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Gene: Cgas MGI:2442261

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Gene Summary

Name:
cyclic GMP-AMP synthase
Synonyms:
Mb21d1,  E330016A19Rik

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal bone mineralization Cgastm1a(EUCOMM)Hmgu HOM Early adult 5.67×10-05
abnormal behavior Cgastm1a(EUCOMM)Hmgu HOM   Early adult 8.88×10-05
increased circulating aspartate transaminase level Cgastm1a(EUCOMM)Hmgu HOM Early adult 1.71×10-11
increased lactate dehydrogenase level Cgastm1a(EUCOMM)Hmgu HOM Early adult 5.53×10-09
decreased prepulse inhibition Cgastm1a(EUCOMM)Hmgu HOM Early adult 1.77×10-07
decreased grip strength Cgastm1a(EUCOMM)Hmgu HOM Early adult 2.06×10-05
abnormal glucose homeostasis Cgastm1a(EUCOMM)Hmgu HOM Early adult 4.57×10-05
increased total body fat amount Cgastm1a(EUCOMM)Hmgu HOM Early adult 1.64×10-05
abnormal tail movements Cgastm1a(EUCOMM)Hmgu HOM   Early adult 1.24×10-07
decreased circulating amylase level Cgastm1a(EUCOMM)Hmgu HOM Early adult 8.25×10-05
increased startle reflex Cgastm1a(EUCOMM)Hmgu HOM Early adult 4.09×10-08

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Cgas mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Cgas by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Human Coronavirus Sensitivity
Susceptibility to coronavirus 229e OMIM:122460
Leishmaniasis, Tegumentary, Susceptibility To
Tegumentary leishmaniasis susceptibility OMIM:602068
Varicella, Severe Recurrent
Severe recurrent varicella OMIM:600670
Coxsackievirus B3 Susceptibility
Recurrent viral infections OMIM:120050
Ciliary Discoordination Due To Random Ciliary Orientation
Recurrent infections OMIM:215518
Immunodeficiency 30
Recurrent mycobacterial infections, Recurrent infections OMIM:614891
Immunodeficiency 31A
BCGitis, Recurrent viral infections, Recurrent mycobacterium avium complex infections, Herpes sim... OMIM:614892
Neutrophil Actin Dysfunction
Recurrent bacterial infections OMIM:257150
Immunodeficiency 31B
Recurrent mycobacterial infections, Recurrent viral infections, Herpes simplex encephalitis OMIM:613796
Hypophosphatemic Rickets, Autosomal Recessive, 1
Rickets, Hypophosphatemic rickets, Hypophosphatemia, Craniosynostosis, Increased bone mineral den... OMIM:241520
Axial Osteomalacia
Increased bone mineral density, Elevated circulating creatine kinase concentration, Osteomalacia OMIM:109130
Aicardi-Goutieres Syndrome 6
Increased circulating Interferon-alpha concentration OMIM:615010
Hypophosphatemic Rickets, Autosomal Dominant
Hypophosphatemia, Hypophosphatemic rickets, Rickets, Osteomalacia OMIM:193100
Hypophosphatasia, Adult
Chondrocalcinosis, Rickets, Osteomalacia, Pathologic fracture, Increased susceptibility to fractu... OMIM:146300
Hypophosphatemic Bone Disease
Hypophosphatemia, Rickets, Osteomalacia OMIM:146350
Hypocalcemic Vitamin D-Resistant Rickets
Coarse metaphyseal trabecularization, Osteomalacia, Recurrent fractures, Hypocalcemia, Hypophosph... ORPHA:93160
Vitamin D-Dependent Rickets, Type 2B, With Normal Vitamin D Receptor
Delayed epiphyseal ossification, Rickets, Rickets of the lower limbs, Sparse bone trabeculae, Gen... OMIM:600785
Fanconi Renotubular Syndrome 2
Osteopenia, Rickets, Glycosuria, Osteomalacia, Hypophosphatemia, Recurrent fractures OMIM:613388
Dermatosparaxis Ehlers-Danlos Syndrome
Osteopenia, Rickets, Abnormality of subcutaneous fat tissue, Osteomalacia, Joint stiffness, Ingui... ORPHA:1901
Renal Tubular Acidosis, Proximal
Elevated circulating creatinine concentration, Rickets, Osteomalacia OMIM:179830
Bile Acid Conjugation Defect 1
Rickets, Conjugated hyperbilirubinemia OMIM:619232
Hereditary Hypophosphatemic Rickets With Hypercalciuria
Increased circulating beta-C-terminal telopeptide concentration, Osteomalacia, Pathologic fractur... ORPHA:157215
Fanconi-Bickel Syndrome
Postprandial hyperglycemia, Osteopenia, Rickets, Glycosuria, Hypophosphatemia, Fasting hypoglycem... ORPHA:2088
Fanconi-Bickel Syndrome
Postprandial hyperglycemia, Hypouricemia, Rickets, Glycosuria, Osteomalacia, Hyperbilirubinemia, ... OMIM:227810
Hypercholanemia, Familial 1
Rickets, Increased serum bile acid concentration OMIM:607748
Fanconi Renotubular Syndrome 4 With Maturity-Onset Diabetes Of The Young
Hypouricemia, Rickets, Glycosuria, Hypoglycemia, Hypophosphatemia, Diabetes mellitus OMIM:616026
Vitamin D Hydroxylation-Deficient Rickets, Type 1B
Delayed epiphyseal ossification, Rickets, Hypocalcemia, Sparse bone trabeculae, Hypophosphatemia,... OMIM:600081
Renal Tubular Acidosis, Distal, 1
Osteomalacia, Pathologic fracture, Elevated circulating creatinine concentration, Hypocalcemia, H... OMIM:179800
Hypophosphatemic Rickets, X-Linked Recessive
