Rhbdf2 | rhomboid 5 homolog 2

GeneMGI:2442473Synonyms: iRhom2, cub, +3 more

Physiological systems

22 / 24 physiological systems tested

9 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Integument Adipose tissue Growth/size/body region Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

13 No significant impact

2 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:20Significant phenotypes
2Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal coat appearance5 supporting datasetsRhbdf2em1(IMPC)WtsiheterozygoteEarly adult2.22x10-11 
abnormal vibrissa morphology3 supporting datasetsRhbdf2em1(IMPC)WtsihomozygoteEarly adult1.6x10-7 
tremors1 supporting datasetRhbdf2Rhbdf2homozygoteEarly adult6.92x10-6 
abnormal response to tactile stimuli1 supporting datasetRhbdf2Rhbdf2homozygoteEarly adult6.77x10-6 
increased total body fat amount1 supporting datasetRhbdf2Rhbdf2homozygoteEarly adult1.98x10-5 
increased circulating magnesium level1 supporting datasetRhbdf2em1(IMPC)WtsihomozygoteEarly adult9.33x10-5 
alopecia1 supporting datasetRhbdf2Rhbdf2homozygoteEarly adult1.18x10-19 
decreased circulating alkaline phosphatase level1 supporting datasetRhbdf2Rhbdf2homozygoteEarly adult9.42x10-9 
increased heart weight1 supporting datasetRhbdf2Rhbdf2homozygoteEarly adult3.25x10-6 
abnormal coat appearance5 supporting datasetsRhbdf2em1(IMPC)WtsihomozygoteEarly adult2.23x10-17 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Rhbdf2em1(IMPC)WtsiPoint Mutationmouse
Rhbdf2tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Rhbdf2tm1b(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Rhbdf2tm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell

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