Gene Summary

Name:
leucine rich repeat and Ig domain containing 2
Synonyms:
LERN3,  Lrrn6c,  B230217C06Rik

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
increased lean body mass Lingo2em1(IMPC)KMPC HOM Early adult 5.12×10-08
decreased total body fat amount Lingo2em1(IMPC)KMPC HOM Early adult 9.81×10-07
abnormal uterus morphology Lingo2em1(IMPC)KMPC HOM Late adult 0.00
abnormal liver morphology Lingo2em1(IMPC)KMPC HOM Late adult 0.00
decreased body length Lingo2em1(IMPC)KMPC HOM   Late adult 9.39×10-05
increased bone mineral content Lingo2em1(IMPC)KMPC HOM Early adult 2.84×10-05
hydrometra Lingo2em1(IMPC)KMPC HOM Late adult 0.00
increased body length Lingo2em1(IMPC)KMPC HOM Early adult 5.39×10-08
increased lean body mass Lingo2em1(IMPC)KMPC HOM Late adult 3.08×10-09
decreased startle reflex Lingo2em1(IMPC)KMPC HOM   Early adult 2.10×10-06
long tibia Lingo2em1(IMPC)KMPC HOM Early adult 1.26×10-05
decreased total body fat amount Lingo2em1(IMPC)KMPC HOM Late adult 1.46×10-05

