Gene: Arhgef4

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Name
Rho guanine nucleotide exchange factor (GEF) 4
MGI ID
MGI:2442507
Synonyms
9330140K16Rik Asef C230030N03Rik
Viability
N/A
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased IgE level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 6.90×10-06
decreased circulating serum albumin level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 3.20×10-11
increased mature B cell number Arhgef4tm1a(KOMP)Wtsi HOM Early adult 1.30×10-08
abnormal behavior Arhgef4tm1a(KOMP)Wtsi HOM Early adult 3.59×10-08
increased circulating creatinine level Arhgef4tm1a(KOMP)Wtsi HOM   Early adult 5.15×10-07
abnormal vibrissa morphology Arhgef4tm1a(KOMP)Wtsi HOM Early adult 7.77×10-06
decreased circulating triglyceride level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 5.39×10-12
increased circulating free fatty acid level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 4.17×10-07
decreased circulating HDL cholesterol level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 4.75×10-07
decreased IgG1 level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 7.13×10-07
decreased T cell number Arhgef4tm1a(KOMP)Wtsi HOM Early adult 8.29×10-09
decreased total body fat amount Arhgef4tm1a(KOMP)Wtsi HOM Early adult 1.27×10-08
increased lean body mass Arhgef4tm1a(KOMP)Wtsi HOM Early adult 3.07×10-10
decreased circulating LDL cholesterol level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 1.51×10-06
decreased circulating cholesterol level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 4.83×10-12
increased circulating total protein level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 4.15×10-05
hypoactivity Arhgef4tm1a(KOMP)Wtsi HOM   Early adult 2.64×10-06
increased startle reflex Arhgef4tm1a(KOMP)Wtsi HOM   Early adult 5.86×10-06
increased heart weight Arhgef4tm1a(KOMP)Wtsi HOM Early adult 4.48×10-05
increased circulating glycerol level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 9.35×10-07
decreased mean corpuscular hemoglobin Arhgef4tm1a(KOMP)Wtsi HOM Early adult 3.23×10-06
decreased hemoglobin content Arhgef4tm1a(KOMP)Wtsi HOM Early adult 3.10×10-05
increased lactate dehydrogenase level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 4.19×10-05
increased bone mineral content Arhgef4tm1a(KOMP)Wtsi HOM Early adult 1.15×10-07
increased circulating alkaline phosphatase level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 9.92×10-07
increased bone mineral density Arhgef4tm1a(KOMP)Wtsi HOM Early adult 1.94×10-08
abnormal response to tactile stimuli Arhgef4tm1a(KOMP)Wtsi HOM Early adult 4.07×10-07
decreased body weight Arhgef4tm1a(KOMP)Wtsi HOM   Early adult 1.26×10-06
decreased circulating alkaline phosphatase level Arhgef4tm1a(KOMP)Wtsi HOM   Early adult 2.94×10-06
decreased circulating free fatty acid level Arhgef4tm1a(KOMP)Wtsi HOM Early adult 2.65×10-05
decreased bone mineral density Arhgef4tm1a(KOMP)Wtsi HOM Early adult 6.37×10-05
decreased grip strength Arhgef4tm1a(KOMP)Wtsi HOM Early adult 9.63×10-05

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (3/590) N/A
Aorta 2 No  (1/590) N/A
Blood vessel 2 No N/A
Bone 2 No N/A
Brain 2 No  (3/590)  (2/2) N/A
Brainstem 2 No  (2/590) N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No  (3/590) N/A
Cerebral cortex 2 No  (2/590) N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No  (1/590) N/A
Hippocampus 2 No  (3/590) N/A
Hypothalamus 2 No  (2/590) N/A
Kidney 2 No  (20/590) N/A
Large intestine 2 No  (10/590) N/A
Liver 2 No N/A
Lower urinary tract 2 No  (1/590) N/A
Lung 2 No  (1/590) N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Esophagus 2 No  (1/2) N/A
Olfactory lobe 2 No  (2/590) N/A
Ovary 2 No  (1/590) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/590) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No  (1/590)  (2/2) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/590) N/A
Prostate gland 2 No  (12/590) N/A
Skeletal muscle tissue 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/590) N/A
Spinal cord 2 No  (2/590)  (2/2) N/A
Spleen 2 No  (2/590) N/A
Stomach 2 No  (13/590) N/A
Striatum 2 No  (3/590) N/A
Testis 2 No  (5/590) N/A
Thymus 2 No N/A
Thyroid gland 2 No  (16/590) N/A
Trachea 2 No  (2/590) N/A
Uterus 2 No N/A
White adipose tissue 2 No N/A
LacZ Section Images

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No Embryo expression data was found for this gene.

 Associated Images

Legacy Phenotype Associated Images

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 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Arhgef4tm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Arhgef4tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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