Gene Summary

Name:
cyclic GMP-AMP synthase
Synonyms:
Mb21d1,  E330016A19Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased circulating amylase level Cgastm1a(EUCOMM)Hmgu HOM Early adult 8.25×10-05
abnormal tail movements Cgastm1a(EUCOMM)Hmgu HOM   Early adult 1.24×10-07
decreased grip strength Cgastm1a(EUCOMM)Hmgu HOM Early adult 2.06×10-05
abnormal bone mineralization Cgastm1a(EUCOMM)Hmgu HOM Early adult 5.67×10-05
increased circulating aspartate transaminase level Cgastm1a(EUCOMM)Hmgu HOM Early adult 1.71×10-11
abnormal behavior Cgastm1a(EUCOMM)Hmgu HOM   Early adult 8.88×10-05
increased startle reflex Cgastm1a(EUCOMM)Hmgu HOM Early adult 4.09×10-08
increased total body fat amount Cgastm1a(EUCOMM)Hmgu HOM Early adult 1.64×10-05
decreased prepulse inhibition Cgastm1a(EUCOMM)Hmgu HOM Early adult 1.77×10-07
increased lactate dehydrogenase level Cgastm1a(EUCOMM)Hmgu HOM Early adult 5.53×10-09
abnormal glucose homeostasis Cgastm1a(EUCOMM)Hmgu HOM Early adult 4.57×10-05

Download data as:  TSV  XLS

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Cgas mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Cgas by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Human Coronavirus Sensitivity
Susceptibility to coronavirus 229e OMIM:122460
Leishmaniasis, Tegumentary, Susceptibility To
Tegumentary leishmaniasis susceptibility OMIM:602068
Varicella, Severe Recurrent
Severe recurrent varicella OMIM:600670
Coxsackievirus B3 Susceptibility
Recurrent viral infections OMIM:120050
Ciliary Discoordination Due To Random Ciliary Orientation
Recurrent infections OMIM:215518
Immunodeficiency 30
Recurrent mycobacterial infections, Recurrent infections OMIM:614891
Immunodeficiency 31A
Herpes simplex encephalitis, Recurrent mycobacterium avium complex infections, BCGitis, Recurrent... OMIM:614892
Neutrophil Actin Dysfunction
Recurrent bacterial infections OMIM:257150
Immunodeficiency 31B
Recurrent mycobacterial infections, Herpes simplex encephalitis, Recurrent viral infections OMIM:613796
Hypophosphatemic Rickets, Autosomal Recessive, 1
Increased bone mineral density, Craniosynostosis, Rickets, Hypophosphatemia, Hypophosphatemic ric... OMIM:241520
Axial Osteomalacia
Increased bone mineral density, Osteomalacia, Elevated circulating creatine kinase concentration OMIM:109130
Hypophosphatemic Rickets, Autosomal Dominant
Hypophosphatemic rickets, Rickets, Osteomalacia, Hypophosphatemia OMIM:193100
Hypophosphatemic Bone Disease
Rickets, Osteomalacia, Hypophosphatemia OMIM:146350
Hypophosphatasia, Adult
Recurrent fractures, Osteomalacia, Rickets, Increased susceptibility to fractures, Pathologic fra... OMIM:146300
Hypocalcemic Vitamin D-Resistant Rickets
Osteomalacia, Recurrent fractures, Bone cyst, Osteolysis, Abnormal adipose tissue morphology, Hyp... ORPHA:93160
Vitamin D-Dependent Rickets, Type 2B, With Normal Vitamin D Receptor
Delayed epiphyseal ossification, Rickets, Sparse bone trabeculae, Generalized bone demineralizati... OMIM:600785
Fanconi Renotubular Syndrome 2
Osteopenia, Recurrent fractures, Osteomalacia, Rickets, Glycosuria, Hypophosphatemia OMIM:613388
Dermatosparaxis Ehlers-Danlos Syndrome
Osteopenia, Inguinal hernia, Abnormality of subcutaneous fat tissue, Osteomalacia, Femoral hernia... ORPHA:1901
Bile Acid Conjugation Defect 1
Conjugated hyperbilirubinemia, Rickets OMIM:619232
Hereditary Hypophosphatemic Rickets With Hypercalciuria
Osteomalacia, Increased circulating beta-C-terminal telopeptide concentration, Reduced bone miner... ORPHA:157215
Fanconi Renotubular Syndrome 3
Glycosuria, Elevated circulating creatinine concentration, Rickets OMIM:615605
Fanconi-Bickel Syndrome