Download data as:  TSV  XLS

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

X-ray

XRay Images Skull Lateral Orientation

10 Images

X-ray

XRay Images Forepaw

10 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

X-ray

XRay Images Forepaw

10 Images

X-ray

XRay Images Skull Lateral Orientation

10 Images

X-ray

XRay Images Hind Leg and Hip

10 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

Eye Morphology

Images Slit Lamp

1 Images

X-ray

XRay Images Hind Leg and Hip

10 Images

Eye Morphology

Images Ophthalmoscopy

1 Images

Human diseases caused by Lingo2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Lingo2 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Uterine Anomalies
Bicornuate uterus, Abnormality of the uterus OMIM:192000
Metaphyseal Dysostosis-Intellectual Disability-Conductive Deafness Syndrome
Narrow iliac wing, Genu varum, Bowing of the legs, Broad tibial metaphyses, Short palm, Short fem... ORPHA:2502
Vitamin D-Dependent Rickets, Type 2B, With Normal Vitamin D Receptor
Bowing of the long bones, Genu varum, Bulging epiphyses, Metaphyseal irregularity, Sparse bone tr... OMIM:600785
Metaphyseal Dysplasia, Braun-Tinschert Type
Upper limb metaphyseal widening, Flared femoral metaphysis, Broad femoral neck, Deformed humerus,... ORPHA:85188
Ovarian Dysgenesis 2
Gonadal hypoplasia, Abnormality of the uterus, Premature ovarian insufficiency, Hypergonadotropic... OMIM:300510
Testicular Regression Syndrome
Absent testis, Abnormal morphology of female internal genitalia, Aplasia/Hypoplasia of the testes... ORPHA:983
Caffey Disease
Cortical irregularity, Bowing of the legs, Tibial bowing, Periosteal thickening of long tubular b... OMIM:114000
Spondyloepimetaphyseal Dysplasia, X-Linked
Cone-shaped metacarpal epiphyses, Delayed ossification of carpal bones, Prominent styloid process... OMIM:300106
Premature Ovarian Failure 3
Premature ovarian insufficiency, Hypoplasia of the uterus OMIM:608996
Weismann-Netter Syndrome
Bowing of the long bones, Abnormal hip bone morphology, Abnormality of the ulna, Tibial bowing, A... ORPHA:3344
Spondyloepimetaphyseal Dysplasia, Missouri Type
Genu varum, Metaphyseal irregularity, Flattened epiphysis, Tibial bowing, Flared metaphysis, Shor... ORPHA:93356
Chondrodysplasia, Lethal, With Long Bone Angulation And Mixed Bone Density
Hypoplasia of the ulna, Fibular hypoplasia, Hypoplasia of the radius, Absent ossification of calv... OMIM:601376
46,Xy Sex Reversal 3
Hypoplasia of the uterus, Penoscrotal hypospadias, Sex reversal, Ambiguous genitalia, Exaggerated... OMIM:612965
Ovarian Dysgenesis 7
Hypoplasia of the uterus OMIM:618117
Hypogonadotropic Hypogonadism 13 With Or Without Anosmia
Hypogonadotropic hypogonadism, Hypoplasia of the uterus OMIM:614842
Diethylstilbestrol Syndrome
Epididymal cyst, Small for gestational age, Micropenis, Cryptorchidism, Abnormality of the uterus... ORPHA:1916
46,Xy Sex Reversal 11
Aplasia of the uterus, Abnormal internal genitalia, Vanishing testis, Urogenital sinus anomaly, G... OMIM:273250
Ovarian Dysgenesis 6
Hypoplasia of the uterus OMIM:618078
Spondylometaphyseal Dysplasia, Sedaghatian Type
Brachydactyly, Widened greater sciatic notch, Metaphyseal irregularity, Cone-shaped metacarpal ep... OMIM:250220
Androgen Insensitivity Syndrome
Abnormal morphology of female internal genitalia, Cryptorchidism, Testicular neoplasm, Aplasia/hy... ORPHA:754
46,Xx Ovotesticular Disorder Of Sex Development
Small scrotum, Polycystic ovaries, Abnormal morphology of female internal genitalia, Cryptorchidi... ORPHA:2138
Leydig Cell Hypoplasia
Hyoplasia of the Leydig cells, Aplasia of the uterus, Female hypogonadism, Cryptorchidism, Microp... ORPHA:755
Osteosclerosis With Ichthyosis And Fractures
Cortical thickening of long bone diaphyses, Tibial bowing, Femoral bowing, Increased bone mineral... OMIM:166740
Léri-Weill Dyschondrosteosis
