Gene Summary

Name:
lysosomal-associated membrane protein 3
Synonyms:
TSC403,  Cd208,  DC-LAMP,  1200002D17Rik

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal sternum morphology Lamp3em1(IMPC)Tcp HOM Early adult 0.00
abnormal lymph node morphology Lamp3em1(IMPC)Tcp HOM Early adult 0.00
abnormal epididymis morphology Lamp3em1(IMPC)Tcp HOM Early adult 0.00
abnormal skin morphology Lamp3em1(IMPC)Tcp HOM Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Skull Lateral Orientation

10 Images

Eye Morphology

Images Ophthalmoscopy

30 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

Gross Pathology and Tissue Collection

Images

8 Images

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

Electrocardiogram (ECG)

Waveform Image

1 Images

Human diseases caused by Lamp3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Lamp3 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Immunodeficiency 32A
Lymphadenopathy OMIM:614893
Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Irf8 Deficiency
Lymphadenopathy ORPHA:319600
Fragile Site, Distamycin A Type, Rare, Fra(16)(Q22.1)
Abnormality of the lymph nodes OMIM:136580
Squamous Cell Carcinoma Of The Esophagus
Lymphadenopathy, Clinodactyly of the 5th toe ORPHA:99977
Immunodeficiency 38 With Basal Ganglia Calcification
Lymphadenopathy OMIM:616126
Hepatic Venoocclusive Disease With Immunodeficiency
Absence of lymph node germinal center OMIM:235550
Pulmonary Nodular Lymphoid Hyperplasia
Follicular hyperplasia, Mediastinal lymphadenopathy ORPHA:60026
Reticuloendotheliosis, X-Linked
Hepatosplenomegaly, Lymphadenopathy OMIM:312500
Mantle Cell Lymphoma
Lymphadenopathy, Splenomegaly ORPHA:52416
Adenocarcinoma Of The Esophagus
Lymphadenopathy, Clinodactyly of the 5th toe ORPHA:99976
Immunodeficiency 75
Hepatosplenomegaly, Follicular hyperplasia, Lymphadenopathy OMIM:619126
Kerion Celsi
Lymphadenopathy ORPHA:499
Immunodeficiency With Hyper-Igm, Type 5
Epididymitis, Lymphadenopathy OMIM:608106
Kimura Disease
Follicular hyperplasia, Lymphadenopathy ORPHA:482
Sternum, Premature Obliteration Of Sutures Of
Cryptorchidism, Short sternum OMIM:184800
Diethylstilbestrol Syndrome
Hypoplasia of the uterus, Cryptorchidism, Micropenis, Hypospadias, Abnormality of the uterus, Abn... ORPHA:1916
Immunodeficiency 104
Lymphadenopathy, Splenomegaly OMIM:608971
Carcinoma Of Esophagus
Lymphadenopathy ORPHA:70482
Immunodeficiency 7
Lymphadenopathy OMIM:615387
Mast Cell Sarcoma
Lymphadenopathy, Mediastinal lymphadenopathy, Splenomegaly ORPHA:66661
Autoinflammation With Episodic Fever And Lymphadenopathy
Lymphadenopathy, Recurrent tonsillitis, Splenomegaly OMIM:618852
Deafness, Autosomal Dominant 34, With Or Without Inflammation
Lymphadenopathy OMIM:617772
Immunodeficiency 72 With Autoinflammation
Clubbing of fingers, Hepatosplenomegaly, Lymphadenopathy OMIM:618982
Burkitt Lymphoma
Abnormality of the spleen, Abnormality of the ovary, Abnormality of the lymph nodes ORPHA:543
Autoimmune Hemolytic Anemia-Autoimmune Thrombocytopenia-Primary Immunodeficiency Syndrome
Lymphadenopathy, Splenomegaly ORPHA:444463
Follicular Lymphoma
Lymphadenopathy, Mediastinal lymphadenopathy, Splenomegaly ORPHA:545
Roifman Syndrome
Epiphyseal dysplasia, Short toe, Clinodactyly of the 5th finger, Delayed proximal femoral epiphys... ORPHA:353298
