Gene Summary

Name:
leucine rich repeat transmembrane neuronal 1
Synonyms:
4632401D06Rik

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal eye morphology Lrrtm1em1(IMPC)Mbp HOM Early adult 0.00
hyperactivity Lrrtm1em1(IMPC)Mbp HOM Early adult 2.75×10-08
abnormal skin morphology Lrrtm1em1(IMPC)Mbp HOM Early adult 0.00
increased exploration in new environment Lrrtm1em1(IMPC)Mbp HOM Early adult 5.09×10-10
decreased exploration in new environment Lrrtm1em1(IMPC)Mbp HOM Early adult 1.30×10-09
decreased locomotor activity Lrrtm1em1(IMPC)Mbp HOM   Early adult 2.99×10-06
decreased thigmotaxis Lrrtm1em1(IMPC)Mbp HOM Early adult 3.16×10-21
abnormal behavior Lrrtm1em1(IMPC)Mbp HOM Early adult 7.21×10-21
decreased anxiety-related response Lrrtm1em1(IMPC)Mbp HOM Early adult 9.58×10-21

Download data as:  TSV  XLS

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

30 Images

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

Human diseases caused by Lrrtm1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Lrrtm1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Familial Alzheimer-Like Prion Disease
Cognitive impairment, Anxiety, Deficit in phonologic short-term memory, Emotional lability, Depre... ORPHA:280397
Severe Primary Trimethylaminuria
Anxiety, Negative affectivity, Aggressive behavior, Emotional lability, Low self esteem, Depression ORPHA:468726
Prkar1B-Related Neurodegenerative Dementia With Intermediate Filaments
Short stepped shuffling gait, Memory impairment, Shuffling gait, Inertia, Frontotemporal dementia... ORPHA:412066
Autism, Susceptibility To, X-Linked 4
Impulsivity, Aggressive behavior, Attention deficit hyperactivity disorder OMIM:300830
Intellectual Developmental Disorder, Autosomal Dominant 52
Anxiety, Hyperactivity OMIM:617796
Spastic Tetraplegia, Thin Corpus Callosum, And Progressive Microcephaly
Irritability, Inability to walk, Hyperactivity OMIM:616657
Intellectual Developmental Disorder, Autosomal Recessive 37
Hyperactivity, Aggressive behavior OMIM:615493
Intellectual Developmental Disorder, Autosomal Recessive 25
Anxiety OMIM:614346
Panic Disorder 1
Anxiety OMIM:167870
Ank3-Related Intellectual Disability-Sleep Disturbance Syndrome
Hyperactivity, Aggressive behavior ORPHA:356996
Epilepsy, Progressive Myoclonic, 12
Dysmetria, Anxiety, Mental deterioration, Ataxia, Depression, Difficulty walking, Attention defic... OMIM:619191
Intellectual Developmental Disorder, Autosomal Recessive 66
Gait ataxia, Attention deficit hyperactivity disorder, Aggressive behavior, Shyness OMIM:618221
Obsessive-Compulsive Disorder
Anxiety, Depression, Skin-picking OMIM:164230
Intellectual Developmental Disorder With Epilepsy, Behavioral Abnormalities, And Coarse Facies
Self-injurious behavior, Anxiety, Hyperactivity, Aggressive behavior OMIM:619031
Hyperlysinemia, Type I
Hyperactivity, Cognitive impairment OMIM:238700
Smith-Magenis syndrome
Hyperactivity, Self-mutilation DECIPHER:8
Gilles De La Tourette Syndrome
Self-mutilation, Aggressive behavior, Attention deficit hyperactivity disorder OMIM:137580
Attention Deficit-Hyperactivity Disorder
Hyperactivity, Attention deficit hyperactivity disorder OMIM:143465
Leukoencephalopathy, Motor Delay, Spasticity, And Dysarthria Syndrome
Anxiety, Bradykinesia, Attention deficit hyperactivity disorder OMIM:618878
Neurodevelopmental Disorder With Hypotonia And Gross Motor And Speech Delay
Inability to walk, Aggressive behavior, Attention deficit hyperactivity disorder OMIM:619639
Intellectual Developmental Disorder, Autosomal Dominant 45
Hyperactivity, Attention deficit hyperactivity disorder OMIM:617600
Glycine Encephalopathy
