Cdc14a | CDC14 cell division cycle 14A

GeneMGI:2442676Synonyms: Cdc14, CDC14A2, +2 more

Physiological systems

17 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Vision/eye Mortality/aging

15 No significant impact

7 Not tested

Gene metrics:2Significant phenotypes
2Associated diseases
Expression examined in:48Adult tissues
50Embryo tissues

Phenotypes

cataract1 supporting datasetCdc14atm1e.1(EUCOMM)HmguheterozygoteEarly adult2.04x10-5 
preweaning lethality, incomplete penetrance1 supporting datasetCdc14atm1e.1(EUCOMM)HmguhomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoteSection images
100% (2/2)0.7% (4/570)
aortaheterozygoteSection images
100% (2/2)0.19% (1/533)
brainheterozygoteSection images
100% (2/2)0.86% (5/579)
brainstemheterozygoteSection images
100% (2/2)0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/2)0% (0/588)
cartilage tissueheterozygoteSection images
100% (2/2)0.22% (1/454)
cerebellumheterozygoteSection images
100% (2/2)0.56% (3/532)
cerebral cortexheterozygoteSection images
100% (2/2)0.41% (2/491)
epididymisheterozygoteSection images
100% (1/1)87.5% (21/24)
esophagusheterozygoteSection images
100% (2/2)1.67% (7/419)
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Histopathology

IMPC related publications

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Cdc14atm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
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