Gene Summary

Name:
lysosomal-associated membrane protein 3
Synonyms:
Cd208,  1200002D17Rik,  DC-LAMP,  TSC403

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal epididymis morphology Lamp3em1(IMPC)Tcp HOM Early adult 0.00
abnormal sternum morphology Lamp3em1(IMPC)Tcp HOM Early adult 0.00
abnormal lymph node morphology Lamp3em1(IMPC)Tcp HOM Early adult 0.00
abnormal skin morphology Lamp3em1(IMPC)Tcp HOM Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

Eye Morphology

Images Ophthalmoscopy

30 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

Gross Pathology and Tissue Collection

Images

8 Images

X-ray

XRay Images Skull Lateral Orientation

10 Images

Electrocardiogram (ECG)

Waveform Image

1 Images

Human diseases caused by Lamp3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Lamp3 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Immunodeficiency 32A
Lymphadenopathy OMIM:614893
Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Irf8 Deficiency
Lymphadenopathy ORPHA:319600
Squamous Cell Carcinoma Of The Esophagus
Clinodactyly of the 5th toe, Lymphadenopathy ORPHA:99977
Immunodeficiency 38 With Basal Ganglia Calcification
Lymphadenopathy OMIM:616126
Hepatic Venoocclusive Disease With Immunodeficiency
Absence of lymph node germinal center OMIM:235550
Pulmonary Nodular Lymphoid Hyperplasia
Mediastinal lymphadenopathy, Follicular hyperplasia ORPHA:60026
Reticuloendotheliosis, X-Linked
Hepatosplenomegaly, Lymphadenopathy OMIM:312500
Mantle Cell Lymphoma
Lymphadenopathy, Splenomegaly ORPHA:52416
Diethylstilbestrol Syndrome
Cryptorchidism, Abnormality of the uterus, Abnormal reproductive system morphology, Abnormal test... ORPHA:1916
Apolipoprotein A-I Deficiency
Lymphadenopathy, Splenomegaly ORPHA:425
Immunodeficiency 75
Hepatosplenomegaly, Follicular hyperplasia, Lymphadenopathy OMIM:619126
Kerion Celsi
Lymphadenopathy ORPHA:499
Adenocarcinoma Of The Esophagus
Clinodactyly of the 5th toe, Lymphadenopathy ORPHA:99976
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Positive
Lymphadenopathy, Splenomegaly OMIM:608971
Kimura Disease
Follicular hyperplasia, Lymphadenopathy ORPHA:482
Immunodeficiency With Hyper-Igm, Type 5
Epididymitis, Lymphadenopathy OMIM:608106
Immunodeficiency 63 With Lymphoproliferation And Autoimmunity
Lymphadenopathy, Splenomegaly OMIM:618495
Sternum, Premature Obliteration Of Sutures Of
Cryptorchidism, Short sternum OMIM:184800
T-Cell Receptor-Alpha/Beta Deficiency
Lymphadenopathy OMIM:615387
Mast Cell Sarcoma
Mediastinal lymphadenopathy, Lymphadenopathy, Splenomegaly ORPHA:66661
Carcinoma Of Esophagus
Lymphadenopathy ORPHA:70482
Fragile Site, Distamycin A Type, Rare, Fra(16)(Q22.1)
Abnormality of the lymph nodes OMIM:136580
Autoinflammation With Episodic Fever And Lymphadenopathy
Recurrent tonsillitis, Lymphadenopathy, Splenomegaly OMIM:618852
Deafness, Autosomal Dominant 34, With Or Without Inflammation
Lymphadenopathy OMIM:617772
Immunodeficiency 72 With Autoinflammation
Clubbing of fingers, Hepatosplenomegaly, Lymphadenopathy OMIM:618982
Proteasome-Associated Autoinflammatory Syndrome 2
Clinodactyly, Brachydactyly, Lymphadenopathy OMIM:618048
Burkitt Lymphoma