Delayed epiphyseal ossification, Rickets, Osteomalacia, Hypophosphatemic rickets, Sparse bone tra... OMIM:300554
Renal Tubular Acidosis Iii
Hypokalemia, Rickets, Osteomalacia OMIM:267200
Fanconi Renotubular Syndrome 3
Elevated circulating creatinine concentration, Rickets, Glycosuria OMIM:615605
Hypophosphatemic Rickets With Hypercalciuria, Hereditary
Delayed epiphyseal ossification, Rickets, Hypophosphatemic rickets, Sparse bone trabeculae, Hypop... OMIM:241530
Fanconi Renotubular Syndrome 1
Rickets, Glycosuria, Osteomalacia, Hypokalemia, Hypophosphatemia OMIM:134600
Autosomal Dominant Hypophosphatemic Rickets
Hypophosphatemia, Rickets, Hypocalcemia, Osteomalacia ORPHA:89937
Vitamin D Hydroxylation-Deficient Rickets, Type 1A
Delayed epiphyseal ossification, Rickets, Hypocalcemia, Sparse bone trabeculae, Hypophosphatemia,... OMIM:264700
Dent Disease 1
Delayed epiphyseal ossification, Rickets, Glycosuria, Osteomalacia, Sparse bone trabeculae, Hypop... OMIM:300009
Aicardi-Goutieres Syndrome 5
Increased circulating interferon-gamma concentration OMIM:612952
Vitamin D-Dependent Rickets, Type 2A
Delayed epiphyseal ossification, Rickets, Sparse bone trabeculae, Hypophosphatemia, Enamel hypopl... OMIM:277440
Renal Tubular Acidosis, Distal, 3, With Or Without Sensorineural Hearing Loss
Hypokalemia, Rickets OMIM:602722
Nephrogenic Syndrome Of Inappropriate Antidiuresis
Hyponatremia, Reduced blood urea nitrogen, Decreased serum creatinine, Decreased circulating reni... OMIM:300539
Hypophosphatemic Rickets, X-Linked Dominant
Rickets, Osteomalacia, Hypophosphatemic rickets, Enamel hypomineralization, Hypophosphatemia, Ost... OMIM:307800
Dent Disease
Delayed epiphyseal ossification, Renal hypophosphatemia, Rickets, Glycosuria, Osteomalacia, Spars... ORPHA:1652
Renal Tubulopathy, Diabetes Mellitus, And Cerebellar Ataxia
Osteoporosis, Type I diabetes mellitus, Rickets OMIM:560000
Cystinosis
Hypokalemia, Type I diabetes mellitus, Hypophosphatemia, Rickets ORPHA:213
Cholestasis, Progressive Familial Intrahepatic, 1
Osteopenia, Rickets, Conjugated hyperbilirubinemia OMIM:211600
Hypertension, Early-Onset, Autosomal Dominant, With Severe Exacerbation In Pregnancy
Decreased circulating renin level OMIM:605115
Fibrous Dysplasia Of Bone
Rickets, Osteomalacia, Cortical irregularity, Pathologic fracture, Hypercalcemia, Fibrous dysplas... ORPHA:249
Hypocalcemic Vitamin D-Dependent Rickets
Delayed epiphyseal ossification, Rickets, Osteomalacia, Increased susceptibility to fractures, Sp... ORPHA:289157
Renal Tubular Acidosis, Distal, 4, With Hemolytic Anemia
Hypokalemia, Rickets OMIM:611590
Liddle Syndrome 2
Hypokalemia, Decreased circulating renin level OMIM:618114
Liddle Syndrome 3
Hypokalemia, Decreased circulating renin level OMIM:618126
Car T Cell Therapy-Associated Cytokine Release Syndrome
Increased circulating interleukin 6 concentration, Abnormal circulating interleukin concentration... ORPHA:542323
Hyperaldosteronism, Familial, Type I
Decreased circulating renin level OMIM:103900
Liddle Syndrome 1
Hypokalemia, Decreased circulating renin level OMIM:177200
Macrophage Activation Syndrome
Increased circulating interleukin 6 concentration, Abnormal circulating interleukin concentration... ORPHA:158061
Hypocalciuric Hypercalcemia, Familial, Type Iii
Hypermagnesemia, Chondrocalcinosis, Osteomalacia, Multiple lipomas, Hypophosphatemia, Hypercalcemia OMIM:600740
Developmental And Epileptic Encephalopathy 68
Flexion contracture, Exaggerated startle response OMIM:618201
Pseudohypoaldosteronism, Type Iic
Hyperchloremia, Hyperkalemia, Decreased circulating renin level OMIM:614492
Apparent Mineralocorticoid Excess
Hypokalemia, Decreased circulating renin level OMIM:218030
Stiff Person Spectrum Disorder
Diabetes mellitus, Exaggerated startle response ORPHA:3198
Infantile Systemic Hyalinosis
Osteopenia, Camptodactyly of finger, Osteomalacia, Joint stiffness, Increased susceptibility to f... ORPHA:2176
Autosomal Recessive Hypophosphatemic Rickets
Abnormal trabecular bone morphology, Renal hypophosphatemia, Pseudo-fractures, Osteomalacia, Rick... ORPHA:289176
Bile Acid Synthesis Defect, Congenital, 1
Hypocholesterolemia, Rickets, Conjugated hyperbilirubinemia OMIM:607765
Congenital Bile Acid Synthesis Defect Type 2
Hyperbilirubinemia, Rickets, Abnormal serum bile acid concentration, Conjugated hyperbilirubinemia ORPHA:79303
Familial Hemophagocytic Lymphohistiocytosis
Abnormality of tumor necrosis factor secretion, Increased circulating interferon-gamma concentrat... ORPHA:540
Wilson Disease
Hypouricemia, Hypoalbuminemia, Chondrocalcinosis, Glycosuria, Hand tremor, Osteomalacia, Hyperbil... OMIM:277900
Hypophosphatemic Rickets And Hyperparathyroidism
Hypophosphatemia, Hypercalcemia, Hypophosphatemic rickets, Rickets OMIM:612089
