Gene Summary

leucine-rich repeat-containing G protein-coupled receptor 6

IMPC Data Collections

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal digit morphology Lgr6em1(IMPC)Ccpcz HOM   Early adult 1.77×10-06
abnormal heart morphology Lgr6em1(IMPC)Ccpcz HOM Early adult 0.00
abnormal tooth morphology Lgr6em1(IMPC)Ccpcz HOM Early adult 0.00
abnormal eye morphology Lgr6em1(IMPC)Ccpcz HOM Early adult 0.00
abnormal skin morphology Lgr6em1(IMPC)Ccpcz HOM Early adult 0.00
abnormal thymus morphology Lgr6em1(IMPC)Ccpcz HOM Early adult 0.00
abnormal spleen morphology Lgr6em1(IMPC)Ccpcz HOM Early adult 0.00
enlarged heart Lgr6em1(IMPC)Ccpcz HOM Early adult 0.00
enlarged thymus Lgr6em1(IMPC)Ccpcz HOM Early adult 0.00

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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.


XRay Images Forepaw

14 Images


XRay Images Whole Body Dorso Ventral

28 Images


XRay Images Skull Dorso Ventral Orientation

14 Images


XRay Images Skull Lateral Orientation

14 Images


XRay Images Hind Leg and Hip

28 Images


XRay Images Whole Body Lateral Orientation

14 Images

Human diseases caused by Lgr6 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Lgr6 by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Anonychia-Microcephaly Syndrome
Carious teeth, Abnormality of the dentition, Bilateral single transverse palmar creases, Clinodac... ORPHA:1094
Regional Odontodysplasia
Carious teeth, Abnormal dental enamel morphology, Delayed eruption of teeth, Short dental root, A... ORPHA:83450
Cardiomegaly OMIM:227150
Amelogenesis Imperfecta
Widely spaced teeth, Yellow-brown discoloration of the teeth, Hypomature dental enamel, Hypocalci... ORPHA:88661
Metaphyseal Chondrodysplasia, Spahr Type
Carious teeth, Short lower limbs, Genu varum, Metaphyseal dysplasia, Abnormality of epiphysis mor... ORPHA:2501
Ectodermal Dysplasia-Syndactyly Syndrome 2
Palmoplantar keratoderma, Cardiomegaly, Enamel hypoplasia, Syndactyly, Thin upper lip vermilion OMIM:613576
Amelogenesis Imperfecta, Hypomaturation Type, Iia1
Carious teeth, Anterior open-bite malocclusion, Abnormal dental enamel morphology, Amelogenesis i... OMIM:204700
Spondyloepimetaphyseal Dysplasia With Abnormal Dentition
Broad femoral neck, Small epiphyses, Discolored lateral incisors, Oligodontia, Tapered finger, Me... OMIM:601668
Agenesis of mandibular premolar, Oligodontia, Delayed eruption of teeth, Short dental root, Agene... ORPHA:99798
Dentinogenesis Imperfecta
Yellow-brown discoloration of the teeth, Hypocalcification of dental enamel, Pulp obliteration, G... ORPHA:49042
Amelogenesis Imperfecta, Type Ij
Carious teeth, Widely spaced teeth, Amelogenesis imperfecta, Increased overbite, Enamel hypoplasia OMIM:617297
Carious teeth, Micrognathia, Hypodontia, Delayed eruption of permanent teeth, Abnormality of pelv... OMIM:265800
Dentin Dysplasia, Type I
Microdontia, Periapical bone loss, Pulp obliteration, Abnormality of dental morphology, Taurodont... OMIM:125400
Pyle Disease
Carious teeth, Metaphyseal dysplasia, Hypoplastic frontal sinuses, Mandibular prognathia, Metaphy... OMIM:265900
Amelogenesis Imperfecta, Hypomaturation Type, Iia5
Carious teeth, Amelogenesis imperfecta OMIM:615887
Lethal Congenital Contracture Syndrome 10
Micrognathia, High palate, Ventricular septal defect, Adducted thumb, Talipes equinovarus, Long p... OMIM:617022
