Gene: Arhgef4

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Name
Rho guanine nucleotide exchange factor (GEF) 4
MGI ID
MGI:2442507
Synonyms
9330140K16Rik Asef C230030N03Rik
Viability
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
increased circulating free fatty acids level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 5.38×10-08
decreased blood urea nitrogen level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 3.41×10-06
decreased circulating LDL cholesterol level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 2.79×10-05
decreased hemoglobin content Arhgef4tm1a(KOMP)Wtsi HOM Early adult 6.55×10-05
increased bone mineral content Arhgef4tm1a(KOMP)Wtsi HOM Early adult 8.64×10-08
increased heart weight Arhgef4tm1a(KOMP)Wtsi HOM Early adult 3.93×10-06
decreased total body fat amount Arhgef4tm1a(KOMP)Wtsi HOM Early adult 1.19×10-09
increased body length Arhgef4tm1a(KOMP)Wtsi HOM   Early adult 1.93×10-05
decreased circulating HDL cholesterol level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 1.86×10-06
decreased circulating cholesterol level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 6.60×10-07
increased lean body mass Arhgef4tm1a(KOMP)Wtsi HOM Early adult 7.76×10-11
abnormal behavior Arhgef4tm1a(KOMP)Wtsi HOM Early adult 1.85×10-08
increased mature B cell number Arhgef4tm1a(KOMP)Wtsi HOM   Early adult 3.18×10-06
abnormal vibrissa morphology Arhgef4tm1a(KOMP)Wtsi HOM Early adult 7.77×10-06
abnormal response to tactile stimuli Arhgef4tm1a(KOMP)Wtsi HOM Early adult 6.20×10-07
decreased circulating triglyceride level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 4.54×10-08
decreased T cell number Arhgef4tm1a(KOMP)Wtsi HOM Early adult 3.47×10-06
increased circulating alanine transaminase level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 1.15×10-05
increased lactate dehydrogenase level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 1.20×10-05
increased circulating calcium level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 4.60×10-06
decreased bone mineral density Arhgef4tm1a(KOMP)Wtsi HOM Early adult 6.37×10-05
decreased circulating serum albumin level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 9.27×10-06
decreased circulating alkaline phosphatase level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 1.60×10-05
increased bone mineral density Arhgef4tm1a(KOMP)Wtsi HOM Early adult 9.03×10-10
increased circulating alkaline phosphatase level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 4.80×10-07

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
2 No  (4/584) N/A
2 No  (1/584) N/A
2 No N/A
2 No N/A
2 No  (4/584)  (2/2) N/A
2 No  (2/584) N/A
2 No N/A
2 No  (1/584) N/A
2 No  (3/584) N/A
2 No  (2/584) N/A
2 No N/A
2 No N/A
2 No  (2/584) N/A
2 No  (3/584) N/A
2 No  (2/584) N/A
2 No  (21/584) N/A
2 No  (10/584) N/A
2 No N/A
2 No  (1/584) N/A
2 No  (2/584) N/A
2 No  (1/584) N/A
2 No N/A
2 No  (1/2) N/A
2 No  (2/584) N/A
2 No  (1/584) N/A
2 No N/A
2 No  (5/584) N/A
2 No  (1/562) N/A
2 No  (2/584)  (2/2) N/A
2 No  (1/176) N/A
2 No  (1/584) N/A
2 No  (12/584) N/A
2 No N/A
2 No  (1/584) N/A
2 No  (9/584) N/A
2 No  (3/584)  (2/2) N/A
2 No  (3/584) N/A
2 No  (12/584) N/A
2 No  (3/584) N/A
2 No  (6/584) N/A
2 No  (1/584) N/A
2 No  (16/584) N/A
2 No  (3/584) N/A
2 No N/A
2 No N/A
LacZ Section Images

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No Embryo expression data was found for this gene.

 Associated Images

Legacy Phenotype Associated Images

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 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Arhgef4tm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Arhgef4tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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