Hyperactivity, Aggressive behavior, Lethargy, Irritability, Impulsivity OMIM:605899
Spinocerebellar Ataxia 14
Dysmetria, Memory impairment, Mental deterioration, Gait ataxia, Progressive cerebellar ataxia, D... OMIM:605361
Chorea, Benign Hereditary
Anxiety, Gait disturbance OMIM:118700
Huntington Disease-Like 1
Dysmetria, Basal ganglia gliosis, Anxiety, Dementia, Aggressive behavior, Unsteady gait, Depression OMIM:603218
Pandas
Abnormal fear/anxiety-related behavior, Emotional lability, Irritability, Separation insecurity, ... ORPHA:66624
Hyperprolinemia, Type I
Hyperactivity, Ataxia, Aggressive behavior OMIM:239500
Intellectual Developmental Disorder, Autosomal Recessive 3
Hyperactivity OMIM:608443
Intellectual Developmental Disorder, Autosomal Recessive 54
Hyperactivity OMIM:617028
Schizophrenia 15
Hyperactivity OMIM:613950
Juvenile Huntington Disease
Dementia, Bradykinesia, Hyperactivity, Ataxia, Progressive cerebellar ataxia, Gait ataxia, Irrita... ORPHA:248111
Microcephaly 2, Primary, Autosomal Recessive, With Or Without Cortical Malformations
Hyperactivity, Impulsivity, Aggressive behavior OMIM:604317
22q13 deletion syndrome (Phelan-Mcdermid syndrome)
Hyperactivity DECIPHER:20
Potocki-Lupski syndrome (17p11.2 duplication syndrome)
Hyperactivity DECIPHER:19
Huntington Disease-Like 2
Anxiety, Dementia, Bradykinesia, Apathy, Irritability, Depression OMIM:606438
Early-Onset Schizophrenia
Suicidal ideation, Cognitive impairment, Lack of peer relationships, No social interaction, Unhap... ORPHA:96369
Lennox-Gastaut Syndrome
Hyperactivity, Mental deterioration, Aggressive behavior, Personality disorder, Falls ORPHA:2382
Immunodeficiency 8
Hyperactivity OMIM:615401
Basal Ganglia Calcification, Idiopathic, 5
Cognitive impairment, Anxiety, Dementia, Athetosis, Apathy, Basal ganglia calcification, Depression OMIM:615483
Intellectual Developmental Disorder, X-Linked 109
Hyperactivity, Impulsivity, Aggressive behavior OMIM:309548
Developmental And Epileptic Encephalopathy 43
Hyperactivity, Ataxia OMIM:617113
Fraxe Intellectual Disability
Hyperactivity, Impulsivity, Aggressive behavior ORPHA:100973
Parkinson Disease 6, Autosomal Recessive Early-Onset
Dementia, Anxiety, Depression, Bradykinesia OMIM:605909
Intellectual Developmental Disorder, Autosomal Dominant 43
Anxiety, Hyperactivity, Impulsivity OMIM:616977
Landau-Kleffner Syndrome
Memory impairment, Anxiety, Hyperactivity, Aggressive behavior, Steppage gait, Emotional lability... ORPHA:98818
Chromosome 3Q29 Deletion Syndrome
Gait ataxia, Anxiety, Hyperactivity, Aggressive behavior OMIM:609425
X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome
Shuffling gait, Abnormal aggressive, impulsive or violent behavior, Hyperactivity, Aggressive beh... ORPHA:3077
Morm Syndrome
Hyperactivity, Aggressive behavior ORPHA:75858
Cognitive Impairment With Or Without Cerebellar Ataxia
Dysmetria, Cognitive impairment, Ataxia, Emotional lability, Attention deficit hyperactivity diso... OMIM:614306
Mannosidosis, Beta A, Lysosomal
Hyperactivity, Aggressive behavior OMIM:248510
Phenylketonuria
Anxiety, Hyperactivity, Aggressive behavior, Irritability, Self-mutilation, Depression, Attention... OMIM:261600
Neurodevelopmental Disorder With Motor And Speech Delay And Behavioral Abnormalities
Hyperactivity, Broad-based gait, Aggressive behavior OMIM:619470
Childhood Disintegrative Disorder
Impaired social interactions, Progressive language deterioration, Anxiety, Dementia, Motor deteri... ORPHA:168782
Intellectual Developmental Disorder, X-Linked 104
Hyperactivity, Ataxia, Aggressive behavior OMIM:300983
Intellectual Disability-Expressive Aphasia-Facial Dysmorphism Syndrome