Ectodermal Dysplasia Syndrome With Distinctive Facial Appearance And Preaxial Polydactyly Of Feet
Carious teeth, Micrognathia, Smooth philtrum, Midline notch of upper alveolar ridge, Malar flatte... OMIM:129540
Mulibrey Nanism
Hepatomegaly, Hypodontia, Pericardial constriction, Hypoplastic frontal sinuses, Thickened cortex... OMIM:253250
Rubinstein-Taybi Syndrome 2
Carious teeth, Micrognathia, High palate, Narrow palate, Increased overbite, Syndactyly, Broad ha... OMIM:613684
Infantile Sialic Acid Storage Disease
Hepatomegaly, High palate, Vacuolated lymphocytes, Metaphyseal irregularity, Gingival overgrowth,... OMIM:269920
Cantu Syndrome
Thick lower lip vermilion, Bicuspid aortic valve, Pericardial effusion, Long philtrum, Metaphysea... OMIM:239850
Timothy Syndrome
Ventricular septal defect, Microdontia, Cardiomegaly, Syndactyly, Tetralogy of Fallot, Thin upper... OMIM:601005
Taurodontism, Microdontia, And Dens Invaginatus
Dens in dente, Pulp calcification, Taurodontia, Microdontia OMIM:313490
Eem Syndrome
Carious teeth, Widely spaced teeth, Microdontia, Finger syndactyly, Selective tooth agenesis, Abn... ORPHA:1897
Congenital Toxoplasmosis
Hepatomegaly, Lymphadenopathy, Anemia, Cardiomegaly, Thrombocytopenia, Jaundice ORPHA:858
Histiocytosis-Lymphadenopathy Plus Syndrome
Hallux valgus, Pancreatic hypoplasia, Lymphadenopathy, Splenomegaly, Hepatosplenomegaly, Camptoda... OMIM:602782
Neurooculocardiogenitourinary Syndrome
Ventricular septal defect, Smooth philtrum, Cardiomegaly, Downturned corners of mouth, Bilateral ... OMIM:618652
X-Linked Intellectual Disability-Cardiomegaly-Congestive Heart Failure Syndrome
Macroorchidism, Smooth philtrum, Mitral valve prolapse, Mandibular prognathia, Cardiomegaly, Abno... ORPHA:324410
Otodental Syndrome
Carious teeth, Pulp calcification, Long philtrum, Odontoma, Abnormal dental enamel morphology, Gi... ORPHA:2791
Short-Rib Thoracic Dysplasia 16 With Or Without Polydactyly
Carious teeth, Widely spaced teeth, Postaxial polydactyly, Short metatarsal, Limb undergrowth, Sa... OMIM:617102
Amelogenesis Imperfecta, Type Ih
Amelogenesis imperfecta, Enamel hypoplasia, Anterior open-bite malocclusion, Dental enamel pits, ... OMIM:616221
Symphalangism, Distal, With Microdontia, Dental Pulp Stones, And Narrowed Zygomatic Arch
Cone-shaped epiphyses of the middle phalanges of the hand, Short middle phalanx of finger, Pulp c... OMIM:606895
Myopathy, Congenital, With Structured Cores And Z-Line Abnormalities
High palate, Cardiomegaly OMIM:618654
Neuraminidase Deficiency
Hepatomegaly, Epiphyseal stippling, Vacuolated lymphocytes, Bone-marrow foam cells, Cardiomegaly,... OMIM:256550
Osteopetrosis, Autosomal Recessive 2
Carious teeth, Thrombocytopenia, Mandibular prognathia, Anemia, Diaphyseal sclerosis, Genu valgum... OMIM:259710
Intellectual Developmental Disorder, X-Linked, Syndromic 32
Macroorchidism, Cardiomegaly OMIM:300886
Isolated Anencephaly
Cleft lip, Thymus hyperplasia ORPHA:563609
Oslam Syndrome
Carious teeth, Increased mean corpuscular volume, Clinodactyly of the 5th finger, Abnormality of ... ORPHA:2760
Lethal Acantholytic Erosive Disorder
Cleft palate, 3-4 finger syndactyly, 2-3 finger syndactyly, Cardiomegaly, Cardiomyopathy, 4-5 fin... ORPHA:158687
Hypophosphatemic Rickets, Autosomal Recessive, 2
Carious teeth, Genu varum, Genu valgum, Pulmonic stenosis, Coxa valga, Hypoplasia of teeth OMIM:613312
Orofaciodigital Syndrome Type 2
Cleft palate, Hamartoma of tongue, Unilateral alveolar cleft of maxilla, Finger syndactyly, Broad... ORPHA:2751
Combined Oxidative Phosphorylation Deficiency 33
Left ventricular hypertrophy, Hepatomegaly, Cardiomegaly, Cardiomyopathy OMIM:617713
Orofaciodigital Syndrome Type 5
High, narrow palate, Hypodontia, Agenesis of canine, Absent cupid's bow, Abnormality of the philt... ORPHA:2919
Amelogenesis Imperfecta, Type Ic
Yellow-brown discoloration of the teeth, Enamel hypomineralization, Anterior open-bite malocclusi... OMIM:204650
Familial Atrial Myxoma
Bacterial endocarditis, Cardiac myxoma, Cardiomegaly, Cholestasis, Pulmonic valve myxoma, Jaundice ORPHA:615
Amelogenesis Imperfecta, Type Iiic
Yellow-brown discoloration of the teeth, Anterior open-bite malocclusion, Hypocalcification of de... OMIM:618386
Crisponi/Cold-Induced Sweating Syndrome 1
Carious teeth, Micrognathia, High palate, Adducted thumb, Talipes equinovarus, Long philtrum, Tap... OMIM:272430
Greenberg Dysplasia
Epiphyseal stippling, Malar flattening, Hepatosplenomegaly, Abnormal ossification involving the f... OMIM:215140
Obesity-Colitis-Hypothyroidism-Cardiac Hypertrophy-Developmental Delay Syndrome
Cardiomegaly ORPHA:88643
Cleidocranial Dysplasia
Sinusitis, Carious teeth, Cleft palate, Abnormal dental enamel morphology, Delayed eruption of te... ORPHA:1452
Oculodentodigital Dysplasia, Autosomal Recessive
Macrodontia of permanent maxillary central incisor, Micrognathia, Broad long bones, Long philtrum... OMIM:257850
Thoc6-Related Developmental Delay-Microcephaly-Facial Dysmorphism Syndrome
Carious teeth, Smooth philtrum, Abnormal heart morphology, Velopharyngeal insufficiency, Thick up... ORPHA:363444
Spondylometaphyseal Dysplasia, Megarbane-Dagher-Melki Type
Metaphyseal cupping, Cardiomegaly, Deep philtrum, Iliac crest serration, Hypoplastic ischia, Shor... OMIM:613320
Amelogenesis Imperfecta, Type If
Dental enamel pits, Abnormality of dental color, Enamel hypoplasia, Amelogenesis imperfecta OMIM:616270
Hypertrichotic Osteochondrodysplasia, Cantu Type
Hypertrophic cardiomyopathy, Broad hallux phalanx, Wide mouth, Long philtrum, Cardiomegaly, Abnor... ORPHA:1517
Hemochromatosis, Type 1
Testicular atrophy, Hepatomegaly, Hepatocellular carcinoma, Cardiomegaly, Cardiomyopathy, Splenom... OMIM:235200
Multiple Joint Dislocations, Short Stature, And Craniofacial Dysmorphism With Or Without Congenital Heart Defects
Hallux valgus, Bicuspid aortic valve, Cleft palate, Talipes equinovarus, Spatulate thumbs, Broad ... OMIM:245600
Amelo-Onycho-Hypohidrotic Syndrome
Abnormal dental enamel morphology, Advanced eruption of teeth, Delayed eruption of teeth, Abnorma... ORPHA:1028
Mucopolysaccharidosis, Type Iva
Carious teeth, Widely spaced teeth, Epiphyseal deformities of tubular bones, Hepatomegaly, Wide m... OMIM:253000
Osteochondrodysplasia, Complex Lethal, Symoens-Barnes-Gistelinck Type
Hypertrophic cardiomyopathy, Micrognathia, Cleft palate, Ventricular septal defect, Adducted thum... OMIM:616897
Distal Trisomy 5Q
Carious teeth, Dextrocardia, Micrognathia, Ventricular septal defect, Long philtrum, Aplasia/Hypo... ORPHA:96097
Amelogenesis Imperfecta, Type Iv
Taurodontia, Yellow-brown discoloration of the teeth, Enamel hypoplasia, Amelogenesis imperfecta OMIM:104510
