Gene: Lyplal1

Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
increased circulating iron level Lyplal1tm1b(KOMP)Wtsi HOM postnatal 5.65×10-05
vertebral fusion Lyplal1tm1a(KOMP)Wtsi HOM postnatal 4.94×10-05
decreased NK T cell number Lyplal1tm1a(KOMP)Wtsi HOM postnatal 5.28×10-05
abnormal vocalization Lyplal1tm1b(KOMP)Wtsi HOM postnatal 2.91×10-05

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 5 No  (2/584) N/A
Aorta 5 No N/A
Blood 3 No N/A
Bone 2 No N/A
Bone marrow 3 No N/A
Brain 5 No  (1/5) N/A
Brainstem 5 No N/A
Brown adipose tissue 5 No N/A
Cartilage tissue 5 No N/A
Cecum 3 No  (12/383)  (2/3) N/A
Cerebellum 5 No N/A
Cerebral cortex 5 No N/A
Chest bone 3 No N/A
Colon 3 No  (12/127)  (2/3) N/A
Diaphragm 3 No N/A
Duodenum 3 No  (2/127) N/A
Epididymis 3 No  (18/134)  (2/3) N/A
Esophagus 5 No  (7/415) N/A
Eye 5 No N/A
Gall bladder 5 No N/A
Gonadal fat pad 3 No N/A
Harderian gland 3 No N/A
Heart 5 No N/A
Hindlimb 3 No N/A
Hippocampus 5 No N/A
Hypothalamus 5 No N/A
Ileum 3 No  (14/127)  (1/3) N/A
Jejunum 3 No  (6/127) N/A
Kidney 5 No  (18/584)  (1/5) N/A
Large intestine 5 No  (10/584) N/A
Liver 5 No N/A
Lower urinary tract 5 No N/A
Lung 5 No N/A
Lymph node 5 No N/A
Mammary gland 5 No N/A
Mesenteric adipose tissue 3 No N/A
Mesenteric lymph node 3 No N/A
Midbrain 3 No N/A
Olfactory lobe 5 No N/A
Oral epithelium 2 No N/A
Ovary 5 No  (1/584) N/A
Oviduct 5 No N/A
Pancreas 5 No  (5/584) N/A
Parathyroid gland 5 No N/A
Parotid gland 3 No N/A
Penis 3 No N/A
Peripheral nervous system 5 No N/A
Peyer's patch 5 No N/A
Pituitary gland 5 No N/A
Prostate gland 5 No  (12/584) N/A
Quadriceps 3 No N/A
Sciatic nerve 3 No N/A
Skeletal muscle 5 No N/A
Skin 5 No N/A
Small intestine 5 No  (9/584) N/A
Spinal cord 5 No N/A
Spleen 5 No  (2/584) N/A
Stomach 5 No  (12/584)  (1/5) N/A
Stomach pyloric region 3 No N/A
Striatum 5 No N/A
Sublingual gland 3 No N/A
Submandibular gland 3 No  (2/132) N/A
Testis 5 No  (2/584)  (3/5)  Wholemount images
Thymus 5 No N/A
Thyroid gland 5 No  (15/584) N/A
Tongue 3 No  (5/127) N/A
Trachea 5 No N/A
Trigeminal V nerve 3 No N/A
Urinary bladder 3 No N/A
Uterus 5 No N/A
Vagina 3 No N/A
Vas deferens 3 No  (15/388)  (2/3) N/A
Vascular system 5 No N/A
Vesicular gland 3 No N/A
White adipose tissue 5 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/485) N/A
Ear 2  (1/485) N/A
Embryo 2  (1/485)  (1/5) N/A
Eye 2  (1/485) N/A
Foot 2  (1/485) N/A
Forebrain 2  (1/485) N/A
Forelimb 2  (1/485) N/A
Hand 2  (1/485) N/A
Head 2  (5/485) N/A
Heart 2  (1/485) N/A
Hindbrain 2  (6/485) N/A
Hindlimb 2  (1/485) N/A
Liver 2  (1/485) N/A
Lung 2  (1/485) N/A
Mandibular process 2  (1/485) N/A
Maxillary process 2  (1/485) N/A
Midbrain 2  (1/485) N/A
Oral cavity 2  (1/485) N/A
Skin 2  (1/485) N/A
Tail 2  (1/485) N/A
Tail somite 2  (1/485) N/A

 Associated Images

X-ray: XRay Images Lateral Orientation
60 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
25 Images
Eye Morphology: Images Slit Lamp
2 Images
X-ray: XRay Images Skull Lateral Orientation
15 Images
X-ray: XRay Images Dorso Ventral
95 Images
X-ray: XRay Images Forepaw
15 Images
Echo: M-Mode Images
28 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images
Embryo LacZ: LacZ images wholemount
8 Images
DSS Histology
8 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Lyplal1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Lyplal1tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue

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