Osteopenia, Hypertriglyceridemia, Diabetes mellitus, Impaired glucose tolerance, Rickets, Glycosu... ORPHA:2088
Fanconi-Bickel Syndrome
Reduced subcutaneous adipose tissue, Hypouricemia, Osteomalacia, Rickets, Hypophosphatemia, Glyco... OMIM:227810
Hypercholanemia, Familial 1
Rickets, Increased serum bile acid concentration OMIM:607748
Fanconi Renotubular Syndrome 4 With Maturity-Onset Diabetes Of The Young
Diabetes mellitus, Hypoglycemia, Hypouricemia, Rickets, Glycosuria, Hypophosphatemia OMIM:616026
Renal Tubular Acidosis, Distal, 1
Osteomalacia, Elevated circulating creatinine concentration, Hypokalemia, Hypocalcemia, Pathologi... OMIM:179800
Vitamin D Hydroxylation-Deficient Rickets, Type 1B
Recurrent fractures, Delayed epiphyseal ossification, Rickets, Sparse bone trabeculae, Hypocalcem... OMIM:600081
Fanconi Renotubular Syndrome 1
Osteomalacia, Rickets, Hypophosphatemia, Hypokalemia, Glycosuria OMIM:134600
Renal Tubular Acidosis Iii
Hypokalemia, Rickets, Osteomalacia OMIM:267200
Hypophosphatemic Rickets, X-Linked Recessive
Recurrent fractures, Osteomalacia, Delayed epiphyseal ossification, Rickets, Sparse bone trabecul... OMIM:300554
Hypophosphatemic Rickets With Hypercalciuria, Hereditary
Recurrent fractures, Abnormal circulating calcium concentration, Delayed epiphyseal ossification,... OMIM:241530
Autosomal Dominant Hypophosphatemic Rickets
Osteomalacia, Rickets, Hypocalcemia, Hypophosphatemia ORPHA:89937
Vitamin D Hydroxylation-Deficient Rickets, Type 1A
Thin bony cortex, Recurrent fractures, Delayed epiphyseal ossification, Rickets, Sparse bone trab... OMIM:264700
Hypophosphatemic Rickets, X-Linked Dominant
Osteomalacia, Abnormal circulating calcium concentration, Osteoarthritis, Enamel hypomineralizati... OMIM:307800
Dent Disease 1
Recurrent fractures, Osteomalacia, Delayed epiphyseal ossification, Rickets, Glycosuria, Sparse b... OMIM:300009
Hypocalcemic Vitamin D-Dependent Rickets
Thin bony cortex, Osteomalacia, Delayed epiphyseal ossification, Rickets, Increased susceptibilit... ORPHA:289157
Renal Tubular Acidosis, Distal, 3, With Or Without Sensorineural Hearing Loss
Hypokalemia, Rickets OMIM:602722
Vitamin D-Dependent Rickets, Type 2A
Thin bony cortex, Recurrent fractures, Delayed epiphyseal ossification, Rickets, Sparse bone trab... OMIM:277440
Dent Disease
Renal hypophosphatemia, Recurrent fractures, Osteomalacia, Elevated circulating creatine kinase c... ORPHA:1652
Cholestasis, Progressive Familial Intrahepatic, 1
Conjugated hyperbilirubinemia, Osteopenia, Rickets OMIM:211600
Cystinosis
Type I diabetes mellitus, Hypokalemia, Rickets, Hypophosphatemia ORPHA:213
Renal Tubulopathy, Diabetes Mellitus, And Cerebellar Ataxia
Type I diabetes mellitus, Osteoporosis, Rickets OMIM:560000
Fibrous Dysplasia Of Bone
Thin bony cortex, Diabetes mellitus, Osteomalacia, Hypercalcemia, Fibrous dysplasia of the bones,... ORPHA:249
Wilson Disease
Decreased circulating ceruloplasmin concentration, Hypouricemia, Dystonia, Osteomalacia, Tremor, ... OMIM:277900
Renal Tubular Acidosis, Distal, 4, With Hemolytic Anemia
Hypokalemia, Rickets OMIM:611590
Hypocalciuric Hypercalcemia, Familial, Type Iii
Osteomalacia, Hypercalcemia, Hypermagnesemia, Multiple lipomas, Hypophosphatemia, Chondrocalcinosis OMIM:600740
Developmental And Epileptic Encephalopathy 68
Exaggerated startle response, Flexion contracture OMIM:618201
Bile Acid Synthesis Defect, Congenital, 1
Conjugated hyperbilirubinemia, Rickets, Hypocholesterolemia OMIM:607765
Infantile Systemic Hyalinosis
Osteopenia, Recurrent fractures, Osteomalacia, Camptodactyly of finger, Joint stiffness, Osteopor... ORPHA:2176
Congenital Bile Acid Synthesis Defect Type 2