Abnormality of the spleen, Abnormality of the ovary, Abnormality of the lymph nodes ORPHA:543
Autoimmune Hemolytic Anemia-Autoimmune Thrombocytopenia-Primary Immunodeficiency Syndrome
Lymphadenopathy, Splenomegaly ORPHA:444463
Roifman Syndrome
Delayed proximal femoral epiphyseal ossification, Broad femoral head, Lymphadenopathy, Irregular ... ORPHA:353298
Follicular Lymphoma
Mediastinal lymphadenopathy, Lymphadenopathy, Splenomegaly ORPHA:545
Alpha-Heavy Chain Disease
Premature ovarian insufficiency, Lymphadenopathy, Splenomegaly ORPHA:100025
Nodular Lymphocyte Predominant Hodgkin Lymphoma
Lymphadenopathy, Splenomegaly ORPHA:86893
Immunodeficiency 64
Clubbing of fingers, Splenomegaly, Mediastinal lymphadenopathy, Hepatosplenomegaly, Lymphadenopat... OMIM:618534
Lymphoproliferative Syndrome 3
Hepatosplenomegaly, Lymphadenopathy OMIM:618261
Familial Papillary Thyroid Carcinoma With Renal Papillary Neoplasia
Chronic noninfectious lymphadenopathy, Abnormality of the lymph nodes ORPHA:97290
Polyglucosan Body Myopathy 1 With Or Without Immunodeficiency
Lymphadenopathy OMIM:615895
Familial Papillary Or Follicular Thyroid Carcinoma
Chronic noninfectious lymphadenopathy, Abnormality of the lymph nodes ORPHA:319487
Granulomatous Slack Skin
Abnormality of the lymph nodes ORPHA:33111
Immunodeficiency With Hyper-Igm, Type 2
Lymphadenopathy OMIM:605258
Immunodeficiency 27A
Splenomegaly, Enlarged mesenteric lymph node, Hepatosplenomegaly, Hypoplasia of the femoral head,... OMIM:209950
Hodgkin Lymphoma
Lymphadenopathy, Splenomegaly ORPHA:98293
Mu-Heavy Chain Disease
Lymphadenopathy, Splenomegaly ORPHA:100024
Autoimmune Lymphoproliferative Syndrome, Type Iii
Generalized lymphadenopathy, Follicular hyperplasia, Splenomegaly, Mediastinal lymphadenopathy, H... OMIM:615559
Candidiasis, Familial, 2
Lymphadenopathy OMIM:212050
Immunodeficiency 55
Lymphadenopathy OMIM:617827
Immunodeficiency 27B
Generalized lymphadenopathy OMIM:615978
Roifman Syndrome
Short toe, Short metacarpal, Splenomegaly, Short digit, Clinodactyly of the 5th finger, Brachydac... OMIM:616651
Rosaï-Dorfman Disease
Lymphadenopathy ORPHA:158014
Immunodeficiency 76
Lymphadenopathy, Splenomegaly OMIM:619164
Immunodeficiency 14A, Autosomal Dominant
Lymphadenopathy, Splenomegaly OMIM:615513
Hemophagocytic Lymphohistiocytosis, Familial, 5, With Or Without Microvillus Inclusion Disease
Hepatosplenomegaly, Lymphadenopathy, Splenomegaly OMIM:613101
Corticosteroid-Sensitive Aseptic Abscess Syndrome
Abnormality of the lymphatic system, Abnormality of the lymph nodes, Abnormal testis morphology ORPHA:54251
Immunodeficiency 73C With Defective Neutrophil Chemotaxis And Hypogammaglobulinemia
Cervical lymphadenopathy OMIM:618987
Laryngeal Neuroendocrine Tumor
Chronic noninfectious lymphadenopathy ORPHA:100083
Immunodeficiency 78 With Autoimmunity And Developmental Delay
Fluctuating splenomegaly, Lymphadenopathy OMIM:619220
Hemophagocytic Lymphohistiocytosis, Familial, 4
Lymphadenopathy, Splenomegaly OMIM:603552
Multiple Synostoses Syndrome 1
Short hallux, Fusion of midphalangeal joints, Dislocated radial head, Aplasia/Hypoplasia of the m... OMIM:186500
Immunodeficiency, Common Variable, 2
Follicular hyperplasia, Lymphadenopathy, Splenomegaly OMIM:240500
Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia
Mediastinal lymphadenopathy, Lymphadenopathy, Splenomegaly OMIM:300853
Immunodeficiency With Hyper-Igm, Type 3
Absence of lymph node germinal center OMIM:606843
Lcat Deficiency
Lymphadenopathy, Splenomegaly ORPHA:650
Immunodeficiency 52
Lymphadenopathy, Splenomegaly OMIM:617514
Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency
Absent tonsils, Absence of lymph node germinal center ORPHA:277
Pfapa Syndrome
Lymphadenopathy, Splenomegaly ORPHA:42642
Leukocyte Adhesion Deficiency, Type Iii
Hepatosplenomegaly, Abnormality of the lymph nodes, Splenomegaly OMIM:612840
Desmoplastic Small Round Cell Tumor
Mediastinal lymphadenopathy, Ovarian neoplasm, Lymphadenopathy, Testicular neoplasm ORPHA:83469
Classic Mycosis Fungoides
Lymphadenopathy, Splenomegaly ORPHA:2584
Immunodeficiency With Hyper-Igm, Type 4
Absence of lymph node germinal center OMIM:608184
Hemangiomas, Cavernous, Of Face And Supraumbilical Midline Raphe
Bifid sternum OMIM:140850
Schnitzler Syndrome
Lymphadenopathy, Splenomegaly ORPHA:37748
Fish-Eye Disease
Lymphadenopathy, Splenomegaly ORPHA:79292
Tularemia
Abnormal nasopharyngeal adenoid morphology, Mediastinal lymphadenopathy, Lymphadenopathy, Cervica... ORPHA:3392
Floating-Harbor Syndrome
Hip dysplasia, Dislocated radial head, Cryptorchidism, Humeral pseudarthrosis, Epididymal cyst, S... ORPHA:2044
Mycosis Fungoides
Lymphadenopathy OMIM:254400
Familial Cold Autoinflammatory Syndrome 2
Lymphadenopathy, Splenomegaly OMIM:611762
Immunodeficiency, Common Variable, 1
Lymphadenopathy, Splenomegaly OMIM:607594
Indolent Systemic Mastocytosis
Lymphadenopathy, Splenomegaly ORPHA:98848
Caspase 8 Deficiency
Lymphadenopathy, Splenomegaly OMIM:607271
Acquired Hypertrichosis Lanuginosa
Ovarian neoplasm, Lymphadenopathy ORPHA:2221
Classic Hodgkin Lymphoma
Bone marrow hypocellularity, Lymphadenopathy, Splenomegaly ORPHA:391
Pleural Mesothelioma
Lymphadenopathy ORPHA:50251
Pseudomyxoma Peritonei
Lymphadenopathy ORPHA:26790
Congenital Toxoplasmosis
Lymphadenopathy ORPHA:858
Floating-Harbor Syndrome
Cryptorchidism, Epididymal cyst, Congenital posterior urethral valve, Hypospadias, Cone-shaped ep... OMIM:136140
Lymphatic Filariasis
Hydrocele testis, Epididymitis, Urethral obstruction, Abnormality of the scrotum, Lymphadenitis, ... ORPHA:2035
Lig4 Syndrome
Cryptorchidism, Clinodactyly of the 5th finger, Lymphadenopathy, Hypoplasia of penis ORPHA:99812
Immunodeficiency 54
Lymphadenopathy, Splenomegaly OMIM:609981
Lymphoproliferative Syndrome 2
Hepatosplenomegaly, Lymphadenopathy, Splenomegaly OMIM:615122
Periodic Fever, Immunodeficiency, And Thrombocytopenia Syndrome
Lymphadenopathy, Splenomegaly OMIM:150550
Autoinflammatory Syndrome, Familial, With Or Without Immunodeficiency
Lymphadenopathy, Splenomegaly OMIM:619375
Cold Agglutinin Disease
Lymphadenopathy, Splenomegaly ORPHA:56425
Histiocytosis-Lymphadenopathy Plus Syndrome
Rocker bottom foot, Camptodactyly of finger, Azoospermia, Hypergonadotropic hypogonadism, Camptod... OMIM:602782
Ras-Associated Autoimmune Leukoproliferative Disorder
Follicular hyperplasia, Splenomegaly OMIM:614470
Combined Immunodeficiency Due To Zap70 Deficiency