Carious teeth, Obtuse angle of mandible, Hepatosplenomegaly, Hypoplasia of the maxilla, Micrognat... ORPHA:763
Craniofaciofrontodigital Syndrome
Palmoplantar cutis laxa, Long philtrum, Abnormal heart morphology, Cubitus valgus, Cardiomegaly, ... OMIM:114620
Carnitine Deficiency, Systemic Primary
Hypertrophic cardiomyopathy, Decreased carnitine level in liver, Hepatomegaly, Endocardial fibroe... OMIM:212140
Mucopolysaccharidosis, Type Iiib
Hepatomegaly, Cardiomegaly, Asymmetric septal hypertrophy, Splenomegaly OMIM:252920
Heterotaxy, Visceral, 1, X-Linked
Dextrocardia, Ventricular septal defect, Abdominal situs inversus, Asplenia, Mitral atresia, Doub... OMIM:306955
Craniometadiaphyseal Dysplasia
Carious teeth, High palate, Genu varum, Microdontia, Broad long bones, Mandibular prognathia, Cub... OMIM:269300
Acrocallosal Syndrome
Smooth philtrum, Cleft palate, Finger syndactyly, Microretrognathia, Triangular mouth, Toe syndac... OMIM:200990
Congenitally Uncorrected Transposition Of The Great Arteries
Hepatomegaly, Ventricular septal defect, Biventricular hypertrophy, Abnormal mitral valve morphol... ORPHA:860
Mucolipidosis Ii Alpha/Beta
Hypertrophic cardiomyopathy, Hepatomegaly, Talipes equinovarus, Long philtrum, Macroglossia, Prog... OMIM:252500
Marfanoid Habitus-Autosomal Recessive Intellectual Disability Syndrome
High palate, Malar flattening, Arachnodactyly, Cardiomegaly, Increased arm span, Thin metatarsal ... ORPHA:2463
Orofaciodigital Syndrome I
Carious teeth, Cleft palate, Syndactyly, Microretrognathia, Agenesis of permanent teeth, High pal... OMIM:311200
Naegeli-Franceschetti-Jadassohn Syndrome
Carious teeth, Interphalangeal joint contracture of finger, Premature loss of teeth, Supernumerar... ORPHA:69087
Acrofacial Dysostosis, Catania Type
Carious teeth, Abnormal palate morphology, Smooth philtrum, Hypoplasia of the zygomatic bone, Sma... ORPHA:1786
Exocrine Pancreatic Insufficiency, Dyserythropoietic Anemia, And Calvarial Hyperostosis
Carious teeth, Hepatomegaly, Anemia, Splenomegaly, Jaundice, Exocrine pancreatic insufficiency, A... OMIM:612714
Sickle Cell Anemia
Leukocytosis, Hepatomegaly, Cardiomegaly, Cholelithiasis, Splenomegaly, Increased red cell sickli... OMIM:603903
Thick lower lip vermilion, Hepatomegaly, Macroglossia, Vacuolated lymphocytes, Absent/hypoplastic... OMIM:230000
Proteus-Like Syndrome
Thymus hyperplasia, Open bite, Mandibular prognathia, Polycystic ovaries, Splenomegaly, Abnormali... ORPHA:2969
Gaucher Disease, Type Iiic
Hepatomegaly, Mitral valve calcification, Cardiomegaly, Mitral stenosis, Splenomegaly, Aortic val... OMIM:231005
Developmental And Epileptic Encephalopathy 95
Widely spaced teeth, Hepatomegaly, Macroglossia, Gingival overgrowth, Cardiomegaly, Deep philtrum... OMIM:618143
Attrv122I Amyloidosis
Hypertrophic cardiomyopathy, Cardiac amyloidosis, Restrictive cardiomyopathy, Anemia, Cardiomegal... ORPHA:85451
Pseudo-Torch Syndrome 3
Leukocytosis, Lymphadenitis, Anemia, Cardiomegaly, Congenital thrombocytopenia OMIM:618886
Attrv30M Amyloidosis
Cardiomegaly, Cardiomyopathy ORPHA:85447
Singleton-Merten Syndrome 1
Carious teeth, Smooth philtrum, Talipes equinovarus, Mitral valve calcification, Hypoplasia of th... OMIM:182250
Carnitine Palmitoyltransferase Ii Deficiency, Lethal Neonatal
