Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
aspartyl-tRNA synthetase
Synonyms:
5730439G15Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Dars mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Dars by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Hypomyelination With Brainstem And Spinal Cord Involvement And Leg Spasticity
Spina bifida occulta OMIM:615281

The table below shows human diseases predicted to be associated to Dars by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Hypomyelination With Brainstem And Spinal Cord Involvement And Leg Spasticity
Spina bifida occulta OMIM:615281

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Dars

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Dars.

There are 9 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
FGF21 modulates mitochondrial stress response in cardiomyocytes only under mild mitochondrial dysfunction. Science advances (April 2022) Dars2tm1a(KOMP)Wtsi PMC8986112
Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR. Science advances (May 2021) Dars2tm1c(KOMP)Wtsi PMC8153728
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Dars2tm1a(KOMP)Wtsi PMC7263671
Neuronal ablation of mt-AspRS in mice induces immune pathway activation prior to severe and progressive cortical and behavioral disruption. Experimental neurology (December 2019) Dars2tm1c(KOMP)Wtsi 31887305
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Dars2tm1a(KOMP)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Dars2tm1a(KOMP)Wtsi PMC6459510
DARS2 protects against neuroinflammation and apoptotic neuronal loss, but is dispensable for myelin producing cells. Human molecular genetics (November 2017) Dars2tm1c(KOMP)Wtsi 28985337
Loss of CLPP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt. EMBO reports (May 2016) Dars2tm1a(KOMP)Wtsi PMC4931557
Tissue-specific loss of DARS2 activates stress responses independently of respiratory chain deficiency in the heart. Cell metabolism (March 2014) Dars2tm1c(KOMP)Wtsi Dars2tm1a(KOMP)Wtsi Dars2tm1b(KOMP)Wtsi 24606902

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

This service may be affected by the Covid-19 pandemic. See how

MGI Allele Allele Type Produced
Darstm370879(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Darsem1(IMPC)Wtsi Exon Deletion Mice

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter