Gene: Kctd15 MGI:2385276
Log in to followPhenotypes
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
abnormal embryo size | Kctd15tm1b(EUCOMM)Wtsi | HOM | E15.5 | 0.00 | ||
increased blood urea nitrogen level | Kctd15tm1b(EUCOMM)Wtsi | HET | Early adult | 4.41×10-05 | ||
increased circulating creatinine level | Kctd15tm1b(EUCOMM)Wtsi | HET | Early adult | 5.35×10-06 | ||
decreased food intake | Kctd15tm1b(EUCOMM)Wtsi | HET | Early adult | 1.18×10-05 | ||
preweaning lethality, complete penetrance | Kctd15tm1b(EUCOMM)Wtsi | HOM | Early adult | 0.00 | ||
decreased circulating alkaline phosphatase level | Kctd15tm1b(EUCOMM)Wtsi | HET | Early adult | 1.09×10-06 |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Adrenal gland | Section images | heterozygote | 100% (2 of 2) |
Brain | Section images | heterozygote | 100% (2 of 2) |
Brainstem | Section images | heterozygote | 100% (2 of 2) |
Cartilage tissue | Section images | heterozygote | 100% (2 of 2) |
Esophagus | Section images | heterozygote | 100% (2 of 2) |
Eye | Section images | heterozygote | 50% (1 of 2) |
Hippocampus | Section images | heterozygote | 100% (2 of 2) |
Hypothalamus | Section images | heterozygote | 100% (2 of 2) |
Liver | Section images | heterozygote | 100% (2 of 2) |
Lung | Section images | heterozygote | 50% (1 of 2) |
Peripheral nervous system | Section images | heterozygote | 50% (1 of 2) |
Skin | Section images | heterozygote | 50% (1 of 2) |
Spinal cord | Section images | heterozygote | 100% (2 of 2) |
Spleen | Section images | heterozygote | 50% (1 of 2) |
Striatum | Section images | heterozygote | 100% (2 of 2) |
Thymus | Section images | heterozygote | 50% (1 of 2) |
Trachea | Section images | heterozygote | 100% (2 of 2) |
Uterus | Section images | heterozygote | 50% (1 of 2) |
Aorta | N/A | heterozygote | 0.0% (0 of 2) |
Cerebellum | N/A | heterozygote | 0.0% (0 of 2) |
Cerebral cortex | N/A | heterozygote | 100% (2 of 2) |
Heart | N/A | heterozygote | 0.0% (0 of 2) |
Kidney | N/A | heterozygote | 100% (2 of 2) |
Large intestine | N/A | heterozygote | 50% (1 of 2) |
Lower urinary tract | N/A | heterozygote | 100% (2 of 2) |
Lymph node | N/A | heterozygote | 0.0% (0 of 2) |
Mammary gland | N/A | heterozygote | 0.0% (0 of 2) |
Olfactory lobe | N/A | heterozygote | 100% (2 of 2) |
Ovary | N/A | heterozygote | 50% (1 of 2) |
Oviduct | N/A | heterozygote | 50% (1 of 2) |
Pancreas | N/A | heterozygote | 0.0% (0 of 2) |
Peyer's patch | N/A | heterozygote | 0.0% (0 of 2) |
Pituitary gland | N/A | heterozygote | Not available |
Prostate gland | N/A | heterozygote | 50% (1 of 2) |
Skeletal muscle | N/A | heterozygote | 50% (1 of 2) |
Small intestine | N/A | heterozygote | 50% (1 of 2) |
Stomach | N/A | heterozygote | 100% (2 of 2) |
Testis | N/A | heterozygote | 50% (1 of 2) |
Thyroid gland | N/A | heterozygote | 100% (2 of 2) |
Vascular system | N/A | heterozygote | 0.0% (0 of 2) |
White adipose tissue | N/A | heterozygote | 0.0% (0 of 2) |
Background staining occurs in wild type mice and embryos at an incidental rate.
Anatomy | Background staining in controls (WT) |
---|---|
adrenal gland | 0.79% (4 of 507) |
aorta | 0.0% |
brain | 0.58% (3 of 513) |
brainstem | 0.39% (2 of 519) |
cartilage tissue | 0.2% (1 of 496) |
cerebellum | 0.59% (3 of 506) |
cerebral cortex | 0.4% (2 of 494) |
esophagus | 1.45% (5 of 345) |
eye | 0.0% |
heart | 0.4% (2 of 496) |
hippocampus | 0.41% (2 of 491) |
hypothalamus | 0.4% (2 of 496) |
kidney | 4.26% (21 of 493) |
large intestine | 5.11% (26 of 509) |
liver | 0.0% |
lower urinary tract | 0.0% |
lung | 0.2% (1 of 502) |
lymph node | 0.2% (1 of 503) |
mammary gland | 0.0% |
olfactory lobe | 0.2% (1 of 502) |
ovary | 0.21% (1 of 487) |
oviduct | 0.0% |
pancreas | 0.83% (4 of 483) |
peripheral nervous system | 0.2% (1 of 507) |
peyers patch | 0.0% |
pituitary gland | 0.2% (1 of 491) |
prostate gland | 2.06% (10 of 486) |
skeletal muscle | 0.0% |
skin | 0.21% (1 of 486) |
small intestine | 4.78% (24 of 502) |
spinal cord | 0.39% (2 of 512) |
spleen | 0.6% (3 of 500) |
stomach | 3.05% (15 of 491) |
striatum | 0.41% (2 of 493) |
testis | 1.23% (6 of 489) |
thymus | 0.21% (1 of 476) |
thyroid gland | 2.63% (13 of 495) |
trachea | 0.6% (3 of 497) |
uterus | 0.2% (1 of 498) |
vascular system | 0.0% |
white adipose tissue | 0.0% |
Human diseases caused by Kctd15 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Kctd15 by phenotypic similarity.
Histopathology
Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.
There is no histopathology data for Kctd15
IMPC related publications
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Kctd15.
There are 1 publication which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression. | PLoS genetics (February 2016) | Kctd15tm1a(EUCOMM)Wtsi | PMC4739719 |
Order Mouse and ES Cells
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
This service may be affected by the Covid-19 pandemic. See how
MGI Allele | Allele Type | Produced |
---|---|---|
Kctd15tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | Mice, Tissue |
Kctd15tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
Kctd15tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | ES Cells |
Kctd15tm47323(L1L2_gt0) | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors |
Kctd15tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | ES Cells |
The IMPC Newsletter
Get highlights of the most important data releases, news and events, delivered straight to your email inbox
Subscribe to newsletter