Genes Phenotypes

Gene: Arhgef4

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Name
Rho guanine nucleotide exchange factor (GEF) 4
MGI ID
MGI:2442507
Synonyms
Asef C230030N03Rik 9330140K16Rik
Viability
N/A
Embryo viewer
N/A
Other links
MGI   Ensembl  
Significant phenotypes (26) Measurements chart (457) All data table (1304)
Expression & images (45) Disease models (0) Order (2)
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased bone mineral density Arhgef4tm1a(KOMP)Wtsi HOM Early adult 4.11×10-07
abnormal vibrissa morphology Arhgef4tm1a(KOMP)Wtsi HOM Early adult 7.87×10-06
cataract Arhgef4tm1a(KOMP)Wtsi HOM Early adult 9.27×10-05
decreased circulating triglyceride level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 3.75×10-08
decreased circulating HDL cholesterol level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 1.03×10-09
increased mature B cell number Arhgef4tm1a(KOMP)Wtsi HOM Early adult 5.95×10-09
decreased IgG1 level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 6.40×10-07
decreased circulating LDL cholesterol level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 2.51×10-06
abnormal behavior Arhgef4tm1a(KOMP)Wtsi HOM Early adult 1.33×10-07
decreased IgE level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 4.02×10-05
decreased circulating cholesterol level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 1.14×10-07
increased circulating total protein level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 7.34×10-07
increased circulating free fatty acid level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 3.61×10-06
decreased total body fat amount Arhgef4tm1a(KOMP)Wtsi HOM Early adult 2.40×10-09
increased lean body mass Arhgef4tm1a(KOMP)Wtsi HOM Early adult 4.97×10-07
decreased hemoglobin content Arhgef4tm1a(KOMP)Wtsi HOM Early adult 9.22×10-05
decreased circulating aspartate transaminase level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 7.67×10-05
decreased T cell number Arhgef4tm1a(KOMP)Wtsi HOM Early adult 3.38×10-08
abnormal response to tactile stimuli Arhgef4tm1a(KOMP)Wtsi HOM Early adult 4.07×10-07
decreased circulating fructosamine level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 7.18×10-05
abnormal lens morphology Arhgef4tm1a(KOMP)Wtsi HOM Early adult 9.64×10-05
decreased body weight Arhgef4tm1a(KOMP)Wtsi HOM Early adult 4.99×10-06
increased bone mineral density Arhgef4tm1a(KOMP)Wtsi HOM Early adult 3.42×10-05
decreased circulating serum albumin level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 8.74×10-08
increased circulating alkaline phosphatase level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 4.01×10-06
decreased circulating alanine transaminase level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 5.94×10-05

Download data as:  TSV  XLS

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No N/A
Blood vessel 2 No N/A
Bone 2 No N/A
Brain 2 No  (2/2) N/A
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584) N/A
Large intestine 2 No  (10/584) N/A
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Esophagus 2 No  (1/2) N/A
Olfactory lobe 2 No N/A
Ovary 2 No  (1/584) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No  (2/2) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle tissue 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No  (2/2) N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No N/A
Testis 2 No  (2/584) N/A
Thymus 2 No N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No N/A
Uterus 2 No N/A
White adipose tissue 2 No N/A
LacZ Wholemount Images
LacZ Section Images
LacZ Section Images
Arhgef4tm1a(KOMP)Wtsi
brain, HET, Female, WTSI
Arhgef4tm1a(KOMP)Wtsi
brain, HET, Female, WTSI
Arhgef4tm1a(KOMP)Wtsi
peripheral nervous system, HET, Female, WTSI
Arhgef4tm1a(KOMP)Wtsi
eye, HET, Female, WTSI
Arhgef4tm1a(KOMP)Wtsi
oesophagus, HET, Female, WTSI

View all 6 images

Arhgef4tm1a(KOMP)Wtsi
brain, HET, Female, WTSI
Arhgef4tm1a(KOMP)Wtsi
brain, HET, Female, WTSI
Arhgef4tm1a(KOMP)Wtsi
peripheral nervous system, HET, Female, WTSI
Arhgef4tm1a(KOMP)Wtsi
spinal cord, HET, Female, WTSI
Arhgef4tm1a(KOMP)Wtsi
oesophagus, HET, Female, WTSI
Arhgef4tm1a(KOMP)Wtsi
spinal cord, HET, Female, WTSI
Arhgef4tm1a(KOMP)Wtsi
oesophagus, HET, Female, WTSI
Arhgef4tm1a(KOMP)Wtsi
eye, HET, Female, WTSI
No Embryo expression data was found for this gene.

 Associated Images

Legacy Phenotype Associated Images
Arhgef4tm1a(KOMP)Wtsi
head, HOM, Male, WTSI
Arhgef4tm1a(KOMP)Wtsi
body, HOM, Male, WTSI
Arhgef4tm1a(KOMP)Wtsi
body, HOM, Male, WTSI
Arhgef4tm1a(KOMP)Wtsi
head, HOM, Male, WTSI
Arhgef4tm1a(KOMP)Wtsi
head, HOM, Male, WTSI

View all 68 images

Arhgef4tm1a(KOMP)Wtsi
back skin, HOM, Female, WTSI

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Arhgef4tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Arhgef4tm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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