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Gene: Lgr6 MGI:2441805

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Gene Summary

Name:
leucine-rich repeat-containing G protein-coupled receptor 6
Synonyms:
A530037C04Rik

Order Alleles

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal spleen morphology Lgr6em1(IMPC)Ccpcz HOM Early adult 0.00
enlarged thymus Lgr6em1(IMPC)Ccpcz HOM Early adult 0.00
abnormal thymus morphology Lgr6em1(IMPC)Ccpcz HOM Early adult 0.00
abnormal heart morphology Lgr6em1(IMPC)Ccpcz HOM Early adult 0.00
abnormal skin morphology Lgr6em1(IMPC)Ccpcz HOM Early adult 0.00
abnormal tooth morphology Lgr6em1(IMPC)Ccpcz HOM Early adult 0.00
increased lymphocyte cell number Lgr6em1(IMPC)Ccpcz HOM   Early adult 6.07×10-05
abnormal eye morphology Lgr6em1(IMPC)Ccpcz HOM Early adult 0.00
enlarged heart Lgr6em1(IMPC)Ccpcz HOM Early adult 0.00

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

17 Images

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X-ray

XRay Images Whole Body Dorso Ventral

34 Images

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X-ray

XRay Images Forepaw

17 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

17 Images

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X-ray

XRay Images Skull Lateral Orientation

17 Images

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X-ray

XRay Images Hind Leg and Hip

34 Images

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Human diseases caused by Lgr6 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Lgr6 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Regional Odontodysplasia
Carious teeth, Multiple unerupted teeth, Tooth abscess, Abnormality of dental color, Short dental... ORPHA:83450
Ethanolaminosis
Cardiomegaly OMIM:227150
Persistent Polyclonal B-Cell Lymphocytosis
Hepatomegaly, Lymphocytosis, Splenomegaly OMIM:606445
Amelogenesis Imperfecta
Yellow-brown discoloration of the teeth, Widely spaced teeth, Enamel hypomineralization, Anterior... ORPHA:88661
Ras-Associated Autoimmune Leukoproliferative Disorder
Pancytopenia, Splenomegaly, Follicular hyperplasia, Hepatomegaly, Lymphocytosis, Neutropenia, Mon... OMIM:614470
Dentin Dysplasia, Type I
Periapical bone loss, Oligodontia, Taurodontia, Microdontia, Enamel hypoplasia, Pulp obliteration... OMIM:125400
Aicardi-Goutieres Syndrome 2
Lymphocytosis OMIM:610181
Oligodontia
Short dental root, Agenesis of mandibular premolar, Abnormality of canine, Peg-shaped maxillary l... ORPHA:99798
Cardiomyopathy, Dilated, 1I
Cardiomegaly, Dilated cardiomyopathy OMIM:604765
Mitochondrial Complex I Deficiency, Nuclear Type 39
Hypertrophic cardiomyopathy, Cryptorchidism, Cardiomegaly, Perimembranous ventricular septal defe... OMIM:620135
Infantile Sialic Acid Storage Disease
Gingival overgrowth, Splenomegaly, Cardiomegaly, Hepatomegaly, Vacuolated lymphocytes, High palate OMIM:269920
Dentinogenesis Imperfecta
Abnormal dental pulp morphology, Yellow-brown discoloration of the teeth, Generalized hypoplasia ... ORPHA:49042
Amelogenesis Imperfecta, Type Ij
Carious teeth, Widely spaced teeth, Increased overbite, Amelogenesis imperfecta, Enamel hypoplasi... OMIM:617297
Congenital Toxoplasmosis
Cardiomegaly, Hepatomegaly, Lymphadenopathy, Thrombocytopenia, Anemia, Jaundice ORPHA:858
Mulibrey Nanism
Microglossia, Dental malocclusion, Dental crowding, Cardiomegaly, Absent frontal sinuses, Hypodon... OMIM:253250
