Gene: Aph1a

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Name
aph1 homolog A, gamma secretase subunit
MGI ID
MGI:2385110
Synonyms
6530402N02Rik
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal embryo size Aph1atm1b(KOMP)Mbp HET E9.5 0.00
abnormal bone structure Aph1atm1b(KOMP)Mbp HET Early adult 2.19×10-06
pallor Aph1atm1b(KOMP)Mbp HOM E9.5 0.00
decreased vertical activity Aph1atm1b(KOMP)Mbp HET Early adult 4.35×10-05
abnormal skin coloration Aph1atm1b(KOMP)Mbp HET Early adult 1.40×10-05
abnormal embryo size Aph1atm1b(KOMP)Mbp HOM E9.5 0.00
preweaning lethality, complete penetrance Aph1atm1b(KOMP)Mbp HOM Early adult 0.00
abnormal embryo size Aph1atm1b(KOMP)Mbp HET E18.5 0.00
pale yolk sac Aph1atm1b(KOMP)Mbp HOM E9.5 0.00
embryonic lethality prior to tooth bud stage Aph1atm1b(KOMP)Mbp HOM E12.5 0.00
hyperactivity Aph1atm1b(KOMP)Mbp HET Early adult 4.03×10-09
abnormal coat appearance Aph1atm1b(KOMP)Mbp HET Early adult 3.12×10-09
increased bone mineral content Aph1atm1b(KOMP)Mbp HET Early adult 2.36×10-05