Lymphadenitis, Hepatosplenomegaly, Abnormality of the lymph nodes, Lymphadenopathy ORPHA:911
Rhabdoid Tumor
Lymphadenopathy ORPHA:69077
Cinca Syndrome
Hepatosplenomegaly, Lymphadenopathy OMIM:607115
Von Hippel-Lindau Syndrome
Epididymal cyst, Papillary cystadenoma of the epididymis OMIM:193300
Omenn Syndrome
Hypoplasia of the thymus, Lymphadenopathy, Splenomegaly OMIM:603554
Middle Ear Neuroendocrine Tumor
Chronic noninfectious lymphadenopathy ORPHA:100084
Granulomatous Disease, Chronic, Autosomal Recessive, 5
Recurrent tonsillitis, Lymphadenitis, Splenomegaly, Hepatosplenomegaly, Lymphadenopathy OMIM:618935
Deafness-Lymphedema-Leukemia Syndrome
Bone marrow hypocellularity, Lymphadenopathy, Splenomegaly ORPHA:3226
Omenn Syndrome
Abnormality of the metaphysis, Short toe, Lymphadenopathy, Splenomegaly ORPHA:39041
Renal Cysts And Diabetes Syndrome
Hypoplasia of the uterus, Epididymal cyst, Bicornuate uterus, Hypospadias, Atretic vas deferens OMIM:137920
Autoimmune Lymphoproliferative Syndrome
Chronic noninfectious lymphadenopathy, Follicular hyperplasia, Splenomegaly OMIM:601859
Systemic-Onset Juvenile Idiopathic Arthritis
Lymphadenopathy, Splenomegaly ORPHA:85414
Immunodeficiency 10
Lymphadenopathy OMIM:612783
Autoimmune Lymphoproliferative Syndrome, Type Iia
Chronic noninfectious lymphadenopathy, Follicular hyperplasia, Lymphadenopathy, Splenomegaly OMIM:603909
Griscelli Syndrome Type 2
Lymphadenopathy, Splenomegaly ORPHA:79477
Lymphoproliferative Syndrome, X-Linked, 1
Lymphadenopathy, Splenomegaly OMIM:308240
Leishmaniasis
Lymphadenopathy, Splenomegaly ORPHA:507
Boutonneuse Fever
Lymphadenopathy, Cervical lymphadenopathy ORPHA:83313
Griscelli Syndrome
Bone marrow hypocellularity, Lymphadenopathy, Splenomegaly ORPHA:381
Cinca Syndrome
Brachydactyly, Lymphadenopathy, Splenomegaly ORPHA:1451
Pyogenic Arthritis-Pyoderma Gangrenosum-Acne Syndrome
Lymphadenopathy ORPHA:69126
H Syndrome
Azoospermia, Camptodactyly, Decreased testicular size, Hypogonadism, Hepatosplenomegaly, Micropen... ORPHA:168569
Nephroblastoma
Lymphadenopathy ORPHA:654
Thyroid Lymphoma
Lymphadenopathy ORPHA:97285
Sézary Syndrome
Lymphadenopathy, Splenomegaly ORPHA:3162
Cyclic Neutropenia
Recurrent tonsillitis, Lymphadenopathy, Cervical lymphadenopathy ORPHA:2686
Squamous Cell Carcinoma Of The Anal Canal
Lymphadenopathy ORPHA:424019
American Trypanosomiasis
Lymphadenopathy, Splenomegaly ORPHA:3386
Scrub Typhus
Lymphadenopathy, Splenomegaly ORPHA:83317
Primary Myelofibrosis
Hepatosplenomegaly, Lymphadenopathy, Splenomegaly ORPHA:824
Proteasome-Associated Autoinflammatory Syndrome 4
Lymphadenopathy, Splenomegaly OMIM:619183
Medullary Thyroid Carcinoma
Lymphadenopathy ORPHA:1332
Autoimmune Lymphoproliferative Syndrome, Type V
Lymphadenopathy, Splenomegaly OMIM:616100
Rheumatoid Factor-Negative Polyarticular Juvenile Idiopathic Arthritis
Abnormal hip joint morphology, Abnormal metatarsal morphology, Abnormal shoulder morphology, Hepa... ORPHA:85408
Aggressive Systemic Mastocytosis
Hepatosplenomegaly, Hypersplenism, Lymphadenopathy ORPHA:98850
Felty Syndrome
Bone marrow hypocellularity, Lymphadenopathy, Splenomegaly ORPHA:47612
Immunodeficiency, Common Variable, 8, With Autoimmunity