Dilated cardiomyopathy, Hepatomegaly, Hepatic calcification, High palate, Tapered finger, Lipid a... OMIM:608836
Carnitine Palmitoyltransferase Ii Deficiency, Infantile
Dilated cardiomyopathy, Hepatomegaly, Cardiomegaly, Macrovesicular hepatic steatosis OMIM:600649
Dentin Dysplasia, Type Ii
Abnormal dentin morphology, Dentinogenesis imperfecta limited to primary teeth, Pulp calcification OMIM:125420
Symptomatic Form Of Hemochromatosis Type 1
Testicular atrophy, Hepatomegaly, Cholangiocarcinoma, Hepatocellular carcinoma, Cardiomegaly, Car... ORPHA:465508
Cardiomyopathy, Familial Hypertrophic, 4
Hypertrophic cardiomyopathy, Hepatomegaly, Pericardial effusion, Ventricular hypertrophy, Cardiom... OMIM:115197
Craniofaciofrontodigital Syndrome
Bicuspid aortic valve, Ventricular septal defect, Palmoplantar cutis laxa, Pericardial effusion, ... ORPHA:363705
Yunis-Varon Syndrome
Short middle phalanx of finger, Syndactyly, Broad secondary alveolar ridge, Short toe, Abnormal p... ORPHA:3472
Gaucher Disease, Perinatal Lethal
Hepatomegaly, Micrognathia, Everted upper lip vermilion, Anemia, Cardiomegaly, Splenomegaly, Hepa... OMIM:608013
Myopathy, Epilepsy, And Progressive Cerebral Atrophy
Micrognathia, Thymus hyperplasia, Arachnodactyly, Talipes equinovarus OMIM:619036
Cardiomyopathy, Familial Hypertrophic 27
Cardiomegaly OMIM:618052
Combined Oxidative Phosphorylation Deficiency 41
Cardiomegaly, Anemia OMIM:618838
Alpha-N-Acetylgalactosaminidase Deficiency
Cardiomegaly, Thick vermilion border ORPHA:3137
Hepatomegaly, High palate, Cardiomegaly, Left ventricular hypertrophy, Hepatosplenomegaly, Overla... ORPHA:79330
Mitochondrial Complex Iv Deficiency, Nuclear Type 20
Hepatomegaly, Cardiomegaly OMIM:619064
Beck-Fahrner Syndrome
Ventricular septal defect, High palate, Long philtrum, Cardiomegaly, Hip dysplasia, Open mouth OMIM:618798
Congenital Tricuspid Valve Dysplasia
Hepatomegaly, Pericardial effusion, Right ventricular hypertrophy, Cardiomegaly, Tricuspid valve ... ORPHA:555874
Intellectual Developmental Disorder, X-Linked, Syndromic 34
Hallux valgus, Malar flattening, Submucous cleft soft palate, Ventricular septal defect, Drooling... OMIM:300967
Mitochondrial Complex I Deficiency, Nuclear Type 36
Perimembranous ventricular septal defect, Cardiomegaly OMIM:619170
Fixed Subaortic Stenosis
Bicuspid aortic valve, Ventricular septal defect, Bacterial endocarditis, Atrioventricular canal ... ORPHA:3092
Idiopathic Pulmonary Hemosiderosis
Iron deficiency anemia, Hepatomegaly, Hepatosplenomegaly, Cardiomegaly ORPHA:99931
Isolated Right Ventricular Hypoplasia
Cardiomegaly, Clubbing, Right atrial enlargement, Atrial septal defect, Muscular ventricular sept... ORPHA:439
Danon Disease
Hypertrophic cardiomyopathy, Dilated cardiomyopathy, Cardiomegaly, Myocardial necrosis, Myocardia... OMIM:300257
Refsum Disease, Classic
Short fourth metatarsal, Cardiomegaly, Cardiomyopathy OMIM:266500
Glycogen Storage Disease Ii
Macroglossia, Hepatomegaly, Cardiomegaly, Splenomegaly OMIM:232300
Shwachman-Diamond Syndrome
Carious teeth, Sinusitis, Neutropenia, Pancreatic hypoplasia, Leukemia, Metaphyseal irregularity,... ORPHA:811
Congenital Disorder Of Glycosylation, Type It
Dilated cardiomyopathy, Hepatomegaly, Micrognathia, Cleft palate, Ventricular septal defect, Pier... OMIM:614921
Carnitine Palmitoyltransferase I Deficiency
Hepatomegaly, Cardiomegaly, Hepatic steatosis OMIM:255120