Celiac Disease, Susceptibility To, 1
Type I diabetes mellitus, Rickets, Hypocalcemia, Enamel hypoplasia, Osteoporosis OMIM:212750
Rod-Cone Dystrophy, Sensorineural Deafness, And Fanconi-Type Renal Dysfunction
Glycosuria, Rickets, Recurrent fractures OMIM:268315
X-Linked Hypophosphatemia
Cellulitis, Limitation of joint mobility, Rickets, Generalized osteosclerosis, Hypophosphatemia, ... ORPHA:89936
Intellectual Developmental Disorder, Autosomal Recessive 54
Exaggerated startle response OMIM:617028
Oligoarticular Juvenile Idiopathic Arthritis
Abnormal circulating interleukin concentration, Increased circulating interferon-gamma concentration ORPHA:85410
Tay-Sachs Disease
Increased serum beta-hexosaminidase, Laryngeal dystonia, Limited elbow extension, Tremor, Limited... ORPHA:845
Stiff-Person Syndrome
Opisthotonus, Diabetes mellitus, Exaggerated startle response OMIM:184850
Spastic Paraplegia, Optic Atrophy, And Neuropathy
Flexion contracture, Exaggerated startle response OMIM:609541
Spastic Paraplegia-Optic Atrophy-Neuropathy Syndrome
Multiple joint contractures, Exaggerated startle response ORPHA:320406
Glycine Encephalopathy With Normal Serum Glycine
Elbow flexion contracture, Hip contracture, Joint hypermobility, Exaggerated startle response, Fl... OMIM:617301
Primary Aldosteronism, Seizures, And Neurologic Abnormalities
Hypokalemia, Athetosis, Decreased circulating renin level OMIM:615474
Neu-Laxova Syndrome
Osteopenia, Rickets, Osteomalacia, Opisthotonus, Osteoporosis, Flexion contracture, Arthrogryposi... ORPHA:2671
Aromatic L-Amino Acid Decarboxylase Deficiency
Blepharospasm, Oculogyric crisis, Limb dystonia, Limb tremor, Torticollis, Exaggerated startle re... OMIM:608643
Hyperaldosteronism, Familial, Type Iii
Hypokalemia, Decreased circulating renin level OMIM:613677
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 4
Flexion contracture, Exaggerated startle response, Elevated circulating creatine kinase concentra... OMIM:253800
Hyperekplexia 2
Hiatus hernia, Exaggerated startle response OMIM:614619
Hyperekplexia 3
Hiatus hernia, Exaggerated startle response OMIM:614618
Mccune-Albright Syndrome
Aneurysmal bone cyst, Osteomalacia, Monostotic fibrous dysplasia, Fibrous dysplasia of the bones,... ORPHA:562
Ectopic Aldosterone-Producing Tumor
Hypokalemia, Decreased circulating renin level ORPHA:231632
Leukodystrophy, Hypomyelinating, 13
Joint contracture, Exaggerated startle response OMIM:616881
Hyperekplexia 1
Umbilical hernia, Inguinal hernia, Exaggerated startle response OMIM:149400
Pigmentary Disorder, Reticulate, With Systemic Manifestations, X-Linked
Increased circulating interleukin 8 concentration, Reduced circulating interferon gamma concentra... OMIM:301220
Rajab Interstitial Lung Disease With Brain Calcifications 1
Hypoalbuminemia, Osteopenia, Rickets, Hypoglycemia, Hypocalcemia, Inguinal hernia, Joint hypermob... OMIM:613658
Lowe Oculocerebrorenal Syndrome
Elevated amniotic fluid alpha-fetoprotein, Joint contracture of the hand, Keloids, Rickets, Campt... OMIM:309000
Familial Hypocalciuric Hypercalcemia
Renal hypophosphatemia, Hypermagnesemia, Chondrocalcinosis, Osteomalacia, Lipoma, Hypocalcemic se... ORPHA:405
Primary Fanconi Renotubular Syndrome
Hypouricemia, Decreased circulating carnitine concentration, Glycosuria, Hypoglycemia, Osteomalac... ORPHA:3337
Neurodegeneration With Developmental Delay, Early Respiratory Failure, Myoclonic Seizures, And Brain Abnormalities
Limb joint contracture, Tremor, Exaggerated startle response OMIM:620327
Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome
Panhypogammaglobulinemia, Abnormal circulating interleukin concentration, Abnormal circulating in... ORPHA:79124
Hyperekplexia-Epilepsy Syndrome
Exaggerated startle response ORPHA:163985
Primary Unilateral Adrenal Hyperplasia
Hypokalemia, Decreased circulating renin level ORPHA:231580
Apparent Mineralocorticoid Excess
Hypokalemia, Decreased circulating renin level ORPHA:320
Multiple Mitochondrial Dysfunctions Syndrome 7
Hypoglycemia, Hyperglycemia, Hyperglycinemia, Exaggerated startle response, Dystonia, Hypernatremia OMIM:620423
Combined Oxidative Phosphorylation Deficiency 58
Hyperprolinemia, Hyperalaninemia, Hypoglycemia, Exaggerated startle response OMIM:620451
Adrenocortical Carcinoma With Pure Aldosterone Hypersecretion
Hypokalemia, Decreased circulating renin level ORPHA:231625
Infantile Nephropathic Cystinosis
Rickets, Glycosuria, Hypokalemia, Hypophosphatemia, Abnormal blood ion concentration ORPHA:411629
Neurodevelopmental Disorder With Or Without Seizures And Gait Abnormalities
Joint contracture, Exaggerated startle response OMIM:617864
Gm2 Gangliosidosis, Ab Variant
Dystonia, Exaggerated startle response ORPHA:309246