Clubbing of fingers, Generalized lymphadenopathy, Lymphadenopathy, Splenomegaly OMIM:614700
Thymic Neuroendocrine Tumor
Mediastinal lymphadenopathy, Chronic noninfectious lymphadenopathy, Neoplasm of the thymus ORPHA:97289
Pulmonary Non-Tuberculous Mycobacterial Infection
Lymphadenopathy ORPHA:411703
Anaplastic Thyroid Carcinoma
Lymphadenopathy ORPHA:142
Niemann-Pick Disease, Type A
Lymphadenopathy, Splenomegaly OMIM:257200
Klatskin Tumor
Lymphadenopathy ORPHA:99978
Craniorachischisis
Bifid sternum ORPHA:63260
Poems Syndrome
Hypogonadism, Clubbing of fingers, Metaphyseal sclerosis, Lymphadenopathy ORPHA:2905
Hypocomplementemic Urticarial Vasculitis
Lymphadenopathy, Splenomegaly ORPHA:36412
Von Hippel-Lindau Disease
Epididymal cyst, Papillary cystadenoma of the epididymis ORPHA:892
Immunodeficiency With Hyper-Igm, Type 1
Absence of lymph node germinal center, Enlarged tonsils, Splenomegaly OMIM:308230
Coccidioidomycosis
Abnormality of long bone morphology, Broad ribs, Broad metatarsal, Abnormal sperm morphology, Abn... ORPHA:228123
Meige Disease
Lymph node hypoplasia, Absence of lymph node germinal center ORPHA:90186
Combined Immunodeficiency Due To Crac Channel Dysfunction
Lymphadenopathy, Splenomegaly ORPHA:169090
Lymphoproliferative Syndrome 1
Lymphadenopathy, Splenomegaly OMIM:613011
Legionnaires Disease
Bone marrow hypocellularity, Lymphadenopathy, Splenomegaly ORPHA:549
Melkersson-Rosenthal Syndrome
Lymphadenopathy ORPHA:2483
Mixed Connective Tissue Disease
Mediastinal lymphadenopathy, Lymphadenopathy, Splenomegaly ORPHA:809
Adult-Onset Still Disease
Bone marrow hypocellularity, Generalized lymphadenopathy, Splenomegaly ORPHA:829
T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency
Hepatosplenomegaly, Lymphadenopathy ORPHA:169154
Pulmonary Capillary Hemangiomatosis
Mediastinal lymphadenopathy, Clubbing of fingers, Lymphadenopathy ORPHA:199241
Immunodeficiency 41 With Lymphoproliferation And Autoimmunity
Hepatosplenomegaly, Enlarged tonsils, Lymphadenopathy OMIM:606367
Proteasome-Associated Autoinflammatory Syndrome 3
Finger swelling, Lymphadenopathy, Splenomegaly OMIM:617591
Immunodeficiency 71 With Inflammatory Disease And Congenital Thrombocytopenia
Lymphadenopathy OMIM:617718
Thymoma
Neoplasm of the thymus, Lymphadenopathy ORPHA:99867
Ulbright-Hodes Syndrome
Cryptorchidism, Hypoplasia of the radius, Humeroradial synostosis, Abnormal penis morphology, Sho... ORPHA:3404
Spondyloenchondrodysplasia With Immune Dysregulation
Metaphyseal sclerosis, Short iliac bones, Metaphyseal irregularity, Metaphyseal dysplasia, Metaph... OMIM:607944
Castleman Disease
Mediastinal lymphadenopathy, Generalized lymphadenopathy, Follicular hyperplasia, Lymphadenopathy ORPHA:160
Hyperimmunoglobulinemia D With Periodic Fever
Lymphadenopathy ORPHA:343
Lassa Fever
Lymphadenopathy ORPHA:99824
Gamma-Heavy Chain Disease
Lymphadenopathy, Splenomegaly ORPHA:100026
Mevalonic Aciduria
Hepatosplenomegaly, Fluctuating splenomegaly, Lymphadenopathy OMIM:610377
Immunodeficiency 73B With Defective Neutrophil Chemotaxis And Lymphopenia
Lymphadenitis, Hepatosplenomegaly, Generalized lymphadenopathy OMIM:618986
Farber Disease