Nodular Lymphocyte Predominant Hodgkin Lymphoma
Lymphadenopathy, Splenomegaly ORPHA:86893
Immunodeficiency 64
Splenomegaly, Cervical lymphadenopathy, Hepatosplenomegaly, Mediastinal lymphadenopathy, Clubbing... OMIM:618534
Lymphoproliferative Syndrome 3
Hepatosplenomegaly, Lymphadenopathy OMIM:618261
Familial Papillary Thyroid Carcinoma With Renal Papillary Neoplasia
Chronic noninfectious lymphadenopathy, Abnormality of the lymph nodes ORPHA:97290
Immunodeficiency With Hyper-Igm, Type 2
Lymphadenopathy OMIM:605258
Familial Papillary Or Follicular Thyroid Carcinoma
Chronic noninfectious lymphadenopathy, Abnormality of the lymph nodes ORPHA:319487
Granulomatous Slack Skin
Abnormality of the lymph nodes ORPHA:33111
Hodgkin Lymphoma
Lymphadenopathy, Splenomegaly ORPHA:98293
Immunodeficiency 76
Lymphadenopathy, Splenomegaly OMIM:619164
Immunodeficiency 27A
Enlarged mesenteric lymph node, Splenomegaly, Hepatosplenomegaly, Hypoplasia of the femoral head,... OMIM:209950
Immunodeficiency 14A, Autosomal Dominant
Lymphadenopathy, Splenomegaly OMIM:615513
Mu-Heavy Chain Disease
Lymphadenopathy, Splenomegaly ORPHA:100024
Immunodeficiency 78 With Autoimmunity And Developmental Delay
Lymphadenopathy, Fluctuating splenomegaly OMIM:619220
Immunodeficiency 73C With Defective Neutrophil Chemotaxis And Hypogammaglobulinemia
Cervical lymphadenopathy OMIM:618987
Roifman Syndrome
Short toe, Clinodactyly of the 5th finger, Splenomegaly, Brachydactyly, Irregular femoral epiphys... OMIM:616651
Autoimmune Lymphoproliferative Syndrome, Type Iii
Splenomegaly, Hepatosplenomegaly, Follicular hyperplasia, Mediastinal lymphadenopathy, Generalize... OMIM:615559
Immunodeficiency, Common Variable, 2
Follicular hyperplasia, Lymphadenopathy, Splenomegaly OMIM:240500
Rosaï-Dorfman Disease
Lymphadenopathy ORPHA:158014
Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia
Lymphadenopathy, Mediastinal lymphadenopathy, Splenomegaly OMIM:300853
Corticosteroid-Sensitive Aseptic Abscess Syndrome
Abnormality of the lymphatic system, Abnormal testis morphology, Abnormality of the lymph nodes ORPHA:54251
Immunodeficiency With Hyper-Igm, Type 3
Absence of lymph node germinal center OMIM:606843
Immunodeficiency 99 With Hypogammaglobulinemia And Autoimmune Cytopenias
Follicular hyperplasia, Lymphadenopathy OMIM:619846
Alpha-Heavy Chain Disease
Lymphadenopathy, Splenomegaly ORPHA:100025
Hemophagocytic Lymphohistiocytosis, Familial, 5, With Or Without Microvillus Inclusion Disease
Hepatosplenomegaly, Lymphadenopathy, Splenomegaly OMIM:613101
Hemophagocytic Lymphohistiocytosis, Familial, 4
Lymphadenopathy, Splenomegaly OMIM:603552
Immunodeficiency 52
Lymphadenopathy, Splenomegaly OMIM:617514
Immunodeficiency 27B
Generalized lymphadenopathy OMIM:615978
Pfapa Syndrome
Lymphadenopathy, Splenomegaly ORPHA:42642
Hemangiomas, Cavernous, Of Face And Supraumbilical Midline Raphe
Bifid sternum OMIM:140850
Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency
Absent tonsils, Absence of lymph node germinal center ORPHA:277
Fish-Eye Disease
Lymphadenopathy, Splenomegaly ORPHA:79292
Desmoplastic Small Round Cell Tumor
Mediastinal lymphadenopathy, Ovarian neoplasm, Testicular neoplasm, Lymphadenopathy ORPHA:83469
