Gene: Arhgef4

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Name
Rho guanine nucleotide exchange factor (GEF) 4
MGI ID
MGI:2442507
Synonyms
9330140K16Rik Asef
View
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
increased lean body mass Arhgef4tm1a(KOMP)Wtsi HOM postnatal 4.97×10-07
decreased total body fat amount Arhgef4tm1a(KOMP)Wtsi HOM postnatal 3.25×10-10
decreased T cell number Arhgef4tm1a(KOMP)Wtsi HOM postnatal 3.38×10-08
decreased circulating HDL cholesterol level Arhgef4tm1a(KOMP)Wtsi HOM postnatal 1.48×10-10
decreased circulating aspartate transaminase level Arhgef4tm1a(KOMP)Wtsi HOM postnatal 1.30×10-05
abnormal response to tactile stimuli Arhgef4tm1a(KOMP)Wtsi HOM postnatal 4.07×10-07
abnormal vibrissa morphology Arhgef4tm1a(KOMP)Wtsi HOM postnatal 2.13×10-05
decreased circulating triglyceride level Arhgef4tm1a(KOMP)Wtsi HOM postnatal 3.75×10-08
decreased IgE level Arhgef4tm1a(KOMP)Wtsi HOM postnatal 4.02×10-05
increased mature B cell number Arhgef4tm1a(KOMP)Wtsi HOM postnatal 5.95×10-09
decreased IgG1 level Arhgef4tm1a(KOMP)Wtsi HOM postnatal 6.40×10-07
decreased circulating LDL cholesterol level Arhgef4tm1a(KOMP)Wtsi HOM postnatal 1.99×10-06
increased circulating free fatty acid level Arhgef4tm1a(KOMP)Wtsi HOM postnatal 1.32×10-05
abnormal behavior Arhgef4tm1a(KOMP)Wtsi HOM postnatal 4.68×10-07
decreased body weight Arhgef4tm1a(KOMP)Wtsi HOM postnatal 2.99×10-06
decreased circulating alanine transaminase level Arhgef4tm1a(KOMP)Wtsi HOM postnatal 1.21×10-05
decreased hemoglobin content Arhgef4tm1a(KOMP)Wtsi HOM postnatal 9.22×10-05
increased circulating total protein level Arhgef4tm1a(KOMP)Wtsi HOM postnatal 7.34×10-07
increased circulating alkaline phosphatase level Arhgef4tm1a(KOMP)Wtsi HOM postnatal 4.01×10-06
decreased bone mineral density Arhgef4tm1a(KOMP)Wtsi HOM postnatal 4.11×10-07
decreased circulating serum albumin level Arhgef4tm1a(KOMP)Wtsi HOM postnatal 6.23×10-07
decreased circulating cholesterol level Arhgef4tm1a(KOMP)Wtsi HOM postnatal 3.84×10-08

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Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No N/A
Blood vessel 2 No N/A
Bone 2 No N/A
Brain 2 No  (2/2) N/A
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584) N/A
Large intestine 2 No  (10/584) N/A
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Esophagus 2 No  (1/2) N/A
Olfactory lobe 2 No N/A
Ovary 2 No  (1/584) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No  (2/2) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle tissue 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No  (2/2) N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No N/A
Testis 2 No  (2/584) N/A
Thymus 2 No N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No N/A
Uterus 2 No N/A
White adipose tissue 2 No N/A
No Embryo expression data was found for this gene.

 Associated Images

Phenotype associated images not available

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Arhgef4tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Arhgef4tm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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