Gene: Arhgef4

Log in to follow

Name
Rho guanine nucleotide exchange factor (GEF) 4
MGI ID
MGI:2442507
Synonyms
Asef C230030N03Rik 9330140K16Rik
Viability
N/A
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased bone mineral density Arhgef4tm1a(KOMP)Wtsi HOM Early adult 4.11×10-07
abnormal vibrissa morphology Arhgef4tm1a(KOMP)Wtsi HOM Early adult 7.87×10-06
cataract Arhgef4tm1a(KOMP)Wtsi HOM Early adult 9.27×10-05
decreased circulating triglyceride level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 3.75×10-08
decreased circulating HDL cholesterol level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 1.03×10-09
increased mature B cell number Arhgef4tm1a(KOMP)Wtsi HOM Early adult 5.95×10-09
decreased IgG1 level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 6.40×10-07
decreased circulating LDL cholesterol level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 2.51×10-06
abnormal behavior Arhgef4tm1a(KOMP)Wtsi HOM Early adult 1.33×10-07
decreased IgE level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 4.02×10-05
decreased circulating cholesterol level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 1.14×10-07
increased circulating total protein level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 7.34×10-07
increased circulating free fatty acid level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 3.61×10-06
decreased total body fat amount Arhgef4tm1a(KOMP)Wtsi HOM Early adult 2.40×10-09
increased lean body mass Arhgef4tm1a(KOMP)Wtsi HOM Early adult 4.97×10-07
decreased hemoglobin content Arhgef4tm1a(KOMP)Wtsi HOM Early adult 9.22×10-05
decreased circulating aspartate transaminase level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 7.67×10-05
decreased T cell number Arhgef4tm1a(KOMP)Wtsi HOM Early adult 3.38×10-08
abnormal response to tactile stimuli Arhgef4tm1a(KOMP)Wtsi HOM Early adult 4.07×10-07
decreased circulating fructosamine level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 7.18×10-05
abnormal lens morphology Arhgef4tm1a(KOMP)Wtsi HOM Early adult 9.64×10-05
decreased body weight Arhgef4tm1a(KOMP)Wtsi HOM Early adult 4.99×10-06
increased bone mineral density Arhgef4tm1a(KOMP)Wtsi HOM Early adult 3.42×10-05
decreased circulating serum albumin level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 8.74×10-08
increased circulating alkaline phosphatase level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 4.01×10-06
decreased circulating alanine transaminase level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 5.94×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No N/A
Blood vessel 2 No N/A
Bone 2 No N/A
Brain 2 No  (2/2) N/A
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584) N/A
Large intestine 2 No  (10/584) N/A
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Esophagus 2 No  (1/2) N/A
Olfactory lobe 2 No N/A
Ovary 2 No  (1/584) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No  (2/2) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle tissue 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No  (2/2) N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No N/A
Testis 2 No  (2/584) N/A
Thymus 2 No N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No N/A
Uterus 2 No N/A
White adipose tissue 2 No N/A
LacZ Section Images

View all 6 images

No Embryo expression data was found for this gene.

 Associated Images

Legacy Phenotype Associated Images

View all 68 images

 Disease Models

No associations by disease annotation and gene orthology found.
Please visit the desktop version to see this section

 Order Mouse and ES Cells

This service may be affected by the Covid-19 pandemic. See how

MGI Allele Allele Type Produced
Arhgef4tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Arhgef4tm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter