Gene Summary

Name:
leucine-rich repeat-containing G protein-coupled receptor 6
Synonyms:
A530037C04Rik

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal tooth morphology Lgr6em1(IMPC)Ccpcz HOM Early adult 0.00
abnormal eye morphology Lgr6em1(IMPC)Ccpcz HOM Early adult 0.00
enlarged heart Lgr6em1(IMPC)Ccpcz HOM Early adult 0.00
abnormal heart morphology Lgr6em1(IMPC)Ccpcz HOM Early adult 0.00
abnormal spleen morphology Lgr6em1(IMPC)Ccpcz HOM Early adult 0.00
enlarged thymus Lgr6em1(IMPC)Ccpcz HOM Early adult 0.00
increased lymphocyte cell number Lgr6em1(IMPC)Ccpcz HOM Early adult 9.94×10-05
abnormal thymus morphology Lgr6em1(IMPC)Ccpcz HOM Early adult 0.00
abnormal skin morphology Lgr6em1(IMPC)Ccpcz HOM Early adult 0.00

Download data as:  TSV  XLS

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Viewing: all phenotypes
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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

34 Images

X-ray

XRay Images Hind Leg and Hip

34 Images

X-ray

XRay Images Whole Body Lateral Orientation

17 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

17 Images

X-ray

XRay Images Skull Lateral Orientation

17 Images

X-ray

XRay Images Forepaw

17 Images

Human diseases caused by Lgr6 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Lgr6 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Regional Odontodysplasia
Macrodontia, Delayed eruption of teeth, Carious teeth, Yellow-brown discoloration of the teeth, D... ORPHA:83450
Ethanolaminosis
Cardiomegaly OMIM:227150
Persistent Polyclonal B-Cell Lymphocytosis
Hepatomegaly, Lymphocytosis, Splenomegaly OMIM:606445
Amelogenesis Imperfecta
Taurodontia, Fragile teeth, Abnormal jaw morphology, Anterior open-bite malocclusion, Multiple un... ORPHA:88661
Ras-Associated Autoimmune Leukoproliferative Disorder
Hepatomegaly, Lymphocytosis, Splenomegaly, Follicular hyperplasia, Autoimmune thrombocytopenia, M... OMIM:614470
Amelogenesis Imperfecta, Hypomaturation Type, Iia1
Amelogenesis imperfecta, Anterior open-bite malocclusion, Abnormal dental enamel morphology, Cari... OMIM:204700
Oligodontia
Eclabion, Abnormality of canine, Delayed eruption of teeth, Microdontia, Hypoplasia of teeth, Peg... ORPHA:99798
Aicardi-Goutieres Syndrome 2
Lymphocytosis OMIM:610181
Amelogenesis Imperfecta, Type Ij
Carious teeth, Enamel hypoplasia, Widely spaced teeth, Increased overbite, Amelogenesis imperfecta OMIM:617297
Dentin Dysplasia, Type I
Taurodontia, Dentinogenesis imperfecta limited to primary teeth, Microdontia, Pulp obliteration, ... OMIM:125400
Cardiomyopathy, Dilated, 1I
Dilated cardiomyopathy, Cardiomegaly OMIM:604765
Dentinogenesis Imperfecta
Persistence of primary teeth, Fragile teeth, Generalized hypoplasia of dental enamel, Grayish ena... ORPHA:49042
Infantile Sialic Acid Storage Disease
High palate, Gingival overgrowth, Hepatomegaly, Vacuolated lymphocytes, Splenomegaly, Cardiomegaly OMIM:269920
Mulibrey Nanism
Myocardial fibrosis, Dental malocclusion, Hepatomegaly, Hypodontia, Enamel hypoplasia, Hypoplasti... OMIM:253250
Ectodermal Dysplasia-Syndactyly Syndrome 2
