Gene: Unk MGI:2442456

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Gene Summary

Name:
unkempt family zinc finger
Synonyms:
B230379M23Rik,  Zc3h5

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased body length Unktm1a(KOMP)Wtsi HOM Early adult 1.95×10-08
increased grip strength Unktm1a(KOMP)Wtsi HOM   Early adult 3.93×10-06
increased erythrocyte cell number Unktm1a(KOMP)Wtsi HOM   Early adult 2.76×10-05
decreased mean corpuscular hemoglobin Unktm1a(KOMP)Wtsi HOM   Early adult 1.07×10-08
preweaning lethality, incomplete penetrance Unktm1a(KOMP)Wtsi HOM   Early adult 0.00
increased bone mineral content Unktm1a(KOMP)Wtsi HOM   Early adult 3.29×10-06

Download data as:  TSV  XLS

Select physiological systems to view:
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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

7 Images

X-ray

XRay Images Skull Lateral Orientation

7 Images

X-ray

XRay Images Whole Body Dorso Ventral

7 Images

X-ray

XRay Images Forepaw

7 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

7 Images

Legacy Phenotype Associated Images

View all 20 images

Human diseases caused by Unk mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Unk by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Adenosine Triphosphate, Elevated, Of Erythrocytes
OMIM:102900
Hemoglobin-Delta locus
OMIM:142000
Hereditary Persistence Of Fetal Hemoglobin-Beta-Thalassemia Syndrome
ORPHA:46532
Hemoglobin E-Beta-Thalassemia Syndrome
ORPHA:231249
Erythrocytosis, Familial, 6
OMIM:617980
Erythrocytosis, Familial, 5
OMIM:617907
Erythrocytosis, Familial, 3
OMIM:609820
Erythrocytosis, Familial, 4
OMIM:611783
Anemia, X-Linked, With Or Without Neutropenia And/Or Platelet Abnormalities
OMIM:300835
Thalassemia, Beta+, Silent Allele
OMIM:187550
Fetal Hemoglobin Quantitative Trait Locus 1
OMIM:141749
Polycythemia Vera
OMIM:263300
Congenital Amegakaryocytic Thrombocytopenia
ORPHA:3319
Hemoglobin H Disease
OMIM:613978
Erythrocytosis, Familial, 7
OMIM:617981
Beta-Thalassemia-X-Linked Thrombocytopenia Syndrome
ORPHA:231393
Delta-Beta-Thalassemia
ORPHA:231237
Acetophenetidin Sensitivity
OMIM:200300
Hemoglobin C-Beta-Thalassemia Syndrome
ORPHA:231242
Methemoglobinemia, Beta Type
OMIM:617971
Methemoglobinemia, Alpha Type
OMIM:617973
Dehydrated Hereditary Stomatocytosis
ORPHA:3202
Erythrocytosis, Familial, 1
OMIM:133100
Erythrocytosis, Familial, 8
OMIM:222800
Methemoglobinemia Due To Deficiency Of Methemoglobin Reductase
OMIM:250800
Cyanosis, Transient Neonatal
OMIM:613977
Primary Familial Polycythemia
ORPHA:90042
Pericardial Effusion, Chronic
OMIM:260900
Alpha-Thalassemia Myelodysplasia Syndrome
OMIM:300448
Erythrocytosis, Familial, 2
OMIM:263400
Alpha-Thalassemia
ORPHA:846
Sickle Cell Anemia
ORPHA:232
Hemolytic Anemia Due To Red Cell Pyruvate Kinase Deficiency
ORPHA:766
Hyperbilirubinemia, Shunt, Primary
OMIM:237800
Anemia, Congenital Dyserythropoietic, Type Iv
OMIM:613673
Anemia, Congenital Dyserythropoietic, Type Ia
OMIM:224120
Alpha-Thalassemia-Myelodysplastic Syndrome
ORPHA:231401
Tempi Syndrome
ORPHA:284227
Anemia, Congenital Dyserythropoietic, Type Ib
OMIM:615631
Diamond-Blackfan Anemia 3
OMIM:610629
Dehydrated Hereditary Stomatocytosis 2
OMIM:616689
Overhydrated Hereditary Stomatocytosis
ORPHA:3203
Beta-Thalassemia
OMIM:613985
Alpha-Thalassemia
OMIM:604131
Beta-Thalassemia
ORPHA:848
Bone Marrow Failure Syndrome 6
OMIM:618849
Poems Syndrome
ORPHA:2905
Hypermanganesemia With Dystonia 1
OMIM:613280
Red Cell Phospholipid Defect With Hemolysis
OMIM:179700
Cryohydrocytosis
OMIM:185020
Glutamate-Cysteine Ligase Deficiency