Leukocyte Adhesion Deficiency, Type Iii
Hepatosplenomegaly, Abnormality of the lymph nodes, Splenomegaly OMIM:612840
Immunodeficiency 103, Susceptibility To Fungal Infections
Lymphadenopathy OMIM:212050
Classic Mycosis Fungoides
Lymphadenopathy, Splenomegaly ORPHA:2584
Immunodeficiency With Hyper-Igm, Type 4
Absence of lymph node germinal center OMIM:608184
Caspase 8 Deficiency
Lymphadenopathy, Splenomegaly OMIM:607271
Immunodeficiency, Common Variable, 1
Lymphadenopathy, Splenomegaly OMIM:607594
Tularemia
Cervical lymphadenopathy, Lymphadenopathy, Mediastinal lymphadenopathy, Abnormal nasopharyngeal a... ORPHA:3392
Schnitzler Syndrome
Lymphadenopathy, Splenomegaly ORPHA:37748
Mycosis Fungoides
Lymphadenopathy OMIM:254400
Immunodeficiency 105
Hepatosplenomegaly, Absence of lymph node germinal center OMIM:619924
Classic Hodgkin Lymphoma
Bone marrow hypocellularity, Lymphadenopathy, Splenomegaly ORPHA:391
Familial Cold Autoinflammatory Syndrome 2
Lymphadenopathy, Splenomegaly OMIM:611762
Acquired Hypertrichosis Lanuginosa
Lymphadenopathy, Ovarian neoplasm ORPHA:2221
Congenital Toxoplasmosis
Lymphadenopathy ORPHA:858
Pleural Mesothelioma
Lymphadenopathy ORPHA:50251
Pseudomyxoma Peritonei
Lymphadenopathy ORPHA:26790
Lymphatic Filariasis
Hydrocele testis, Orchitis, Lymphadenitis, Abnormality of the lymphatic system, Epididymitis, Ure... ORPHA:2035
Indolent Systemic Mastocytosis
Lymphadenopathy, Splenomegaly ORPHA:98848
Hereditary Amyloidosis With Primary Renal Involvement
Abnormality of the lymph nodes, Hepatosplenomegaly, Oligospermia, Hypogonadism, Lymphadenopathy, ... ORPHA:85450
Immunodeficiency 54
Lymphadenopathy, Splenomegaly OMIM:609981
Proteasome-Associated Autoinflammatory Syndrome 2
Lymphadenopathy, Brachydactyly, Clinodactyly OMIM:618048
Immunodeficiency 63 With Lymphoproliferation And Autoimmunity
Lymphadenopathy, Splenomegaly OMIM:618495
Cold Agglutinin Disease
Lymphadenopathy, Splenomegaly ORPHA:56425
Lig4 Syndrome
Cryptorchidism, Clinodactyly of the 5th finger, Hypoplasia of penis, Lymphadenopathy ORPHA:99812
Heme Oxygenase 1 Deficiency
Cervical lymphadenopathy, Lymphadenopathy, Asplenia OMIM:614034
Periodic Fever, Immunodeficiency, And Thrombocytopenia Syndrome
Lymphadenopathy, Splenomegaly OMIM:150550
Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation
Splenomegaly, Aplasia of the thymus, Genital ulcers, Generalized lymphadenopathy, Lymph node hypo... OMIM:602450
Autoinflammatory Syndrome, Familial, With Or Without Immunodeficiency
Lymphadenopathy, Splenomegaly OMIM:619375
Lymphoproliferative Syndrome 2
Hepatosplenomegaly, Lymphadenopathy, Splenomegaly OMIM:615122
Histiocytosis-Lymphadenopathy Plus Syndrome
Micropenis, Hypergonadotropic hypogonadism, Cervical lymphadenopathy, Camptodactyly of finger, Sp... OMIM:602782
Floating-Harbor Syndrome
Dislocated radial head, Cone-shaped epiphyses of the phalanges of the hand, Clinodactyly of the 5... OMIM:136140
Combined Immunodeficiency Due To Zap70 Deficiency
Hepatosplenomegaly, Lymphadenitis, Lymphadenopathy, Abnormality of the lymph nodes ORPHA:911
Omenn Syndrome
Abnormal metaphysis morphology, Short toe, Lymphadenopathy, Splenomegaly ORPHA:39041
Cinca Syndrome
Hepatosplenomegaly, Lymphadenopathy OMIM:607115
Rhabdoid Tumor
Lymphadenopathy ORPHA:69077