Enamel hypoplasia, Thin upper lip vermilion, Cardiomegaly OMIM:613576
Congenital Toxoplasmosis
Hepatomegaly, Thrombocytopenia, Anemia, Lymphadenopathy, Jaundice, Cardiomegaly ORPHA:858
Taurodontism, Microdontia, And Dens Invaginatus
Dens in dente, Taurodontia, Microdontia, Pulp calcification OMIM:313490
T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency
Lymphopenia, Lymphocytosis, Eosinophilia, Hepatosplenomegaly, Autoimmune thrombocytopenia, T lymp... ORPHA:169154
Otodental Dysplasia
Taurodontia, Agenesis of premolar, Long philtrum, Delayed eruption of teeth, Pulp calcification, ... OMIM:166750
Lymphoproliferative Syndrome, X-Linked, 1
Neutropenia, Hepatomegaly, Lymphocytosis, Hemophagocytosis, Splenomegaly, Fulminant hepatitis, Ap... OMIM:308240
Lethal Congenital Contracture Syndrome 10
High palate, Narrow palate, Micrognathia, Hypoplasia of the thymus, Long philtrum, Ventricular se... OMIM:617022
Isolated Anencephaly
Thymus hyperplasia, Cleft lip ORPHA:563609
Neuraminidase Deficiency
Hepatomegaly, Vacuolated lymphocytes, Splenomegaly, Bone-marrow foam cells, Cardiomyopathy, Cardi... OMIM:256550
Otodental Syndrome
Gingival overgrowth, Taurodontia, Periodontitis, Agenesis of premolar, Abnormality of canine, Abn... ORPHA:2791
Amelogenesis Imperfecta, Type Ic
Taurodontia, Anterior open-bite malocclusion, Enamel hypomineralization, Yellow-brown discolorati... OMIM:204650
Acquired Partial Lipodystrophy
Hepatic steatosis, Lymphocytosis ORPHA:79087
Amelogenesis Imperfecta, Type Ih
Anterior open-bite malocclusion, Enamel hypoplasia, Yellow-brown discoloration of the teeth, Dent... OMIM:616221
Neurooculocardiogenitourinary Syndrome
Atrial septal defect, Ventricular septal defect, Downturned corners of mouth, Patent foramen oval... OMIM:618652
Myopathy, Congenital, With Structured Cores And Z-Line Abnormalities
High palate, Cardiomegaly OMIM:618654
Intellectual Developmental Disorder, X-Linked, Syndromic 32
Cardiomegaly, Macroorchidism OMIM:300886
Pseudo-Torch Syndrome 3
Leukocytosis, Lymphadenitis, Congenital thrombocytopenia, Anemia, Cardiomegaly OMIM:618886
Combined Immunodeficiency Due To Zap70 Deficiency
Lymphocytosis, Abnormality of the lymph nodes, Lymphadenitis, Eosinophilia, Hepatosplenomegaly, A... ORPHA:911
Acute Panmyelosis With Myelofibrosis
Lymphocytosis, Acute myelomonocytic leukemia, Splenomegaly, Pancytopenia, Bone marrow hypocellula... ORPHA:86843
Combined Oxidative Phosphorylation Deficiency 33
Left ventricular hypertrophy, Hepatomegaly, Cardiomyopathy, Cardiomegaly OMIM:617713
Sickle Cell Anemia
Cholelithiasis, Hepatomegaly, Leukocytosis, Splenomegaly, Hemolytic anemia, Target cells, Cardiom... OMIM:603903
Timothy Syndrome
Microdontia, Tetralogy of Fallot, Ventricular septal defect, Patent foramen ovale, Thin upper lip... OMIM:601005
Familial Atrial Myxoma
Bacterial endocarditis, Cholestasis, Pulmonic valve myxoma, Jaundice, Cardiomegaly, Cardiac myxoma ORPHA:615
X-Linked Intellectual Disability-Cardiomegaly-Congestive Heart Failure Syndrome
Aortic valve stenosis, Everted lower lip vermilion, Mitral valve prolapse, Protruding tongue, Smo... ORPHA:324410