Hyperactivity, Abnormal social behavior ORPHA:436151
Glycosylphosphatidylinositol Biosynthesis Defect 17
Overfriendliness, Dysplastic corpus callosum, Aggressive behavior, Primary microcephaly OMIM:618010
Xq25 Microduplication Syndrome
Anxiety, Hyperactivity ORPHA:521258
Chromosome Xq25 Duplication Syndrome
Anxiety, Hyperactivity OMIM:300979
Coffin-Siris Syndrome 8
Self-injurious behavior, Hyperactivity, Aggressive behavior OMIM:618362
Intellectual Developmental Disorder, X-Linked, Syndromic, Houge Type
Hyperactivity, Impulsivity, Attention deficit hyperactivity disorder OMIM:301008
Pitt-Hopkins-Like Syndrome 1
Impaired social interactions, Focal cortical dysplasia, Progressive language deterioration, Hyper... OMIM:610042
Early-Onset Autosomal Dominant Alzheimer Disease
Semantic dementia, Neurofibrillary tangles, Memory impairment, Abnormal social behavior, Disinhib... ORPHA:1020
11Q22.2Q22.3 Microdeletion Syndrome
Abnormal social behavior, Anxiety, Poor eye contact, Hypoplasia of the corpus callosum, Attention... ORPHA:444002
Angelman Syndrome Due To Imprinting Defect In 15Q11-Q13
Happy demeanor, Hyperactivity, Ataxia, Inappropriate laughter, Broad-based gait ORPHA:411515
Microcephaly, Seizures, And Developmental Delay
Hyperactivity, Ataxia OMIM:613402
Succinic Semialdehyde Dehydrogenase Deficiency
Self-injurious behavior, Hyperactivity, Anxiety, Ataxia, Aggressive behavior OMIM:271980
Encephalopathy, Progressive, With Or Without Lipodystrophy
Hyperactivity, Mental deterioration, Ataxia OMIM:615924
Usmani-Riazuddin Syndrome, Autosomal Dominant
Self-injurious behavior, Hyperactivity, Anxiety, Aggressive behavior, Depression OMIM:619467
Dystonia, Dopa-Responsive, Due To Sepiapterin Reductase Deficiency
Hyperactivity, Ataxia, Aggressive behavior OMIM:612716
Neurodevelopmental Disorder With Behavioral Abnormalities, Absent Speech, And Hypotonia
Self-injurious behavior, Hyperactivity, Inability to walk, Paroxysmal bursts of laughter OMIM:618718
Cln5 Disease
Dysmetria, Anxiety, Hyperactivity, Inability to walk, Mental deterioration, Ataxia, Aggressive be... ORPHA:228360
Intellectual Developmental Disorder, Autosomal Recessive 38
Hyperactivity, Self-mutilation, Aggressive behavior, Unsteady gait OMIM:615516
Intellectual Developmental Disorder, X-Linked 107
Anxiety, Hyperactivity, Aggressive behavior, Attention deficit hyperactivity disorder OMIM:301013
Dopa-Responsive Dystonia
Abnormal social behavior, Anxiety, Inability to walk, Panic attack, Lethargy, Emotional lability,... ORPHA:255
Neurodevelopmental Disorder With Epilepsy And Hypoplasia Of The Corpus Callosum
Hyperactivity, Dysmetria, Inability to walk, Gait disturbance OMIM:618090
Intellectual Developmental Disorder, Autosomal Recessive 39
Hyperactivity, Aggressive behavior OMIM:615541
Female Restricted Epilepsy With Intellectual Disability
Anxiety, Hyperactivity, Impulsivity, Aggressive behavior ORPHA:101039
X-Linked Intellectual Disability-Hypotonia-Movement Disorder Syndrome
Hyperactivity, Broad-based gait, Aggressive behavior ORPHA:457260
Clcn4-Related X-Linked Intellectual Disability Syndrome
Self-injurious behavior, Anxiety, Hyperactivity, Aggressive behavior, Unsteady gait, Progressive ... ORPHA:485350
Intellectual Developmental Disorder With Abnormal Behavior, Microcephaly, And Short Stature
Hyperactivity, Aggressive behavior OMIM:618342
Neurodevelopmental Disorder With Movement Abnormalities, Abnormal Gait, And Autistic Features
Happy demeanor, Hyperactivity, Broad-based gait, Unsteady gait OMIM:617865
Guanidinoacetate Methyltransferase Deficiency
Self-injurious behavior, Hyperactivity, Athetosis, Ataxia, Aggressive behavior ORPHA:382
Hsd10 Disease