Camurati-Engelmann Disease
Carious teeth, Cortical thickening of long bone diaphyses, Abnormality of the ulna, Metaphyseal d... ORPHA:1328
Mitochondrial Complex Iv Deficiency, Nuclear Type 7
Hypertrophic cardiomyopathy, Ventricular hypertrophy, Cardiomegaly OMIM:619051
Acyl-Coa Dehydrogenase, Very Long-Chain, Deficiency Of
Hypertrophic cardiomyopathy, Hepatomegaly, Hepatocellular necrosis, Cardiomegaly, Hepatic steatos... OMIM:201475
Corneodermatoosseous Syndrome
Carious teeth, Palmoplantar keratoderma, Abnormal dental enamel morphology, Abnormality of finger... ORPHA:3194
Coronary Arterial Fistula
Bicuspid aortic valve, Bacterial endocarditis, Right ventricular dilatation, Abnormal heart morph... ORPHA:2041
Eec Syndrome
Carious teeth, Toe syndactyly, Cleft palate, Microdontia, Xerostomia, Aplasia/Hypoplasia of the t... ORPHA:1896
Fibrosis, Neurodegeneration, And Cerebral Angiomatosis
Hepatomegaly, Hepatocellular necrosis, Cardiomegaly, Anisocytosis, Poikilocytosis, Chronic hemoly... OMIM:618278
Medium Chain Acyl-Coa Dehydrogenase Deficiency
Hepatic steatosis, Cardiomegaly, Hepatomegaly ORPHA:42
Abnormality of the dentition, Cardiomegaly, Hepatomegaly, Abnormality of the gallbladder ORPHA:349
Sandhoff Disease
Macroglossia, Hepatomegaly, Hepatosplenomegaly, Cardiomegaly OMIM:268800
Bohring-Opitz Syndrome
Micrognathia, Cleft palate, Bilateral wrist flexion contracture, Annular pancreas, Prominent pala... ORPHA:97297
Proteasome-Associated Autoinflammatory Syndrome 1
Thick lower lip vermilion, Hallux valgus, Hepatomegaly, Flexion contracture of toe, Hypoplastic s... OMIM:256040
Paternal Uniparental Disomy Of Chromosome 6
Hepatomegaly, Micrognathia, High palate, Ventricular septal defect, Macroglossia, Gingival overgr... ORPHA:96191
Truncus Arteriosus
Ventricular septal defect, Truncus arteriosus, Right ventricular hypertrophy, Abnormal heart morp... ORPHA:3384
Aorta Coarctation
Bicuspid aortic valve, Perimembranous ventricular septal defect, Cardiomegaly, Abnormal left vent... ORPHA:1457
Proteus Syndrome
Carious teeth, Hallux valgus, Ovarian neoplasm, Sirenomelia, Thymus hyperplasia, Neoplasm of the ... ORPHA:744
Mucopolysaccharidosis Type 3
Hepatomegaly, Abnormal mitral valve morphology, Macroglossia, Abnormal aortic valve morphology, A... ORPHA:581
Hsd10 Disease, Infantile Type
Hypertrophic cardiomyopathy, Cardiomegaly ORPHA:391428
Glycogen Storage Disease Of Heart, Lethal Congenital
Macroglossia, Cardiomyopathy, Cardiomegaly, Biventricular hypertrophy OMIM:261740
Amyloidosis, Hereditary, Transthyretin-Related
Cardiomegaly, Cardiomyopathy OMIM:105210
Dysferlin-Related Limb-Girdle Muscular Dystrophy R2
Right ventricular hypertrophy, Cardiomegaly, Proximal muscle weakness in upper limbs, Scapular wi... ORPHA:268
Cirrhotic Cardiomyopathy
Left atrial enlargement, Hepatomegaly, Cardiomegaly, Left ventricular hypertrophy, Cirrhosis, Rig... ORPHA:57777
Complete Atrioventricular Septal Defect
Complete atrioventricular canal defect, Primum atrial septal defect, Hepatomegaly, Displacement o... ORPHA:1329
Glycogen Storage Disease Due To Acid Maltase Deficiency, Infantile Onset
Hypertrophic cardiomyopathy, Hepatomegaly, Macroglossia, Cardiomegaly, Left ventricular hypertrop... ORPHA:308552
Carnitine Palmitoyl Transferase Ii Deficiency, Neonatal Form