Conjugated hyperbilirubinemia, Rickets, Hyperbilirubinemia, Abnormal serum bile acid concentration ORPHA:79303
Stiff Person Spectrum Disorder
Exaggerated startle response, Diabetes mellitus ORPHA:3198
Hypophosphatemic Rickets And Hyperparathyroidism
Hypophosphatemic rickets, Rickets, Hypercalcemia, Hypophosphatemia OMIM:612089
Autosomal Recessive Hypophosphatemic Rickets
Abnormal trabecular bone morphology, Increased bone mineral density, Renal hypophosphatemia, Oste... ORPHA:289176
Celiac Disease, Susceptibility To, 1
Osteoporosis, Rickets, Hypocalcemia, Type I diabetes mellitus, Enamel hypoplasia OMIM:212750
X-Linked Hypophosphatemia
Odontodysplasia, Craniosynostosis, Generalized osteosclerosis, Limitation of joint mobility, Rick... ORPHA:89936
Rod-Cone Dystrophy, Sensorineural Deafness, And Fanconi-Type Renal Dysfunction
Rickets, Recurrent fractures, Glycosuria OMIM:268315
Intellectual Developmental Disorder, Autosomal Recessive 54
Exaggerated startle response OMIM:617028
Stiff-Person Syndrome
Exaggerated startle response, Diabetes mellitus, Opisthotonus OMIM:184850
Spastic Paraplegia, Optic Atrophy, And Neuropathy
Exaggerated startle response, Flexion contracture OMIM:609541
Aromatic L-Amino Acid Decarboxylase Deficiency
Torticollis, Exaggerated startle response, Oculogyric crisis, Limb tremor, Choreoathetosis, Athet... OMIM:608643
Lowe Oculocerebrorenal Syndrome
Elevated circulating creatine kinase concentration, Elevated maternal serum alpha-fetoprotein, Os... OMIM:309000
Glycine Encephalopathy With Normal Serum Glycine
Joint laxity, Hip contracture, Exaggerated startle response, Flexion contracture, Elbow flexion c... OMIM:617301
Spastic Paraplegia-Optic Atrophy-Neuropathy Syndrome
Exaggerated startle response, Multiple joint contractures ORPHA:320406
Neu-Laxova Syndrome
Osteopenia, Osteomalacia, Flexion contracture, Osteoporosis, Rickets, Opisthotonus, Arthrogryposi... ORPHA:2671
Primary Fanconi Renotubular Syndrome
Hypouricemia, Osteomalacia, Hypoglycemia, Bicarbonaturia, Hypophosphatemia, Increased susceptibil... ORPHA:3337
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 4
Exaggerated startle response, Flexion contracture, Elevated circulating creatine kinase concentra... OMIM:253800
Mccune-Albright Syndrome
Recurrent fractures, Osteomalacia, Fibrous dysplasia of the bones, Polyostotic fibrous dysplasia,... ORPHA:562
Hyperekplexia 2
Exaggerated startle response, Hiatus hernia OMIM:614619
Hyperekplexia 3
Exaggerated startle response, Hiatus hernia OMIM:614618
Hyperekplexia 1
Umbilical hernia, Exaggerated startle response, Inguinal hernia OMIM:149400
Leukodystrophy, Hypomyelinating, 13
Exaggerated startle response, Joint contracture OMIM:616881
Tay-Sachs Disease
Exaggerated startle response, Increased serum beta-hexosaminidase, Tremor, Dystonia, Limited knee... ORPHA:845
Rajab Interstitial Lung Disease With Brain Calcifications 1
Osteopenia, Joint laxity, Inguinal hernia, Hypoglycemia, Rickets, Reduced bone mineral density, H... OMIM:613658
Neurodegeneration With Developmental Delay, Early Respiratory Failure, Myoclonic Seizures, And Brain Abnormalities
Tremor, Exaggerated startle response, Limb joint contracture OMIM:620327
Familial Hypocalciuric Hypercalcemia
Renal hypophosphatemia, Osteomalacia, Hypercalcemia, Hypermagnesemia, Lipoma, Chondrocalcinosis, ... ORPHA:405
Hyperekplexia-Epilepsy Syndrome
Exaggerated startle response ORPHA:163985
Infantile Nephropathic Cystinosis
Rickets, Abnormal blood ion concentration, Hypophosphatemia, Hypokalemia, Glycosuria ORPHA:411629
Occipital Horn Syndrome
