Genes Phenotypes

Gene: Arhgef4

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Name
Rho guanine nucleotide exchange factor (GEF) 4
MGI ID
MGI:2442507
Synonyms
9330140K16Rik Asef
Viability
Homozygous - Viable
Embryo Screen
N/A
Other links
MGI   Ensembl  
Significant phenotypes (22) Measurements chart (477) All data table (2422)
Expression & images (45) Disease models (0) Order (2)
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
increased lean body mass Arhgef4tm1a(KOMP)Wtsi HOM postnatal 4.97×10-07
decreased total body fat amount Arhgef4tm1a(KOMP)Wtsi HOM postnatal 3.25×10-10
decreased T cell number Arhgef4tm1a(KOMP)Wtsi HOM postnatal 3.38×10-08
decreased circulating HDL cholesterol level Arhgef4tm1a(KOMP)Wtsi HOM postnatal 1.48×10-10
decreased circulating aspartate transaminase level Arhgef4tm1a(KOMP)Wtsi HOM postnatal 1.30×10-05
decreased circulating triglyceride level Arhgef4tm1a(KOMP)Wtsi HOM postnatal 3.75×10-08
abnormal response to tactile stimuli Arhgef4tm1a(KOMP)Wtsi HOM postnatal 4.07×10-07
increased circulating total protein level Arhgef4tm1a(KOMP)Wtsi HOM postnatal 7.34×10-07
decreased body weight Arhgef4tm1a(KOMP)Wtsi HOM postnatal 2.99×10-06
increased mature B cell number Arhgef4tm1a(KOMP)Wtsi HOM postnatal 5.95×10-09
abnormal behavior Arhgef4tm1a(KOMP)Wtsi HOM postnatal 4.68×10-07
decreased IgG1 level Arhgef4tm1a(KOMP)Wtsi HOM postnatal 6.40×10-07
decreased circulating LDL cholesterol level Arhgef4tm1a(KOMP)Wtsi HOM postnatal 1.99×10-06
decreased IgE level Arhgef4tm1a(KOMP)Wtsi HOM postnatal 4.02×10-05
decreased circulating alanine transaminase level Arhgef4tm1a(KOMP)Wtsi HOM postnatal 1.21×10-05
decreased circulating serum albumin level Arhgef4tm1a(KOMP)Wtsi HOM postnatal 6.23×10-07
increased circulating free fatty acid level Arhgef4tm1a(KOMP)Wtsi HOM postnatal 1.32×10-05
decreased bone mineral density Arhgef4tm1a(KOMP)Wtsi HOM postnatal 4.11×10-07
abnormal vibrissa morphology Arhgef4tm1a(KOMP)Wtsi HOM postnatal 2.13×10-05
decreased circulating cholesterol level Arhgef4tm1a(KOMP)Wtsi HOM postnatal 3.84×10-08
increased circulating alkaline phosphatase level Arhgef4tm1a(KOMP)Wtsi HOM postnatal 4.01×10-06
decreased hemoglobin content Arhgef4tm1a(KOMP)Wtsi HOM postnatal 9.22×10-05

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No N/A
Blood vessel 2 No N/A
Bone 2 No N/A
Brain 2 No  (2/2) N/A
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584) N/A
Large intestine 2 No  (10/584) N/A
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Esophagus 2 No  (1/2) N/A
Olfactory lobe 2 No N/A
Ovary 2 No  (1/584) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No  (2/2) N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle tissue 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No  (2/2) N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No N/A
Testis 2 No  (2/584) N/A
Thymus 2 No N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No N/A
Uterus 2 No N/A
White adipose tissue 2 No N/A
LacZ Wholemount Images
LacZ Section Images
No Embryo expression data was found for this gene.

 Associated Images

Phenotype associated images not available

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

MGI Allele Allele Type Produced
Arhgef4tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Arhgef4tm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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