Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

RAD9 checkpoint clamp component B

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Rad9b mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Rad9b by phenotypic similarity.

Disease Similarity of
Matching phenotypes Source
Spina Bifida-Hypospadias Syndrome
Spina bifida, Spinal dysraphism ORPHA:3176
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Frontal Encephalocele
Aplasia/Hypoplasia of the corpus callosum, Spina bifida, Hydrocephalus, Cerebral calcification ORPHA:1931
Neural Tube Defects, X-Linked
Spina bifida, Anencephaly OMIM:301410
Anencephaly 1
Spina bifida, Anencephaly OMIM:206500
Holoprosencephaly, Spina bifida, Hydrocephalus ORPHA:945
Ophthalmoplegia, External, And Myopia
Spina bifida OMIM:311000
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome
Spina bifida, Anencephaly ORPHA:2476
Nevus Comedonicus Syndrome
Spina bifida, Microcephaly, Spina bifida occulta ORPHA:64754
Camptodactyly With Muscular Hypoplasia, Skeletal Dysplasia, And Abnormal Palmar Creases
Spina bifida OMIM:211960
Fryns Microphthalmia Syndrome
Neural tube defect OMIM:600776
Schisis Association
Spina bifida, Anencephaly, Microcephaly ORPHA:63862
Chiari Malformation Type Ii
Agenesis of corpus callosum, Spina bifida, Hydrocephalus, Myelomeningocele OMIM:207950
Neural tube defect, Cerebral white matter atrophy, Abnormal cerebral morphology, Subcortical cere... ORPHA:79321
Caudal Duplication
Spina bifida, Myelomeningocele ORPHA:1756
Sirenomelia, Myelomeningocele, Anencephaly, Cervical spina bifida, Spinal dysraphism ORPHA:63260
Amish Lethal Microcephaly
Spina bifida, Agenesis of corpus callosum, Microcephaly, Lissencephaly ORPHA:99742
Acropectorovertebral Dysplasia
Spina bifida ORPHA:957
Blepharocheilodontic Syndrome 1
Neural tube defect OMIM:119580
Camptodactyly Syndrome, Guadalajara Type 1
Spina bifida, Intrauterine growth retardation, Microcephaly ORPHA:1327
Isolated Klippel-Feil Syndrome
Spina bifida ORPHA:2345
Anophthalmia Plus Syndrome
Spina bifida ORPHA:1104
Cerebrocostomandibular Syndrome
Meningocele, Hydranencephaly, Intrauterine growth retardation, Myelomeningocele, Spina bifida, Po... ORPHA:1393
Czeizel-Losonci Syndrome
Spina bifida, Hydrocephalus, Myelomeningocele, Spina bifida occulta ORPHA:2437
Lung Agenesis-Heart Defect-Thumb Anomalies Syndrome
Spina bifida, Patent ductus arteriosus ORPHA:1120
Spina bifida, Sirenomelia ORPHA:3169
Male Pseudohermaphroditism/Mental Retardation Syndrome, Verloes Type
Cervical spina bifida OMIM:600122
Fountain Syndrome
Spina bifida, Spina bifida occulta ORPHA:3219
Waardenburg Syndrome Type 1
Meningocele, Spina bifida ORPHA:894
Myelomeningocele, Anencephaly, Holoprosencephaly, Lissencephaly, Spina bifida, Hydrocephalus, Spi... ORPHA:63259
Posterior Meningocele
Meningocele, Occipital meningocele, Neural tube defect, Hydrocephalus, Lipomyelomeningocele ORPHA:268810
Neu-Laxova Syndrome
Abnormal cortical gyration, Intrauterine growth retardation, Absent septum pellucidum, Pachygyria... ORPHA:2671
Pelvis-Shoulder Dysplasia
Spina bifida, Hydrocephalus, Hydranencephaly ORPHA:2839
Neu-Laxova Syndrome 1
Short umbilical cord, Hydranencephaly, Intrauterine growth retardation, Stillbirth, Small placent... OMIM:256520
Mosaic Trisomy 9
Microcephaly, Spina bifida, Intrauterine growth retardation, Patent ductus arteriosus ORPHA:99776
Vacterl With Hydrocephalus
Arrhinencephaly, Intrauterine growth retardation, Spina bifida, Hydrocephalus, Aqueductal stenosis ORPHA:3412
Trisomy 18
Intrauterine growth retardation, Anencephaly, Holoprosencephaly, Spina bifida, Aplasia/Hypoplasia... ORPHA:3380
Trisomy 20P