Occipital Horn Syndrome
Synostosis of joints, Osteopenia, Atypical scarring of skin, Keloids, Rickets, Osteomalacia, Ingu... ORPHA:198
Developmental And Epileptic Encephalopathy 8
Exaggerated startle response OMIM:300607
Neurodevelopmental Disorder With Cerebellar Atrophy And With Or Without Seizures
Truncal titubation, Tremor, Exaggerated startle response OMIM:618056
Infection-Related Hemolytic Uremic Syndrome
Abnormal circulating chemokine concentration, Abnormal circulating interferon concentration, Incr... ORPHA:544482
Distal Renal Tubular Acidosis
Rickets, Osteomalacia, Increased susceptibility to fractures, Hypokalemia, Reduced bone mineral d... ORPHA:18
Plaa-Associated Neurodevelopmental Disorder
Dystonia, Contractures of the large joints, Exaggerated startle response, Hyperextensibility of t... ORPHA:521426
Spastic Tetraplegia And Axial Hypotonia, Progressive
Exaggerated startle response OMIM:618598
Neurodevelopmental Disorder With Speech Impairment And With Or Without Seizures
Exaggerated startle response OMIM:620114
Cystinosis, Nephropathic
Decreased circulating carnitine concentration, Rickets, Glycosuria, Hypomagnesemia, Hypophosphate... OMIM:219800
Oculocerebrorenal Syndrome Of Lowe
Atypical scarring of skin, Osteomalacia, Abnormal dental enamel morphology, Umbilical hernia, Joi... ORPHA:534
Cystinosis, Late-Onset Juvenile Or Adolescent Nephropathic Type
Rickets OMIM:219900
Sudden Infant Death With Dysgenesis Of The Testes Syndrome
Exaggerated startle response OMIM:608800
Gm2-Gangliosidosis, Ab Variant
Dystonia, Exaggerated startle response OMIM:272750
Sandhoff Disease, Infantile Form
Exaggerated startle response ORPHA:309155
Tay-Sachs Disease
Exaggerated startle response OMIM:272800
Hypomagnesemia 3, Renal
Hyperphosphatemia, Increased circulating beta-C-terminal telopeptide concentration, Rickets, Hypo... OMIM:248250
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome Due To A Point Mutation
Dystonia, Exaggerated startle response ORPHA:438216
Asparagine Synthetase Deficiency
Hypoasparaginemia, Tremor, Exaggerated startle response OMIM:615574
Peripartum Cardiomyopathy
Increased circulating interferon-gamma concentration ORPHA:563
Pancreatic Triacylglycerol Lipase Deficiency
Osteoporosis, Rickets, Osteomalacia ORPHA:309031
Congenital Adrenal Hyperplasia Due To 11-Beta-Hydroxylase Deficiency
Hypokalemia, Decreased circulating renin level ORPHA:90795
Neurodevelopmental Disorder With Progressive Microcephaly, Spasticity, And Brain Anomalies
Contractures of the large joints, Exaggerated startle response OMIM:617527
Gm1 Gangliosidosis Type 1
Abnormal odontoid tissue morphology, Exaggerated startle response ORPHA:79255
Congenital Adrenal Hyperplasia Due To 17-Alpha-Hydroxylase Deficiency
Hypokalemia, Decreased circulating renin level ORPHA:90793
Sandhoff Disease
Exaggerated startle response OMIM:268800
Developmental And Epileptic Encephalopathy 49
Exaggerated startle response OMIM:617281
Immunodeficiency 82 With Systemic Inflammation
Hypoalbuminemia, Osteomalacia, Osteomyelitis, Arthritis, Elevated circulating C-reactive protein ... OMIM:619381
Adrenal Hyperplasia, Congenital, Due To Steroid 11-Beta-Hydroxylase Deficiency
Hypokalemia, Decreased circulating renin level OMIM:202010
Microcephalic Osteodysplastic Primordial Dwarfism Types I And Iii
Osteopenia, Rickets, Osteomalacia, Osteoporosis, Abnormally ossified vertebrae ORPHA:2636
Autoimmune Enteropathy And Endocrinopathy-Susceptibility To Chronic Infections Syndrome
Abnormal circulating interferon-gamma concentration ORPHA:391487
Antley-Bixler Syndrome With Genital Anomalies And Disordered Steroidogenesis
Joint contracture of the hand, Hypoglycemia, Carpal synostosis, Humeroradial synostosis, Decrease... OMIM:201750
Proteasome-Associated Autoinflammatory Syndrome 1
Increased circulating interleukin 8 concentration, Increased circulating interferon-gamma concent... OMIM:256040
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome
Osteopenia, Decreased circulating iron concentration, Uterine prolapse, Joint hypermobility, Exag... ORPHA:438213
Aicardi-Goutières Syndrome
Increased circulating interferon-gamma concentration ORPHA:51
Neurodevelopmental Disorder With Microcephaly, Epilepsy, And Hypomyelination
Exaggerated startle response OMIM:618367
Generalized Arterial Calcification Of Infancy
Abnormal calcification of the carpal bones, Hypophosphatemic rickets, Fused cervical vertebrae, O... ORPHA:51608
Neurodevelopmental-Craniofacial Syndrome With Variable Renal And Cardiac Abnormalities
Exaggerated startle response, Joint hypermobility OMIM:619522

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cgas

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cgas.