Omenn Syndrome
Hypoplasia of the thymus, Lymphadenopathy, Splenomegaly OMIM:603554
Middle Ear Neuroendocrine Tumor
Chronic noninfectious lymphadenopathy ORPHA:100084
Systemic-Onset Juvenile Idiopathic Arthritis
Lymphadenopathy, Splenomegaly ORPHA:85414
Granulomatous Disease, Chronic, Autosomal Recessive, 5
Recurrent tonsillitis, Splenomegaly, Hepatosplenomegaly, Lymphadenitis, Lymphadenopathy OMIM:618935
Deafness-Lymphedema-Leukemia Syndrome
Bone marrow hypocellularity, Lymphadenopathy, Splenomegaly ORPHA:3226
Immunodeficiency 94 With Autoinflammation And Dysmorphic Facies
Hepatosplenomegaly, Lymphadenopathy OMIM:619750
Immunodeficiency 10
Lymphadenopathy OMIM:612783
Autoimmune Lymphoproliferative Syndrome, Type Iia
Chronic noninfectious lymphadenopathy, Lymphadenopathy, Follicular hyperplasia, Splenomegaly OMIM:603909
Griscelli Syndrome Type 2
Lymphadenopathy, Splenomegaly ORPHA:79477
Leishmaniasis
Lymphadenopathy, Splenomegaly ORPHA:507
Boutonneuse Fever
Cervical lymphadenopathy, Lymphadenopathy ORPHA:83313
Lymphoproliferative Syndrome, X-Linked, 1
Lymphadenopathy, Splenomegaly OMIM:308240
Niemann-Pick Disease, Type A
Lymphadenopathy, Splenomegaly OMIM:257200
Cinca Syndrome
Lymphadenopathy, Brachydactyly, Splenomegaly ORPHA:1451
Griscelli Syndrome
Bone marrow hypocellularity, Lymphadenopathy, Splenomegaly ORPHA:381
Pyogenic Arthritis-Pyoderma Gangrenosum-Acne Syndrome
Lymphadenopathy ORPHA:69126
Sézary Syndrome
Lymphadenopathy, Splenomegaly ORPHA:3162
Immunodeficiency 91 And Hyperinflammation
Hepatosplenomegaly, Lymphadenopathy OMIM:619644
Nephroblastoma
Lymphadenopathy ORPHA:654
Floating-Harbor Syndrome
Dislocated radial head, Short clavicles, Precocious puberty, Epididymal cyst, Cryptorchidism, Hyp... ORPHA:2044
Thyroid Lymphoma
Lymphadenopathy ORPHA:97285
H Syndrome
Micropenis, Hepatosplenomegaly, Camptodactyly, Hallux valgus, Decreased testicular size, Hypogona... ORPHA:168569
Cyclic Neutropenia
Cervical lymphadenopathy, Lymphadenopathy, Recurrent tonsillitis ORPHA:2686
Squamous Cell Carcinoma Of The Anal Canal
Lymphadenopathy ORPHA:424019
Proteasome-Associated Autoinflammatory Syndrome 4
Lymphadenopathy, Splenomegaly OMIM:619183
Primary Myelofibrosis
Hepatosplenomegaly, Lymphadenopathy, Splenomegaly ORPHA:824
American Trypanosomiasis
Lymphadenopathy, Splenomegaly ORPHA:3386
Immunodeficiency 97 With Autoinflammation
Hepatosplenomegaly, Lymphadenopathy, Mediastinal lymphadenopathy, Splenomegaly OMIM:619802
Scrub Typhus
Lymphadenopathy, Splenomegaly ORPHA:83317
Aggressive Systemic Mastocytosis
Hepatosplenomegaly, Lymphadenopathy, Hypersplenism ORPHA:98850
Pulmonary Non-Tuberculous Mycobacterial Infection
Lymphadenopathy ORPHA:411703
Diffuse Cutaneous Mastocytosis
Lymphadenopathy, Abnormality of the spleen ORPHA:79456
Immune Dysregulation With Autoimmunity, Immunodeficiency, And Lymphoproliferation
Lymphadenopathy, Splenomegaly OMIM:616100
Felty Syndrome
Bone marrow hypocellularity, Lymphadenopathy, Splenomegaly ORPHA:47612
Anaplastic Thyroid Carcinoma
Lymphadenopathy ORPHA:142
Immunodeficiency, Common Variable, 8, With Autoimmunity
Clubbing of fingers, Lymphadenopathy, Generalized lymphadenopathy, Splenomegaly OMIM:614700
Medullary Thyroid Carcinoma
Lymphadenopathy ORPHA:1332
Hypocomplementemic Urticarial Vasculitis