Ectodermal Dysplasia-Syndactyly Syndrome 2
Cardiomegaly, Enamel hypoplasia, Thin upper lip vermilion OMIM:613576
T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency
Decreased proportion of CD8-positive T cells, Lymphopenia, Hepatosplenomegaly, Decreased proporti... ORPHA:169154
Lymphoproliferative Syndrome, X-Linked, 1
Abnormal T cell count, Aplastic anemia, Hemophagocytosis, Pancytopenia, Abnormal B cell count, Sp... OMIM:308240
Amelogenesis Imperfecta, Hypomaturation Type, Iia1
Carious teeth, Yellow-brown discoloration of the teeth, Enamel hypomineralization, Amelogenesis i... OMIM:204700
Ciliary Dyskinesia, Primary, 53
Polysplenia, Abdominal situs inversus, Situs inversus totalis, Patent foramen ovale, Chronic sinu... OMIM:620642
Isolated Anencephaly
Cleft lip, Thymus hyperplasia ORPHA:563609
Sickle Cell Disease
Splenic infarction, Cholelithiasis, Increased red cell sickling tendency, Leukocytosis, Splenomeg... OMIM:603903
Neuraminidase Deficiency
Cardiomyopathy, Splenomegaly, Cardiomegaly, Hepatomegaly, Vacuolated lymphocytes, Bone-marrow foa... OMIM:256550
Amelogenesis Imperfecta, Type Ic
Yellow-brown discoloration of the teeth, Enamel hypomineralization, Taurodontia, Amelogenesis imp... OMIM:204650
Otodental Syndrome
Abnormality of canine, Abnormal dental pulp morphology, Carious teeth, Periodontitis, Abnormal mo... ORPHA:2791
Immunodeficiency 112
Reduced natural killer cell count, Increased T cell count, Decreased proportion of class-switched... OMIM:620449
Amelogenesis Imperfecta, Type Ih
Dental enamel pits, Yellow-brown discoloration of the teeth, Amelogenesis imperfecta, Enamel hypo... OMIM:616221
Neurooculocardiogenitourinary Syndrome
Downturned corners of mouth, Bilateral cryptorchidism, Patent foramen ovale, Ventricular septal d... OMIM:618652
Congenital Myopathy 8
Cardiomegaly, High palate OMIM:618654
Acquired Partial Lipodystrophy
Lymphocytosis, Hepatic steatosis ORPHA:79087
Uruguay Faciocardiomusculoskeletal Syndrome
Ventricular hypertrophy, Retrognathia, Cardiomyopathy, Hyperplasia of the maxilla, Hypertrophic c... OMIM:300280
Intellectual Developmental Disorder, X-Linked, Syndromic 32
Cardiomegaly, Macroorchidism OMIM:300886
Pseudo-Torch Syndrome 3
Lymphadenitis, Leukocytosis, Cardiomegaly, Congenital thrombocytopenia, Anemia OMIM:618886
Combined Immunodeficiency Due To Zap70 Deficiency
Lymphadenitis, Abnormal lymph node morphology, Decreased proportion of CD8-positive T cells, Hepa... ORPHA:911
Acute Panmyelosis With Myelofibrosis
Bone marrow hypocellularity, Acute myelomonocytic leukemia, Pancytopenia, Splenomegaly, Acute mye... ORPHA:86843
Cardiomyopathy, Familial Hypertrophic, 27
Cardiomyocyte hypertrophy, Hypertrophic cardiomyopathy, Concentric hypertrophic cardiomyopathy, E... OMIM:618052
Familial Atrial Myxoma
Pulmonic valve myxoma, Bacterial endocarditis, Cholestasis, Cardiomegaly, Cardiac myxoma, Jaundice ORPHA:615
Amelogenesis Imperfecta, Hypomaturation Type, Iia2
Amelogenesis imperfecta, Anterior open-bite malocclusion, Yellow-brown discoloration of the teeth... OMIM:612529
Amelogenesis Imperfecta, Type Iiic
Amelogenesis imperfecta, Yellow-brown discoloration of the teeth, Anterior open-bite malocclusion... OMIM:618386
Obesity-Colitis-Hypothyroidism-Cardiac Hypertrophy-Developmental Delay Syndrome
Cardiomegaly ORPHA:88643