Abnormal hip bone morphology, Genu varum, Abnormality of the ulna, Clinodactyly of the 5th finger... ORPHA:240
Ovarian Dysgenesis 5
Hypoplasia of the uterus OMIM:617690
Premature Ovarian Failure 7
Hypoplasia of the uterus, Premature ovarian insufficiency, Gonadal dysgenesis, Clitoral hypertrophy OMIM:612964
Hypogonadotropic Hypogonadism 8 With Or Without Anosmia
Hypogonadotropic hypogonadism, Azoospermia, Cryptorchidism, Micropenis, Hypoplasia of the uterus,... OMIM:614837
Leri-Weill Dyschondrosteosis
Dorsal subluxation of ulna, Hypoplasia of the ulna, Coxa valga, Abnormal femoral neck morphology,... OMIM:127300
46,Xy Gonadal Dysgenesis-Motor And Sensory Neuropathy Syndrome
Hypoplasia of the uterus, Gonadal dysgenesis with female appearance, male, Abnormal vagina morpho... ORPHA:168563
Fibular Aplasia, Tibial Campomelia, And Oligosyndactyly Syndrome
Hand oligodactyly, Tibial bowing, Foot oligodactyly, Fibular aplasia, Short tibia, Syndactyly OMIM:246570
Perrault Syndrome 6
Hypoplasia of the uterus, Premature ovarian insufficiency, Streak ovary OMIM:617565
Spondylometaepiphyseal Dysplasia, Short Limb-Hand Type
Bowing of the legs, Short long bone, Flared iliac wing, Short metacarpal, Epiphyseal stippling, A... OMIM:271665
46,Xy Sex Reversal 7
Abnormality of the epididymis, Hypoplasia of the uterus, Gonadal dysgenesis, male, Gonadoblastoma... OMIM:233420
Spondyloepimetaphyseal Dysplasia, Missouri Type
Genu varum, Flattened epiphysis, Flared iliac wing, Rhizomelia, Tibial bowing, Metaphyseal cuppin... OMIM:602111
Complete Androgen Insensitivity Syndrome
Abnormality of the uterine cervix, Aplasia of the uterus, Abnormal morphology of female internal ... ORPHA:99429
Fibular Hemimelia
Fibular hypoplasia, Abnormal bone ossification, Short tibia, Short toe, Abnormal morphology of ul... ORPHA:93323
Mullerian Aplasia And Hyperandrogenism
Aplasia of the uterus, Aplasia of the vagina, Aplasia/Hypoplasia of the fallopian tube OMIM:158330
Short-Limb Skeletal Dysplasia With Severe Combined Immunodeficiency
Reduced bone mineral density, Long fibula, Abnormality of the metaphysis, Inguinal hernia ORPHA:935
Partial Androgen Insensitivity Syndrome
Aplasia of the uterus, Perineal hypospadias, Azoospermia, Micropenis, Blind vagina, Aplasia of th... ORPHA:90797
Hypophosphatemic Rickets, X-Linked Dominant
Bowing of the legs, Metaphyseal irregularity, Abnormality of pelvic girdle bone morphology, Trape... OMIM:307800
Perrault Syndrome 3
Hypergonadotropic hypogonadism, Hypoplasia of the uterus OMIM:614129
Testicular Agenesis
Absent testis, Micropenis, Absent external genitalia, Abnormal vas deferens morphology, Urethrova... ORPHA:325124
Hypogonadotropic Hypogonadism 12 With Or Without Anosmia
Hypogonadotropic hypogonadism, Cryptorchidism, Micropenis, Hypoplasia of the ovary, Hypoplasia of... OMIM:614841
Premature Ovarian Failure 6
Hypoplasia of the uterus, Premature ovarian insufficiency, Streak ovary OMIM:612310
Premature Ovarian Failure 18
Premature ovarian insufficiency, Hypoplasia of the uterus, Hypoplasia of the ovary OMIM:619203
46,Xx Sex Reversal 2
Perineal hypospadias, Small scrotum, Ovotestis, Hypoplasia of the vagina, Azoospermia, Micropenis... OMIM:278850
Ovarian Dysgenesis 9
Premature ovarian insufficiency, Hypoplasia of the uterus, Hypoplasia of the ovary OMIM:619665
Mayer-Rokitansky-Kuster-Hauser Syndrome
Aplasia of the vagina, Hypoplasia of the uterus OMIM:277000
Spondylometaphyseal Dysplasia, Sedaghatian Type
Short palm, Short metacarpal, Rhizomelic arm shortening, Cone-shaped epiphysis, Metaphyseal chond... ORPHA:93317
Renal And Mullerian Duct Hypoplasia
Aplasia of the uterus, Anteriorly displaced urethral meatus, Hydrocele testis OMIM:266810
Spondyloepimetaphyseal Dysplasia, Genevieve Type
Irregular epiphyses, Narrow iliac wing, Metaphyseal irregularity, Short femoral neck, Flared meta... OMIM:610442