Osteopenia, Inguinal hernia, Femoral hernia, Osteomalacia, Scarring, Hiatus hernia, Osteoporosis,... ORPHA:198
Gm2 Gangliosidosis, Ab Variant
Exaggerated startle response, Dystonia ORPHA:309246
Neurodevelopmental Disorder With Or Without Seizures And Gait Abnormalities
Exaggerated startle response, Joint contracture OMIM:617864
Developmental And Epileptic Encephalopathy 8
Exaggerated startle response OMIM:300607
Neurodevelopmental Disorder With Cerebellar Atrophy And With Or Without Seizures
Tremor, Exaggerated startle response, Truncal titubation OMIM:618056
Infection-Related Hemolytic Uremic Syndrome
Increased circulating interleukin 6 concentration, Abnormality of chemokine secretion, Abnormalit... ORPHA:544482
Distal Renal Tubular Acidosis
Osteomalacia, Rickets, Increased susceptibility to fractures, Reduced bone mineral density, Hypok... ORPHA:18
Plaa-Associated Neurodevelopmental Disorder
Hyperextensibility of the finger joints, Exaggerated startle response, Contractures of the large ... ORPHA:521426
Spastic Tetraplegia And Axial Hypotonia, Progressive
Exaggerated startle response OMIM:618598
Neurodevelopmental Disorder With Speech Impairment And With Or Without Seizures
Exaggerated startle response OMIM:620114
Cystinosis, Nephropathic
Hyponatremia, Diabetes mellitus, Rickets, Reduced blood urea nitrogen, Hypophosphatemia, Glycosur... OMIM:219800
Oculocerebrorenal Syndrome Of Lowe
Hyponatremia, Inguinal hernia, Hypoammonemia, Osteomalacia, Recurrent fractures, Joint stiffness,... ORPHA:534
Cystinosis, Late-Onset Juvenile Or Adolescent Nephropathic Type
Rickets OMIM:219900
Gm2-Gangliosidosis, Ab Variant
Exaggerated startle response, Dystonia OMIM:272750
Tay-Sachs Disease
Exaggerated startle response OMIM:272800
Sudden Infant Death With Dysgenesis Of The Testes Syndrome
Exaggerated startle response OMIM:608800
Sandhoff Disease, Infantile Form
Exaggerated startle response ORPHA:309155
Asparagine Synthetase Deficiency
Tremor, Exaggerated startle response, Hypoasparaginemia OMIM:615574
Pancreatic Triacylglycerol Lipase Deficiency
Osteoporosis, Osteomalacia, Rickets ORPHA:309031
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome Due To A Point Mutation
Exaggerated startle response, Dystonia ORPHA:438216
Gm1 Gangliosidosis Type 1
Exaggerated startle response, Abnormal odontoid tissue morphology, Dystonia ORPHA:79255
Neurodevelopmental Disorder With Progressive Microcephaly, Spasticity, And Brain Anomalies
Contractures of the large joints, Exaggerated startle response OMIM:617527
Sandhoff Disease
Exaggerated startle response OMIM:268800
Developmental And Epileptic Encephalopathy 49
Exaggerated startle response OMIM:617281
Immunodeficiency 82 With Systemic Inflammation
Osteomyelitis, Osteomalacia, Elevated circulating C-reactive protein concentration, Arthritis, Hy... OMIM:619381
Microcephalic Osteodysplastic Primordial Dwarfism Types I And Iii
Osteopenia, Abnormally ossified vertebrae, Osteomalacia, Osteoporosis, Rickets ORPHA:2636
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome
Osteopenia, Joint laxity, Exaggerated startle response, Decreased serum iron, Osteoporosis, Dysto... ORPHA:438213
Neurodevelopmental Disorder With Microcephaly, Epilepsy, And Hypomyelination
Exaggerated startle response OMIM:618367
Generalized Arterial Calcification Of Infancy
Hypophosphatemic rickets, Fused cervical vertebrae, Osteomalacia, Abnormal calcification of the c... ORPHA:51608
Neurodevelopmental-Craniofacial Syndrome With Variable Renal And Cardiac Abnormalities
Exaggerated startle response, Joint hypermobility OMIM:619522

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cgas

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cgas.