High, narrow palate, Hepatic calcification, Hepatomegaly, Cardiomegaly, Cardiomyopathy, Hepatic s... ORPHA:228308
Familial Aortic Dissection
Cardiomegaly ORPHA:229
Neurodegeneration With Ataxia And Late-Onset Optic Atrophy
Cardiomegaly, Cardiomyopathy, Increased hepatic glycogen content OMIM:619259
Lacrimoauriculodentodigital Syndrome
Carious teeth, Radial deviation of the 3rd finger, Hypoplasia of the radius, Broad hallux, 2-3 fi... OMIM:149730
Naxos Disease
Dilated cardiomyopathy, Abnormal morphology of right ventricular trabeculae, Palmoplantar keratod... OMIM:601214
Familial Thoracic Aortic Aneurysm And Aortic Dissection
High, narrow palate, Bicuspid aortic valve, Cardiomegaly, Arachnodactyly, Retrognathia ORPHA:91387
Williams Syndrome
Carious teeth, Hallux valgus, Bicuspid aortic valve, Abnormal dental enamel morphology, Overridin... ORPHA:904
Hepatomegaly, Hepatic fibrosis, Talipes equinovarus, Acanthocytosis, Cardiomegaly, Anemia, Cirrho... ORPHA:14
Leigh Syndrome With Nephrotic Syndrome
Cardiomegaly ORPHA:255249
Beckwith-Wiedemann Syndrome
Hypertrophic cardiomyopathy, Hepatomegaly, Cleft palate, Wide mouth, Macroglossia, Mandibular pro... ORPHA:116
Alpha-N-Acetylgalactosaminidase Deficiency Type 2
Telangiectasia of the oral mucosa, Cardiomegaly, Thick vermilion border, Lip telangiectasia ORPHA:79280
Beckwith-Wiedemann Syndrome
Hepatomegaly, Macroglossia, Cardiomegaly, Cardiomyopathy, Hepatoblastoma, Pancreatic hyperplasia,... OMIM:130650
Familial Idiopathic Dilatation Of The Right Atrium
Hepatomegaly, Atrial septal dilatation, Right ventricular hypertrophy, Cardiomegaly, Right atrial... ORPHA:1677
Histiocytoid Cardiomyopathy
Hepatomegaly, Ventricular septal defect, Cleft palate, Polycystic ovaries, Cardiomegaly ORPHA:137675
Absence Of The Pulmonary Artery
Truncus arteriosus, Abnormal heart morphology, Cardiomegaly, Atrial septal defect, Tetralogy of F... ORPHA:980
Enamel-Renal Syndrome
Gingival overgrowth, Abnormal dental enamel morphology, Amelogenesis imperfecta, Delayed eruption... ORPHA:1031
Glycogen Storage Disease Due To Acid Maltase Deficiency
Hypertrophic cardiomyopathy, Hepatomegaly, Macroglossia, Impaired mastication, Cardiomegaly, Left... ORPHA:365
Tropical Endomyocardial Fibrosis
Left atrial enlargement, Hepatomegaly, Myocardial calcification, Endocardial fibrosis, Coronary a... ORPHA:75565
Aicardi-Goutières Syndrome
Hypertrophic cardiomyopathy, Chronic lymphatic leukemia, Cardiomegaly, Hepatosplenomegaly, Neonat... ORPHA:51
Congenital Tracheomalacia
Ventricular septal defect, Abnormal heart morphology, Single ventricle, Cardiomegaly, Atrial sept... ORPHA:95430
Congenital Total Pulmonary Venous Return Anomaly
Dextrocardia, Hepatomegaly, Ventricular septal defect, Mixed total anomalous pulmonary venous con... ORPHA:99125
Generalized Arterial Calcification Of Infancy
Abnormal calcification of the carpal bones, Stippled calcification of the shoulder, Stippled calc... ORPHA:51608


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Lgr6

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Lgr6.

No publications found that use IMPC mice or data for Lgr6.

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MGI Allele Allele Type Produced
Lgr6em1(IMPC)Ccpcz Inter-exon deletion Mice
Lgr6tm102274(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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