Type I Interferon Response Is Mediated by NLRX1-cGAS-STING Signaling in Brain Injury. |
Frontiers in molecular neuroscience (February 2022) |
Cgastm1d(EUCOMM)Hmgu
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PMC8916033
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STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses. |
Cell metabolism (January 2022) |
Cgastm1a(EUCOMM)Hmgu
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PMC8733004
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B Cell Intrinsic STING Signaling Is Not Required for Autoreactive Germinal Center Participation. |
Frontiers in immunology (December 2021) |
Cgastm1d(EUCOMM)Hmgu
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PMC8685402
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Genome instability independent of type I interferon signaling drives neuropathology caused by impaired ribonucleotide excision repair. |
Neuron (October 2021) |
Cgastm1d(EUCOMM)Hmgu
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34655526
|
Downregulation of mitochondrial biogenesis by virus infection triggers antiviral responses by cyclic GMP-AMP synthase. |
PLoS pathogens (October 2021) |
Cgastm1a(EUCOMM)Hmgu
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PMC8516216
|
Interferon b drives intestinal regeneration after radiation. |
Science advances (October 2021) |
Cgastm1d(EUCOMM)Hmgu
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PMC8494436
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DNA hypomethylation leads to cGAS-induced autoinflammation in the epidermis. |
The EMBO journal (September 2021) |
Cgastm1d(EUCOMM)Hmgu
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PMC8591534
|
cGAS-STING and MyD88 Pathways Synergize in Ly6Chi Monocyte to Promote Streptococcus pneumoniae-Induced Late-Stage Lung IFNγ Production. |
Frontiers in immunology (August 2021) |
Cgastm1d(EUCOMM)Hmgu
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PMC8427188
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Neutrophil extracellular traps promote tPA-induced brain hemorrhage via cGAS in mice with stroke. |
Blood (July 2021) |
Cgastm1d(EUCOMM)Hmgu
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PMC8288643
|
Endogenous retroviruses promote homeostatic and inflammatory responses to the microbiota. |
Cell (June 2021) |
Cgastm1d(EUCOMM)Hmgu
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PMC8381240
|
cGAS restricts colon cancer development by protecting intestinal barrier integrity. |
Proceedings of the National Academy of Sciences of the United States of America (June 2021) |
Cgastm1a(EUCOMM)Hmgu
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PMC8201956
|
Microbial and genetic-based framework identifies drug targets in inflammatory bowel disease. |
Theranostics (June 2021) |
Cgastm1a(EUCOMM)Hmgu
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PMC8210594
|
IRGM1 links mitochondrial quality control to autoimmunity. |
Nature immunology (January 2021) |
Cgastm1d(EUCOMM)Hmgu
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33510463
|
Virus infection is controlled by hematopoietic and stromal cell sensing of murine cytomegalovirus through STING. |
eLife (July 2020) |
Cgastm1d(EUCOMM)Hmgu
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PMC7413665
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Absence of cGAS-mediated type I IFN responses in HIV-1-infected T cells. |
Proceedings of the National Academy of Sciences of the United States of America (July 2020) |
Cgastm1a(EUCOMM)Hmgu
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PMC7431009
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Mitochondrial stress-activated cGAS-STING pathway inhibits thermogenic program and contributes to overnutrition-induced obesity in mice. |
Communications biology (May 2020) |
Cgastm1d(EUCOMM)Hmgu
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PMC7244732
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The role of the adaptor molecule STING during Schistosoma mansoni infection. |
Scientific reports (May 2020) |
Cgastm1a(EUCOMM)Hmgu
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PMC7220917
|
The early local and systemic Type I interferon responses to ultraviolet B light exposure are cGAS dependent. |
Scientific reports (May 2020) |
Cgastm1d(EUCOMM)Hmgu
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PMC7220927