There are 112 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Activation of cGAS-STING signaling pathway promotes liver fibrosis and hepatic sinusoidal microthrombosis. International immunopharmacology (November 2023) Cgastm1d(EUCOMM)Hmgu 37951190
Effector memory T cells induce innate inflammation by triggering DNA damage and a non-canonical STING pathway in dendritic cells. Cell reports (October 2023) Cgastm1d(EUCOMM)Hmgu PMC10654673
cGAS-STING Pathway Activation during Trypanosoma cruzi Infection Leads to Tissue-Dependent Parasite Control. Journal of immunology (Baltimore, Md. : 1950) (October 2023) Cgastm1d(EUCOMM)Hmgu 37603014
Nuclear envelope disruption triggers hallmarks of aging in lung alveolar macrophages. Nature aging (September 2023) Cgastm1d(EUCOMM)Hmgu 37723209
Activation of the cGAS/STING Axis in Genome-Damaged Hematopoietic Cells Does Not Impact Blood Cell Formation or Leukemogenesis. Cancer research (September 2023) Cgastm1d(EUCOMM)Hmgu 37335136
Fanconi anemia DNA crosslink repair factors protect against LINE-1 retrotransposition during mouse development. Nature structural & molecular biology (August 2023) Cgastm1d(EUCOMM)Hmgu 37580626
TLR2 is non-redundant in the population and subpopulation responses to Mycobacterium tuberculosis in macrophages and in vivo. mSystems (July 2023) Cgastm1d(EUCOMM)Hmgu PMC10506474
Borrelia burgdorferi Engages Mammalian Type I IFN Responses via the cGAS-STING Pathway. Journal of immunology (Baltimore, Md. : 1950) (June 2023) Cgastm1d(EUCOMM)Hmgu 37067290
Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience. Nature neuroscience (April 2023) Cgastm1d(EUCOMM)Hmgu PMC10166855
Sterile liver injury induces a protective tissue-resident cDC1-ILC1 circuit through cDC1-intrinsic cGAS-STING-dependent IL-12 production. Cell reports (February 2023) Cgastm1d(EUCOMM)Hmgu 36807146
Activation of innate immune cGAS-STING pathway contributes to Alzheimer's pathogenesis in 5×FAD mice. Nature aging (January 2023) Cgastm1d(EUCOMM)Hmgu 37118112
Innate immune signaling drives late cardiac toxicity following DNA-damaging cancer therapies. The Journal of experimental medicine (December 2022) Cgastm1d(EUCOMM)Hmgu 36534085
Genetic Ablation of the DNA Damage Response Pathway Attenuates Lamin-Associated Dilated Cardiomyopathy in Mice. JACC. Basic to translational science (October 2022) Cgastm1a(EUCOMM)Hmgu PMC9831927
Blocking cGAS/STING signaling protects against sepsis-associated acute liver injury. International immunopharmacology (October 2022) Cgastm1d(EUCOMM)Hmgu 36252490
Beta-Glucan from S. cerevisiae Protected AOM-Induced Colon Cancer in cGAS-Deficient Mice Partly through Dectin-1-Manipulated Macrophage Cell Energy. International journal of molecular sciences (September 2022) Cgastm1d(EUCOMM)Hmgu PMC9505986
Inhibition of cGAS in Paraventricular Nucleus Attenuates Hypertensive Heart Injury Via Regulating Microglial Autophagy. Molecular neurobiology (September 2022) Cgastm1d(EUCOMM)Hmgu PMC9450841
Monocyte-derived macrophages aggravate pulmonary vasculitis via cGAS/STING/IFN-mediated nucleic acid sensing. The Journal of experimental medicine (August 2022) Cgastm1a(EUCOMM)Hmgu PMC9402992
The matricellular protein SPARC induces inflammatory interferon-response in macrophages during aging. Immunity (August 2022) Cgastm1d(EUCOMM)Hmgu 35963236
cGAS modulates cytokine secretion and bacterial burdens by altering the release of mitochondrial DNA in pseudomonas pulmonary infection. Immunology (May 2022) Cgastm1d(EUCOMM)Hmgu 35420160
The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis. Immunity (May 2022) Cgastm1d(EUCOMM)Hmgu 35545033
STING Is Required in Conventional Dendritic Cells for DNA Vaccine Induction of Type I T Helper Cell- Dependent Antibody Responses. Frontiers in immunology (April 2022) Cgastm1d(EUCOMM)Hmgu PMC9072870
Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS. Molecular cell (April 2022) Cgastm1d(EUCOMM)Hmgu 35460603
Thymidine starvation promotes c-di-AMP-dependent inflammation during pathogenic bacterial infection. Cell host & microbe (April 2022) Cgastm1a(EUCOMM)Hmgu 35439435
Lung type II alveolar epithelial cells collaborate with CCR2+ inflammatory monocytes in host defense against poxvirus infection. Nature communications (March 2022) Cgastm1d(EUCOMM)Hmgu PMC8964745
Type I Interferon Response Is Mediated by NLRX1-cGAS-STING Signaling in Brain Injury. Frontiers in molecular neuroscience (February 2022) Cgastm1d(EUCOMM)Hmgu PMC8916033
