Gene Summary

Name:
cyclic GMP-AMP synthase
Synonyms:
E330016A19Rik,  Mb21d1

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal tail movements Cgastm1a(EUCOMM)Hmgu HOM   Early adult 1.24×10-07
increased circulating aspartate transaminase level Cgastm1a(EUCOMM)Hmgu HOM Early adult 1.80×10-26
increased startle reflex Cgastm1a(EUCOMM)Hmgu HOM Early adult 4.09×10-08
increased total body fat amount Cgastm1a(EUCOMM)Hmgu HOM Early adult 1.64×10-05
abnormal behavior Cgastm1a(EUCOMM)Hmgu HOM   Early adult 8.88×10-05
increased lactate dehydrogenase level Cgastm1a(EUCOMM)Hmgu HOM Early adult 5.10×10-19

Download data as:  TSV  XLS

Select physiological systems to view:
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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Cgas mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Cgas by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Leishmaniasis, Tegumentary, Susceptibility To
Tegumentary leishmaniasis susceptibility OMIM:602068
Human Coronavirus Sensitivity
Susceptibility to coronavirus 229e OMIM:122460
Varicella, Severe Recurrent
Severe recurrent varicella OMIM:600670
Coxsackievirus B3 Susceptibility
Recurrent viral infections OMIM:120050
Ciliary Discoordination Due To Random Ciliary Orientation
Recurrent infections OMIM:215518
Immunodeficiency 53
Recurrent respiratory infections, Recurrent otitis media, Recurrent infections OMIM:617585
Monocyte and dendritic cell deficiency, autosomal recessive
Recurrent infections OMIM:614894
Tuftsin Deficiency
Recurrent infections OMIM:191150
Immunodeficiency 30
Recurrent infections, Recurrent mycobacterial infections OMIM:614891
Immunodeficiency 34
Recurrent mycobacterial infections, Severe recurrent varicella OMIM:300645
Immunodeficiency 32A
Recurrent infections OMIM:614893
Pentosuria
Abnormality of circulating enzyme level, Abnormal circulating carbohydrate concentration ORPHA:2843
Neutrophil Actin Dysfunction
Recurrent bacterial infections OMIM:257150
Neutropenia, Severe Congenital, 7, Autosomal Recessive
Recurrent infections OMIM:617014
Immunodeficiency 31B
Herpes simplex encephalitis, Recurrent viral infections, Recurrent mycobacterial infections OMIM:613796
Hyperekplexia 3
Exaggerated startle response OMIM:614618
Developmental And Epileptic Encephalopathy 8
Exaggerated startle response OMIM:300607
Developmental And Epileptic Encephalopathy 68
Exaggerated startle response, Flexion contracture OMIM:618201
Hyperekplexia 1
Exaggerated startle response, Umbilical hernia, Inguinal hernia OMIM:149400
Spastic Paraplegia, Optic Atrophy, And Neuropathy
Exaggerated startle response, Flexion contracture OMIM:609541
Hyperekplexia-Epilepsy Syndrome
Exaggerated startle response ORPHA:163985
Hyperekplexia 2
Exaggerated startle response OMIM:614619
Spastic Paraplegia-Optic Atrophy-Neuropathy Syndrome
Multiple joint contractures, Exaggerated startle response ORPHA:320406
Neurodevelopmental Disorder With Microcephaly, Epilepsy, And Hypomyelination
Exaggerated startle response OMIM:618367
Glycine Encephalopathy With Normal Serum Glycine
Hip contracture, Arthrogryposis multiplex congenita, Exaggerated startle response, Flexion contra... OMIM:617301
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 4
Elevated circulating creatine kinase concentration, Exaggerated startle response, Flexion contrac... OMIM:253800
Spastic Tetraplegia And Axial Hypotonia, Progressive
Exaggerated startle response OMIM:618598
Infection-Related Hemolytic Uremic Syndrome
Abnormality of chemokine secretion, Increased circulating interleukin 6, Abnormality of interfero... ORPHA:544482
Stiff Person Spectrum Disorder
Exaggerated startle response ORPHA:3198
Tay-Sachs Disease
Exaggerated startle response OMIM:272800
Stiff-Person Syndrome
Opisthotonus, Exaggerated startle response OMIM:184850
Gm2 Gangliosidosis, Ab Variant
Exaggerated startle response ORPHA:309246
Gm2-Gangliosidosis, Ab Variant
Exaggerated startle response OMIM:272750
Asparagine Synthetase Deficiency
Exaggerated startle response OMIM:615574
Tay-Sachs Disease
Tremor, Increased serum beta-hexosaminidase, Exaggerated startle response ORPHA:845
Aromatic L-Amino Acid Decarboxylase Deficiency
Limb tremor, Exaggerated startle response OMIM:608643
Gm1 Gangliosidosis Type 1
Exaggerated startle response, Abnormal odontoid tissue morphology ORPHA:79255
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome Due To A Point Mutation
Exaggerated startle response ORPHA:438216
Neurodevelopmental Disorder With Progressive Microcephaly, Spasticity, And Brain Anomalies
Contractures of the large joints, Exaggerated startle response OMIM:617527
Sandhoff Disease
Exaggerated startle response OMIM:268800
Plaa-Associated Neurodevelopmental Disorder
Contractures of the large joints, Exaggerated startle response ORPHA:521426
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome
Uterine prolapse, Exaggerated startle response, Decreased serum iron ORPHA:438213
Neurodevelopmental-Craniofacial Syndrome With Variable Renal And Cardiac Abnormalities
Exaggerated startle response OMIM:619522