There are 121 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Zebularine potentiates anti-tumor immunity by inducing tumor immunogenicity and improving antigen processing through cGAS-STING pathway. Communications biology (May 2024) Cgastm1d(EUCOMM)Hmgu PMC11099016
Synthetic cationic helical polypeptides for the stimulation of antitumour innate immune pathways in antigen-presenting cells. Nature biomedical engineering (April 2024) Cgastm1d(EUCOMM)Hmgu 38641710
Type-I-interferon-responsive microglia shape cortical development and behavior. Cell (March 2024) Cgastm1d(EUCOMM)Hmgu 38490196
STING dependent BAX-IRF3 signaling results in apoptosis during late-stage Coxiella burnetii infection. Cell death & disease (March 2024) Cgastm1d(EUCOMM)Hmgu PMC10924102
Engineering cGAS-agonistic oligonucleotides as therapeutics for cancer immunotherapy. Molecular therapy. Nucleic acids (January 2024) Cgastm1d(EUCOMM)Hmgu PMC10863322
Activation of cGAS-STING signaling pathway promotes liver fibrosis and hepatic sinusoidal microthrombosis. International immunopharmacology (November 2023) Cgastm1d(EUCOMM)Hmgu 37951190
Effector memory T cells induce innate inflammation by triggering DNA damage and a non-canonical STING pathway in dendritic cells. Cell reports (October 2023) Cgastm1d(EUCOMM)Hmgu PMC10654673
cGAS-STING Pathway Activation during Trypanosoma cruzi Infection Leads to Tissue-Dependent Parasite Control. Journal of immunology (Baltimore, Md. : 1950) (October 2023) Cgastm1d(EUCOMM)Hmgu 37603014
Nuclear envelope disruption triggers hallmarks of aging in lung alveolar macrophages. Nature aging (September 2023) Cgastm1d(EUCOMM)Hmgu 37723209
Activation of the cGAS/STING Axis in Genome-Damaged Hematopoietic Cells Does Not Impact Blood Cell Formation or Leukemogenesis. Cancer research (September 2023) Cgastm1d(EUCOMM)Hmgu 37335136
Fanconi anemia DNA crosslink repair factors protect against LINE-1 retrotransposition during mouse development. Nature structural & molecular biology (August 2023) Cgastm1d(EUCOMM)Hmgu 37580626
TLR2 is non-redundant in the population and subpopulation responses to Mycobacterium tuberculosis in macrophages and in vivo. mSystems (July 2023) Cgastm1d(EUCOMM)Hmgu PMC10506474
Gut lumen-leaked microbial DNA causes myocardial inflammation and impairs cardiac contractility in ageing mouse heart. Frontiers in immunology (July 2023) Cgastm1d(EUCOMM)Hmgu 37520546
Borrelia burgdorferi Engages Mammalian Type I IFN Responses via the cGAS-STING Pathway. Journal of immunology (Baltimore, Md. : 1950) (June 2023) Cgastm1d(EUCOMM)Hmgu 37067290
Role of the cGAS/STING pathway in the control of Brucella abortus infection acquired through the respiratory route. Frontiers in immunology (May 2023) Cgastm1a(EUCOMM)Hmgu PMC10227575
Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience. Nature neuroscience (April 2023) Cgastm1d(EUCOMM)Hmgu PMC10166855
Sterile liver injury induces a protective tissue-resident cDC1-ILC1 circuit through cDC1-intrinsic cGAS-STING-dependent IL-12 production. Cell reports (February 2023) Cgastm1d(EUCOMM)Hmgu 36807146
Activation of innate immune cGAS-STING pathway contributes to Alzheimer's pathogenesis in 5×FAD mice. Nature aging (January 2023) Cgastm1d(EUCOMM)Hmgu 37118112
Innate immune signaling drives late cardiac toxicity following DNA-damaging cancer therapies. The Journal of experimental medicine (December 2022) Cgastm1d(EUCOMM)Hmgu 36534085
Genetic Ablation of the DNA Damage Response Pathway Attenuates Lamin-Associated Dilated Cardiomyopathy in Mice. JACC. Basic to translational science (October 2022) Cgastm1a(EUCOMM)Hmgu PMC9831927
Blocking cGAS/STING signaling protects against sepsis-associated acute liver injury. International immunopharmacology (October 2022) Cgastm1d(EUCOMM)Hmgu 36252490
Beta-Glucan from S. cerevisiae Protected AOM-Induced Colon Cancer in cGAS-Deficient Mice Partly through Dectin-1-Manipulated Macrophage Cell Energy. International journal of molecular sciences (September 2022) Cgastm1d(EUCOMM)Hmgu PMC9505986
Inhibition of cGAS in Paraventricular Nucleus Attenuates Hypertensive Heart Injury Via Regulating Microglial Autophagy. Molecular neurobiology (September 2022) Cgastm1d(EUCOMM)Hmgu PMC9450841
Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing. The Journal of experimental medicine (August 2022) Cgastm1a(EUCOMM)Hmgu PMC9402992
The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging. Immunity (August 2022) Cgastm1d(EUCOMM)Hmgu 35963236
Microglial AIM2 alleviates antiviral-related neuro-inflammation in mouse models of Parkinson's disease. Glia (August 2022) Cgastm1d(EUCOMM)Hmgu 35959803
cGAS modulates cytokine secretion and bacterial burdens by altering the release of mitochondrial DNA in pseudomonas pulmonary infection. Immunology (May 2022) Cgastm1d(EUCOMM)Hmgu 35420160