Developmental And Epileptic Encephalopathy 68
Failure to thrive, Flexion contracture, Exaggerated startle response OMIM:618201
Perrault Syndrome 4
Obesity, Premature ovarian insufficiency, Bicornuate uterus, Hypoplasia of the uterus, Hypoplasia... OMIM:615300
Kennerknecht Syndrome
Omphalocele, Hypoplasia of the uterus, Agonadism, Abdominal obesity OMIM:600908
Hyperekplexia 1
Inguinal hernia, Umbilical hernia, Hip dislocation, Exaggerated startle response OMIM:149400
Vaginal Atresia
Vaginal hematocele, Uterus didelphys, Vaginal atresia, Transverse vaginal septum, Abnormality of ... ORPHA:65681
Estrogen Resistance
Hypoplasia of the uterus OMIM:615363
Lethal Omphalocele-Cleft Palate Syndrome
Bifid uterus, Omphalocele ORPHA:2736
Mullerian Duct Aplasia, Unilateral Renal Agenesis, And Cervicothoracic Somite Anomalies
Azoospermia, Bicornuate uterus, Hypoplasia of the uterus OMIM:601076
Hyperekplexia 3
Exaggerated startle response OMIM:614618
Lumbar Syndrome
Hypoplastic labia majora, Cryptorchidism, Micropenis, Bifid uterus, Bifid scrotum, Ambiguous geni... ORPHA:83628
Hydatidiform Mole
Enlarged uterus ORPHA:99927
Developmental And Epileptic Encephalopathy 8
Exaggerated startle response OMIM:300607
Müllerian Aplasia And Hyperandrogenism
Abnormality of the ovary, Abnormal vagina morphology, Obesity, Hypoplasia of the uterus ORPHA:247768
Normosmic Congenital Hypogonadotropic Hypogonadism
Hypogonadotropic hypogonadism, Female hypogonadism, Cryptorchidism, Azoospermia, Micropenis, Non-... ORPHA:432
Congenital Adrenal Hyperplasia Due To 17-Alpha-Hydroxylase Deficiency
Aplasia of the uterus, Precocious puberty in females, Micropenis, Ovarian cyst, Ambiguous genital... ORPHA:90793
Amed Syndrome, Digenic
Failure to thrive, Hypoplasia of the uterus OMIM:619151
Glycine Encephalopathy With Normal Serum Glycine
Flexion contracture, Talipes equinovarus, Hand clenching, Hip contracture, Arthrogryposis multipl... OMIM:617301
Satoyoshi Syndrome
Abnormality of the ovary, Hypoplasia of the ovary, Hypoplasia of the uterus, Abnormality of the u... ORPHA:3130
Townes-Brocks Syndrome 2
Bifid uterus, Rectovaginal fistula, Hypospadias OMIM:617466
46,Xy Disorder Of Sex Development-Adrenal Insufficiency Due To Cyp11A1 Deficiency
Aplasia of the uterus, Cryptorchidism, Abnormal vagina morphology, Midshaft hypospadias, Abnormal... ORPHA:168558
Spastic Tetraplegia And Axial Hypotonia, Progressive
Overlapping toe, Exaggerated startle response OMIM:618598
Inherited Isolated Adrenal Insufficiency Due To Partial Cyp11A1 Deficiency
Aplasia of the uterus, Cryptorchidism, Abnormal vagina morphology, Midshaft hypospadias, Abnormal... ORPHA:289548
Hypoparathyroidism, Sensorineural Deafness, And Renal Dysplasia Syndrome
Aplasia of the uterus, Uterus didelphys, Aplasia of the vagina, Septate vagina OMIM:146255
Seckel Syndrome 7
Hypoplasia of the uterus OMIM:614851
Mayer-Rokitansky-Küster-Hauser Syndrome
Aplasia of the uterus, Hypoplasia of the vagina ORPHA:3109
Cardiac-Urogenital Syndrome
Aplasia of the uterus, Accessory spleen, Hepatopulmonary fusion, Cryptorchidism, Micropenis, Bifi... OMIM:618280
46,Xy Sex Reversal 4
Hypoplastic labia majora, Gonadal dysgenesis, Sex reversal, Hypergonadotropic hypogonadism, Hypop... OMIM:154230
Hyperekplexia-Epilepsy Syndrome
Exaggerated startle response ORPHA:163985
46,Xy Disorder Of Sex Development Due To Isolated 17,20-Lyase Deficiency
Hypoplasia of the vagina, Polycystic ovaries, Cryptorchidism, Micropenis, Male pseudohermaphrodit... ORPHA:90796
Plaa-Associated Neurodevelopmental Disorder
Dystonia, Postaxial foot polydactyly, Rocker bottom foot, Contractures of the large joints, Failu... ORPHA:521426
Gm1 Gangliosidosis Type 1
Short long bone, Flared iliac wing, Acetabular dysplasia, Abnormal odontoid tissue morphology, Br... ORPHA:79255
Hyperekplexia 2
Exaggerated startle response OMIM:614619
Oeis Complex