cGAS exacerbates Schistosoma japonicum infection in a STING-type I IFN-dependent and independent manner. PLoS pathogens (February 2022) Cgastm1d(EUCOMM)Hmgu PMC8809611
STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses. Cell metabolism (January 2022) Cgastm1a(EUCOMM)Hmgu PMC8733004
B Cell Intrinsic STING Signaling Is Not Required for Autoreactive Germinal Center Participation. Frontiers in immunology (December 2021) Cgastm1d(EUCOMM)Hmgu PMC8685402
Interference on Cytosolic DNA Activation Attenuates Sepsis Severity: Experiments on Cyclic GMP-AMP Synthase (cGAS) Deficient Mice. International journal of molecular sciences (October 2021) Cgastm1d(EUCOMM)Hmgu PMC8583992
Genome instability independent of type I interferon signaling drives neuropathology caused by impaired ribonucleotide excision repair. Neuron (October 2021) Cgastm1d(EUCOMM)Hmgu 34655526
Downregulation of mitochondrial biogenesis by virus infection triggers antiviral responses by cyclic GMP-AMP synthase. PLoS pathogens (October 2021) Cgastm1a(EUCOMM)Hmgu PMC8516216
Interferon b drives intestinal regeneration after radiation. Science advances (October 2021) Cgastm1d(EUCOMM)Hmgu PMC8494436
DNA hypomethylation leads to cGAS-induced autoinflammation in the epidermis. The EMBO journal (September 2021) Cgastm1d(EUCOMM)Hmgu PMC8591534
Deficiency of cGAS signaling protects against sepsis-associated encephalopathy. Biochemical and biophysical research communications (September 2021) Cgastm1d(EUCOMM)Hmgu 34507063
cGAS-STING and MyD88 Pathways Synergize in Ly6Chi Monocyte to Promote Streptococcus pneumoniae-Induced Late-Stage Lung IFNγ Production. Frontiers in immunology (August 2021) Cgastm1d(EUCOMM)Hmgu PMC8427188
Single-cell analysis reveals divergent responses of human dendritic cells to the MVA vaccine. Science signaling (August 2021) Cgastm1d(EUCOMM)Hmgu 34429383
Tonic prime-boost of STING signalling mediates Niemann-Pick disease type C. Nature (July 2021) Cgastm1a(EUCOMM)Hmgu PMC8859990
Neutrophil extracellular traps promote tPA-induced brain hemorrhage via cGAS in mice with stroke. Blood (July 2021) Cgastm1d(EUCOMM)Hmgu PMC8288643
Endogenous retroviruses promote homeostatic and inflammatory responses to the microbiota. Cell (June 2021) Cgastm1d(EUCOMM)Hmgu PMC8381240
cGAS restricts colon cancer development by protecting intestinal barrier integrity. Proceedings of the National Academy of Sciences of the United States of America (June 2021) Cgastm1a(EUCOMM)Hmgu PMC8201956
Microbial and genetic-based framework identifies drug targets in inflammatory bowel disease. Theranostics (June 2021) Cgastm1a(EUCOMM)Hmgu PMC8210594
Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility. Immunity (May 2021) Cgastm1d(EUCOMM)Hmgu 34015257
AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis. The Journal of experimental medicine (May 2021) Cgastm1d(EUCOMM)Hmgu PMC7961553
TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections. Proceedings of the National Academy of Sciences of the United States of America (April 2021) Cgastm1a(EUCOMM)Hmgu PMC8040795
cGAS promotes sepsis in radiotherapy of cancer by up-regulating caspase-11 signaling. Biochemical and biophysical research communications (March 2021) Cgastm1d(EUCOMM)Hmgu 33721834
SENP3 senses oxidative stress to facilitate STING-dependent dendritic cell antitumor function. Molecular cell (March 2021) Cgastm1d(EUCOMM)Hmgu 33434504
IRGM1 links mitochondrial quality control to autoimmunity. Nature immunology (January 2021) Cgastm1d(EUCOMM)Hmgu 33510463
Streptavidin Promotes DNA Binding and Activation of cGAS to Enhance Innate Immunity. iScience (August 2020) Cgastm1d(EUCOMM)Hmgu PMC7476851
Virus infection is controlled by hematopoietic and stromal cell sensing of murine cytomegalovirus through STING. eLife (July 2020) Cgastm1d(EUCOMM)Hmgu PMC7413665
Absence of cGAS-mediated type I IFN responses in HIV-1-infected T cells. Proceedings of the National Academy of Sciences of the United States of America (July 2020) Cgastm1a(EUCOMM)Hmgu PMC7431009
DNA damage/cGAS-triggered up-regulation of MALAT1 promotes undesirable inflammatory responses in radiotherapy of cancer. Biochemical and biophysical research communications (June 2020) Cgastm1d(EUCOMM)Hmgu 32532422
cGAS-STING-mediated DNA sensing maintains CD8+ T cell stemness and promotes antitumor T cell therapy. Science translational medicine (June 2020) Cgastm1d(EUCOMM)Hmgu 32581136
Mitochondrial stress-activated cGAS-STING pathway inhibits thermogenic program and contributes to overnutrition-induced obesity in mice. Communications biology (May 2020) Cgastm1d(EUCOMM)Hmgu PMC7244732
