Usp1 | ubiquitin specific peptidase 1

Physiological systems

15 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Homeostasis/metabolism Growth/size/body region Vision/eye Hematopoietic system Craniofacial

10 No significant impact

9 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Viability data
Body weight measurements
Embryo imaging data
Gene metrics:9Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal snout morphology1 supporting datasetUsp1tm1b(KOMP)WtsihomozygoteEarly adult8.23x10-11 
increased circulating potassium level1 supporting datasetUsp1tm1b(KOMP)WtsihomozygoteEarly adult2.23x10-6 
increased mean corpuscular hemoglobin1 supporting datasetUsp1tm1b(KOMP)WtsihomozygoteEarly adult1.05x10-18 
increased blood urea nitrogen level1 supporting datasetUsp1tm1b(KOMP)WtsihomozygoteEarly adult6.53x10-5 
increased circulating insulin level1 supporting datasetUsp1tm1b(KOMP)WtsihomozygoteEarly adult9.77x10-9 
increased circulating creatinine level1 supporting datasetUsp1tm1b(KOMP)WtsihomozygoteEarly adult8.48x10-6 
abnormal eyelid aperture1 supporting datasetUsp1tm1b(KOMP)WtsihomozygoteEarly adult3.96x10-6 
decreased body length1 supporting datasetUsp1tm1b(KOMP)WtsihomozygoteEarly adult1.3x10-12 
decreased erythrocyte cell number1 supporting datasetUsp1tm1b(KOMP)WtsihomozygoteEarly adult1.96x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Usp1tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Usp1tm1b(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Usp1tm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell
Usp1tm299930(L1L2_Bact_P)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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