Rectovaginal fistula, Cryptorchidism, Micropenis, Ambiguous genitalia, female, Absent scrotum, Ve... OMIM:258040
Satoyoshi Syndrome
Hypoplasia of the uterus OMIM:600705
Spondylocostal Dysostosis With Anal Atresia And Urogenital Anomalies
Aplasia of the uterus, Inguinal hernia, Aplasia of the vagina, Absent external genitalia, Urethra... OMIM:271520
Adrenal Hyperplasia, Congenital, Due To Steroid 11-Beta-Hydroxylase Deficiency
Hypoplasia of the vagina, Long penis, Ambiguous genitalia, female, Precocious puberty in males, H... OMIM:202010
Aromatic L-Amino Acid Decarboxylase Deficiency
Oculogyric crisis, Blepharospasm, Athetosis, Limb dystonia, Limb tremor, Exaggerated startle resp... OMIM:608643
Asparagine Synthetase Deficiency
Failure to thrive, Large hands, Exaggerated startle response OMIM:615574
Spastic Paraplegia, Optic Atrophy, And Neuropathy
Flexion contracture, Exaggerated startle response OMIM:609541
Spastic Paraplegia-Optic Atrophy-Neuropathy Syndrome
Multiple joint contractures, Exaggerated startle response ORPHA:320406
Classic Congenital Adrenal Hyperplasia Due To 21-Hydroxylase Deficiency
Aplasia of the uterus, Hypogonadotropic hypogonadism, Precocious puberty in females, Premature pu... ORPHA:90794
Popliteal Pterygium Syndrome
Hypoplastic labia majora, Small scrotum, Hypoplasia of the vagina, Cryptorchidism, Bifid scrotum,... OMIM:119500
Neurodevelopmental Disorder With Microcephaly, Epilepsy, And Hypomyelination
Exaggerated startle response OMIM:618367
Gm2 Gangliosidosis, Ab Variant
Dystonia, Exaggerated startle response ORPHA:309246
Hypoparathyroidism-Sensorineural Deafness-Renal Disease Syndrome
Aplasia of the uterus, Uterus didelphys, Vaginal atresia, Septate vagina ORPHA:2237
Neurodevelopmental Disorder With Progressive Microcephaly, Spasticity, And Brain Anomalies
Postaxial polydactyly, Rocker bottom foot, Contractures of the large joints, Long fingers, Failur... OMIM:617527
Microphthalmia, Syndromic 9
Hypoplastic spleen, Cryptorchidism, Congenital diaphragmatic hernia, Inguinal hernia, Multilobula... OMIM:601186
Renal Cysts And Diabetes Syndrome
Epididymal cyst, Exocrine pancreatic insufficiency, Pancreatic hypoplasia, Atretic vas deferens, ... OMIM:137920
Gm2-Gangliosidosis, Ab Variant
Dystonia, Exaggerated startle response OMIM:272750
Estrogen Resistance Syndrome
Enlarged polycystic ovaries, Hypoplasia of the uterus ORPHA:785
Chromosome 17Q12 Deletion Syndrome
Aplasia of the uterus, Cryptorchidism, Ovarian cyst, Aplasia of the vagina, Elevated hepatic tran... OMIM:614527
Acromesomelic Dysplasia 3
Hypergonadotropic hypogonadism, Hypoplasia of the uterus OMIM:609441
Stiff Person Spectrum Disorder
Exaggerated startle response ORPHA:3198
Linear Skin Defects With Multiple Congenital Anomalies 1
Ovotestis, Chordee, Micropenis, Congenital diaphragmatic hernia, Hypoplasia of the uterus, Hyposp... OMIM:309801
Tay-Sachs Disease
Exaggerated startle response OMIM:272800
Thrombocytopenia-Absent Radius Syndrome
Aplasia of the uterus ORPHA:3320
Pontocerebellar Hypoplasia Type 7
Aplasia of the uterus, Cryptorchidism, Micropenis, Absent penis, Abnormal scrotal rugation, Ambig... ORPHA:284339
Stiff-Person Syndrome
Opisthotonus, Exaggerated startle response OMIM:184850
Woodhouse-Sakati Syndrome
Hypogonadotropic hypogonadism, Micropenis, Hypoplasia of the fallopian tube, Premature ovarian in... OMIM:241080
Microcephaly-Corpus Callosum Hypoplasia-Intellectual Disability-Facial Dysmorphism Syndrome
Inguinal hernia, Aplasia of the uterus, Aplasia of the vagina ORPHA:457284
Craniofrontonasal Dysplasia-Poland Anomaly Syndrome
Bifid uterus, Abnormal reproductive system morphology ORPHA:1521
Phocomelia, Schinzel Type
Cryptorchidism, Aplasia of the uterus, Hypoplasia of penis ORPHA:2879
Exstrophy-Epispadias Complex
Bifid penis, Cryptorchidism, Absent penis, Bifid uterus, Inguinal hernia, Omphalocele, Epispadias... ORPHA:322