Abnormal social behavior, Ataxia, Microcephaly, Gait disturbance, Frontotemporal cerebral atrophy... ORPHA:391417
Intellectual Developmental Disorder, Autosomal Recessive 61
Hyperactivity, Aggressive behavior OMIM:617773
Clark-Baraitser Syndrome
Hyperactivity, Aggressive behavior OMIM:617752
Rasmussen Subacute Encephalitis
Cognitive impairment, Memory impairment, Hyperactivity, Inability to walk, Emotional lability, Ir... ORPHA:1929
Childhood-Onset Motor And Cognitive Regression Syndrome With Extrapyramidal Movement Disorder
Hyperactivity, Inability to walk, Aggressive behavior, Gait ataxia, Impulsivity ORPHA:500180
Ck Syndrome
Irritability, Hyperactivity, Aggressive behavior ORPHA:251383
X-Linked Adrenoleukodystrophy
Cognitive impairment, Disinhibition, Dementia, Hyperactivity, Aggressive behavior, Inappropriate ... ORPHA:43
Hereditary Geniospasm
Abnormal social behavior ORPHA:53372
Ck Syndrome
Irritability, Hyperactivity, Aggressive behavior OMIM:300831
Intellectual Developmental Disorder, X-Linked 30
Anxiety, Hyperactivity, Aggressive behavior OMIM:300558
Mitochondrial Complex Iii Deficiency, Nuclear Type 7
Hyperactivity, Aggressive behavior OMIM:615824
Graves Disease, Susceptibility To, 1
Irritability, Hyperactivity OMIM:275000
Late Infantile Neuronal Ceroid Lipofuscinosis
Low frustration tolerance, Anxiety, Dementia, Motor deterioration, Mental deterioration, Inabilit... ORPHA:168491
Language Delay And Attention Deficit-Hyperactivity Disorder/Cognitive Impairment With Or Without Cardiac Arrhythmia
Hyperactivity, Attention deficit hyperactivity disorder OMIM:617182
Autosomal Recessive Non-Syndromic Intellectual Disability
Depression, Impulsivity, Hyperactivity ORPHA:88616
Intellectual Developmental Disorder, Autosomal Dominant 7
Happy demeanor, Hyperactivity, Ataxia, Inappropriate laughter, Gait disturbance OMIM:614104
Gand Syndrome
Hyperactivity, Inappropriate laughter OMIM:615074
Neurodevelopmental Disorder With Brain Abnormalities, Poor Growth, And Dysmorphic Facies
Hyperactivity, Aggressive behavior OMIM:615286
Intellectual Developmental Disorder, X-Linked, Syndromic, Snijders Blok Type
Hyperactivity, Broad-based gait, Aggressive behavior OMIM:300958
Metachromatic Leukodystrophy, Adult Form
Memory impairment, Abnormal social behavior, Dementia, Emotional lability, Progressive psychomoto... ORPHA:309271
Infantile Neuroaxonal Dystrophy
Psychomotor deterioration, Hyperactivity, Mental deterioration, Ataxia, Unsteady gait, Emotional ... ORPHA:35069
Metachromatic Leukodystrophy, Juvenile Form
Abnormal social behavior, Emotional lability, Progressive psychomotor deterioration, Progressive ... ORPHA:309263
Gomez-Lopez-Hernandez Syndrome
Cognitive impairment, Self-injurious behavior, Hyperactivity, Ataxia, Bipolar affective disorder,... OMIM:601853
Neurodegeneration With Brain Iron Accumulation 2B
Dysmetria, Hyperactivity, Bradykinesia, Mental deterioration, Emotional lability, Gait ataxia, Dy... OMIM:610217
X-Linked Intellectual Disability-Acromegaly-Hyperactivity Syndrome
Hyperactivity, Aggressive behavior ORPHA:85327
Severe Motor And Intellectual Disabilities-Sensorineural Deafness-Dystonia Syndrome
Hyperactivity, Aggressive behavior ORPHA:369939
2Q23.1 Microdeletion Syndrome
Self-injurious behavior, Hyperactivity, Ataxia, Paroxysmal bursts of laughter ORPHA:228402
Adenylosuccinase Deficiency
Happy demeanor, Hyperactivity, Inability to walk, Aggressive behavior, Inappropriate laughter, Ga... OMIM:103050
Symptomatic Form Of Fragile X Syndrome In Female Carriers
Impaired social interactions, Self-injurious behavior, Anxiety, Hyperactivity, Aggressive behavio... ORPHA:449291