Lymphadenopathy, Splenomegaly ORPHA:36412
Poems Syndrome
Clubbing of fingers, Lymphadenopathy, Hypogonadism, Metaphyseal sclerosis ORPHA:2905
Castleman Disease
Generalized lymphadenopathy, Lymphadenopathy, Mediastinal lymphadenopathy, Follicular hyperplasia ORPHA:160
Coccidioidomycosis
Mediastinal lymphadenopathy, Abnormality of the male genitalia, Abnormality of the spleen, Abnorm... ORPHA:228123
Craniorachischisis
Bifid sternum ORPHA:63260
Rheumatoid Factor-Negative Polyarticular Juvenile Idiopathic Arthritis
Abnormal metatarsal morphology, Hepatosplenomegaly, Abnormal metacarpophalangeal joint morphology... ORPHA:85408
Immunodeficiency 98 With Autoinflammation, X-Linked
Bone marrow hypocellularity, Lymphadenopathy, Splenomegaly OMIM:301078
Pulmonary Capillary Hemangiomatosis
Clubbing of fingers, Lymphadenopathy, Mediastinal lymphadenopathy ORPHA:199241
Combined Immunodeficiency Due To Crac Channel Dysfunction
Lymphadenopathy, Splenomegaly ORPHA:169090
Klatskin Tumor
Lymphadenopathy ORPHA:99978
T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency
Hepatosplenomegaly, Lymphadenopathy ORPHA:169154
Legionnaires Disease
Bone marrow hypocellularity, Lymphadenopathy, Splenomegaly ORPHA:549
Melkersson-Rosenthal Syndrome
Lymphadenopathy ORPHA:2483
Lymphoproliferative Syndrome 1
Lymphadenopathy, Splenomegaly OMIM:613011
Meige Disease
Lymph node hypoplasia, Absence of lymph node germinal center ORPHA:90186
Proteasome-Associated Autoinflammatory Syndrome 3
Finger swelling, Lymphadenopathy, Splenomegaly OMIM:617591
Immunodeficiency 41 With Lymphoproliferation And Autoimmunity
Hepatosplenomegaly, Lymphadenopathy, Enlarged tonsils OMIM:606367
Mixed Connective Tissue Disease
Lymphadenopathy, Mediastinal lymphadenopathy, Splenomegaly ORPHA:809
Spondyloenchondrodysplasia With Immune Dysregulation
Metaphyseal irregularity, Metaphyseal dysplasia, Metaphyseal sclerosis, Metaphyseal widening, Sho... OMIM:607944
Gamma-Heavy Chain Disease
Lymphadenopathy, Splenomegaly ORPHA:100026
Macrophage Activation Syndrome
Lymphadenopathy, Splenomegaly ORPHA:158061
Ulbright-Hodes Syndrome
Aplasia/Hypoplasia of the ulna, Short sternum, Short metacarpal, Thin ribs, Short ribs, Hypoplasi... ORPHA:3404
Immunodeficiency 71 With Inflammatory Disease And Congenital Thrombocytopenia
Lymphadenopathy OMIM:617718
Familial Hemophagocytic Lymphohistiocytosis
Lymphadenopathy, Splenomegaly ORPHA:540
Von Hippel-Lindau Syndrome
Papillary cystadenoma of the epididymis, Epididymal cyst OMIM:193300
Hyperimmunoglobulinemia D With Periodic Fever
Lymphadenopathy ORPHA:343
Immunodeficiency With Hyper-Igm, Type 1
Enlarged tonsils, Absence of lymph node germinal center, Splenomegaly OMIM:308230
Renal Cysts And Diabetes Syndrome
Hypoplasia of the uterus, Bicornuate uterus, Atretic vas deferens, Hypospadias, Epididymal cyst OMIM:137920
Farber Disease
Hepatosplenomegaly, Short toe, Lymphadenopathy, Short finger ORPHA:333
Polyglucosan Body Myopathy 1 With Or Without Immunodeficiency
Lymphadenitis, Lymphadenopathy, Splenomegaly OMIM:615895
Mevalonic Aciduria
Hepatosplenomegaly, Lymphadenopathy, Fluctuating splenomegaly OMIM:610377
Pancreatoblastoma
Abnormality of the lymph nodes ORPHA:677
Acute Interstitial Pneumonia
Lymphadenopathy ORPHA:79126
Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked
Lymphadenopathy OMIM:304790
Hyper-Igd Syndrome
Hepatosplenomegaly, Lymphadenitis, Lymphadenopathy, Splenomegaly OMIM:260920
Familial Pancreatic Carcinoma
Hepatosplenomegaly, Ovarian carcinoma, Lymphadenopathy ORPHA:1333
Aregenerative Anemia
Bone marrow hypocellularity, Lymphadenopathy ORPHA:101096
Hemophagocytic Lymphohistiocytosis, Familial, 2
Hepatosplenomegaly, Lymphadenopathy, Splenomegaly OMIM:603553
Pediatric Systemic Lupus Erythematosus
Lymphadenopathy ORPHA:93552
Coffin-Lowry Syndrome
Drumstick terminal phalanges, Uterine prolapse, Hyperextensibility of the finger joints, Tapered ... OMIM:303600
Granulomatous Disease, Chronic, Autosomal Recessive, 1
Lymphadenitis, Lymphadenopathy, Splenomegaly OMIM:233700
Granulomatous Disease, Chronic, Autosomal Recessive, 2
Lymphadenitis, Lymphadenopathy, Splenomegaly OMIM:233710
Hemophagocytic Lymphohistiocytosis, Familial, 1
Lymphadenopathy, Splenomegaly OMIM:267700
Tumor Necrosis Factor Receptor 1 Associated Periodic Syndrome
Orchitis, Lymphadenopathy, Abnormal sacroiliac joint morphology, Splenomegaly ORPHA:32960
Autosomal Recessive Malignant Osteopetrosis
Splenomegaly, Abnormal rib morphology, Abnormal epiphysis morphology, Bowing of the long bones, A... ORPHA:667
Granulomatous Disease, Chronic, Autosomal Recessive, 4
Lymphadenitis, Lymphadenopathy, Splenomegaly OMIM:233690
Kikuchi-Fujimoto Disease
Abnormality of the lymph nodes, Cervical lymphadenopathy, Splenomegaly, Generalized lymphadenopat... ORPHA:50918
Autoinflammation, Panniculitis, And Dermatosis Syndrome
Lymphadenopathy OMIM:617099
Proteasome-Associated Autoinflammatory Syndrome 1
Splenomegaly, Camptodactyly of finger, Long fingers, Finger swelling, Hypoplastic scapulae, Epidi... OMIM:256040
Graft Versus Host Disease
Hepatosplenomegaly, Lymphadenopathy ORPHA:39812
Acute Promyelocytic Leukemia
Lymphadenopathy ORPHA:520
Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome
Hepatosplenomegaly, Absence of lymph node germinal center ORPHA:79124
Drug Reaction With Eosinophilia And Systemic Symptoms
Lymphadenopathy ORPHA:139402
Waldenström Macroglobulinemia
Lymphadenopathy, Splenomegaly ORPHA:33226
Chediak-Higashi Syndrome
Lymphadenopathy, Splenomegaly OMIM:214500
Lymphangioleiomyomatosis
Abnormal morphology of female internal genitalia, Pulmonary lymphangiomyomatosis, Lymphadenopathy... ORPHA:538
Hennekam Syndrome
Lymphangioma, Splenomegaly, Pulmonary lymphangiectasia, Camptodactyly of finger, Lymphadenopathy,... ORPHA:2136
Carney Triad
Lymphadenopathy, Mediastinal lymphadenopathy ORPHA:139411
Systemic Mastocytosis With Associated Hematologic Neoplasm
Lymphadenopathy, Splenomegaly ORPHA:98849
Malt Lymphoma
Lymphadenopathy, Mediastinal lymphadenopathy ORPHA:52417
Neurologic, Endocrine, And Pancreatic Disease, Multisystem, Infantile-Onset 2
Accessory spleen, Polysplenia, Lymphadenopathy, Splenomegaly OMIM:619418
Q Fever
Hepatosplenomegaly, Lymphadenopathy, Splenomegaly ORPHA:781
Selective Igm Deficiency
Lymphadenitis, Lymphadenopathy ORPHA:331235
Vasculitis, Autoinflammation, Immunodeficiency, And Hematologic Defects Syndrome
Bone marrow hypocellularity, Hepatosplenomegaly, Lymphadenopathy, Splenomegaly OMIM:615688
Autoimmune Lymphoproliferative Syndrome
