundice, Reduced... OMIM:224100
Low Phospholipid-Associated Cholelithiasis
Intrahepatic cholestasis, Cholelithiasis, Biliary cirrhosis, Elevated circulating hepatic transam... ORPHA:69663
Beta-Thalassemia
Cholelithiasis, Hepatitis, Hypertrophic cardiomyopathy, Microcytic anemia, Splenomegaly, Abnormal... ORPHA:848
Benign Recurrent Intrahepatic Cholestasis
Cholestatic liver disease, Cholelithiasis, Elevated circulating hepatic transaminase concentratio... ORPHA:65682
Craniorachischisis
Spinal dysraphism, Myelomeningocele, Sirenomelia, Cervical spina bifida, Anencephaly ORPHA:63260
Autosomal Recessive Polycystic Kidney Disease
Hepatic fibrosis, Periportal fibrosis, Elevated gamma-glutamyltransferase level, Gastrointestinal... ORPHA:731
Beta-Thalassemia Intermedia
Extramedullary hematopoiesis, Persistence of hemoglobin F, Hepatosplenomegaly, High-output conges... ORPHA:231222
X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome
Abnormal fear-induced behavior, Irritability, Aggressive behavior, Hyperactivity, Anorexia, Abnor... ORPHA:3077
Aprosencephaly Syndrome
Aprosencephaly, Anencephaly OMIM:207770
Meckel Syndrome, Type 1
Malformation of the hepatic ductal plate, Accessory spleen, Ventriculomegaly, Occipital encephalo... OMIM:249000
Mitochondrial Dna Depletion Syndrome 4A (Alpers Type)
Hepatic failure, Elevated circulating hepatic transaminase concentration, Cerebellar atrophy, Mic... OMIM:203700
Autosomal Erythropoietic Protoporphyria
Microcytic anemia, Cholelithiasis, Cirrhosis, Decreased liver function ORPHA:79278
Cranioectodermal Dysplasia 2
Portal fibrosis, Elevated circulating hepatic transaminase concentration, Biliary cirrhosis, Poly... OMIM:613610
Short-Rib Thoracic Dysplasia 1 With Or Without Polydactyly
Hepatic fibrosis, Pulmonary insufficiency, Bile duct proliferation, Pancreatic fibrosis, Jaundice... OMIM:208500
Biliary, Renal, Neurologic, And Skeletal Syndrome
Elevated gamma-glutamyltransferase level, Lateral ventricle dilatation, Cholestasis, Congenital h... OMIM:619534
Cholestasis, Progressive Familial Intrahepatic, 9
Malformation of the hepatic ductal plate, Intrahepatic cholestasis, Micronodular cirrhosis, Porta... OMIM:619849
Caroli Disease
Intrahepatic cholestasis, Cholelithiasis, Hepatic fibrosis, Biliary cirrhosis, Elevated gamma-glu... ORPHA:53035
Congenital Bile Acid Synthesis Defect Type 2
Giant cell hepatitis, Hepatic failure, Elevated circulating hepatic transaminase concentration, I... ORPHA:79303
Congenital Disorder Of Glycosylation, Type Iiw
Elevated gamma-glutamyltransferase level, Elevated circulating hepatic transaminase concentration... OMIM:619525
Hemolytic Anemia, Nonspherocytic, Due To Glucose Phosphate Isomerase Deficiency
Spontaneous hemolytic crises, Cholelithiasis, Pigment gallstones, Decreased glucosephosphate isom... OMIM:613470
Coach Syndrome 1
Hepatic fibrosis, Cerebellar vermis hypoplasia, Elevated circulating hepatic transaminase concent... OMIM:216360
Hyperbiliverdinemia
Cholestasis, Cholelithiasis, Decreased liver function OMIM:614156
Cholestasis, Progressive Familial Intrahepatic, 1