The role of the adaptor molecule STING during Schistosoma mansoni infection. Scientific reports (May 2020) Cgastm1a(EUCOMM)Hmgu PMC7220917
The early local and systemic Type I interferon responses to ultraviolet B light exposure are cGAS dependent. Scientific reports (May 2020) Cgastm1d(EUCOMM)Hmgu PMC7220927
Hepatic gap junctions amplify alcohol liver injury by propagating cGAS-mediated IRF3 activation. Proceedings of the National Academy of Sciences of the United States of America (May 2020) Cgastm1c(EUCOMM)Hmgu PMC7261084
Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity. Immunity (April 2020) Cgastm1d(EUCOMM)Hmgu 32277911
Inhibition of cGAS-Mediated Interferon Response Facilitates Transgene Expression. iScience (March 2020) Cgastm1d(EUCOMM)Hmgu PMC7155207
mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury. Immunity (March 2020) Cgastm1d(EUCOMM)Hmgu 32164878
TMEM173 Drives Lethal Coagulation in Sepsis. Cell host & microbe (March 2020) Cgastm1d(EUCOMM)Hmgu PMC7316085
The cGAS-STING pathway is a therapeutic target in a preclinical model of hepatocellular carcinoma. Oncogene (November 2019) Cgastm1d(EUCOMM)Hmgu 31740782
Self-DNA release and STING-dependent sensing drives inflammation to cigarette smoke in mice. Scientific reports (October 2019) Cgastm1a(EUCOMM)Hmgu PMC6795997
Influenza A virus M2 protein triggers mitochondrial DNA-mediated antiviral immune responses. Nature communications (October 2019) Cgastm1d(EUCOMM)Hmgu PMC6789137
Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity. Cell reports (October 2019) Cgastm1d(EUCOMM)Hmgu 31665636
Chromatin-bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death. The EMBO journal (September 2019) Cgastm1a(EUCOMM)Hmgu PMC6826206
Sterile Lung Inflammation Induced by Silica Exacerbates Mycobacterium tuberculosis Infection via STING-Dependent Type 2 Immunity. Cell reports (May 2019) Cgastm1a(EUCOMM)Hmgu 31141689
cGAS facilitates sensing of extracellular cyclic dinucleotides to activate innate immunity. EMBO reports (March 2019) Cgastm1d(EUCOMM)Hmgu 30872316
Autophagy induction via STING trafficking is a primordial function of the cGAS pathway. Nature (March 2019) Cgastm1a(EUCOMM)Hmgu 30842662
Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA. Cell (February 2019) Cgastm1a(EUCOMM)Hmgu 30827685
STING-associated lung disease in mice relies on T cells but not type I interferon. The Journal of allergy and clinical immunology (February 2019) Cgastm1d(EUCOMM)Hmgu 30772497
STING-dependent sensing of self-DNA drives silica-induced lung inflammation. Nature communications (December 2018) Cgastm1a(EUCOMM)Hmgu PMC6283886
Nuclear cGAS suppresses DNA repair and promotes tumorigenesis. Nature (October 2018) Cgastm1d(EUCOMM)Hmgu 30356214
ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING. The Journal of experimental medicine (September 2018) Cgastm1d(EUCOMM)Hmgu PMC6219748
Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis. Immunity (August 2018) Cgastm1d(EUCOMM)Hmgu PMC6347470
Species-Specific Deamidation of cGAS by Herpes Simplex Virus UL37 Protein Facilitates Viral Replication. Cell host & microbe (August 2018) Cgastm1d(EUCOMM)Hmgu PMC6094942
The cGAS/STING Pathway Is Important for Dendritic Cell Activation but Is Not Essential to Induce Protective Immunity against Mycobacterium tuberculosis Infection. Journal of innate immunity (May 2018) Cgastm1a(EUCOMM)Hmgu PMC6757162
Extrinsic Phagocyte-Dependent STING Signaling Dictates the Immunogenicity of Dying Cells. Cancer cell (April 2018) Cgastm1d(EUCOMM)Hmgu 29706455
IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation. Cell (March 2018) Cgastm1d(EUCOMM)Hmgu 29576451
Oral Antibiotic Treatment of Mice Exacerbates the Disease Severity of Multiple Flavivirus Infections. Cell reports (March 2018) Cgastm1d(EUCOMM)Hmgu PMC5908250
The cGAS/STING Pathway Detects Streptococcus pneumoniae but Appears Dispensable for Antipneumococcal Defense in Mice and Humans. Infection and immunity (February 2018) Cgastm1d(EUCOMM)Hmgu PMC5820968
cGAS-mediated control of blood-stage malaria promotes Plasmodium-specific germinal center responses. JCI insight (January 2018) Cgastm1d(EUCOMM)Hmgu PMC5821207
Brucella abortus Triggers a cGAS-Independent STING Pathway To Induce Host Protection That Involves Guanylate-Binding Proteins and Inflammasome Activation. Journal of immunology (Baltimore, Md. : 1950) (December 2017) Cgastm1d(EUCOMM)Hmgu PMC5760291
STING-Dependent Signaling Underlies IL-10 Controlled Inflammatory Colitis. Cell reports (December 2017) Cgastm1d(EUCOMM)Hmgu PMC6082386