Splenomegaly, Chronic noninfectious lymphadenopathy, Bone marrow hypocellularity, Lymphadenopathy... ORPHA:3261
Von Hippel-Lindau Disease
Papillary cystadenoma of the epididymis, Epididymal cyst ORPHA:892
Thymic Aplasia
Lymphadenopathy, Aplasia of the thymus ORPHA:83471
Immunodeficiency 55
Lymphadenopathy OMIM:617827
Granulomatous Disease, Chronic, X-Linked
Lymphadenitis, Lymphadenopathy, Splenomegaly OMIM:306400
Familial Mediterranean Fever
Lymphadenopathy, Orchitis, Splenomegaly ORPHA:342
Brucellosis
Orchitis, Splenomegaly, Epididymitis, Sacroiliac arthritis, Lymphadenopathy, Hypersplenism ORPHA:1304
Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome
Lymphadenopathy, Splenomegaly ORPHA:37042
Chédiak-Higashi Syndrome
Hepatosplenomegaly, Lymphadenopathy, Splenomegaly ORPHA:167
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Negative
Absent peripheral lymph nodes in presence of infection OMIM:600802
X-Linked Lymphoproliferative Disease
Enlarged tonsils, Splenomegaly, Cervical lymphadenopathy, Hepatosplenomegaly, Bone marrow hypocel... ORPHA:2442
Common Variable Immunodeficiency
Lymphadenopathy, Splenomegaly ORPHA:1572
Multiple Myeloma
Lymphadenopathy, Splenomegaly ORPHA:29073
Igg4-Related Submandibular Gland Disease
Prostatitis, Lymphadenopathy ORPHA:449432
Igg4-Related Kidney Disease
Urethritis, Lymphadenitis, Prostatitis, Lymphadenopathy ORPHA:449395
Behçet Disease
Lymphadenopathy, Orchitis, Splenomegaly ORPHA:117
Ileal Neuroendocrine Tumor
Lymphadenopathy ORPHA:100078
Jejunal Neuroendocrine Tumor
Lymphadenopathy ORPHA:100077
Igg4-Related Ophthalmic Disease
Prostatitis, Orchitis, Lymphadenopathy ORPHA:449563
Chikungunya
Cervical lymphadenopathy, Lymphadenopathy ORPHA:324625
Sarcoidosis
Abnormality of the lymph nodes, Lymphadenopathy, Abnormal reproductive system morphology ORPHA:797
Crimean-Congo Hemorrhagic Fever
Epididymitis, Lymphadenopathy, Orchitis, Splenomegaly ORPHA:99827
Duodenal Neuroendocrine Tumor
Lymphadenopathy ORPHA:100076
Primary Sjögren Syndrome
Lymphadenopathy, Vaginal dryness ORPHA:289390
Immunodeficiency 82 With Systemic Inflammation
Anoperineal fistula, Follicular hyperplasia, Lymphadenopathy, Splenomegaly OMIM:619381
Adenocarcinoma Of The Anal Canal
Lymphadenopathy ORPHA:424016
Marburg Hemorrhagic Fever
Lymphadenopathy, Orchitis ORPHA:99826
Cushing Syndrome Due To Ectopic Acth Secretion
Neoplasm of the thymus, Prostate cancer, Abnormality of the lymph nodes ORPHA:99889
Blau Syndrome
Camptodactyly of finger, Lymphadenopathy, Splenomegaly ORPHA:90340
Igg4-Related Dacryoadenitis And Sialadenitis
Lymphadenopathy ORPHA:79078
African Trypanosomiasis
Hepatosplenomegaly, Lymphadenopathy, Splenomegaly ORPHA:3385
Leptospirosis
Lymphadenopathy ORPHA:509

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Lamp3

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Lamp3.

No publications found that use IMPC mice or data for Lamp3.

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MGI Allele Allele Type Produced
Lamp3tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Lamp3tm1(KOMP)Mbp Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Lamp3em1(IMPC)Tcp Indel Mice
Lamp3tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells

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