The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis. Immunity (May 2022) Cgastm1d(EUCOMM)Hmgu 35545033
STING Is Required in Conventional Dendritic Cells for DNA Vaccine Induction of Type I T Helper Cell- Dependent Antibody Responses. Frontiers in immunology (April 2022) Cgastm1d(EUCOMM)Hmgu PMC9072870
Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS. Molecular cell (April 2022) Cgastm1d(EUCOMM)Hmgu 35460603
Thymidine starvation promotes c-di-AMP-dependent inflammation during pathogenic bacterial infection. Cell host & microbe (April 2022) Cgastm1a(EUCOMM)Hmgu 35439435
Lung type II alveolar epithelial cells collaborate with CCR2+ inflammatory monocytes in host defense against poxvirus infection. Nature communications (March 2022) Cgastm1d(EUCOMM)Hmgu PMC8964745
Type I Interferon Response Is Mediated by NLRX1-cGAS-STING Signaling in Brain Injury. Frontiers in molecular neuroscience (February 2022) Cgastm1d(EUCOMM)Hmgu PMC8916033
cGAS exacerbates Schistosoma japonicum infection in a STING-type I IFN-dependent and independent manner. PLoS pathogens (February 2022) Cgastm1d(EUCOMM)Hmgu PMC8809611
STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses. Cell metabolism (January 2022) Cgastm1a(EUCOMM)Hmgu PMC8733004
B Cell Intrinsic STING Signaling Is Not Required for Autoreactive Germinal Center Participation. Frontiers in immunology (December 2021) Cgastm1d(EUCOMM)Hmgu PMC8685402
Interference on Cytosolic DNA Activation Attenuates Sepsis Severity: Experiments on Cyclic GMP-AMP Synthase (cGAS) Deficient Mice. International journal of molecular sciences (October 2021) Cgastm1d(EUCOMM)Hmgu PMC8583992
Genome instability independent of type I interferon signaling drives neuropathology caused by impaired ribonucleotide excision repair. Neuron (October 2021) Cgastm1d(EUCOMM)Hmgu 34655526
Downregulation of mitochondrial biogenesis by virus infection triggers antiviral responses by cyclic GMP-AMP synthase. PLoS pathogens (October 2021) Cgastm1a(EUCOMM)Hmgu PMC8516216
Interferon b drives intestinal regeneration after radiation. Science advances (October 2021) Cgastm1d(EUCOMM)Hmgu PMC8494436
DNA hypomethylation leads to cGAS-induced autoinflammation in the epidermis. The EMBO journal (September 2021) Cgastm1d(EUCOMM)Hmgu PMC8591534
Deficiency of cGAS signaling protects against sepsis-associated encephalopathy. Biochemical and biophysical research communications (September 2021) Cgastm1d(EUCOMM)Hmgu 34507063
cGAS-STING and MyD88 Pathways Synergize in Ly6Chi Monocyte to Promote Streptococcus pneumoniae-Induced Late-Stage Lung IFNγ Production. Frontiers in immunology (August 2021) Cgastm1d(EUCOMM)Hmgu PMC8427188
Single-cell analysis reveals divergent responses of human dendritic cells to the MVA vaccine. Science signaling (August 2021) Cgastm1d(EUCOMM)Hmgu 34429383
Tonic prime-boost of STING signalling mediates Niemann-Pick disease type C. Nature (July 2021) Cgastm1a(EUCOMM)Hmgu PMC8859990
Neutrophil extracellular traps promote tPA-induced brain hemorrhage via cGAS in mice with stroke. Blood (July 2021) Cgastm1d(EUCOMM)Hmgu PMC8288643
Endogenous retroviruses promote homeostatic and inflammatory responses to the microbiota. Cell (June 2021) Cgastm1d(EUCOMM)Hmgu PMC8381240
cGAS restricts colon cancer development by protecting intestinal barrier integrity. Proceedings of the National Academy of Sciences of the United States of America (June 2021) Cgastm1a(EUCOMM)Hmgu PMC8201956
Microbial and genetic-based framework identifies drug targets in inflammatory bowel disease. Theranostics (June 2021) Cgastm1a(EUCOMM)Hmgu PMC8210594
Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility. Immunity (May 2021) Cgastm1d(EUCOMM)Hmgu 34015257
AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis. The Journal of experimental medicine (May 2021) Cgastm1d(EUCOMM)Hmgu PMC7961553
TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections. Proceedings of the National Academy of Sciences of the United States of America (April 2021) Cgastm1a(EUCOMM)Hmgu PMC8040795
cGAS promotes sepsis in radiotherapy of cancer by up-regulating caspase-11 signaling. Biochemical and biophysical research communications (March 2021) Cgastm1d(EUCOMM)Hmgu 33721834
SENP3 senses oxidative stress to facilitate STING-dependent dendritic cell antitumor function. Molecular cell (March 2021) Cgastm1d(EUCOMM)Hmgu 33434504
IRGM1 links mitochondrial quality control to autoimmunity. Nature immunology (January 2021) Cgastm1d(EUCOMM)Hmgu 33510463
STING controls nociception via type I interferon signalling in sensory neurons. Nature (January 2021) Cgastm1d(EUCOMM)Hmgu PMC7977781
Streptavidin Promotes DNA Binding and Activation of cGAS to Enhance Innate Immunity. iScience (August 2020) Cgastm1d(EUCOMM)Hmgu PMC7476851
Virus infection is controlled by hematopoietic and stromal cell sensing of murine cytomegalovirus through STING. eLife (July 2020) Cgastm1d(EUCOMM)Hmgu PMC7413665