Cntnap2-Related Developmental And Epileptic Encephalopathy
Low frustration tolerance, Progressive language deterioration, Hyperactivity, Mental deterioratio... ORPHA:163681
Non-Progressive Cerebellar Ataxia With Intellectual Disability
Abnormal cortical gyration, Dysmetria, Memory impairment, Abnormal social behavior, Hypoplastic h... ORPHA:314647
Hypomagnesemia, Seizures, And Mental Retardation 2
Self-biting, Hyperactivity OMIM:618314
Myoclonic-Astatic Epilepsy
Hyperactivity, Ataxia, Unsteady gait, Abnormal emotion/affect behavior, Attention deficit hyperac... ORPHA:1942
Fragile X Syndrome
Self-biting, Hyperactivity OMIM:300624
Intellectual Developmental Disorder, X-Linked, Syndromic, Cabezas Type
Gait ataxia, Hyperactivity, Aggressive behavior, Mood swings OMIM:300354
Severe Neurodegenerative Syndrome With Lipodystrophy
Cognitive impairment, Hyperactivity, Ataxia, Gait ataxia, Progressive psychomotor deterioration ORPHA:363400
Severe Intellectual Disability-Short Stature-Behavioral Abnormalities-Facial Dysmorphism Syndrome
Irritability, Hyperactivity, Aggressive behavior ORPHA:391307
X-Linked Creatine Transporter Deficiency
Ataxia, Hyperactivity, Self-mutilation, Athetosis ORPHA:52503
Intellectual Developmental Disorder, X-Linked 21
Hyperactivity, Impulsivity OMIM:300143
Chromosome 2Q37 Deletion Syndrome
Self-injurious behavior, Hyperactivity, Aggressive behavior OMIM:600430
Mucopolysaccharidosis, Type Iiib
Hyperactivity, Progressive neurologic deterioration, Aggressive behavior OMIM:252920
Childhood Absence Epilepsy
Abnormal social behavior, Anxiety, Low self esteem, Depression, Attention deficit hyperactivity d... ORPHA:64280
Metachromatic Leukodystrophy, Late Infantile Form
Abnormal social behavior, Emotional lability, Gait ataxia, Progressive gait ataxia, Tip-toe gait,... ORPHA:309256
Developmental Delay With Variable Intellectual Impairment And Behavioral Abnormalities
Anxiety, Hyperactivity, Ataxia, Aggressive behavior OMIM:618430
Cri-Du-Chat Syndrome
Anxiety, Hyperactivity, Conspicuously happy disposition, Aggressive behavior, Self-mutilation, Di... OMIM:123450
Lamb-Shaffer Syndrome
Microcephaly, Hyperactivity, Ataxia, Abnormal social behavior ORPHA:530983
Inverted Duplicated Chromosome 15 Syndrome
Self-biting, Hyperactivity, Aggressive behavior ORPHA:3306
Intellectual Developmental Disorder, X-Linked 77
Hyperactivity OMIM:300454
Niemann-Pick Disease Type C
Cerebral atrophy, Cognitive impairment, Low frustration tolerance, Abnormal social behavior, Disi... ORPHA:646
Angelman Syndrome Due To Maternal 15Q11Q13 Deletion
Happy demeanor, Hyperactivity, Ataxia, Inappropriate laughter, Gait imbalance, Broad-based gait ORPHA:98794
16P12.1P12.3 Triplication Syndrome
Nail-biting, Anxiety, Hyperactivity, Skin-picking, Attention deficit hyperactivity disorder ORPHA:485405
Intellectual Developmental Disorder, X-Linked, Syndromic, Billuart Type
Gait ataxia, Hyperactivity, Low frustration tolerance, Self-mutilation OMIM:300486
Glass Syndrome
Happy demeanor, Broad-based gait, Aggressive behavior, Hyperactivity OMIM:612313
Severe Intellectual Disability-Poor Language-Strabismus-Grimacing Face-Long Fingers Syndrome
Hyperactivity, Low frustration tolerance, Self-mutilation, Inappropriate laughter ORPHA:363686
13Q12.3 Microdeletion Syndrome
Hyperactivity, Self-mutilation ORPHA:412035
Intellectual Developmental Disorder, X-Linked, Syndromic, Lujan-Fryns Type
Emotional lability, Hyperactivity, Low frustration tolerance, Aggressive behavior OMIM:309520
Citrullinemia Type Ii
Memory impairment, Hyperactivity, Aggressive behavior, Lethargy, Irritability ORPHA:247585
Insensitivity To Pain, Congenital, With Anhidrosis