X-Linked Intellectual Disability-Cardiomegaly-Congestive Heart Failure Syndrome
Aortic valve stenosis, Protruding tongue, Mitral valve prolapse, Cardiomegaly, Smooth philtrum, E... ORPHA:324410
Mucopolysaccharidosis, Type Iiib
Hepatomegaly, Asymmetric septal hypertrophy, Cardiomegaly, Splenomegaly OMIM:252920
Amelogenesis Imperfecta, Hypomaturation Type, Iia5
Amelogenesis imperfecta, Carious teeth, Yellow-brown discoloration of the teeth OMIM:615887
Lethal Congenital Contracture Syndrome 10
Narrow palate, Long philtrum, Micrognathia, Ventricular septal defect, Cardiomegaly, Hypoplasia o... OMIM:617022
Hemochromatosis, Type 1
Cardiomyopathy, Splenomegaly, Cardiomegaly, Hepatomegaly, Cirrhosis, Testicular atrophy, Hepatoce... OMIM:235200
Combined Oxidative Phosphorylation Deficiency 8
Hypertrophic cardiomyopathy, Cardiomegaly OMIM:614096
Immunodeficiency 92
Thrombocytosis, Leukocytosis, Sclerosing cholangitis, Lymphocytosis, Decreased proportion of clas... OMIM:619652
Amelogenesis Imperfecta, Type If
Dental enamel pits, Abnormality of dental color, Amelogenesis imperfecta, Enamel hypoplasia OMIM:616270
Exocrine Pancreatic Insufficiency, Dyserythropoietic Anemia, And Calvarial Hyperostosis
Carious teeth, Exocrine pancreatic insufficiency, Splenomegaly, Anemia of inadequate production, ... OMIM:612714
Amelo-Onycho-Hypohidrotic Syndrome
Yellow-brown discoloration of the teeth, Delayed eruption of teeth, Tooth agenesis, Abnormal dent... ORPHA:1028
Amelogenesis Imperfecta, Type Ie
Amelogenesis imperfecta, Enamel hypoplasia, Anterior open-bite malocclusion, Abnormal dentin morp... OMIM:301200
Amelogenesis Imperfecta, Type Iv
Taurodontia, Amelogenesis imperfecta, Yellow-brown discoloration of the teeth, Enamel hypoplasia OMIM:104510
Attrv122I Amyloidosis
Aortic valve stenosis, Restrictive cardiomyopathy, Hypertrophic cardiomyopathy, Cardiomegaly, Lef... ORPHA:85451
Diffuse Cutaneous Mastocytosis
Abnormality of the spleen, Abnormality of the liver, Lymphocytosis, Lymphadenopathy, Hepatomegaly... ORPHA:79456
Congenitally Uncorrected Transposition Of The Great Arteries
Biventricular hypertrophy, Dextrotransposition of the great arteries, Abnormal pulmonary valve mo... ORPHA:860
Proteus-Like Syndrome
Thymus hyperplasia, Abnormality of the parathyroid gland, Open bite, Splenomegaly, Polycystic ova... ORPHA:2969
Acute Monoblastic/Monocytic Leukemia
Hypochromic anemia, Acute monocytic leukemia, Cervical lymphadenopathy, Leukocytosis, Lymphocytos... ORPHA:514
Combined Oxidative Phosphorylation Deficiency 41
Anemia, Cardiomegaly OMIM:618838
Gaucher Disease, Type Iiic
Aortic valve calcification, Pancytopenia, Splenomegaly, Mitral stenosis, Cardiomegaly, Mitral val... OMIM:231005
Carnitine Palmitoyltransferase Ii Deficiency, Infantile
Cardiomegaly, Hepatomegaly, Macrovesicular hepatic steatosis, Dilated cardiomyopathy OMIM:600649
Attrv30M Amyloidosis
Cardiomegaly, Cardiomyopathy ORPHA:85447
Cantu Syndrome
Congenital hypertrophy of left ventricle, Long philtrum, Thick lower lip vermilion, Thick upper l... OMIM:239850
Carnitine Deficiency, Systemic Primary
Cardiomyopathy, Hypertrophic cardiomyopathy, Decreased carnitine level in liver, Endocardial fibr... OMIM:212140
Mitochondrial Complex I Deficiency, Nuclear Type 36
Cardiomegaly, Perimembranous ventricular septal defect OMIM:619170
Osteopetrosis, Autosomal Recessive 2