|
Hepatic gap junctions amplify alcohol liver injury by propagating cGAS-mediated IRF3 activation. |
Proceedings of the National Academy of Sciences of the United States of America (May 2020) |
Cgastm1c(EUCOMM)Hmgu
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PMC7261084
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Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity. |
Immunity (April 2020) |
Cgastm1d(EUCOMM)Hmgu
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32277911
|
mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury. |
Immunity (March 2020) |
Cgastm1d(EUCOMM)Hmgu
|
32164878
|
TMEM173 Drives Lethal Coagulation in Sepsis. |
Cell host & microbe (March 2020) |
Cgastm1d(EUCOMM)Hmgu
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PMC7316085
|
Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice. |
Scientific reports (October 2019) |
Cgastm1a(EUCOMM)Hmgu
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PMC6795997
|
Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses. |
Nature communications (October 2019) |
Cgastm1d(EUCOMM)Hmgu
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PMC6789137
|
Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity. |
Cell reports (October 2019) |
Cgastm1d(EUCOMM)Hmgu
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31665636
|
Chromatin-bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death. |
The EMBO journal (September 2019) |
Cgastm1a(EUCOMM)Hmgu
|
PMC6826206
|
Sterile Lung Inflammation Induced by Silica Exacerbates Mycobacterium tuberculosis Infection via STING-Dependent Type 2 Immunity. |
Cell reports (May 2019) |
Cgastm1a(EUCOMM)Hmgu
|
31141689
|
cGAS facilitates sensing of extracellular cyclic dinucleotides to activate innate immunity. |
EMBO reports (March 2019) |
Cgastm1d(EUCOMM)Hmgu
|
30872316
|
Autophagy induction via STING trafficking is a primordial function of the cGAS pathway. |
Nature (March 2019) |
Cgastm1a(EUCOMM)Hmgu
|
30842662
|
Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA. |
Cell (February 2019) |
Cgastm1a(EUCOMM)Hmgu
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30827685
|
STING-associated lung disease in mice relies on T cells but not type I interferon. |
The Journal of allergy and clinical immunology (February 2019) |
Cgastm1d(EUCOMM)Hmgu
|
30772497
|
STING-dependent sensing of self-DNA drives silica-induced lung inflammation. |
Nature communications (December 2018) |
Cgastm1a(EUCOMM)Hmgu
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PMC6283886
|
Nuclear cGAS suppresses DNA repair and promotes tumorigenesis. |
Nature (October 2018) |
Cgastm1d(EUCOMM)Hmgu
|
30356214
|
ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING. |
The Journal of experimental medicine (September 2018) |
Cgastm1d(EUCOMM)Hmgu
|
PMC6219748
|
Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis. |
Immunity (August 2018) |
Cgastm1d(EUCOMM)Hmgu
|
PMC6347470
|
Species-Specific Deamidation of cGAS by Herpes Simplex Virus UL37 Protein Facilitates Viral Replication. |
Cell host & microbe (August 2018) |
Cgastm1d(EUCOMM)Hmgu
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PMC6094942
|
Extrinsic Phagocyte-Dependent STING Signaling Dictates the Immunogenicity of Dying Cells. |
Cancer cell (April 2018) |
Cgastm1d(EUCOMM)Hmgu
|
29706455
|
IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation. |
Cell (March 2018) |
Cgastm1d(EUCOMM)Hmgu
|
29576451
|
Oral Antibiotic Treatment of Mice Exacerbates the Disease Severity of Multiple Flavivirus Infections. |
Cell reports (March 2018) |
Cgastm1d(EUCOMM)Hmgu
|
PMC5908250
|
cGAS-mediated control of blood-stage malaria promotes Plasmodium-specific germinal center responses. |
JCI insight (January 2018) |
Cgastm1d(EUCOMM)Hmgu
|
PMC5821207
|
Brucella abortus Triggers a cGAS-Independent STING Pathway To Induce Host Protection That Involves Guanylate-Binding Proteins and Inflammasome Activation. |
Journal of immunology (Baltimore, Md. : 1950) (December 2017) |
Cgastm1d(EUCOMM)Hmgu
|
PMC5760291
|
STING-Dependent Signaling Underlies IL-10 Controlled Inflammatory Colitis. |
Cell reports (December 2017) |
Cgastm1d(EUCOMM)Hmgu
|
PMC6082386
|
cGAS drives noncanonical-inflammasome activation in age-related macular degeneration. |
Nature medicine (November 2017) |
Cgastm1d(EUCOMM)Hmgu
|
PMC5760363
|
IRF3 and type I interferons fuel a fatal response to myocardial infarction. |