Cardiomyopathy, Familial Hypertrophic 27
Right ventricular hypertrophy, Concentric hypertrophic cardiomyopathy, Endocardial fibroelastosis... OMIM:618052
Hemochromatosis, Type 1
Testicular atrophy, Hepatomegaly, Splenomegaly, Cirrhosis, Hepatocellular carcinoma, Cardiomyopat... OMIM:235200
Mucopolysaccharidosis, Type Iiib
Asymmetric septal hypertrophy, Hepatomegaly, Cardiomegaly, Splenomegaly OMIM:252920
Obesity-Colitis-Hypothyroidism-Cardiac Hypertrophy-Developmental Delay Syndrome
Cardiomegaly ORPHA:88643
Amelogenesis Imperfecta, Type Iiic
Amelogenesis imperfecta, Hypocalcification of dental enamel, Yellow-brown discoloration of the te... OMIM:618386
Immunodeficiency 92
Hepatomegaly, Lymphocytosis, Leukocytosis, Sclerosing cholangitis, B lymphocytopenia, Thrombocyto... OMIM:619652
Attrv122I Amyloidosis
Cardiac amyloidosis, Aortic valve stenosis, Restrictive cardiomyopathy, Left ventricular hypertro... ORPHA:85451
Amelogenesis Imperfecta, Type If
Enamel hypoplasia, Amelogenesis imperfecta, Dental enamel pits, Abnormality of dental color OMIM:616270
Osteopetrosis, Autosomal Recessive 2
Mandibular osteomyelitis, Persistence of primary teeth, Extramedullary hematopoiesis, Hepatosplen... OMIM:259710
Exocrine Pancreatic Insufficiency, Dyserythropoietic Anemia, And Calvarial Hyperostosis
Anemia of inadequate production, Exocrine pancreatic insufficiency, Hepatomegaly, Splenomegaly, C... OMIM:612714
Amelo-Onycho-Hypohidrotic Syndrome
Abnormal dental enamel morphology, Tooth agenesis, Everted lower lip vermilion, Delayed eruption ... ORPHA:1028
Gaucher Disease, Type Iiic
Mitral stenosis, Aortic valve calcification, Hepatomegaly, Splenomegaly, Mitral valve calcificati... OMIM:231005
Carnitine Deficiency, Systemic Primary
Hepatomegaly, Endocardial fibroelastosis, Decreased carnitine level in liver, Hypertrophic cardio... OMIM:212140
Amelogenesis Imperfecta, Type Iv
Enamel hypoplasia, Yellow-brown discoloration of the teeth, Taurodontia, Amelogenesis imperfecta OMIM:104510
Diffuse Cutaneous Mastocytosis
Hepatomegaly, Lymphocytosis, Myeloproliferative disorder, Abnormality of the spleen, Lymphadenopa... ORPHA:79456
Congenitally Uncorrected Transposition Of The Great Arteries
Abnormal pulmonary valve morphology, Abnormal mitral valve morphology, Anomalous pulmonary venous... ORPHA:860
X-Linked Lymphoproliferative Disease
Hemophagocytosis, Cervical lymphadenopathy, Aplastic anemia, B lymphocytopenia, Myocarditis, Incr... ORPHA:2442
Proteus-Like Syndrome
Splenomegaly, Open bite, Abnormality of the parathyroid gland, Thymus hyperplasia, Polycystic ova... ORPHA:2969
Acute Monoblastic/Monocytic Leukemia
Lymphocytosis, Leukocytosis, Hypochromic anemia, Acute monocytic leukemia, Cervical lymphadenopat... ORPHA:514
Cantu Syndrome
Thick upper lip vermilion, Bicuspid aortic valve, Congenital hypertrophy of left ventricle, Gingi... OMIM:239850
Combined Oxidative Phosphorylation Deficiency 41
Anemia, Cardiomegaly OMIM:618838
Carnitine Palmitoyltransferase Ii Deficiency, Infantile
Dilated cardiomyopathy, Hepatomegaly, Macrovesicular hepatic steatosis, Cardiomegaly OMIM:600649