Carious teeth, Mandibular osteomyelitis, Extramedullary hematopoiesis, Hepatosplenomegaly, Pancyt... OMIM:259710
Timothy Syndrome
Tetralogy of Fallot, Patent foramen ovale, Ventricular septal defect, Cardiomegaly, Thin upper li... OMIM:601005
Drug Reaction With Eosinophilia And Systemic Symptoms
Hepatitis, Eosinophilia, Lymphocytosis, Lymphadenopathy, Enanthema, Myocarditis ORPHA:139402
Gaucher Disease, Perinatal Lethal
Everted upper lip vermilion, Retrognathia, Hepatosplenomegaly, Micrognathia, Open mouth, Splenome... OMIM:608013
Idiopathic Pulmonary Hemosiderosis
Hepatomegaly, Hepatosplenomegaly, Iron deficiency anemia, Cardiomegaly ORPHA:99931
Mitochondrial Complex Iv Deficiency, Nuclear Type 20
Hepatomegaly, Cardiomegaly OMIM:619064
Histiocytosis-Lymphadenopathy Plus Syndrome
Pancreatic hypoplasia, Retrognathia, Decreased response to growth hormone stimulation test, Cervi... OMIM:602782
Heterotaxy, Visceral, 1, X-Linked
Ventricular septal defect, Atrial septal defect, Dextrocardia, Single ventricle, Hepatomegaly, Hy... OMIM:306955
Oslam Syndrome
Abnormality of neutrophils, Carious teeth, Increased mean corpuscular volume ORPHA:2760
Fixed Subaortic Stenosis
Bacterial endocarditis, Abnormal heart morphology, Atrioventricular canal defect, Ventricular sep... ORPHA:3092
Alpha-N-Acetylgalactosaminidase Deficiency
Cardiomegaly, Thick vermilion border ORPHA:3137
Congenital Tricuspid Valve Dysplasia
Abnormal tricuspid valve annulus morphology, Patent foramen ovale, Cardiomegaly, Tricuspid valve ... ORPHA:555874
Cardiomyopathy, Familial Hypertrophic, 4
Ventricular hypertrophy, Hypertrophic cardiomyopathy, Muscular ventricular septal defect, Myofibe... OMIM:115197
Autoimmune Lymphoproliferative Syndrome
Lymphopenia, Hypersplenism, Decreased proportion of CD4-positive helper T cells, Abnormal proport... ORPHA:3261
Combined Oxidative Phosphorylation Deficiency 10
Hypertrophic cardiomyopathy, Cardiomegaly, Pericardial effusion OMIM:614702
Mogs-Cdg
Retrognathia, Hepatosplenomegaly, Cardiomegaly, Left ventricular hypertrophy, Atrial septal defec... ORPHA:79330
Wolcott-Rallison Syndrome
Exocrine pancreatic insufficiency, Abnormality of the liver, Lymphocytosis, Iron deficiency anemi... ORPHA:1667
Mitochondrial Complex Iv Deficiency, Nuclear Type 7
Hypertrophic cardiomyopathy, Ventricular hypertrophy, Cardiomegaly OMIM:619051
Symptomatic Form Of Hfe-Related Hemochromatosis
Cardiomyopathy, Portal hypertension, Splenomegaly, Cardiomegaly, Hepatomegaly, Cirrhosis, Cholang... ORPHA:465508
Fibrosis, Neurodegeneration, And Cerebral Angiomatosis
Ventricular hypertrophy, Hepatocellular necrosis, Hepatosplenomegaly, Elliptocytosis, Reticulocyt... OMIM:618278
Osteochondrodysplasia, Complex Lethal, Symoens-Barnes-Gistelinck Type
Unilateral cleft lip, Hypertrophic cardiomyopathy, Micrognathia, Ventricular septal defect, Cardi... OMIM:616897
Congenital Disorder Of Glycosylation, Type It
Bifid uvula, Intrahepatic cholestasis, Dilated cardiomyopathy, Hepatitis, Micrognathia, Hepatic s... OMIM:614921
Beck-Fahrner Syndrome
Long philtrum, Open mouth, Ventricular septal defect, Cardiomegaly, High palate OMIM:618798
Coronary Arterial Fistula
Aortic valve stenosis, Bacterial endocarditis, Abnormal heart morphology, Patent foramen ovale, C... ORPHA:2041
Acyl-Coa Dehydrogenase, Very Long-Chain, Deficiency Of
Periportal fibrosis, Hepatocellular necrosis, Hypertrophic cardiomyopathy, Hepatic steatosis, Car... OMIM:201475
