Gene: Wdr59

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Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, complete penetrance Wdr59tm1b(EUCOMM)Wtsi HOM Early adult 0.00
prenatal lethality prior to heart atrial septation Wdr59tm1b(EUCOMM)Wtsi HOM E15.5 0.00
embryonic lethality prior to tooth bud stage Wdr59tm1b(EUCOMM)Wtsi HOM E12.5 0.00
decreased leukocyte cell number Wdr59tm1b(EUCOMM)Wtsi HET Early adult 8.26×10-08
abnormal embryo size Wdr59tm1b(EUCOMM)Wtsi HOM E12.5 0.00
decreased hematocrit Wdr59tm1b(EUCOMM)Wtsi HET Early adult 1.23×10-05
abnormal pericardium morphology Wdr59tm1b(EUCOMM)Wtsi HOM E12.5 0.00
decreased erythrocyte cell number Wdr59tm1b(EUCOMM)Wtsi HET Early adult 1.83×10-05
thrombocytopenia Wdr59tm1b(EUCOMM)Wtsi HET Early adult 4.27×10-06
abnormal heart morphology Wdr59tm1b(EUCOMM)Wtsi HOM E12.5 0.00
embryonic growth retardation Wdr59tm1b(EUCOMM)Wtsi HOM E12.5 0.00

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No N/A
Bone 2 No N/A
Brain 2 No N/A
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cecum 2 No  (12/379) N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (2/2)  Wholemount images
Large intestine 2 No  (10/584) N/A
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No N/A
Oral epithelium 2 No N/A
Ovary 2 No  (1/584) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584)  Wholemount images
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No N/A
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No N/A
Thyroid gland 2 No  (15/584)  Wholemount images
Trachea 2 No N/A
Trigeminal V nerve 2 No N/A
Uterus 2 No N/A
Vas deferens 2 No  (15/388)  Wholemount images
Vascular system 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 2  (1/57)  (2/2) N/A
Axial skeleton 2  (1/61) N/A
Brain 2  (6/504)  (2/2) N/A
Central nervous system ganglion 2  (1/70) N/A
Cranium 2  (1/61) N/A
Dorsal root ganglion 2  (1/57) N/A
Ear 2  (1/504) N/A
Embryo 2  (1/505)  (2/2) N/A
Outer ear 2  (1/66) N/A
Eye 2  (1/504) N/A
Femur pre-cartilage condensation 2  (1/52) N/A
Foot 2  (1/504) N/A
Forearm 2  (1/297) N/A
Forebrain 2  (1/504) N/A
Forelimb 2  (1/504) N/A
Fronto-nasal process 2  (1/58) N/A
Gut 2  (1/56) N/A
Hand 2  (1/503) N/A
Head 2  (5/504)  (2/2) N/A
Head mesenchyme 2  (1/57) N/A
Heart 2  (1/504)  (2/2) N/A
Heart ventricle 2  (1/57)  (2/2) N/A
Hindbrain 2  (6/504)  (2/2) N/A
Hindlimb 2  (1/503) N/A
Humerus pre-cartilage condensation 2  (1/61) N/A
Inner ear 2  (1/61) N/A
Intestine 2  (1/55) N/A
Liver 2  (1/504) N/A
Lower leg 2  (1/297) N/A
Lung 2  (1/500) N/A
Mandibular process 2  (1/504) N/A
Maxillary process 2  (1/504) N/A
Mesonephros of female 2  (1/52) N/A
Mesonephros of male 2  (1/52) N/A
Metanephros 2  (1/52) N/A
Midbrain 2  (1/504) N/A
Nasal septum 2  (1/57) N/A
Nose 2  (1/70) N/A
Notochord 2  (1/57) N/A
Oral cavity 2  (1/504) N/A
Outflow tract 2  (1/57) N/A
Pancreas 2  (1/52) N/A
Pericardium 2  (1/52) N/A
Pharynx 2  (1/52) N/A
Radius-ulna pre-cartilage condensation 2  (1/61) N/A
Rib pre-cartilage condensation 2  (1/54) N/A
Skeleton 2  (1/70) N/A
Skin 2  (1/504) N/A
Spinal cord 2  (1/69) N/A
Stomach 2  (1/52) N/A
Tail 2  (1/504) N/A
Tail somite 2  (1/504) N/A
Thoracic vertebral cartilage condensation 2  (1/52) N/A
Tongue 2  (1/52) N/A
Trachea 2  (1/56) N/A
Trunk mesenchyme 2  (1/57) N/A
Umbilical artery embryonic part 2  (1/57) N/A
Umbilical vein embryonic part 2  (1/57) N/A
Upper arm 2  (1/297) N/A
Upper leg 2  (1/297) N/A
Urinary system 2  (1/56) N/A
Vibrissa 2  (1/66) N/A

 Associated Images

Adult LacZ: LacZ Images Wholemount
4 Images
X-ray: XRay Images Whole Body Dorso Ventral
10 Images
X-ray: XRay Images Forepaw
10 Images
X-ray: XRay Images Skull Lateral Orientation
10 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
Embryo LacZ: LacZ images wholemount
4 Images
X-ray: XRay Images Whole Body Lateral Orientation
10 Images
Legacy Phenotype Associated Images

View all 15 images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Wdr59tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue
Wdr59tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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