Attrv30M Amyloidosis
Cardiomyopathy, Cardiomegaly ORPHA:85447
Gaucher Disease, Perinatal Lethal
Narrow mouth, Hepatomegaly, Splenomegaly, Everted upper lip vermilion, Retrognathia, Hepatospleno... OMIM:608013
Immunodeficiency 71 With Inflammatory Disease And Congenital Thrombocytopenia
Thrombocytopenia, Lymphocytosis, Decreased mean platelet volume, Lymphadenopathy OMIM:617718
Histiocytosis-Lymphadenopathy Plus Syndrome
Histiocytosis, Atrial septal defect, Decreased response to growth hormone stimulation test, Hepat... OMIM:602782
Mitochondrial Complex Iv Deficiency, Nuclear Type 20
Hepatomegaly, Cardiomegaly OMIM:619064
Autoimmune Lymphoproliferative Syndrome
Abnormal proportion of CD8-positive T cells, Hepatomegaly, Bone marrow hypocellularity, Reticuloc... ORPHA:3261
Drug Reaction With Eosinophilia And Systemic Symptoms
Enanthema, Lymphocytosis, Eosinophilia, Myocarditis, Hepatitis, Lymphadenopathy ORPHA:139402
Fixed Subaortic Stenosis
Bacterial endocarditis, Abnormal cardiac septum morphology, Bicuspid aortic valve, Atrioventricul... ORPHA:3092
Oslam Syndrome
Increased mean corpuscular volume, Abnormality of neutrophils, Carious teeth ORPHA:2760
Idiopathic Pulmonary Hemosiderosis
Hepatosplenomegaly, Hepatomegaly, Cardiomegaly, Iron deficiency anemia ORPHA:99931
Mitochondrial Complex I Deficiency, Nuclear Type 36
Perimembranous ventricular septal defect, Cardiomegaly OMIM:619170
Alpha-N-Acetylgalactosaminidase Deficiency
Thick vermilion border, Cardiomegaly ORPHA:3137
Congenital Tricuspid Valve Dysplasia
Tricuspid valve prolapse, Right atrial enlargement, Anomalous pulmonary venous return, Hepatomega... ORPHA:555874
Fucosidosis
Hepatomegaly, Vacuolated lymphocytes, Macroglossia, Splenomegaly, Absent/hypoplastic paranasal si... OMIM:230000
Heterotaxy, Visceral, 1, X-Linked
Hepatomegaly, Atrioventricular canal defect, Biliary atresia, Enlarged kidney, Ventricular septal... OMIM:306955
Symptomatic Form Of Hemochromatosis Type 1
Testicular atrophy, Cholangiocarcinoma, Hepatomegaly, Splenomegaly, Cirrhosis, Hepatocellular car... ORPHA:465508
Cardiomyopathy, Familial Hypertrophic, 4
Right atrial enlargement, Hepatomegaly, Myofiber disarray, Muscular ventricular septal defect, Ve... OMIM:115197
Fibrosis, Neurodegeneration, And Cerebral Angiomatosis
Decreased mean corpuscular volume, Hepatocellular necrosis, Hepatomegaly, Microvesicular hepatic ... OMIM:618278
Wolcott-Rallison Syndrome
Double outlet right ventricle, Exocrine pancreatic insufficiency, Atrial septal defect, Lymphocyt... ORPHA:1667
Craniofaciofrontodigital Syndrome
Dental malocclusion, Abnormality of the dentition, Long philtrum, Cardiomegaly, Abnormal heart mo... OMIM:114620
Mogs-Cdg
Hydrocele testis, High palate, Atrial septal defect, Hepatomegaly, Retrognathia, Left ventricular... ORPHA:79330
Danon Disease
Myocardial fibrosis, Myocardial necrosis, Dilated cardiomyopathy, Hypertrophic cardiomyopathy, Ca... OMIM:300257
Mitochondrial Complex Iv Deficiency, Nuclear Type 7
Ventricular hypertrophy, Hypertrophic cardiomyopathy, Cardiomegaly OMIM:619051
Congenital Disorder Of Glycosylation, Type It