Sandhoff Disease
Hepatomegaly, Macroglossia, Hepatosplenomegaly, Cardiomegaly OMIM:268800
Craniofaciofrontodigital Syndrome
Aortic valve stenosis, Long philtrum, Abnormal heart valve morphology, Gingival overgrowth, Promi... ORPHA:363705
Medium Chain Acyl-Coa Dehydrogenase Deficiency
Hepatomegaly, Cardiomegaly, Hepatic steatosis ORPHA:42
Autoinflammatory Disease, Systemic, With Vasculitis
Hepatic fibrosis, Parotitis, Cholestasis, Hepatosplenomegaly, Leukocytosis, Splenomegaly, Oral ul... OMIM:620376
Double Outlet Left Ventricle
Cryptorchidism, Ventricular septal defect, Cardiomegaly, Bicuspid pulmonary valve, Orofacial clef... ORPHA:3427
Myopathy, Epilepsy, And Progressive Cerebral Atrophy
Micrognathia, Thymus hyperplasia OMIM:619036
Fucosidosis
Hepatomegaly, Abnormality of the dentition, Abnormality of the gallbladder, Cardiomegaly ORPHA:349
Long-Olsen-Distelmaier Syndrome
Cardiomegaly, Dilated cardiomyopathy, Secundum atrial septal defect, Ventricular septal defect OMIM:620609
Intellectual Developmental Disorder, X-Linked, Syndromic 34
High, narrow palate, Dental crowding, Widely spaced teeth, Left ventricular noncompaction, Left v... OMIM:300967
Kikuchi-Fujimoto Disease
Abnormal lymph node morphology, Cervical lymphadenopathy, Leukopenia, Enlargement of parotid glan... ORPHA:50918
Isolated Right Ventricular Hypoplasia
Muscular ventricular septal defect, Patent foramen ovale, Cardiomegaly, Atrial septal defect, Rig... ORPHA:439
Cirrhotic Cardiomyopathy
Cardiomegaly, Left atrial enlargement, Left ventricular hypertrophy, Cirrhosis, Jaundice, Hepatom... ORPHA:57777
Aorta Coarctation
Hypoplastic left heart, Tetralogy of Fallot, Cardiomegaly, Bicuspid aortic valve, Perimembranous ... ORPHA:1457
Fucosidosis
Macroglossia, Absent/hypoplastic paranasal sinuses, Thick lower lip vermilion, Splenomegaly, Card... OMIM:230000
Spondylometaphyseal Dysplasia, Megarbane-Dagher-Melki Type
Cardiomegaly, Deep philtrum OMIM:613320
Paternal Uniparental Disomy Of Chromosome 6
Retrognathia, Micrognathia, Gingival overgrowth, Cryptorchidism, Ventricular septal defect, Cardi... ORPHA:96191
Lethal Acantholytic Erosive Disorder
Cardiomegaly, Cleft palate, Natal tooth, Cardiomyopathy ORPHA:158687
Combined Oxidative Phosphorylation Deficiency 33
Hepatomegaly, Left ventricular hypertrophy, Cardiomegaly, Cardiomyopathy OMIM:617713
Hsd10 Disease, Infantile Type
Hypertrophic cardiomyopathy, Cardiomegaly ORPHA:391428
Marfanoid Habitus-Autosomal Recessive Intellectual Disability Syndrome
Narrow mouth, Malar flattening, Cardiomegaly, High palate, Abnormal thymus morphology, Broad phil... ORPHA:2463
Refsum Disease, Classic
Cardiomegaly, Cardiomyopathy OMIM:266500
Developmental And Epileptic Encephalopathy 95
Widely spaced teeth, Gingival overgrowth, Cryptorchidism, Cardiomegaly, Deep philtrum, Hepatomega... OMIM:618143
Multiple Joint Dislocations, Short Stature, And Craniofacial Dysmorphism With Or Without Congenital Heart Defects
Microretrognathia, Long philtrum, Micrognathia, Narrow mouth, Mitral valve prolapse, Patent foram... OMIM:245600
Cantú Syndrome
Long philtrum, Hypertrophic cardiomyopathy, Abnormal heart valve morphology, Cardiomegaly, Thick ... ORPHA:1517
Glycogen Storage Disease Ii
Hepatomegaly, Macroglossia, Cardiomegaly, Splenomegaly OMIM:232300
Carnitine Palmitoyltransferase Ii Deficiency, Lethal Neonatal