Epistaxis, Cholelithiasis, Splenomegaly, Cirrhosis, Intrahepatic cholestasis with episodic jaundi... OMIM:211600
Hemolytic Anemia, Nonspherocytic, Due To Hexokinase Deficiency
Normocytic anemia, Cholelithiasis, Splenomegaly, Cholecystitis, Reticulocytosis, Nonspherocytic h... OMIM:235700
Liver Disease, Severe Congenital
Portal inflammation, Hepatic steatosis, Abnormal hepatic echogenicity, Hepatomegaly, Jaundice, Pa... OMIM:619991
Alpha-Thalassemia
Cholelithiasis, Extramedullary hematopoiesis, Congestive heart failure, Microcytic anemia, Hemogl... ORPHA:846
Septopreoptic Holoprosencephaly
Abnormal midbrain morphology, Hypoplasia of the pons, Ethmoidal encephalocele, Rhombencephalosyna... ORPHA:280195
Rajab Interstitial Lung Disease With Brain Calcifications 1
Elevated circulating hepatic transaminase concentration, Decreased liver function, Cholestasis, P... OMIM:613658
Gcgr-Related Hyperglucagonemia
Cholelithiasis, Neoplasm of the pancreas, Abnormal biliary tract morphology ORPHA:438274
Dehydrated Hereditary Stomatocytosis
Cholelithiasis, Increased circulating lactate dehydrogenase concentration, Polycythemia, Increase... ORPHA:3202
Pyruvate Kinase Deficiency Of Red Cells
Cholelithiasis, Reduced red cell pyruvate kinase level, Erythroid hyperplasia, Splenomegaly, Chol... OMIM:266200
Blepharocheilodontic Syndrome 1
Neural tube defect OMIM:119580
Cholestasis, Benign Recurrent Intrahepatic, 2
Intrahepatic cholestasis, Cholelithiasis, Elevated circulating alkaline phosphatase concentration... OMIM:605479
Myotonic Dystrophy 1
Cholelithiasis, Atrial flutter, Hypogonadism, First degree atrioventricular block, Testicular atr... OMIM:160900
Protoporphyria, Erythropoietic, 1
Cholelithiasis, Hemolytic anemia, Hepatic failure OMIM:177000
Congenital Bile Acid Synthesis Defect Type 4
Cholestatic liver disease, Giant cell hepatitis, Cholelithiasis, Elevated circulating hepatic tra... ORPHA:79095
Cimdag Syndrome
Cerebellar vermis hypoplasia, Cholelithiasis, Polymicrogyria, Hypogonadism, Pontocerebellar atrop... OMIM:619273
Glycogen Storage Disease Vii
Cholelithiasis, Increased circulating lactate dehydrogenase concentration, Reduced muscle 6-phosp... OMIM:232800
Sickle Cell Anemia
Splenic infarction, Cholelithiasis, Pigment gallstones, Increased circulating lactate dehydrogena... ORPHA:232
Isolated Posterior Meningocele
Hydrocephalus, Lipomyelomeningocele, Meningocele, Occipital meningocele, Neural tube defect ORPHA:268810
Alg3-Cdg
Cardiomyopathy, Neural tube defect ORPHA:79321
Primary Hepatic Neuroendocrine Carcinoma
Elevated gamma-glutamyltransferase level, Elevated circulating hepatic transaminase concentration... ORPHA:100085
Sickle Cell Disease
Splenic infarction, Cholelithiasis, Priapism, Increased red cell sickling tendency, Hemolytic ane... OMIM:603903
Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema
Cholelithiasis, Hepatitis, Increased mean corpuscular hemoglobin concentration, Splenomegaly, Ret... OMIM:194380
Cystic Echinococcosis
Cholestatic liver disease, Peritoneal abscess, Elevated gamma-glutamyltransferase level, Abnormal... ORPHA:400
Hereditary Spherocytosis
