Gene: Aph1a

Name
aph1 homolog A, gamma secretase subunit
MGI ID
MGI:2385110
Synonyms
6530402N02Rik
Viability
Homozygous - Lethal
Other links
View data by physiological system
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
embryonic lethality prior to tooth bud stage Aph1atm1b(KOMP)Mbp HOM embryonic day 12.5 0.00
pallor Aph1atm1b(KOMP)Mbp HOM embryonic day 9.5 0.00
preweaning lethality, complete penetrance Aph1atm1b(KOMP)Mbp HOM n/a 0.00
abnormal bone structure Aph1atm1b(KOMP)Mbp HET postnatal 5.30×10-09
abnormal embryo size Aph1atm1b(KOMP)Mbp HOM embryonic day 9.5 0.00
pale yolk sac Aph1atm1b(KOMP)Mbp HOM embryonic day 9.5 0.00
abnormal embryo size Aph1atm1b(KOMP)Mbp HET embryonic day 9.5 0.00
abnormal embryo size Aph1atm1b(KOMP)Mbp HET embryonic day 18.5 0.00
decreased total body fat amount Aph1atm1b(KOMP)Mbp HET postnatal 2.50×10-05
increased bone mineral content Aph1atm1b(KOMP)Mbp HET postnatal 1.01×10-06

Download data as:  TSV  XLS

Filtered by: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2)  Wholemount images
Aorta 2 No  (2/2) N/A
Bone 2 No  (2/2) N/A
Brain 2 No  (2/2) N/A
Brainstem 2 No  (2/2) N/A
Brown adipose tissue 2 No  (2/2) N/A
Cartilage tissue 2 No  (2/2) N/A
Cecum 2 No  (12/383) N/A
Cerebellum 2 No  (2/2) N/A
Cerebral cortex 2 No  (2/2) N/A
Esophagus 2 No  (7/415)  (2/2) N/A
Eye 2 No N/A
Gall bladder 2 No  (2/2) N/A
Heart 2 No  (2/2) N/A
Hippocampus 2 No  (2/2) N/A
Hypothalamus 2 No  (2/2) N/A
Kidney 2 No  (18/584)  (2/2) N/A
Large intestine 2 No  (10/584)  (2/2) N/A
Liver 2 No  (2/2) N/A
Lower urinary tract 2 No  (2/2) N/A
Lung 2 No  (2/2) N/A
Lymph node 2 No  (2/2) N/A
Mammary gland 2 No  (1/2)  Wholemount images
Mesenteric lymph node 2 No  (2/2)  Wholemount images
Olfactory lobe 2 No  (2/2) N/A
Oral epithelium 2 No N/A
Ovary 2 No  (1/584)  (1/2)  Wholemount images
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/584)  (2/2) N/A
Parathyroid gland 2 No  (2/2) N/A
Peripheral nervous system 2 No  (2/2)  Wholemount images
Peyer's patch 2 No  (2/2) N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584)  (1/2) N/A
Skeletal muscle 2 No  (2/2) N/A
Skin 2 No  (2/2)  Wholemount images
Small intestine 2 No  (9/584)  (2/2) N/A
Spinal cord 2 No  (2/2) N/A
Spleen 2 No  (2/584)  (2/2) N/A
Stomach 2 No  (12/584)  (2/2) N/A
Striatum 2 No  (2/2) N/A
Testis 2 No  (2/584)  (1/2) N/A
Thymus 2 No  (2/2) N/A
Thyroid gland 2 No  (15/584)  (2/2) N/A
Trachea 2 No  (2/2) N/A
Trigeminal V nerve 2 No  (2/2)  Wholemount images
Urinary bladder 2 No  (2/2) N/A
Uterus 2 No  (1/2)  Wholemount images
Vas deferens 2 No  (15/388)  (1/2) N/A
Vascular system 2 No  (2/2) N/A
White adipose tissue 2 No  (2/2) N/A
No Embryo expression data was found for this gene.

 Associated Images

Eye Morphology: VIP of right fundus
6 Images
Adult LacZ: LacZ Images Wholemount
8 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Aph1atm1b(KOMP)Mbp Reporter-tagged deletion allele (post-Cre) Mice, Tissue
Aph1atm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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