cGAS drives noncanonical-inflammasome activation in age-related macular degeneration. Nature medicine (November 2017) Cgastm1d(EUCOMM)Hmgu PMC5760363
IRF3 and type I interferons fuel a fatal response to myocardial infarction. Nature medicine (November 2017) Cgastm1d(EUCOMM)Hmgu 29106401
STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum. Cell (October 2017) Cgastm1a(EUCOMM)Hmgu 29056340
A noncanonical function of cGAMP in inflammasome priming and activation. The Journal of experimental medicine (October 2017) Cgastm1c(EUCOMM)Hmgu Cgastm1a(EUCOMM)Hmgu Cgastm1d(EUCOMM)Hmgu PMC5716045
Mycobacterium tuberculosis is protected from NADPH oxidase and LC3-associated phagocytosis by the LCP protein CpsA. Proceedings of the National Academy of Sciences of the United States of America (September 2017) Cgastm1a(EUCOMM)Hmgu Cgastm1d(EUCOMM)Hmgu PMC5642705
Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein α Signaling. Immunity (August 2017) Cgastm1a(EUCOMM)Hmgu PMC5564225
Opposing roles of Toll-like receptor and cytosolic DNA-STING signaling pathways for Staphylococcus aureus cutaneous host defense. PLoS pathogens (July 2017) Cgastm1d(EUCOMM)Hmgu PMC5526579
cGAS is essential for cellular senescence. Proceedings of the National Academy of Sciences of the United States of America (May 2017) Cgastm1a(EUCOMM)Hmgu PMC5468617
cGAS is essential for the antitumor effect of immune checkpoint blockade. Proceedings of the National Academy of Sciences of the United States of America (January 2017) Cgastm1a(EUCOMM)Hmgu PMC5320994
Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS. Nature communications (November 2016) Cgastm1d(EUCOMM)Hmgu PMC5109551
Cross-Regulation of Two Type I Interferon Signaling Pathways in Plasmacytoid Dendritic Cells Controls Anti-malaria Immunity and Host Mortality. Immunity (October 2016) Cgastm1d(EUCOMM)Hmgu 27793594
The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA. Immunity (August 2016) Cgastm1a(EUCOMM)Hmgu PMC4988931
Vaginal Exposure to Zika Virus during Pregnancy Leads to Fetal Brain Infection. Cell (August 2016) Cgastm1d(EUCOMM)Hmgu PMC5006689
Restriction by SAMHD1 Limits cGAS/STING-Dependent Innate and Adaptive Immune Responses to HIV-1. Cell reports (July 2016) Cgastm1a(EUCOMM)Hmgu PMC4978700
AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity. Proceedings of the National Academy of Sciences of the United States of America (July 2016) Cgastm1d(EUCOMM)Hmgu PMC4987819
Diminished Innate Antiviral Response to Adenovirus Vectors in cGAS/STING-Deficient Mice Minimally Impacts Adaptive Immunity. Journal of virology (June 2016) Cgastm1d(EUCOMM)Hmgu PMC4907218
The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons. Immunity (March 2016) Cgastm1d(EUCOMM)Hmgu PMC4852885
Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response. The EMBO journal (February 2016) Cgastm1a(EUCOMM)Hmgu PMC4855687
RNase H2 catalytic core Aicardi-Goutières syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice. The Journal of experimental medicine (February 2016) Cgastm1a(EUCOMM)Hmgu PMC4813680
A cGAS-Independent STING/IRF7 Pathway Mediates the Immunogenicity of DNA Vaccines. Journal of immunology (Baltimore, Md. : 1950) (November 2015) Cgastm1d(EUCOMM)Hmgu PMC4685033
Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation. Immunity (August 2015) Cgastm1a(EUCOMM)Hmgu PMC4575271
Viruses transfer the antiviral second messenger cGAMP between cells. Science (New York, N.Y.) (July 2015) Cgastm1a(EUCOMM)Hmgu PMC4617605
Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi-Goutières Syndrome. Journal of immunology (Baltimore, Md. : 1950) (July 2015) Cgastm1a(EUCOMM)Hmgu PMC4546858
Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis. Cell host & microbe (June 2015) Cgastm1a(EUCOMM)Hmgu PMC4499468
The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy. Cell host & microbe (June 2015) Cgastm1d(EUCOMM)Hmgu PMC4466081
Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA. Cell (December 2014) Cgastm1a(EUCOMM)Hmgu PMC4272443
Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathway. PLoS pathogens (April 2014) Cgastm1a(EUCOMM)Hmgu PMC3990710
Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity. Nature (November 2013) Cgastm1c(EUCOMM)Hmgu Cgastm1a(EUCOMM)Hmgu Cgastm1d(EUCOMM)Hmgu PMC4077721
Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects. Science (New York, N.Y.) (August 2013) Cgastm1a(EUCOMM)Hmgu PMC3863637

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