Spontaneous hemolytic crises, Cholelithiasis, Restrictive cardiomyopathy, Increased mean corpuscu... ORPHA:822
Gaucher Disease Type 1
Splenic infarction, Cholelithiasis, Hepatic failure, Hepatosplenomegaly, Hypersplenism, Portal hy... ORPHA:77259
Primary Sclerosing Cholangitis
Cholestasis, Acute hepatic failure, Hepatosplenomegaly, Abnormal biliary tract morphology, Cirrho... ORPHA:171
Peroxisome Biogenesis Disorder 12A (Zellweger)
Hepatic failure, Cholelithiasis, Elevated circulating hepatic transaminase concentration, Hydroce... OMIM:614886
Spherocytosis, Type 1
Cholelithiasis, Splenomegaly, Reticulocytosis, Spherocytosis, Jaundice, Hemolytic anemia OMIM:182900
Glycogen Storage Disease Xii
Normocytic anemia, Cholelithiasis, Increased circulating lactate dehydrogenase concentration, Cho... OMIM:611881
Agammaglobulinemia-Microcephaly-Craniosynostosis-Severe Dermatitis Syndrome
Cholelithiasis, Severe B lymphocytopenia, Pancreatic hypoplasia, Cryptorchidism, Biliary hyperpla... ORPHA:83617
Gallbladder Disease 4
Cholelithiasis OMIM:611465
Combined Immunodeficiency-Enteropathy Spectrum
Peritoneal abscess, Hepatitis, Autoimmune hemolytic anemia, Hypoplasia of the thymus, Abnormal du... ORPHA:436252
Arima Syndrome
Hepatic fibrosis, Cerebellar vermis hypoplasia, Hypoplasia of the brainstem, Brainstem dysplasia,... OMIM:243910
Slc35A2-Cdg
Abnormal midbrain morphology, Elevated circulating hepatic transaminase concentration, Cerebellar... ORPHA:356961
Pancreatic Colipase Deficiency
Exocrine pancreatic insufficiency, Cholelithiasis, Megaloblastic anemia ORPHA:309108
Ketamine-Induced Biliary Dilatation
Abnormal biliary tract morphology ORPHA:293807
Triosephosphate Isomerase Deficiency
Normocytic anemia, Cholelithiasis, Congestive heart failure, Cholecystitis, Splenomegaly, Macrocy... OMIM:615512
Sialuria
Hepatomegaly, Hepatosplenomegaly, Elevated circulating hepatic transaminase concentration, Cholel... ORPHA:3166
Mitochondrial Complex Iii Deficiency, Nuclear Type 10
Cholelithiasis, Hypertrophic cardiomyopathy, Persistent fetal circulation, Thrombocytopenia, Brad... OMIM:618775
Hereditary Elliptocytosis
Cholelithiasis, Stomatocytosis, Abnormal erythrocyte morphology, Elliptocytosis, Splenomegaly, Re... ORPHA:288
Adult Krabbe Disease
Abnormal midbrain morphology, Abnormal medulla oblongata morphology, Abnormal circulating enzyme ... ORPHA:206448
Combined Oxidative Phosphorylation Deficiency 59
Hypertrophic cardiomyopathy, Severely reduced left ventricular ejection fraction, Cholelithiasis,... OMIM:620646
Generalized Pseudohypoaldosteronism Type 1
Hypovolemic shock, Cholelithiasis, Arrhythmia ORPHA:171876
Primary Biliary Cholangitis
Hepatic fibrosis, Hepatic failure, Biliary cirrhosis, Elevated gamma-glutamyltransferase level, H... ORPHA:186
Iniencephaly
Rhizomelia, Spinal dysraphism, Myelomeningocele, Encephalocele, Spina bifida, Hydrocephalus, Holo... ORPHA:63259
Hypercholesterolemia Due To Cholesterol 7Alpha-Hydroxylase Deficiency
Acute hepatic steatosis, Hepatitis, Cholestasis, Hepatic steatosis, Cholesterol gallstones, Macro... ORPHA:209902
X-Linked Female Restricted Facial Dysmorphism-Short Stature-Choanal Atresia-Intellectual Disability