Nature medicine (November 2017) |
Cgastm1d(EUCOMM)Hmgu
|
29106401
|
STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum. |
Cell (October 2017) |
Cgastm1a(EUCOMM)Hmgu
|
29056340
|
A noncanonical function of cGAMP in inflammasome priming and activation. |
The Journal of experimental medicine (October 2017) |
Cgastm1c(EUCOMM)Hmgu
Cgastm1a(EUCOMM)Hmgu
Cgastm1d(EUCOMM)Hmgu
|
PMC5716045
|
Mycobacterium tuberculosis is protected from NADPH oxidase and LC3-associated phagocytosis by the LCP protein CpsA. |
Proceedings of the National Academy of Sciences of the United States of America (September 2017) |
Cgastm1a(EUCOMM)Hmgu
Cgastm1d(EUCOMM)Hmgu
|
PMC5642705
|
Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein α Signaling. |
Immunity (August 2017) |
Cgastm1a(EUCOMM)Hmgu
|
PMC5564225
|
Opposing roles of Toll-like receptor and cytosolic DNA-STING signaling pathways for Staphylococcus aureus cutaneous host defense. |
PLoS pathogens (July 2017) |
Cgastm1d(EUCOMM)Hmgu
|
PMC5526579
|
cGAS is essential for cellular senescence. |
Proceedings of the National Academy of Sciences of the United States of America (May 2017) |
Cgastm1a(EUCOMM)Hmgu
|
PMC5468617
|
cGAS is essential for the antitumor effect of immune checkpoint blockade. |
Proceedings of the National Academy of Sciences of the United States of America (January 2017) |
Cgastm1a(EUCOMM)Hmgu
|
PMC5320994
|
Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS. |
Nature communications (November 2016) |
Cgastm1d(EUCOMM)Hmgu
|
PMC5109551
|
Cross-Regulation of Two Type I Interferon Signaling Pathways in Plasmacytoid Dendritic Cells Controls Anti-malaria Immunity and Host Mortality. |
Immunity (October 2016) |
Cgastm1d(EUCOMM)Hmgu
|
27793594
|
The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA. |
Immunity (August 2016) |
Cgastm1a(EUCOMM)Hmgu
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PMC4988931
|
Vaginal Exposure to Zika Virus during Pregnancy Leads to Fetal Brain Infection. |
Cell (August 2016) |
Cgastm1d(EUCOMM)Hmgu
|
PMC5006689
|
Restriction by SAMHD1 Limits cGAS/STING-Dependent Innate and Adaptive Immune Responses to HIV-1. |
Cell reports (July 2016) |
Cgastm1a(EUCOMM)Hmgu
|
PMC4978700
|
AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity. |
Proceedings of the National Academy of Sciences of the United States of America (July 2016) |
Cgastm1d(EUCOMM)Hmgu
|
PMC4987819
|
Diminished Innate Antiviral Response to Adenovirus Vectors in cGAS/STING-Deficient Mice Minimally Impacts Adaptive Immunity. |
Journal of virology (June 2016) |
Cgastm1d(EUCOMM)Hmgu
|
PMC4907218
|
The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons. |
Immunity (March 2016) |
Cgastm1d(EUCOMM)Hmgu
|
PMC4852885
|
Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response. |
The EMBO journal (February 2016) |
Cgastm1a(EUCOMM)Hmgu
|
PMC4855687
|
RNase H2 catalytic core Aicardi-Goutières syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice. |
The Journal of experimental medicine (February 2016) |
Cgastm1a(EUCOMM)Hmgu
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PMC4813680
|
A cGAS-Independent STING/IRF7 Pathway Mediates the Immunogenicity of DNA Vaccines. |
Journal of immunology (Baltimore, Md. : 1950) (November 2015) |
Cgastm1d(EUCOMM)Hmgu
|
PMC4685033
|
Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation. |
Immunity (August 2015) |
Cgastm1a(EUCOMM)Hmgu
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PMC4575271
|
Viruses transfer the antiviral second messenger cGAMP between cells. |
Science (New York, N.Y.) (July 2015) |
Cgastm1a(EUCOMM)Hmgu
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PMC4617605
|
Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi-Goutières Syndrome. |
Journal of immunology (Baltimore, Md. : 1950) (July 2015) |
Cgastm1a(EUCOMM)Hmgu
|
PMC4546858
|
Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA. |
Cell (December 2014) |
Cgastm1a(EUCOMM)Hmgu
|
PMC4272443
|
Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathway. |
PLoS pathogens (April 2014) |
Cgastm1a(EUCOMM)Hmgu
|
PMC3990710
|
Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity. |
Nature (November 2013) |
Cgastm1c(EUCOMM)Hmgu
Cgastm1a(EUCOMM)Hmgu
Cgastm1d(EUCOMM)Hmgu
|
PMC4077721
|
Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects. |
Science (New York, N.Y.) (August 2013) |
Cgastm1a(EUCOMM)Hmgu
|
PMC3863637
|