Hepatomegaly, Cleft palate, Increased hepatic glycogen content, Micrognathia, Chronic hepatitis, ... OMIM:614921
Carnitine Palmitoyltransferase I Deficiency
Hepatic steatosis, Hepatomegaly, Cardiomegaly OMIM:255120
Beck-Fahrner Syndrome
High palate, Long philtrum, Ventricular septal defect, Open mouth, Cardiomegaly OMIM:618798
Osteochondrodysplasia, Complex Lethal, Symoens-Barnes-Gistelinck Type
Cleft palate, Micrognathia, Ventricular septal defect, Unilateral cleft lip, Hypertrophic cardiom... OMIM:616897
Craniofaciofrontodigital Syndrome
Bicuspid aortic valve, Gingival overgrowth, Atrial septal defect, Aortic valve stenosis, Prominen... ORPHA:363705
Coronary Arterial Fistula
Bacterial endocarditis, Bicuspid aortic valve, Atrial septal defect, Aortic valve stenosis, Paten... ORPHA:2041
Acyl-Coa Dehydrogenase, Very Long-Chain, Deficiency Of
Hepatocellular necrosis, Hepatomegaly, Periportal fibrosis, Hypertrophic cardiomyopathy, Hepatic ... OMIM:201475
Medium Chain Acyl-Coa Dehydrogenase Deficiency
Hepatic steatosis, Hepatomegaly, Cardiomegaly ORPHA:42
Sandhoff Disease
Macroglossia, Hepatosplenomegaly, Hepatomegaly, Cardiomegaly OMIM:268800
Fucosidosis
Abnormality of the gallbladder, Abnormality of the dentition, Hepatomegaly, Cardiomegaly ORPHA:349
Kikuchi-Fujimoto Disease
Hepatomegaly, Lymphocytosis, Splenomegaly, Cervical lymphadenopathy, Abnormality of the lymph nod... ORPHA:50918
Myopathy, Epilepsy, And Progressive Cerebral Atrophy
Thymus hyperplasia, Micrognathia OMIM:619036
Intellectual Developmental Disorder, X-Linked, Syndromic 34
Left ventricular noncompaction cardiomyopathy, Wide mouth, Narrow mouth, Atrial septal defect, Hi... OMIM:300967
Spondylometaphyseal Dysplasia, Megarbane-Dagher-Melki Type
Deep philtrum, Cardiomegaly OMIM:613320
Refsum Disease, Classic
Cardiomyopathy, Cardiomegaly OMIM:266500
Aorta Coarctation
Bicuspid aortic valve, Hypoplastic left heart, Aortic valve atresia, Tetralogy of Fallot, Abnorma... ORPHA:1457
Paternal Uniparental Disomy Of Chromosome 6
High palate, Gingival overgrowth, Hepatomegaly, Macroglossia, Retrognathia, Micrognathia, Ventric... ORPHA:96191
Cantú Syndrome
Wide mouth, Long philtrum, Thick vermilion border, Abnormal heart valve morphology, Hypertrophic ... ORPHA:1517
Glycogen Storage Disease Of Heart, Lethal Congenital
Macroglossia, Biventricular hypertrophy, Cardiomyopathy, Cardiomegaly OMIM:261740
Marfanoid Habitus-Autosomal Recessive Intellectual Disability Syndrome
High palate, Narrow mouth, Malar flattening, Abnormality of the thymus, Broad philtrum, Cardiomegaly ORPHA:2463
Isolated Right Ventricular Hypoplasia
Right atrial enlargement, Atrial septal defect, Muscular ventricular septal defect, Patent forame... ORPHA:439
Cirrhotic Cardiomyopathy
Right atrial enlargement, Hepatomegaly, Left ventricular hypertrophy, Cirrhosis, Left atrial enla... ORPHA:57777
Developmental And Epileptic Encephalopathy 95
Gingival overgrowth, Hepatomegaly, Macroglossia, Deep philtrum, Widely spaced teeth, Cryptorchidi... OMIM:618143
Hsd10 Disease, Infantile Type
Hypertrophic cardiomyopathy, Cardiomegaly ORPHA:391428
Glycogen Storage Disease Ii