Spina bifida, Umbilical hernia ORPHA:261318
Lumbar Syndrome
Spina bifida, Myelomeningocele ORPHA:83628
Aicardi Syndrome
Dilated third ventricle, Partial agenesis of the corpus callosum, Cavum septum pellucidum, Pachyg... OMIM:304050
Focal Dermal Hypoplasia
Spina bifida, Umbilical hernia, Patent ductus arteriosus ORPHA:2092
Waardenburg Syndrome, Type 1
Spina bifida, Myelomeningocele OMIM:193500
Basal Cell Nevus Syndrome
Spina bifida, Hydrocephalus, Calcification of falx cerebri OMIM:109400
Fibular Hemimelia
Spina bifida ORPHA:93323
Cloacal Exstrophy
Spina bifida, Myelomeningocele ORPHA:93929
Nail-Patella Syndrome
Spina bifida OMIM:161200
Neurodevelopmental Disorder With Dysmorphic Facies And Thin Corpus Callosum
Partial agenesis of the corpus callosum, Spina bifida, Thin corpus callosum, Patent ductus arteri... OMIM:619480
Limb Body Wall Complex
Short umbilical cord, Myelomeningocele, Anencephaly, Spina bifida, Hydrocephalus, Spina bifida oc... ORPHA:2369
22Q11.2 Deletion Syndrome
Meningocele, Arrhinencephaly, Intrauterine growth retardation, Occipital myelomeningocele, Patent... ORPHA:567
Hallermann-Streiff Syndrome
Spina bifida, Microcephaly OMIM:234100
Intellectual Disability-Cardiac Anomalies-Short Stature-Joint Laxity Syndrome
Spina bifida, Periventricular leukomalacia, Hypoplasia of the corpus callosum, Agenesis of corpus... ORPHA:508498
Jacobsen Syndrome
Intrauterine growth retardation, Pachygyria, Spina bifida, Cerebral atrophy, Agenesis of corpus c... ORPHA:2308
Pagod Syndrome
Meningocele, Spina bifida, Microcephaly ORPHA:991
Fanconi Anemia
Intrauterine growth retardation, Patent ductus arteriosus, Spina bifida, Hydrocephalus, Umbilical... ORPHA:84
Alobar Holoprosencephaly
Abnormal hypothalamus physiology, Abnormal morphology of the olfactory bulb, Neural tube defect, ... ORPHA:93925
Midline Interhemispheric Variant Of Holoprosencephaly
Abnormal hypothalamus physiology, Abnormal morphology of the olfactory bulb, Neural tube defect, ... ORPHA:93926
Lobar Holoprosencephaly
Abnormal hypothalamus physiology, Abnormal morphology of the olfactory bulb, Neural tube defect, ... ORPHA:93924
Semilobar Holoprosencephaly
Abnormal hypothalamus physiology, Abnormal morphology of the olfactory bulb, Neural tube defect, ... ORPHA:220386
Neurofibromatosis, Type I
Spina bifida, Hydrocephalus, Aqueductal stenosis OMIM:162200
Thrombocytopenia-Absent Radius Syndrome
Cavum septum pellucidum, Spina bifida OMIM:274000
Koolen-De Vries Syndrome Due To A Point Mutation
Pineal cyst, Spina bifida, Hydrocephalus, Decreased response to growth hormone stimulation test, ... ORPHA:363965
17Q21.31 Microdeletion Syndrome
Pineal cyst, Spina bifida, Hydrocephalus, Decreased response to growth hormone stimulation test, ... ORPHA:363958
Schinzel-Giedion Syndrome
Hypoplasia of the corpus callosum, Cerebral cortical atrophy, Umbilical hernia, Neural tube defect ORPHA:798
Vater/Vacterl Association
Patent urachus, Spina bifida, Intrauterine growth retardation, Patent ductus arteriosus OMIM:192350
Exstrophy-Epispadias Complex
Spina bifida, Hydrocephalus, Microcephaly ORPHA:322
Split Cord Malformation
Meningocele, Myelomeningocele, Hydrocephalus, Cervical spina bifida, Lipomyelomeningocele ORPHA:573278


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Rad9b

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Rad9b.

No publications found that use IMPC mice or data for Rad9b.

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MGI Allele Allele Type Produced
Rad9btm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Rad9btm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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