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2)  Wholemount images
Aorta 2 No  (2/2) N/A
Bone 2 No  (2/2) N/A
Brain 2 No  (2/2) N/A
Brainstem 2 No  (2/2) N/A
Brown adipose tissue 2 No  (2/2) N/A
Cartilage tissue 2 No  (2/2) N/A
Cecum 2 No  (12/379) N/A
Cerebellum 2 No  (2/2) N/A
Cerebral cortex 2 No  (2/2) N/A
Esophagus 2 No  (7/415)  (2/2) N/A
Eye 2 No N/A
Gall bladder 2 No  (2/2) N/A
Heart 2 No  (2/2) N/A
Hippocampus 2 No  (2/2) N/A
Hypothalamus 2 No  (2/2) N/A
Kidney 2 No  (18/584)  (2/2) N/A
Large intestine 2 No  (10/584)  (2/2) N/A
Liver 2 No  (2/2) N/A
Lower urinary tract 2 No  (2/2) N/A
Lung 2 No  (2/2) N/A
Lymph node 2 No  (2/2) N/A
Mammary gland 2 No  (1/2)  Wholemount images
Mesenteric lymph node 2 No  (2/2)  Wholemount images
Olfactory lobe 2 No  (2/2) N/A
Oral epithelium 2 No N/A
Ovary 2 No  (1/584)  (1/2)  Wholemount images
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/584)  (2/2) N/A
Parathyroid gland 2 No  (2/2) N/A
Peripheral nervous system 2 No  (2/2)  Wholemount images
Peyer's patch 2 No  (2/2) N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584)  (1/2) N/A
Skeletal muscle 2 No  (2/2) N/A
Skin 2 No  (2/2)  Wholemount images
Small intestine 2 No  (9/584)  (2/2) N/A
Spinal cord 2 No  (2/2) N/A
Spleen 2 No  (2/584)  (2/2) N/A
Stomach 2 No  (12/584)  (2/2) N/A
Striatum 2 No  (2/2) N/A
Testis 2 No  (2/584)  (1/2) N/A
Thymus 2 No  (2/2) N/A
Thyroid gland 2 No  (15/584)  (2/2) N/A
Trachea 2 No  (2/2) N/A
Trigeminal V nerve 2 No  (2/2)  Wholemount images
Urinary bladder 2 No  (2/2) N/A
Uterus 2 No  (1/2)  Wholemount images
Vas deferens 2 No  (15/388)  (1/2) N/A
Vascular system 2 No  (2/2) N/A
White adipose tissue 2 No  (2/2) N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 2  (1/57)  (2/2) N/A
Axial skeleton 2  (1/61)  (2/2) N/A
Brain 2  (6/504)  (2/2) N/A
Central nervous system ganglion 2  (1/70)  (2/2) N/A
Cranium 2  (1/61)  (2/2) N/A
Dorsal root ganglion 2  (1/57)  (2/2) N/A
Ear 2  (1/504)  (2/2) N/A
Embryo 2  (1/505)  (2/2) N/A
Outer ear 2  (1/66)  (2/2) N/A
Eye 2  (1/504)  (2/2) N/A
Femur pre-cartilage condensation 2  (1/52)  (2/2) N/A
Foot 2  (1/504)  (2/2) N/A
Forearm 2  (1/297)  (2/2) N/A
Forebrain 2  (1/504)  (2/2) N/A
Forelimb 2  (1/504)  (2/2) N/A
Fronto-nasal process 2  (1/58)  (2/2) N/A
Gut 2  (1/56)  (2/2) N/A
Hand 2  (1/503)  (2/2) N/A
Head 2  (5/504)  (2/2) N/A
Head mesenchyme 2  (1/57)  (2/2) N/A
Heart 2  (1/504)  (2/2) N/A
Heart ventricle 2  (1/57)  (2/2) N/A
Hindbrain 2  (6/504)  (2/2) N/A
Hindlimb 2  (1/503)  (2/2) N/A
Humerus pre-cartilage condensation 2  (1/61)  (2/2) N/A
Inner ear 2  (1/61)  (2/2) N/A
Intestine 2  (1/55)  (2/2) N/A
Liver 2  (1/504)  (2/2) N/A
Lower leg 2  (1/297)  (2/2) N/A
Lung 2  (1/500)  (2/2) N/A
Mandibular process 2  (1/504)  (2/2) N/A
Maxillary process 2  (1/504)  (2/2) N/A
Mesonephros of female 2  (1/52)  (1/2) N/A
Mesonephros of male 2  (1/52)  (1/2) N/A
Metanephros 2  (1/52)  (2/2) N/A
Midbrain 2  (1/504)  (2/2) N/A
Nasal septum 2  (1/57)  (2/2) N/A
Nose 2  (1/70)  (2/2) N/A
Notochord 2  (1/57)  (2/2) N/A
Oral cavity 2  (1/504)  (2/2) N/A
Outflow tract 2  (1/57)  (2/2) N/A
Pancreas 2  (1/52)  (2/2) N/A
Pericardium 2  (1/52)  (2/2) N/A
Pharynx 2  (1/52)  (2/2) N/A
Radius-ulna pre-cartilage condensation 2  (1/61)  (2/2) N/A
Rib pre-cartilage condensation 2  (1/54)  (2/2) N/A
Skeleton 2  (1/70)  (2/2) N/A
Skin 2  (1/504)  (2/2) N/A
Spinal cord 2  (1/69)  (2/2) N/A
Stomach 2  (1/52)  (2/2) N/A
Tail 2  (1/504)  (2/2) N/A
Tail somite 2  (1/504)  (2/2) N/A
Thoracic vertebral cartilage condensation 2  (1/52)  (2/2) N/A
Tongue 2  (1/52)  (2/2) N/A
Trachea 2  (1/56)  (2/2) N/A
Trunk mesenchyme 2  (1/57)  (2/2) N/A
Umbilical artery embryonic part 2  (1/57)  (2/2) N/A
Umbilical vein embryonic part 2  (1/57)  (2/2) N/A
Upper arm 2  (1/297)  (2/2) N/A
Upper leg 2  (1/297)  (2/2) N/A
Urinary system 2  (1/56)  (2/2) N/A
Vibrissa 2  (1/66)  (2/2) N/A

 Associated Images

X-ray: XRay Images Skull Lateral Orientation
11 Images
X-ray: XRay Images Whole Body Lateral Orientation
11 Images
X-ray: XRay Images Forepaw
11 Images
Adult LacZ: LacZ Images Wholemount
8 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
11 Images
X-ray: XRay Images Whole Body Dorso Ventral
11 Images
Eye Morphology: VIP of right fundus
6 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Aph1atm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Aph1atm1b(KOMP)Mbp Reporter-tagged deletion allele (post-Cre) Mice, Tissue

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