Macroglossia, Hepatomegaly, Cardiomegaly, Splenomegaly OMIM:232300
Amyloidosis, Hereditary, Transthyretin-Related
Cardiomyopathy, Cardiomegaly OMIM:105210
Carnitine Palmitoyltransferase Ii Deficiency, Lethal Neonatal
High palate, Narrow palate, Hepatomegaly, Lipid accumulation in hepatocytes, Hepatic calcificatio... OMIM:608836
Lethal Acantholytic Erosive Disorder
Natal tooth, Cleft palate, Cardiomyopathy, Cardiomegaly ORPHA:158687
Multiple Joint Dislocations, Short Stature, And Craniofacial Dysmorphism With Or Without Congenital Heart Defects
Bicuspid aortic valve, Narrow mouth, Atrial septal defect, Microretrognathia, Cleft palate, Left ... OMIM:245600
Mucopolysaccharidosis Type 3
Abnormal mitral valve morphology, Craniofacial hyperostosis, Hepatomegaly, Macroglossia, Splenome... ORPHA:581
Truncus Arteriosus
Atrial septal defect, Right ventricular hypertrophy, Pulmonic stenosis, Hypoplasia of the thymus,... ORPHA:3384
Ogden Syndrome
Hydrocele testis, High palate, Abnormality of the dentition, Short philtrum, Enlarged kidney, Ven... OMIM:300855
Complete Atrioventricular Septal Defect
Hepatomegaly, Primum atrial septal defect, Right ventricular hypertrophy, Displacement of the pap... ORPHA:1329
Glycogen Storage Disease Due To Acid Maltase Deficiency, Infantile Onset
Hepatomegaly, Macroglossia, Left ventricular hypertrophy, Difficulty in tongue movements, Hypertr... ORPHA:308552
Mucolipidosis Ii Alpha/Beta
Wide mouth, Gingival overgrowth, Hepatomegaly, Macroglossia, Splenomegaly, Micrognathia, Long phi... OMIM:252500
Autoinflammatory Syndrome, Familial, X-Linked, Behcet-Like 2
Lymphocytosis, Iron deficiency anemia, Thrombocytosis, Perianal abscess, Oral ulcer, Reduced natu... OMIM:301074
Carnitine Palmitoyl Transferase Ii Deficiency, Neonatal Form
Hepatomegaly, High, narrow palate, Hepatic calcification, Abnormal myocardium morphology, Hepatic... ORPHA:228308
Liver Disease, Severe Congenital
Hydrocele testis, Exocrine pancreatic insufficiency, Hepatomegaly, Pancreatic hypoplasia, Ventric... OMIM:619991
Bohring-Opitz Syndrome
Cholelithiasis, Abnormal cardiac septum morphology, Annular pancreas, Cleft palate, Retrognathia,... ORPHA:97297
Neurodegeneration With Ataxia And Late-Onset Optic Atrophy
Increased hepatic glycogen content, Cardiomyopathy, Cardiomegaly OMIM:619259
Onychotrichodysplasia And Neutropenia
Chronic neutropenia, Lymphocytosis, Neutropenia OMIM:258360
Familial Aortic Dissection
Cardiomegaly ORPHA:229
Naxos Disease
Right ventricular cardiomyopathy, Abnormal morphology of right ventricular trabeculae, Dilated ca... OMIM:601214
Beckwith-Wiedemann Syndrome
Wide mouth, Exocrine pancreatic insufficiency, Abnormal pancreas morphology, Hepatomegaly, Crypto... ORPHA:116
Abetalipoproteinemia
Hepatomegaly, Cirrhosis, Reticulocytosis, Acanthocytosis, Hepatic fibrosis, Anemia, Hepatic steat... ORPHA:14
Neurodevelopmental Disorder With Microcephaly, Cerebral Atrophy, And Visual Impairment
Partial atrioventricular canal defect, Bicuspid aortic valve, Atrial septal defect, Secundum atri... OMIM:620066
Leigh Syndrome With Nephrotic Syndrome
Cardiomegaly ORPHA:255249