Narrow palate, Dilated cardiomyopathy, Lipid accumulation in hepatocytes, Cardiomegaly, Hepatic c... OMIM:608836
Neurodevelopmental Disorder With Intracranial Hemorrhage, Seizures, And Spasticity
Narrow palate, Microretrognathia, Hepatic sinusoidal dilatation, Tented upper lip vermilion, Sple... OMIM:620371
Mucopolysaccharidosis Type 3
Abnormality of the dentition, Craniofacial hyperostosis, Recurrent tonsillitis, Adenoiditis, Sple... ORPHA:581
Ogden Syndrome
Everted upper lip vermilion, Thick upper lip vermilion, Micrognathia, Cryptorchidism, Ventricular... OMIM:300855
Carnitine Palmitoyltransferase I Deficiency
Hepatomegaly, Cardiomegaly, Hepatic steatosis OMIM:255120
Autoinflammatory Syndrome, Familial, X-Linked, Behcet-Like 2
Decreased proportion of memory B cells, Reduced natural killer cell count, Oral ulcer, Perianal a... OMIM:301074
Truncus Arteriosus
Abnormal heart morphology, Tetralogy of Fallot, Abnormal heart valve morphology, Ventricular sept... ORPHA:3384
Complete Atrioventricular Septal Defect
Primum atrial septal defect, Displacement of the papillary muscles, Abnormal cardiac atrium morph... ORPHA:1329
Mucolipidosis Ii Alpha/Beta
Long philtrum, Hypertrophic cardiomyopathy, Progressive alveolar ridge hypertropy, Micrognathia, ... OMIM:252500
Arterial Calcification, Generalized, Of Infancy, 2
Cardiomegaly, Right atrial enlargement OMIM:614473
Carnitine Palmitoyl Transferase Ii Deficiency, Neonatal Form
High, narrow palate, Cardiomyopathy, Hepatic steatosis, Cardiomegaly, Hepatic calcification, Abno... ORPHA:228308
Immunodeficiency 71 With Inflammatory Disease And Congenital Thrombocytopenia
Decreased mean platelet volume, Cervical lymphadenopathy, Lymphocytosis, Lymphadenopathy, Thrombo... OMIM:617718
Bohring-Opitz Syndrome
Cholelithiasis, Cleft lip, Annular pancreas, Retrognathia, Prominent palatine ridges, Micrognathi... ORPHA:97297
Glycogen Storage Disease Due To Acid Maltase Deficiency, Infantile Onset
Hypertrophic cardiomyopathy, Cardiomegaly, Left ventricular hypertrophy, Hepatomegaly, Macroglossia ORPHA:308552
Liver Disease, Severe Congenital
Portal inflammation, Dilatation of the ventricular cavity, Micrognathia, Hepatic steatosis, Ventr... OMIM:619991
Danon Disease
Myocardial necrosis, Dilated cardiomyopathy, Hypertrophic cardiomyopathy, Cardiomegaly, Myocardia... OMIM:300257
Neurodegeneration With Ataxia And Late-Onset Optic Atrophy
Cardiomegaly, Cardiomyopathy, Increased hepatic glycogen content OMIM:619259
Onychotrichodysplasia And Neutropenia
Lymphocytosis, Chronic neutropenia, Neutropenia OMIM:258360
Familial Aortic Dissection
Cardiomegaly ORPHA:229
Glycogen Storage Disease Of Heart, Lethal Congenital
Macroglossia, Cardiomyopathy, Biventricular hypertrophy, Hypertrophic cardiomyopathy, Cardiomegal... OMIM:261740
Amyloidosis, Hereditary Systemic 1
Cardiomegaly, Cardiomyopathy OMIM:105210
Naxos Disease
Dilated cardiomyopathy, Abnormal heart morphology, Right ventricular cardiomyopathy, Cardiomegaly... OMIM:601214
Beckwith-Wiedemann Syndrome
Mandibular prognathia, Visceromegaly, Polycythemia, Abnormal pancreas morphology, Hypertrophic ca... ORPHA:116
Abetalipoproteinemia
Hepatic fibrosis, Acanthocytosis, Reticulocytosis, Hepatic steatosis, Cardiomegaly, Hepatomegaly,... ORPHA:14
Neurodevelopmental Disorder With Microcephaly, Cerebral Atrophy, And Visual Impairment
Secundum atrial septal defect, Partial atrioventricular canal defect, Ventricular septal defect, ... OMIM:620066
