Gene: Tardbp

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Name
TAR DNA binding protein
MGI ID
MGI:2387629
Synonyms
1190002A23Rik TDP-43 Tdp43
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
increased mean platelet volume Tardbptm1b(EUCOMM)Wtsi HET Early adult 3.05×10-28
abnormal startle reflex Tardbptm1b(EUCOMM)Wtsi HET Early adult 7.76×10-09
decreased basophil cell number Tardbptm1b(EUCOMM)Wtsi HET Early adult 2.09×10-06
preweaning lethality, complete penetrance Tardbptm1b(EUCOMM)Wtsi HOM Early adult 0.00
decreased mean platelet volume Tardbptm1b(EUCOMM)Wtsi HET Early adult 3.05×10-28
decreased neutrophil cell number Tardbptm1b(EUCOMM)Wtsi HET Early adult 2.69×10-05
increased fasting circulating glucose level Tardbptm1b(EUCOMM)Wtsi HET Early adult 1.82×10-05
increased lymphocyte cell number Tardbptm1b(EUCOMM)Wtsi HET Early adult 1.07×10-05
embryonic lethality prior to organogenesis Tardbptm1b(EUCOMM)Wtsi HOM E9.5 0.00
decreased blood urea nitrogen level Tardbptm1b(EUCOMM)Wtsi HET Early adult 8.75×10-05

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No N/A
Bone 2 No N/A
Brain 2 No N/A
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (2/2)  Wholemount images
Large intestine 2 No  (10/584) N/A
Liver 2 No N/A
Lower urinary tract 2 No  (2/2)  Wholemount images
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No N/A
Oral epithelium 2 No N/A
Ovary 2 No  (1/584)  (1/2)  Wholemount images
Oviduct 2 No N/A
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No  (2/2)  Wholemount images
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584) N/A
Striatum 2 No N/A
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No N/A
Uterus 2 No N/A
Vascular system 2 No N/A
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/504) N/A
Ear 2  (1/504) N/A
Embryo 2  (1/505) N/A
Eye 2  (1/504) N/A
Foot 2  (1/504) N/A
Forebrain 2  (1/504) N/A
Forelimb 2  (1/504) N/A
Hand 2  (1/503) N/A
Head 2  (5/504) N/A
Heart 2  (1/504) N/A
Hindbrain 2  (6/504) N/A
Hindlimb 2  (1/503) N/A
Liver 2  (1/504) N/A
Lung 2  (1/500) N/A
Mandibular process 2  (1/504) N/A
Maxillary process 2  (1/504) N/A
Midbrain 2  (1/504) N/A
Oral cavity 2  (1/504) N/A
Skin 2  (1/504) N/A
Tail 2  (1/504) N/A
Tail somite 2  (1/504) N/A

 Associated Images

X-ray: XRay Images Whole Body Lateral Orientation
11 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
11 Images
X-ray: XRay Images Whole Body Dorso Ventral
11 Images
Echo: M-Mode Images
32 Images
Adult LacZ: LacZ Images Wholemount
5 Images
Embryo LacZ: LacZ images wholemount
4 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Tardbptm1(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Tardbptm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Tardbptm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice

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