Emotional lability, Hyperactivity, Self-mutilation OMIM:256800
48,Xxxy Syndrome
Abnormal social behavior, Abnormal aggressive, impulsive or violent behavior, Anxiety, Irritabili... ORPHA:96263
Angelman Syndrome
Happy demeanor, Self-injurious behavior, Anxiety, Inability to walk, Hyperactivity, Ataxia, Aggre... ORPHA:72
X-Linked Cerebral Adrenoleukodystrophy
Dysmetria, Memory impairment, Hyperactivity, Inability to walk, Mental deterioration, Ataxia, Gai... ORPHA:139396
Argininemia
Irritability, Spastic gait, Hyperactivity OMIM:207800
Rauch-Steindl Syndrome
Anxiety, Hyperactivity, Aggressive behavior OMIM:619695
Intellectual Developmental Disorder, Autosomal Recessive 71
Hyperactivity, Attention deficit hyperactivity disorder OMIM:618504
Dihydropyrimidine Dehydrogenase Deficiency
Cerebral atrophy, Abnormal social behavior, Hyperintensity of cerebral white matter on MRI, Abnor... ORPHA:1675
Angelman Syndrome
Hyperactivity, Broad-based gait, Progressive gait ataxia, Paroxysmal bursts of laughter OMIM:105830
Prader-Willi Syndrome Due To Translocation
Impaired social interactions, Happy demeanor, Anterior pituitary hypoplasia, Abnormal social beha... ORPHA:177907
Neurodegeneration With Brain Iron Accumulation 1
Dementia, Bradykinesia, Mental deterioration, Ataxia, Akinesia, Hyperactivity, Gait disturbance, ... OMIM:234200
Intellectual Developmental Disorder, X-Linked 98
Self-biting, Anxiety, Hyperactivity, Ataxia, Aggressive behavior OMIM:300912
47,Xyy Syndrome
Hyperactivity, Impulsivity, Attention deficit hyperactivity disorder ORPHA:8
Tuberous Sclerosis Complex
Cortical tubers, Abnormal social behavior, Self-injurious behavior, Anxiety, Hyperactivity, Aggre... ORPHA:805
Choreoacanthocytosis
Socially inappropriate behavior, Falls, Self-injurious behavior, Anxiety, Bradykinesia, Mental de... ORPHA:2388
Fg Syndrome Type 1
Small pituitary gland, Abnormal social behavior, Aplasia/Hypoplasia of the corpus callosum, Broad... ORPHA:93932
Wiedemann-Steiner Syndrome
Low frustration tolerance, Psychomotor deterioration, Anxiety, Hyperactivity, Aggressive behavior ORPHA:319182
Mend Syndrome
Abnormal social behavior, Hyperactivity, Aggressive behavior, Hypoplasia of the corpus callosum ORPHA:401973
Cerebellar Dysfunction With Variable Cognitive And Behavioral Abnormalities
Dysmetria, Hyperactivity, Ataxia, Aggressive behavior, Unsteady gait, Gait ataxia, Broad-based ga... OMIM:614756
Koolen-De Vries Syndrome Due To A Point Mutation
Pineal cyst, Agenesis of corpus callosum, Abnormal social behavior, Anxiety, Inappropriate laught... ORPHA:363965
17Q21.31 Microdeletion Syndrome
Pineal cyst, Agenesis of corpus callosum, Abnormal social behavior, Anxiety, Inappropriate laught... ORPHA:363958
Spastic Tetraplegia-Thin Corpus Callosum-Progressive Postnatal Microcephaly Syndrome
Hair-pulling, Hyperactivity, Irritability ORPHA:447997
Hereditary Sensory And Autonomic Neuropathy Type 4
Nail-biting, Hyperactivity, Self-mutilation, Abnormal emotion/affect behavior, Impulsivity, Diffi... ORPHA:642
Williams Syndrome
Dysmetria, Abnormality of the diencephalon, Abnormal social behavior, Anxiety, Ataxia, Microcepha... ORPHA:904
Histidinemia
Hyperactivity ORPHA:2157

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Lrrtm1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Lrrtm1.

No publications found that use IMPC mice or data for Lrrtm1.

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MGI Allele Allele Type Produced
Lrrtm1em1(IMPC)Mbp Whole-gene deletion Mice, Tissue
Lrrtm1tm445183(L1L2_GT0_LF2A_LacZ_BetactP_neo) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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