Absence of cGAS-mediated type I IFN responses in HIV-1-infected T cells. Proceedings of the National Academy of Sciences of the United States of America (July 2020) Cgastm1a(EUCOMM)Hmgu PMC7431009
DNA damage/cGAS-triggered up-regulation of MALAT1 promotes undesirable inflammatory responses in radiotherapy of cancer. Biochemical and biophysical research communications (June 2020) Cgastm1d(EUCOMM)Hmgu 32532422
cGAS-STING-mediated DNA sensing maintains CD8+ T cell stemness and promotes antitumor T cell therapy. Science translational medicine (June 2020) Cgastm1d(EUCOMM)Hmgu 32581136
Mitochondrial stress-activated cGAS-STING pathway inhibits thermogenic program and contributes to overnutrition-induced obesity in mice. Communications biology (May 2020) Cgastm1d(EUCOMM)Hmgu PMC7244732
The role of the adaptor molecule STING during Schistosoma mansoni infection. Scientific reports (May 2020) Cgastm1a(EUCOMM)Hmgu PMC7220917
The early local and systemic Type I interferon responses to ultraviolet B light exposure are cGAS dependent. Scientific reports (May 2020) Cgastm1d(EUCOMM)Hmgu PMC7220927
Hepatic gap junctions amplify alcohol liver injury by propagating cGAS-mediated IRF3 activation. Proceedings of the National Academy of Sciences of the United States of America (May 2020) Cgastm1c(EUCOMM)Hmgu PMC7261084
Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity. Immunity (April 2020) Cgastm1d(EUCOMM)Hmgu 32277911
Inhibition of cGAS-Mediated Interferon Response Facilitates Transgene Expression. iScience (March 2020) Cgastm1d(EUCOMM)Hmgu PMC7155207
mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury. Immunity (March 2020) Cgastm1d(EUCOMM)Hmgu 32164878
TMEM173 Drives Lethal Coagulation in Sepsis. Cell host & microbe (March 2020) Cgastm1d(EUCOMM)Hmgu PMC7316085
The cGAS-STING pathway is a therapeutic target in a preclinical model of hepatocellular carcinoma. Oncogene (November 2019) Cgastm1d(EUCOMM)Hmgu 31740782
Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice. Scientific reports (October 2019) Cgastm1a(EUCOMM)Hmgu PMC6795997
Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses. Nature communications (October 2019) Cgastm1d(EUCOMM)Hmgu PMC6789137
Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity. Cell reports (October 2019) Cgastm1d(EUCOMM)Hmgu 31665636
Chromatin-bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death. The EMBO journal (September 2019) Cgastm1a(EUCOMM)Hmgu PMC6826206
Sterile Lung Inflammation Induced by Silica Exacerbates Mycobacterium tuberculosis Infection via STING-Dependent Type 2 Immunity. Cell reports (May 2019) Cgastm1a(EUCOMM)Hmgu 31141689
cGAS facilitates sensing of extracellular cyclic dinucleotides to activate innate immunity. EMBO reports (March 2019) Cgastm1d(EUCOMM)Hmgu 30872316
Autophagy induction via STING trafficking is a primordial function of the cGAS pathway. Nature (March 2019) Cgastm1a(EUCOMM)Hmgu 30842662
Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA. Cell (February 2019) Cgastm1a(EUCOMM)Hmgu 30827685
STING-associated lung disease in mice relies on T cells but not type I interferon. The Journal of allergy and clinical immunology (February 2019) Cgastm1d(EUCOMM)Hmgu 30772497
STING-dependent sensing of self-DNA drives silica-induced lung inflammation. Nature communications (December 2018) Cgastm1a(EUCOMM)Hmgu PMC6283886
Nuclear cGAS suppresses DNA repair and promotes tumorigenesis. Nature (October 2018) Cgastm1d(EUCOMM)Hmgu 30356214
ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING. The Journal of experimental medicine (September 2018) Cgastm1d(EUCOMM)Hmgu PMC6219748
Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis. Immunity (August 2018) Cgastm1d(EUCOMM)Hmgu PMC6347470
Species-Specific Deamidation of cGAS by Herpes Simplex Virus UL37 Protein Facilitates Viral Replication. Cell host & microbe (August 2018) Cgastm1d(EUCOMM)Hmgu PMC6094942
The cGAS/STING Pathway Is Important for Dendritic Cell Activation but Is Not Essential to Induce Protective Immunity against Mycobacterium tuberculosis Infection. Journal of innate immunity (May 2018) Cgastm1a(EUCOMM)Hmgu PMC6757162
Extrinsic Phagocyte-Dependent STING Signaling Dictates the Immunogenicity of Dying Cells. Cancer cell (April 2018) Cgastm1d(EUCOMM)Hmgu 29706455
IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation. Cell (March 2018) Cgastm1d(EUCOMM)Hmgu 29576451
Oral Antibiotic Treatment of Mice Exacerbates the Disease Severity of Multiple Flavivirus Infections. Cell reports (March 2018) Cgastm1d(EUCOMM)Hmgu PMC5908250
The cGAS/STING Pathway Detects Streptococcus pneumoniae but Appears Dispensable for Antipneumococcal Defense in Mice and Humans. Infection and immunity (February 2018) Cgastm1d(EUCOMM)Hmgu PMC5820968
cGAS-mediated control of blood-stage malaria promotes Plasmodium-specific germinal center responses. JCI insight (January 2018) Cgastm1d(EUCOMM)Hmgu PMC5821207