Short finger, Hepatosplenomegaly, Lymphadenopathy, Short toe ORPHA:333
Familial Hemophagocytic Lymphohistiocytosis
Lymphadenopathy, Splenomegaly ORPHA:540
Hyper-Igd Syndrome
Lymphadenitis, Hepatosplenomegaly, Lymphadenopathy, Splenomegaly OMIM:260920
Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked
Lymphadenopathy OMIM:304790
Familial Pancreatic Carcinoma
Hepatosplenomegaly, Lymphadenopathy, Ovarian carcinoma ORPHA:1333
Pancreatoblastoma
Abnormality of the lymph nodes ORPHA:677
Aregenerative Anemia
Bone marrow hypocellularity, Lymphadenopathy ORPHA:101096
Cutaneous Neuroendocrine Carcinoma
Chronic noninfectious lymphadenopathy ORPHA:79140
Acute Interstitial Pneumonia
Lymphadenopathy ORPHA:79126
Pediatric Systemic Lupus Erythematosus
Lymphadenopathy ORPHA:93552
Granulomatous Disease, Chronic, Autosomal Recessive, 1
Lymphadenitis, Lymphadenopathy, Splenomegaly OMIM:233700
Granulomatous Disease, Chronic, Autosomal Recessive, 2
Lymphadenitis, Lymphadenopathy, Splenomegaly OMIM:233710
Coffin-Lowry Syndrome
Drumstick terminal phalanges, Narrow iliac wing, Short metacarpal, Bifid sternum, Uterine prolaps... OMIM:303600
Granulomatous Disease, Chronic, Autosomal Recessive, 4
Lymphadenitis, Lymphadenopathy, Splenomegaly OMIM:233690
Granulomatous Disease, Chronic, X-Linked
Lymphadenitis, Lymphadenopathy, Splenomegaly OMIM:306400
Hemophagocytic Lymphohistiocytosis, Familial, 2
Hepatosplenomegaly, Lymphadenopathy, Splenomegaly OMIM:603553
Graft Versus Host Disease
Hepatosplenomegaly, Lymphadenopathy ORPHA:39812
Acute Promyelocytic Leukemia
Lymphadenopathy ORPHA:520
Proteasome-Associated Autoinflammatory Syndrome 1
Clubbing of fingers, Camptodactyly of finger, Epididymitis, Hypoplastic scapulae, Flexion contrac... OMIM:256040
Chediak-Higashi Syndrome
Lymphadenopathy, Splenomegaly OMIM:214500
Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome
Absence of lymph node germinal center, Hepatosplenomegaly ORPHA:79124
Autoinflammation, Panniculitis, And Dermatosis Syndrome
Lymphadenopathy OMIM:617099
Tumor Necrosis Factor Receptor 1 Associated Periodic Syndrome
Abnormal sacroiliac joint morphology, Orchitis, Lymphadenopathy, Splenomegaly ORPHA:32960
Hemophagocytic Lymphohistiocytosis, Familial, 1
Lymphadenopathy, Splenomegaly OMIM:267700
Drug Rash With Eosinophilia And Systemic Symptoms
Lymphadenopathy ORPHA:139402
Carney Triad
Mediastinal lymphadenopathy, Lymphadenopathy ORPHA:139411
Lymphangioleiomyomatosis
Pulmonary lymphangiomyomatosis, Abnormal morphology of female internal genitalia, Abnormality of ... ORPHA:538
Hennekam Syndrome
Camptodactyly of finger, Finger syndactyly, Pulmonary lymphangiectasia, Splenomegaly, Lymphangiom... ORPHA:2136
Autosomal Recessive Malignant Osteopetrosis
Abnormality of epiphysis morphology, Bowing of the long bones, Abnormality of the metaphysis, Spl... ORPHA:667
Kikuchi-Fujimoto Disease
Generalized lymphadenopathy, Splenomegaly, Abnormality of the lymph nodes, Lymphadenopathy, Cervi... ORPHA:50918
Systemic Mastocytosis With Associated Hematologic Neoplasm
Lymphadenopathy, Splenomegaly ORPHA:98849
Autoimmune Lymphoproliferative Syndrome
Chronic noninfectious lymphadenopathy, Hypersplenism, Splenomegaly, Bone marrow hypocellularity, ... ORPHA:3261