Cerebellar vermis hypoplasia, Abnormal cortical gyration, Ventriculomegaly, Cardiomyopathy, Hypop... ORPHA:480880
Sacral Defect With Anterior Meningocele
Myelomeningocele, Myeloschisis, Hydrocephalus, Meningocele, Dermal sinus tract OMIM:600145
Gallbladder Neuroendocrine Tumor
Biliary tract neoplasm, Elevated gamma-glutamyltransferase level, Cholecystitis, Elevated alkalin... ORPHA:100086
Cerebrotendinous Xanthomatosis
Cholelithiasis, Cerebellar atrophy, Abnormal dentate nucleus morphology, Angina pectoris, Myocard... OMIM:213700
Autoimmune Polyendocrine Syndrome, Type I, With Or Without Reversible Metaphyseal Dysplasia
Cholelithiasis, Female hypogonadism, Male hypogonadism, Premature ovarian insufficiency, Chronic ... OMIM:240300
Mitchell-Riley Syndrome
Annular pancreas, Pancreatic hypoplasia, Cholestasis, Absent gallbladder, Biliary atresia, Acholi... OMIM:615710
Ppoma
Intrahepatic cholestasis, Cholelithiasis, Gastrointestinal hemorrhage, Pituitary adenoma, Increas... ORPHA:97278
Hereditary Hemorrhagic Telangiectasia
Nasal mucosa telangiectasia, Telangiectasia, Cirrhosis, Retinal telangiectasia, Cholelithiasis, G... ORPHA:774
Trichohepatoneurodevelopmental Syndrome
Cholelithiasis, Decreased liver function, Exocrine pancreatic insufficiency, Splenomegaly, Elevat... OMIM:618268
Cerebellar-Facial-Dental Syndrome
Abnormal midbrain morphology, Ventriculomegaly, Inferior cerebellar vermis hypoplasia, Hypoplasia... ORPHA:444072
Grfoma
Intrahepatic cholestasis, Cholelithiasis, Gastrointestinal hemorrhage, Pituitary adenoma, Increas... ORPHA:97261
8P Inverted Duplication/Deletion Syndrome
Cerebellar hypoplasia, Aplasia/Hypoplasia of the gallbladder, Cryptorchidism, Dandy-Walker malfor... ORPHA:96092
Metachromatic Leukodystrophy
Abnormal circulating enzyme concentration or activity, Hemobilia, Neoplasm of the gallbladder, Ab... ORPHA:512
Aprosencephaly And Cerebellar Dysgenesis
Aprosencephaly OMIM:601374
Neurodevelopmental Disorder With Dysmorphic Facies And Thin Corpus Callosum
Cyst of the ductus choledochus, Patent ductus arteriosus, Spina bifida OMIM:619480
Intellectual Developmental Disorder, X-Linked, Syndromic, Claes-Jensen Type
Decreased testicular size, Cholelithiasis, Cryptorchidism OMIM:300534
Gaucher Disease-Ophthalmoplegia-Cardiovascular Calcification Syndrome
Hepatic fibrosis, Cholelithiasis, Ventriculomegaly, Abnormality of the spleen, Hepatosplenomegaly... ORPHA:2072
Basel-Vanagaite-Smirin-Yosef Syndrome
Pulmonary arterial hypertension, Cholelithiasis, Dilated third ventricle, Lateral ventricle dilat... ORPHA:464738
Chronic Visceral Acid Sphingomyelinase Deficiency
Cholelithiasis, Hepatic failure, Decreased liver function, Hypersplenism, Abnormal cerebellum mor... ORPHA:77293
Gaucher Disease
Splenic infarction, Cholelithiasis, Hepatic failure, Ventriculomegaly, Hepatitis, Pancytopenia, L... ORPHA:355
Porphyria, Congenital Erythropoietic
Cholelithiasis, Reduced erythrocyte uroporphyrinogen III cosynthase activity, Splenomegaly, Throm... OMIM:263700
Steinert Myotonic Dystrophy