Brucella abortus Triggers a cGAS-Independent STING Pathway To Induce Host Protection That Involves Guanylate-Binding Proteins and Inflammasome Activation. Journal of immunology (Baltimore, Md. : 1950) (December 2017) Cgastm1d(EUCOMM)Hmgu PMC5760291
STING-Dependent Signaling Underlies IL-10 Controlled Inflammatory Colitis. Cell reports (December 2017) Cgastm1d(EUCOMM)Hmgu PMC6082386
cGAS drives noncanonical-inflammasome activation in age-related macular degeneration. Nature medicine (November 2017) Cgastm1d(EUCOMM)Hmgu PMC5760363
IRF3 and type I interferons fuel a fatal response to myocardial infarction. Nature medicine (November 2017) Cgastm1d(EUCOMM)Hmgu 29106401
STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum. Cell (October 2017) Cgastm1a(EUCOMM)Hmgu 29056340
A noncanonical function of cGAMP in inflammasome priming and activation. The Journal of experimental medicine (October 2017) Cgastm1c(EUCOMM)Hmgu Cgastm1a(EUCOMM)Hmgu Cgastm1d(EUCOMM)Hmgu PMC5716045
Mycobacterium tuberculosis is protected from NADPH oxidase and LC3-associated phagocytosis by the LCP protein CpsA. Proceedings of the National Academy of Sciences of the United States of America (September 2017) Cgastm1a(EUCOMM)Hmgu Cgastm1d(EUCOMM)Hmgu PMC5642705
Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein α Signaling. Immunity (August 2017) Cgastm1a(EUCOMM)Hmgu PMC5564225
Opposing roles of Toll-like receptor and cytosolic DNA-STING signaling pathways for Staphylococcus aureus cutaneous host defense. PLoS pathogens (July 2017) Cgastm1d(EUCOMM)Hmgu PMC5526579
cGAS is essential for cellular senescence. Proceedings of the National Academy of Sciences of the United States of America (May 2017) Cgastm1a(EUCOMM)Hmgu PMC5468617
cGAS is essential for the antitumor effect of immune checkpoint blockade. Proceedings of the National Academy of Sciences of the United States of America (January 2017) Cgastm1a(EUCOMM)Hmgu PMC5320994
Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS. Nature communications (November 2016) Cgastm1d(EUCOMM)Hmgu PMC5109551
Cross-Regulation of Two Type I Interferon Signaling Pathways in Plasmacytoid Dendritic Cells Controls Anti-malaria Immunity and Host Mortality. Immunity (October 2016) Cgastm1d(EUCOMM)Hmgu 27793594
The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA. Immunity (August 2016) Cgastm1a(EUCOMM)Hmgu PMC4988931
Vaginal Exposure to Zika Virus during Pregnancy Leads to Fetal Brain Infection. Cell (August 2016) Cgastm1d(EUCOMM)Hmgu PMC5006689
Restriction by SAMHD1 Limits cGAS/STING-Dependent Innate and Adaptive Immune Responses to HIV-1. Cell reports (July 2016) Cgastm1a(EUCOMM)Hmgu PMC4978700
AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity. Proceedings of the National Academy of Sciences of the United States of America (July 2016) Cgastm1d(EUCOMM)Hmgu PMC4987819
Diminished Innate Antiviral Response to Adenovirus Vectors in cGAS/STING-Deficient Mice Minimally Impacts Adaptive Immunity. Journal of virology (June 2016) Cgastm1d(EUCOMM)Hmgu PMC4907218
The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons. Immunity (March 2016) Cgastm1d(EUCOMM)Hmgu PMC4852885
Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response. The EMBO journal (February 2016) Cgastm1a(EUCOMM)Hmgu PMC4855687
RNase H2 catalytic core Aicardi-Goutières syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice. The Journal of experimental medicine (February 2016) Cgastm1a(EUCOMM)Hmgu PMC4813680
A cGAS-Independent STING/IRF7 Pathway Mediates the Immunogenicity of DNA Vaccines. Journal of immunology (Baltimore, Md. : 1950) (November 2015) Cgastm1d(EUCOMM)Hmgu PMC4685033
Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation. Immunity (August 2015) Cgastm1a(EUCOMM)Hmgu PMC4575271
Viruses transfer the antiviral second messenger cGAMP between cells. Science (New York, N.Y.) (July 2015) Cgastm1a(EUCOMM)Hmgu PMC4617605
Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi-Goutières Syndrome. Journal of immunology (Baltimore, Md. : 1950) (July 2015) Cgastm1a(EUCOMM)Hmgu PMC4546858
Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis. Cell host & microbe (June 2015) Cgastm1a(EUCOMM)Hmgu PMC4499468
The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy. Cell host & microbe (June 2015) Cgastm1d(EUCOMM)Hmgu PMC4466081
Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA. Cell (December 2014) Cgastm1a(EUCOMM)Hmgu PMC4272443
Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathway. PLoS pathogens (April 2014) Cgastm1a(EUCOMM)Hmgu PMC3990710
Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity. Nature (November 2013) Cgastm1c(EUCOMM)Hmgu Cgastm1a(EUCOMM)Hmgu Cgastm1d(EUCOMM)Hmgu PMC4077721
Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects. Science (New York, N.Y.) (August 2013) Cgastm1a(EUCOMM)Hmgu PMC3863637

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