Woodhouse-Sakati Syndrome
Hypoplasia of the uterus, Micropenis, Abnormal spermatogenesis, Hypoplasia of the fallopian tube,... ORPHA:3464
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome Due To A Point Mutation
Dystonia, Exaggerated startle response ORPHA:438216
Blepharophimosis, Ptosis, And Epicanthus Inversus
Premature ovarian insufficiency, Hypoplasia of the uterus OMIM:110100
Thrombocytopenia-Absent Radius Syndrome
Aplasia of the uterus, Hepatosplenomegaly, Pancreatic cysts OMIM:274000
Coffin-Siris Syndrome 9
Hypoplasia of the uterus OMIM:615866
Tay-Sachs Disease
Laryngeal dystonia, Dystonia, Tremor, Exaggerated startle response ORPHA:845
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 4
Flexion contracture, Exaggerated startle response OMIM:253800
Hydrolethalus Syndrome 1
Accessory spleen, Abnormal vagina morphology, Bifid uterus, Omphalocele, Hypospadias OMIM:236680
Sandhoff Disease
Exaggerated startle response OMIM:268800
Limb-Mammary Syndrome
Aplasia of the uterus, Aplasia of the ovary ORPHA:69085
Wolf-Hirschhorn Syndrome
Aplasia of the uterus, Small for gestational age, Accessory spleen, Cryptorchidism, Failure to th... OMIM:194190
Townes-Brocks Syndrome 1
Rectovaginal fistula, Small for gestational age, Cryptorchidism, Bifid uterus, Bifid scrotum, Ure... OMIM:107480
Neu-Laxova Syndrome 1
Cryptorchidism, Yellow subcutaneous tissue covered by thin, scaly skin, Bifid uterus, Camptodacty... OMIM:256520
Ehlers-Danlos Syndrome, Vascular Type
Cervical insufficiency, Cryptorchidism, Uterine prolapse, Cigarette-paper scars, Inguinal hernia,... OMIM:130050
Loeys-Dietz Syndrome
Camptodactyly of finger, Atypical scarring of skin, Uterine rupture ORPHA:60030
Rubinstein-Taybi Syndrome 1
Keloids, Papillary cystadenoma of the epididymis, Flexion contracture, Enamel hypoplasia, Cryptor... OMIM:180849
Coffin-Siris Syndrome 1
Aplasia of the uterus, Cryptorchidism, Congenital diaphragmatic hernia, Inguinal hernia, Umbilica... OMIM:135900
Okamoto Syndrome
Bifid uterus, Omphalocele, Splenomegaly ORPHA:2729
Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Plus
Polycystic ovaries, Streak ovary, Premature ovarian insufficiency, Hypergonadotropic hypogonadism... ORPHA:572333
Ulna And Fibula, Absence Of, With Severe Limb Deficiency
Aplasia of the uterus, Small scrotum, Cryptorchidism, Anteriorly displaced genitalia, Elbow flexi... OMIM:276820
Neurodevelopmental-Craniofacial Syndrome With Variable Renal And Cardiac Abnormalities
Broad toe, Clinodactyly of the 5th finger, Tapered finger, Short thumb, Short 5th finger, Short f... OMIM:619522
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome
Osteopenia, Dystonia, Uterine prolapse, Osteoporosis, Exaggerated startle response, Hip dysplasia ORPHA:438213
Peters-Plus Syndrome
Hypoplastic labia majora, Decreased body weight, Hypoplasia of the vagina, Cryptorchidism, Clitor... OMIM:261540
Norrie Disease
Cryptorchidism, Failure to thrive, Cachexia, Uterine rupture ORPHA:649
Vascular Ehlers-Danlos Syndrome
Cryptorchidism, Uterine prolapse, Cigarette-paper scars, Inguinal hernia, Cystocele, Uterine rupt... ORPHA:286
Pallister-Killian Syndrome
Hypoplastic labia majora, Aplasia of the uterus, Small scrotum, Flexion contracture, Enamel hypop... OMIM:601803
Peters Plus Syndrome
Cryptorchidism, Clitoral hypoplasia, Inguinal hernia, Umbilical hernia, Hypoplasia of the uterus,... ORPHA:709

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Lingo2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Lingo2.

No publications found that use IMPC mice or data for Lingo2.

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MGI Allele Allele Type Produced
Lingo2tm47327(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Lingo2em1(IMPC)KMPC Deletion Mice
Lingo2tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells

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