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cgas

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cgas.

There are 69 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Type I Interferon Response Is Mediated by NLRX1-cGAS-STING Signaling in Brain Injury. Frontiers in molecular neuroscience (February 2022) Cgastm1d(EUCOMM)Hmgu PMC8916033
STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses. Cell metabolism (January 2022) Cgastm1a(EUCOMM)Hmgu PMC8733004
B Cell Intrinsic STING Signaling Is Not Required for Autoreactive Germinal Center Participation. Frontiers in immunology (December 2021) Cgastm1d(EUCOMM)Hmgu PMC8685402
Genome instability independent of type I interferon signaling drives neuropathology caused by impaired ribonucleotide excision repair. Neuron (October 2021) Cgastm1d(EUCOMM)Hmgu 34655526
Downregulation of mitochondrial biogenesis by virus infection triggers antiviral responses by cyclic GMP-AMP synthase. PLoS pathogens (October 2021) Cgastm1a(EUCOMM)Hmgu PMC8516216
Interferon b drives intestinal regeneration after radiation. Science advances (October 2021) Cgastm1d(EUCOMM)Hmgu PMC8494436
DNA hypomethylation leads to cGAS-induced autoinflammation in the epidermis. The EMBO journal (September 2021) Cgastm1d(EUCOMM)Hmgu PMC8591534
cGAS-STING and MyD88 Pathways Synergize in Ly6Chi Monocyte to Promote Streptococcus pneumoniae-Induced Late-Stage Lung IFNγ Production. Frontiers in immunology (August 2021) Cgastm1d(EUCOMM)Hmgu PMC8427188
Neutrophil extracellular traps promote tPA-induced brain hemorrhage via cGAS in mice with stroke. Blood (July 2021) Cgastm1d(EUCOMM)Hmgu PMC8288643
Endogenous retroviruses promote homeostatic and inflammatory responses to the microbiota. Cell (June 2021) Cgastm1d(EUCOMM)Hmgu PMC8381240
cGAS restricts colon cancer development by protecting intestinal barrier integrity. Proceedings of the National Academy of Sciences of the United States of America (June 2021) Cgastm1a(EUCOMM)Hmgu PMC8201956
Microbial and genetic-based framework identifies drug targets in inflammatory bowel disease. Theranostics (June 2021) Cgastm1a(EUCOMM)Hmgu PMC8210594
IRGM1 links mitochondrial quality control to autoimmunity. Nature immunology (January 2021) Cgastm1d(EUCOMM)Hmgu 33510463
Virus infection is controlled by hematopoietic and stromal cell sensing of murine cytomegalovirus through STING. eLife (July 2020) Cgastm1d(EUCOMM)Hmgu PMC7413665
Absence of cGAS-mediated type I IFN responses in HIV-1-infected T cells. Proceedings of the National Academy of Sciences of the United States of America (July 2020) Cgastm1a(EUCOMM)Hmgu PMC7431009
Mitochondrial stress-activated cGAS-STING pathway inhibits thermogenic program and contributes to overnutrition-induced obesity in mice. Communications biology (May 2020) Cgastm1d(EUCOMM)Hmgu PMC7244732
The role of the adaptor molecule STING during Schistosoma mansoni infection. Scientific reports (May 2020) Cgastm1a(EUCOMM)Hmgu PMC7220917
The early local and systemic Type I interferon responses to ultraviolet B light exposure are cGAS dependent. Scientific reports (May 2020) Cgastm1d(EUCOMM)Hmgu PMC7220927
Hepatic gap junctions amplify alcohol liver injury by propagating cGAS-mediated IRF3 activation. Proceedings of the National Academy of Sciences of the United States of America (May 2020) Cgastm1c(EUCOMM)Hmgu PMC7261084
Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity. Immunity (April 2020) Cgastm1d(EUCOMM)Hmgu 32277911
mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury. Immunity (March 2020) Cgastm1d(EUCOMM)Hmgu 32164878
TMEM173 Drives Lethal Coagulation in Sepsis. Cell host & microbe (March 2020) Cgastm1d(EUCOMM)Hmgu PMC7316085
Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice. Scientific reports (October 2019) Cgastm1a(EUCOMM)Hmgu PMC6795997
Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses. Nature communications (October 2019) Cgastm1d(EUCOMM)Hmgu PMC6789137
Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity. Cell reports (October 2019) Cgastm1d(EUCOMM)Hmgu 31665636
Chromatin-bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death. The EMBO journal (September 2019) Cgastm1a(EUCOMM)Hmgu PMC6826206
Sterile Lung Inflammation Induced by Silica Exacerbates Mycobacterium tuberculosis Infection via STING-Dependent Type 2 Immunity. Cell reports (May 2019) Cgastm1a(EUCOMM)Hmgu 31141689
cGAS facilitates sensing of extracellular cyclic dinucleotides to activate innate immunity. EMBO reports (March 2019) Cgastm1d(EUCOMM)Hmgu 30872316
Autophagy induction via STING trafficking is a primordial function of the cGAS pathway. Nature (March 2019) Cgastm1a(EUCOMM)Hmgu 30842662
Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA. Cell (February 2019) Cgastm1a(EUCOMM)Hmgu 30827685
STING-associated lung disease in mice relies on T cells but not type I interferon. The Journal of allergy and clinical immunology (February 2019) Cgastm1d(EUCOMM)Hmgu 30772497
STING-dependent sensing of self-DNA drives silica-induced lung inflammation. Nature communications (December 2018) Cgastm1a(EUCOMM)Hmgu PMC6283886
Nuclear cGAS suppresses DNA repair and promotes tumorigenesis. Nature (October 2018) Cgastm1d(EUCOMM)Hmgu 30356214
ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING. The Journal of experimental medicine (September 2018) Cgastm1d(EUCOMM)Hmgu PMC6219748
Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis. Immunity (August 2018) Cgastm1d(EUCOMM)Hmgu PMC6347470
Species-Specific Deamidation of cGAS by Herpes Simplex Virus UL37 Protein Facilitates Viral Replication. Cell host & microbe (August 2018) Cgastm1d(EUCOMM)Hmgu PMC6094942
Extrinsic Phagocyte-Dependent STING Signaling Dictates the Immunogenicity of Dying Cells. Cancer cell (April 2018) Cgastm1d(EUCOMM)Hmgu 29706455
IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation. Cell (March 2018) Cgastm1d(EUCOMM)Hmgu 29576451
Oral Antibiotic Treatment of Mice Exacerbates the Disease Severity of Multiple Flavivirus Infections. Cell reports (March 2018) Cgastm1d(EUCOMM)Hmgu PMC5908250
cGAS-mediated control of blood-stage malaria promotes Plasmodium-specific germinal center responses. JCI insight (January 2018) Cgastm1d(EUCOMM)Hmgu PMC5821207
Brucella abortus Triggers a cGAS-Independent STING Pathway To Induce Host Protection That Involves Guanylate-Binding Proteins and Inflammasome Activation. Journal of immunology (Baltimore, Md. : 1950) (December 2017) Cgastm1d(EUCOMM)Hmgu PMC5760291
STING-Dependent Signaling Underlies IL-10 Controlled Inflammatory Colitis. Cell reports (December 2017) Cgastm1d(EUCOMM)Hmgu PMC6082386
cGAS drives noncanonical-inflammasome activation in age-related macular degeneration. Nature medicine (November 2017) Cgastm1d(EUCOMM)Hmgu PMC5760363
IRF3 and type I interferons fuel a fatal response to myocardial infarction. Nature medicine (November 2017) Cgastm1d(EUCOMM)Hmgu 29106401
STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum. Cell (October 2017) Cgastm1a(EUCOMM)Hmgu 29056340
A noncanonical function of cGAMP in inflammasome priming and activation. The Journal of experimental medicine (October 2017) Cgastm1c(EUCOMM)Hmgu Cgastm1a(EUCOMM)Hmgu Cgastm1d(EUCOMM)Hmgu PMC5716045
Mycobacterium tuberculosis is protected from NADPH oxidase and LC3-associated phagocytosis by the LCP protein CpsA. Proceedings of the National Academy of Sciences of the United States of America (September 2017) Cgastm1a(EUCOMM)Hmgu Cgastm1d(EUCOMM)Hmgu PMC5642705
Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein α Signaling. Immunity (August 2017) Cgastm1a(EUCOMM)Hmgu PMC5564225
Opposing roles of Toll-like receptor and cytosolic DNA-STING signaling pathways for Staphylococcus aureus cutaneous host defense. PLoS pathogens (July 2017) Cgastm1d(EUCOMM)Hmgu PMC5526579
cGAS is essential for cellular senescence. Proceedings of the National Academy of Sciences of the United States of America (May 2017) Cgastm1a(EUCOMM)Hmgu PMC5468617
cGAS is essential for the antitumor effect of immune checkpoint blockade. Proceedings of the National Academy of Sciences of the United States of America (January 2017) Cgastm1a(EUCOMM)Hmgu PMC5320994
Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS. Nature communications (November 2016) Cgastm1d(EUCOMM)Hmgu PMC5109551
Cross-Regulation of Two Type I Interferon Signaling Pathways in Plasmacytoid Dendritic Cells Controls Anti-malaria Immunity and Host Mortality. Immunity (October 2016) Cgastm1d(EUCOMM)Hmgu 27793594
The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA. Immunity (August 2016) Cgastm1a(EUCOMM)Hmgu PMC4988931
Vaginal Exposure to Zika Virus during Pregnancy Leads to Fetal Brain Infection. Cell (August 2016) Cgastm1d(EUCOMM)Hmgu PMC5006689
Restriction by SAMHD1 Limits cGAS/STING-Dependent Innate and Adaptive Immune Responses to HIV-1. Cell reports (July 2016) Cgastm1a(EUCOMM)Hmgu PMC4978700
AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity. Proceedings of the National Academy of Sciences of the United States of America (July 2016) Cgastm1d(EUCOMM)Hmgu PMC4987819
Diminished Innate Antiviral Response to Adenovirus Vectors in cGAS/STING-Deficient Mice Minimally Impacts Adaptive Immunity. Journal of virology (June 2016) Cgastm1d(EUCOMM)Hmgu PMC4907218
The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons. Immunity (March 2016) Cgastm1d(EUCOMM)Hmgu PMC4852885
Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response. The EMBO journal (February 2016) Cgastm1a(EUCOMM)Hmgu PMC4855687
RNase H2 catalytic core Aicardi-Goutières syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice. The Journal of experimental medicine (February 2016) Cgastm1a(EUCOMM)Hmgu PMC4813680
A cGAS-Independent STING/IRF7 Pathway Mediates the Immunogenicity of DNA Vaccines. Journal of immunology (Baltimore, Md. : 1950) (November 2015) Cgastm1d(EUCOMM)Hmgu PMC4685033
Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation. Immunity (August 2015) Cgastm1a(EUCOMM)Hmgu PMC4575271
Viruses transfer the antiviral second messenger cGAMP between cells. Science (New York, N.Y.) (July 2015) Cgastm1a(EUCOMM)Hmgu PMC4617605
Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi-Goutières Syndrome. Journal of immunology (Baltimore, Md. : 1950) (July 2015) Cgastm1a(EUCOMM)Hmgu PMC4546858
Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA. Cell (December 2014) Cgastm1a(EUCOMM)Hmgu PMC4272443
Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathway. PLoS pathogens (April 2014) Cgastm1a(EUCOMM)Hmgu PMC3990710
Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity. Nature (November 2013) Cgastm1c(EUCOMM)Hmgu Cgastm1a(EUCOMM)Hmgu Cgastm1d(EUCOMM)Hmgu PMC4077721
Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects. Science (New York, N.Y.) (August 2013) Cgastm1a(EUCOMM)Hmgu PMC3863637

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MGI Allele Allele Type Produced
Cgastm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Cgastm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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