Abca8a | ATP-binding cassette, sub-family A member 8a

Physiological systems

17 / 24 physiological systems tested

3 Significantly impacted by the knock-out

 Integument Hematopoietic system Mortality/aging

14 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Gene metrics:3Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal vibrissa morphology1 supporting datasetAbca8aem1(IMPC)JhomozygoteEarly adult1.73x10-6 
preweaning lethality, incomplete penetrance1 supporting datasetAbca8aem1(IMPC)JhomozygoteEarly adultN/A * 
increased hematocrit1 supporting datasetAbca8aem1(IMPC)JhomozygoteEarly adult8.16x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Abca8aem1(IMPC)JExon Deletionmouse
Abca8atm115090(L1L2_Pgk_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector
Abca8atm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell
Abca8atm284069(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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