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Gene: Arhgef4

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Name
Rho guanine nucleotide exchange factor (GEF) 4
MGI ID
MGI:2442507
Synonyms
9330140K16Rik Asef C230030N03Rik
Viability
No data available
Embryo viewer
N/A
Other links
MGI   Ensembl  
Significant phenotypes (25) Measurements chart (248) All data table (1267)
Expression & images (45) Disease models (0) Order (2)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
increased circulating free fatty acids level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 5.38×10-08
decreased blood urea nitrogen level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 3.41×10-06
decreased circulating LDL cholesterol level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 2.79×10-05
decreased hemoglobin content Arhgef4tm1a(KOMP)Wtsi HOM Early adult 6.55×10-05
increased bone mineral content Arhgef4tm1a(KOMP)Wtsi HOM Early adult 8.64×10-08
increased heart weight Arhgef4tm1a(KOMP)Wtsi HOM Early adult 3.93×10-06
decreased total body fat amount Arhgef4tm1a(KOMP)Wtsi HOM Early adult 1.19×10-09
increased body length Arhgef4tm1a(KOMP)Wtsi HOM   Early adult 1.93×10-05
decreased circulating HDL cholesterol level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 1.86×10-06
decreased circulating cholesterol level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 6.60×10-07
increased lean body mass Arhgef4tm1a(KOMP)Wtsi HOM Early adult 7.76×10-11
abnormal behavior Arhgef4tm1a(KOMP)Wtsi HOM Early adult 1.85×10-08
increased mature B cell number Arhgef4tm1a(KOMP)Wtsi HOM   Early adult 3.18×10-06
abnormal vibrissa morphology Arhgef4tm1a(KOMP)Wtsi HOM Early adult 7.77×10-06
abnormal response to tactile stimuli Arhgef4tm1a(KOMP)Wtsi HOM Early adult 6.20×10-07
decreased circulating triglyceride level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 4.54×10-08
decreased T cell number Arhgef4tm1a(KOMP)Wtsi HOM Early adult 3.47×10-06
increased circulating alanine transaminase level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 1.15×10-05
increased lactate dehydrogenase level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 1.20×10-05
increased circulating calcium level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 4.60×10-06
decreased bone mineral density Arhgef4tm1a(KOMP)Wtsi HOM Early adult 6.37×10-05
decreased circulating serum albumin level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 9.27×10-06
decreased circulating alkaline phosphatase level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 1.60×10-05
increased bone mineral density Arhgef4tm1a(KOMP)Wtsi HOM Early adult 9.03×10-10
increased circulating alkaline phosphatase level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 4.80×10-07

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
2 No  (4/584) N/A
2 No  (1/584) N/A
2 No N/A
2 No N/A
2 No  (4/584)  (2/2) N/A
2 No  (2/584) N/A
2 No N/A
2 No  (1/584) N/A
2 No  (3/584) N/A
2 No  (2/584) N/A
2 No N/A
2 No N/A
2 No  (2/584) N/A
2 No  (3/584) N/A
2 No  (2/584) N/A
2 No  (21/584) N/A
2 No  (10/584) N/A
2 No N/A
2 No  (1/584) N/A
2 No  (2/584) N/A
2 No  (1/584) N/A
2 No N/A
2 No  (1/2) N/A
2 No  (2/584) N/A
2 No  (1/584) N/A
2 No N/A
2 No  (5/584) N/A
2 No  (1/562) N/A
2 No  (2/584)  (2/2) N/A
2 No  (1/176) N/A
2 No  (1/584) N/A
2 No  (12/584) N/A
2 No N/A
2 No  (1/584) N/A
2 No  (9/584) N/A
2 No  (3/584)  (2/2) N/A
2 No  (3/584) N/A
2 No  (12/584) N/A
2 No  (3/584) N/A
2 No  (6/584) N/A
2 No  (1/584) N/A
2 No  (16/584) N/A
2 No  (3/584) N/A
2 No N/A
2 No N/A
LacZ Wholemount Images
LacZ Section Images
LacZ Section Images
Arhgef4tm1a(KOMP)Wtsi
brain, HET, Female, WTSI
Arhgef4tm1a(KOMP)Wtsi
peripheral nervous system, HET, Female, WTSI
Arhgef4tm1a(KOMP)Wtsi
eye, HET, Female, WTSI
Arhgef4tm1a(KOMP)Wtsi
brain, HET, Female, WTSI
Arhgef4tm1a(KOMP)Wtsi
oesophagus, HET, Female, WTSI

View all 6 images

Arhgef4tm1a(KOMP)Wtsi
brain, HET, Female, WTSI
Arhgef4tm1a(KOMP)Wtsi
peripheral nervous system, HET, Female, WTSI
Arhgef4tm1a(KOMP)Wtsi
brain, HET, Female, WTSI
Arhgef4tm1a(KOMP)Wtsi
spinal cord, HET, Female, WTSI
Arhgef4tm1a(KOMP)Wtsi
oesophagus, HET, Female, WTSI
Arhgef4tm1a(KOMP)Wtsi
spinal cord, HET, Female, WTSI
Arhgef4tm1a(KOMP)Wtsi
oesophagus, HET, Female, WTSI
Arhgef4tm1a(KOMP)Wtsi
eye, HET, Female, WTSI
No Embryo expression data was found for this gene.

 Associated Images

Legacy Phenotype Associated Images
Arhgef4tm1a(KOMP)Wtsi
body, HOM, Male, WTSI
Arhgef4tm1a(KOMP)Wtsi
head, HOM, Male, WTSI
Arhgef4tm1a(KOMP)Wtsi
forearm, HOM, Male, WTSI
Arhgef4tm1a(KOMP)Wtsi
body, HOM, Male, WTSI
Arhgef4tm1a(KOMP)Wtsi
body, HOM, Male, WTSI

View all 68 images

Arhgef4tm1a(KOMP)Wtsi
back skin, HOM, Female, WTSI

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Arhgef4tm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Arhgef4tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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