Tmem63b | transmembrane protein 63b

Physiological systems

19 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Homeostasis/metabolism Limbs/digits/tail Vision/eye Behavior/neurological Skeleton Mortality/aging

13 No significant impact

5 Not tested

Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
44Embryo tissues

Phenotypes

hyperactivity5 supporting datasetsTmem63btm1b(EUCOMM)WtsiheterozygoteEarly adult3.78x10-7 
abnormal cornea morphology2 supporting datasetsTmem63btm1b(EUCOMM)WtsiheterozygoteEarly adult8.27x10-8 
short tibia2 supporting datasetsTmem63btm1b(EUCOMM)WtsiheterozygoteEarly adult1.45x10-6 
preweaning lethality, complete penetrance1 supporting datasetTmem63btm1b(EUCOMM)WtsihomozygoteEarly adultN/A * 
limb grasping1 supporting datasetTmem63btm1b(EUCOMM)WtsiheterozygoteEarly adult1.36x10-5 
increased circulating bilirubin level1 supporting datasetTmem63btm1b(EUCOMM)WtsiheterozygoteEarly adult1.18x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Tmem63btm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Tmem63btm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Tmem63btm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse

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