Prolonged PR interval, Cholelithiasis, Elevated circulating hepatic transaminase concentration, M... ORPHA:273
Distal Duplication 5Q
Aplasia/Hypoplasia of the gallbladder, Cryptorchidism ORPHA:96097
Cerebrotendinous Xanthomatosis
Cholelithiasis, Myelopathy, Cerebellar atrophy, Abnormal circulating enzyme concentration or acti... ORPHA:909
Bohring-Opitz Syndrome
Ventriculomegaly, Cholelithiasis, Annular pancreas, Bradycardia, Dandy-Walker malformation ORPHA:97297
Amoebiasis Due To Free-Living Amoebae
Abnormal midbrain morphology, Increased red blood cell count, Abnormal medulla oblongata morpholo... ORPHA:68
Semilobar Holoprosencephaly
Abnormal heart morphology, Hydrocephalus, Short stature, Growth delay, Neural tube defect ORPHA:220386
Alobar Holoprosencephaly
Abnormal heart morphology, Hydrocephalus, Short stature, Growth delay, Neural tube defect ORPHA:93925
Midline Interhemispheric Variant Of Holoprosencephaly
Abnormal heart morphology, Hydrocephalus, Short stature, Growth delay, Neural tube defect ORPHA:93926
Lobar Holoprosencephaly
Abnormal heart morphology, Hydrocephalus, Short stature, Growth delay, Neural tube defect ORPHA:93924
Intellectual Developmental Disorder, X-Linked, Syndromic, With Pigmentary Mosaicism And Coarse Facies
Cholelithiasis, Umbilical hernia, Hepatosplenomegaly, Cholecystitis, Hepatomegaly OMIM:301066
Trisomy 8P
Annular pancreas, Cryptorchidism, Aplasia/Hypoplasia of the gallbladder, Hydrocephalus, Heart mur... ORPHA:264450
Pancreatic Hypoplasia-Diabetes-Congenital Heart Disease Syndrome
Anterior pituitary agenesis, Pancreatic hypoplasia, Umbilical hernia, Exocrine pancreatic insuffi... ORPHA:2255
Japanese Encephalitis
Abnormal midbrain morphology, Abnormal substantia nigra morphology, Abnormal pons morphology, Neu... ORPHA:79139
Neurofibroma
Intestinal bleeding, Enlargement of parotid gland, Abnormal biliary tract morphology ORPHA:252183
22Q11.2 Deletion Syndrome
Hypertensive crisis, Cholelithiasis, Gastrointestinal hemorrhage, Umbilical hernia, Cryptorchidis... ORPHA:567
Schinzel-Giedion Syndrome
Abnormal heart morphology, Neural tube defect, Umbilical hernia ORPHA:798
Duplication Of The Pituitary Gland
Abnormal midbrain morphology, Encephalocele, Abnormal pituitary gland morphology ORPHA:314621
Williams Syndrome
Cholelithiasis, Chiari malformation, Congestive heart failure, Hypertrophic cardiomyopathy, Umbil... ORPHA:904
Digeorge Syndrome
Cholelithiasis, Parathyroid hypoplasia, Umbilical hernia, Hepatic steatosis, Ovarian cyst, Spleno... OMIM:188400
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Abnormal midbrain morphology, Elevated circulating hepatic transaminase concentration, Increased ... ORPHA:293987

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Dennd1a

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Dennd1a.

No publications found that use IMPC mice or data for Dennd1a.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Dennd1atm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Dennd1aem1(IMPC)Mbp Exon Deletion Mice, Tissue
Dennd1atm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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