Alpha-N-Acetylgalactosaminidase Deficiency Type 2
Cardiomegaly, Lip telangiectasia, Telangiectasia of the oral mucosa, Thick vermilion border ORPHA:79280
Beckwith-Wiedemann Syndrome
Pancreatic hyperplasia, Cardiomyopathy, Cryptorchidism, Cardiomegaly, Hepatoblastoma, Hepatomegal... OMIM:130650
Yunis-Varon Syndrome
High, narrow palate, Cardiomyopathy, Tetralogy of Fallot, Gingival recession, Broad secondary alv... ORPHA:3472
Familial Idiopathic Dilatation Of The Right Atrium
Abnormality of the hepatic vasculature, Cardiomegaly, Hepatomegaly, Right atrial enlargement, Atr... ORPHA:1677
Proteasome-Associated Autoinflammatory Syndrome 1
Parotitis, Microcytic anemia, Thick lower lip vermilion, Splenomegaly, Recurrent sinusitis, Cardi... OMIM:256040
Histiocytoid Cardiomyopathy
Ventricular septal defect, Cardiomegaly, Polycystic ovaries, Hepatomegaly, Cleft palate ORPHA:137675
Williams Syndrome
Carious teeth, Open bite, Micrognathia, Cryptorchidism, Mitral valve prolapse, Ventricular septal... ORPHA:904
Neurodegeneration And Seizures Due To Copper Transport Defect
Cardiomegaly OMIM:620306
Congenital Tracheomalacia
Abnormal heart morphology, Tetralogy of Fallot, Ventricular septal defect, Cardiomegaly, Atrial s... ORPHA:95430
Familial Thoracic Aortic Aneurysm And Aortic Dissection
Cardiomegaly, Bicuspid aortic valve, Retrognathia, High, narrow palate ORPHA:91387
Interatrial Communication
Right ventricular dilatation, Secundum atrial septal defect, Cardiomegaly, Sinus venosus atrial s... ORPHA:1478
Singleton-Merten Syndrome 1
Aortic valve stenosis, Aortic valve calcification, Hypoplasia of the maxilla, Carious teeth, Erup... OMIM:182250
Tropical Endomyocardial Fibrosis
Restrictive cardiomyopathy, Endocardial fibrosis, Coronary artery stenosis, Right ventricular car... ORPHA:75565
Arterial Calcification, Generalized, Of Infancy, 1
Cardiomegaly, Dilated cardiomyopathy OMIM:208000
Absence Of The Pulmonary Artery
Abnormal heart morphology, Tetralogy of Fallot, Patent foramen ovale, Truncus arteriosus, Cardiom... ORPHA:980
Dysferlin-Related Limb-Girdle Muscular Dystrophy R2
Cardiomegaly, Right ventricular hypertrophy ORPHA:268
Proteus Syndrome
Carious teeth, Thymus hyperplasia, Tooth agenesis, Abnormal dental enamel morphology, Neoplasm of... ORPHA:744
Aicardi-Goutières Syndrome
Neonatal alloimmune thrombocytopenia, Hypertrophic cardiomyopathy, Hepatosplenomegaly, Chronic ly... ORPHA:51
Glycogen Storage Disease Due To Acid Maltase Deficiency
Hypertrophic cardiomyopathy, Cardiomegaly, Left ventricular hypertrophy, Hepatomegaly, Macroglossia ORPHA:365
Congenital Total Pulmonary Venous Return Anomaly
Hypoplastic left heart, Mixed total anomalous pulmonary venous connection, Atrial situs ambiguous... ORPHA:99125
Generalized Arterial Calcification Of Infancy
Ventricular hypertrophy, Pancreatic calcification, Cardiomegaly, Hepatic calcification, Pericardi... ORPHA:51608

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Lgr6

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Lgr6.

No publications found that use IMPC mice or data for Lgr6.

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MGI Allele Allele Type Produced
Lgr6em1(IMPC)Ccpcz Inter-exon deletion Mice
Lgr6tm102274(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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