ORPHA:33574
Spherocytosis, Type 5
OMIM:612690
Anemia, Congenital Dyserythropoietic, Type Ii
OMIM:224100
Solute carrier family 4 (anion exchanger), member 1
OMIM:109270
Livedoid Vasculopathy
ORPHA:542643
Osteopetrosis, Autosomal Recessive 4
OMIM:611490
Spherocytosis, Type 2
OMIM:616649
Fumarase Deficiency
OMIM:606812
Elliptocytosis 2
OMIM:130600
Spherocytosis, Type 4
OMIM:612653
Familial Pseudohyperkalemia
ORPHA:90044
Thrombocytopenia With Beta-Thalassemia, X-Linked
OMIM:314050
Hb Bart'S Hydrops Fetalis
ORPHA:163596
Renal Tubular Acidosis, Distal, 4, With Hemolytic Anemia
OMIM:611590
Anemia, Nonspherocytic Hemolytic, Due To G6Pd Deficiency
OMIM:300908
Beta-Thalassemia Intermedia
ORPHA:231222
Hemolytic Anemia, Nonspherocytic, Due To Hexokinase Deficiency
OMIM:235700
Spherocytosis, Type 1
OMIM:182900
Overhydrated Hereditary Stomatocytosis
OMIM:185000
Glut1 Deficiency Syndrome 2
OMIM:612126
Hereditary Elliptocytosis
ORPHA:288
Glycogen Storage Disease Vii
OMIM:232800
Thrombotic Thrombocytopenic Purpura
ORPHA:54057
Cirrhosis-Dystonia-Polycythemia-Hypermanganesemia Syndrome
ORPHA:309854
Von Hippel-Lindau Syndrome
OMIM:193300
Nephropathy With Pretibial Epidermolysis Bullosa And Deafness
OMIM:609057
Phosphoglycerate Kinase 1 Deficiency
OMIM:300653
Methemoglobinemia And Ambiguous Genitalia
OMIM:250790
Hepatocellular Carcinoma
ORPHA:88673
Diamond-Blackfan Anemia 6
OMIM:612561
Dominant Beta-Thalassemia
ORPHA:231226
Harderoporphyria
OMIM:618892
Beta-Thalassemia Major
ORPHA:231214
Sitosterolemia 1
OMIM:210250
Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema
OMIM:194380
Glycogen Storage Disease Due To Phosphoglycerate Kinase 1 Deficiency
ORPHA:713
Alpha-Thalassemia-Intellectual Disability Syndrome Linked To Chromosome 16
ORPHA:98791
Shwachman-Diamond Syndrome 1
OMIM:260400
Leukocyte Adhesion Deficiency
ORPHA:2968
Von Hippel-Lindau Disease
ORPHA:892
Hereditary Spherocytosis
ORPHA:822
Pyruvate Kinase Deficiency Of Red Cells
OMIM:266200
Fibrosis, Neurodegeneration, And Cerebral Angiomatosis
OMIM:618278
Hereditary Methemoglobinemia
ORPHA:621
Beckwith-Wiedemann Syndrome
ORPHA:116
Acquired Methemoglobinemia
ORPHA:464453
Blackfan-Diamond Anemia
ORPHA:124
Alpha-Thalassemia/Mental Retardation Syndrome, Chromosome 16-Related
OMIM:141750
Thrombotic Thrombocytopenic Purpura, Hereditary
OMIM:274150
Telangiectasia, Hereditary Hemorrhagic, Type 2
OMIM:600376
Lead Poisoning
ORPHA:330015
Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1
OMIM:235400
Alpha-Thalassemia-X-Linked Intellectual Disability Syndrome
ORPHA:847
Alpha-Thalassemia/Mental Retardation Syndrome, X-Linked
OMIM:301040
Telangiectasia, Hereditary Hemorrhagic, Type 1
OMIM:187300
Congenital Erythropoietic Porphyria
ORPHA:79277
Kasabach-Merritt Syndrome
ORPHA:2330
Shiga Toxin-Associated Hemolytic Uremic Syndrome
ORPHA:90038

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Unk

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Unk.

There are 3 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
The zinc finger/RING domain protein Unkempt regulates cognitive flexibility. Scientific reports (August 2021) Unktm1c(KOMP)Wtsi Unktm1a(KOMP)Wtsi PMC8357790
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Unktm1a(KOMP)Wtsi PMC5827107
Highly variable penetrance of abnormal phenotypes in embryonic lethal knockout mice. Wellcome open research (January 2016) Unktm1a(KOMP)Wtsi PMC5159622

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MGI Allele Allele Type Produced
Unktm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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