Alpha-N-Acetylgalactosaminidase Deficiency Type 2
Thick vermilion border, Lip telangiectasia, Cardiomegaly, Telangiectasia of the oral mucosa ORPHA:79280
Proteasome-Associated Autoinflammatory Syndrome 1
Hepatomegaly, Macroglossia, Splenomegaly, Thrombocytopenia, Recurrent sinusitis, Elevated circula... OMIM:256040
Beckwith-Wiedemann Syndrome
Hepatomegaly, Hepatoblastoma, Macroglossia, Pancreatic hyperplasia, Enlarged kidney, Cryptorchidi... OMIM:130650
Yunis-Varon Syndrome
Atrial septal defect, High, narrow palate, Glossoptosis, Micrognathia, Short philtrum, Thin vermi... ORPHA:3472
Familial Idiopathic Dilatation Of The Right Atrium
Right atrial enlargement, Abnormality of the hepatic vasculature, Hepatomegaly, Right ventricular... ORPHA:1677
Proteus Syndrome
Tooth agenesis, Ovarian neoplasm, Lymphangioma, Splenomegaly, Neoplasm of the thymus, Testicular ... ORPHA:744
Tropical Endomyocardial Fibrosis
Hepatomegaly, Right ventricular cardiomyopathy, Splenomegaly, Restrictive cardiomyopathy, Eosinop... ORPHA:75565
Histiocytoid Cardiomyopathy
Hepatomegaly, Cleft palate, Ventricular septal defect, Polycystic ovaries, Cardiomegaly ORPHA:137675
Williams Syndrome
Cholelithiasis, Abnormal cardiac septum morphology, Wide mouth, Microdontia, Carious teeth, Ventr... ORPHA:904
Congenital Tracheomalacia
Atrial septal defect, Single ventricle, Tetralogy of Fallot, Ventricular septal defect, Partial a... ORPHA:95430
Familial Thoracic Aortic Aneurysm And Aortic Dissection
Retrognathia, Bicuspid aortic valve, High, narrow palate, Cardiomegaly ORPHA:91387
Singleton-Merten Syndrome 1
Aortic valve calcification, Eruption failure, Aortic valve stenosis, Mitral valve calcification, ... OMIM:182250
Dysferlin-Related Limb-Girdle Muscular Dystrophy R2
Cardiomegaly, Right ventricular hypertrophy ORPHA:268
Aicardi-Goutières Syndrome
Neonatal alloimmune thrombocytopenia, Hepatosplenomegaly, Chronic lymphatic leukemia, Prolonged n... ORPHA:51
Absence Of The Pulmonary Artery
Abnormal cardiac septum morphology, Atrial septal defect, Tetralogy of Fallot, Truncus arteriosus... ORPHA:980
Arterial Calcification, Generalized, Of Infancy, 1
Dilated cardiomyopathy, Cardiomegaly OMIM:208000
Glycogen Storage Disease Due To Acid Maltase Deficiency
Hepatomegaly, Macroglossia, Left ventricular hypertrophy, Difficulty in tongue movements, Hypertr... ORPHA:365
Congenital Total Pulmonary Venous Return Anomaly
Double outlet right ventricle, Cardiac total anomalous pulmonary venous connection, Atrial septal... ORPHA:99125
Generalized Arterial Calcification Of Infancy
Hepatic calcification, Myocardial calcification, Ventricular hypertrophy, Pancreatic calcificatio... ORPHA:51608

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Lgr6

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Lgr6.

No publications found that use IMPC mice or data for Lgr6.

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MGI Allele Allele Type Produced
Lgr6em1(IMPC)Ccpcz Inter-exon deletion Mice
Lgr6tm102274(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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