Waldenström Macroglobulinemia
Lymphadenopathy, Splenomegaly ORPHA:33226
Malt Lymphoma
Mediastinal lymphadenopathy, Lymphadenopathy ORPHA:52417
Malakoplakia
Orchitis, Follicular hyperplasia, Prostate neoplasm ORPHA:556
Selective Igm Deficiency
Lymphadenitis, Lymphadenopathy ORPHA:331235
Vasculitis, Autoinflammation, Immunodeficiency, And Hematologic Defects Syndrome
Hepatosplenomegaly, Bone marrow hypocellularity, Lymphadenopathy, Splenomegaly OMIM:615688
Q Fever
Hepatosplenomegaly, Lymphadenopathy, Splenomegaly ORPHA:781
Common Variable Immunodeficiency
Lymphadenopathy, Splenomegaly ORPHA:1572
Chédiak-Higashi Syndrome
Hepatosplenomegaly, Lymphadenopathy, Splenomegaly ORPHA:167
Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome
Lymphadenopathy, Splenomegaly ORPHA:37042
X-Linked Lymphoproliferative Disease
Enlarged tonsils, Splenomegaly, Hepatosplenomegaly, Bone marrow hypocellularity, Lymphadenopathy,... ORPHA:2442
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Negative
Absent peripheral lymph nodes in presence of infection OMIM:600802
Familial Mediterranean Fever
Orchitis, Lymphadenopathy, Splenomegaly ORPHA:342
Tangier Disease
Chronic noninfectious lymphadenopathy, Orange discolored tonsils, Hepatosplenomegaly ORPHA:31150
Brucellosis
Epididymitis, Orchitis, Hypersplenism, Splenomegaly, Sacroiliac arthritis, Lymphadenopathy ORPHA:1304
Igg4-Related Kidney Disease
Lymphadenitis, Prostatitis, Urethritis, Lymphadenopathy ORPHA:449395
Cherubism
Submandibular lymph node enlargement OMIM:118400
Multiple Myeloma
Lymphadenopathy, Splenomegaly ORPHA:29073
Gallbladder Neuroendocrine Tumor
Chronic noninfectious lymphadenopathy ORPHA:100086
Igg4-Related Submandibular Gland Disease
Prostatitis, Lymphadenopathy ORPHA:449432
Chikungunya
Lymphadenopathy, Cervical lymphadenopathy ORPHA:324625
Ileal Neuroendocrine Tumor
Lymphadenopathy ORPHA:100078
Jejunal Neuroendocrine Tumor
Lymphadenopathy ORPHA:100077
Igg4-Related Ophthalmic Disease
Prostatitis, Orchitis, Lymphadenopathy ORPHA:449563
Behçet Disease
Orchitis, Lymphadenopathy, Splenomegaly ORPHA:117
Duodenal Neuroendocrine Tumor
Lymphadenopathy ORPHA:100076
Sarcoidosis, Susceptibility To, 1
Mediastinal lymphadenopathy, Clubbing, Generalized lymphadenopathy, Splenomegaly OMIM:181000
Primary Sjögren Syndrome
Vaginal dryness, Lymphadenopathy ORPHA:289390
Sarcoidosis
Abnormal reproductive system morphology, Abnormality of the lymph nodes, Lymphadenopathy ORPHA:797
Adenocarcinoma Of The Anal Canal
Lymphadenopathy ORPHA:424016
African Trypanosomiasis
Hepatosplenomegaly, Lymphadenopathy, Splenomegaly ORPHA:3385
Blau Syndrome
Camptodactyly of finger, Lymphadenopathy, Splenomegaly ORPHA:90340
Leptospirosis
Lymphadenopathy ORPHA:509

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Lamp3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Lamp3.

No publications found that use IMPC mice or data for Lamp3.

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MGI Allele Allele Type Produced
Lamp3tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Lamp3tm1(KOMP)Mbp Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Lamp3em1(IMPC)Tcp Indel Mice

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