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Gene: Spns2

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Name
spinster homolog 2
MGI ID
MGI:2384936
Synonyms
N/A
Viability
Data available
Embryo viewer
N/A
Other links
MGI   Ensembl  
Significant phenotypes (30) Measurements chart (315) All data table (802)
Expression & images (45) Disease models (0) Histopathology (2) Order (3)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
corneal opacity Spns2tm1b(KOMP)Wtsi HOM Early adult 5.05×10-11
abnormal eyelid aperture Spns2tm1a(KOMP)Wtsi HOM Early adult 7.27×10-06
absent pinna reflex Spns2tm1a(KOMP)Wtsi HOM Early adult 5.54×10-30
corneal opacity Spns2tm1a(KOMP)Wtsi HOM Early adult 1.34×10-21
increased mean corpuscular volume Spns2tm1b(KOMP)Wtsi HOM   Early adult 2.72×10-06
abnormal cornea morphology Spns2tm1b(KOMP)Wtsi HOM Early adult 9.77×10-11
increased bone mineral density Spns2tm1a(KOMP)Wtsi HOM Early adult 1.40×10-06
abnormal eye size Spns2tm1a(KOMP)Wtsi HOM Early adult 3.32×10-08
abnormal cornea morphology Spns2tm1a(KOMP)Wtsi HOM Early adult 1.24×10-20
narrow eye opening Spns2tm1b(KOMP)Wtsi HOM Early adult 8.60×10-09
decreased body weight Spns2tm1a(KOMP)Wtsi HOM   Early adult 6.29×10-05
decreased bone mineral content Spns2tm1b(KOMP)Wtsi HOM Early adult 3.36×10-05
increased circulating sodium level Spns2tm1b(KOMP)Wtsi HOM   Early adult 6.50×10-05
corneal vascularization Spns2tm1b(KOMP)Wtsi HOM Early adult 5.05×10-11
abnormal iris morphology Spns2tm1a(KOMP)Wtsi HOM Early adult 6.91×10-06
abnormal eye pigmentation Spns2tm1a(KOMP)Wtsi HOM Early adult 4.04×10-25
increased bone mineral content Spns2tm1a(KOMP)Wtsi HOM Early adult 4.28×10-06
decreased leukocyte cell number Spns2tm1b(KOMP)Wtsi HOM Early adult 4.08×10-39
decreased leukocyte cell number Spns2tm1a(KOMP)Wtsi HOM Early adult 1.23×10-23
abnormal rib morphology Spns2tm1a(KOMP)Wtsi HOM Early adult 3.83×10-05
corneal vascularization Spns2tm1a(KOMP)Wtsi HOM Early adult 4.21×10-21
excessive tearing Spns2tm1a(KOMP)Wtsi HOM Early adult 5.58×10-06
decreased circulating glucose level Spns2tm1a(KOMP)Wtsi HOM Early adult 7.13×10-05
abnormal eye morphology Spns2tm1a(KOMP)Wtsi HOM Early adult 6.79×10-09
abnormal iris morphology Spns2tm1b(KOMP)Wtsi HOM Early adult 9.70×10-05
abnormal behavior Spns2tm1a(KOMP)Wtsi HOM Early adult 9.80×10-05
trunk curl Spns2tm1b(KOMP)Wtsi HOM Early adult 8.60×10-09
abnormal pupil morphology Spns2tm1a(KOMP)Wtsi HOM   Early adult 1.75×10-05
absent pinna reflex Spns2tm1b(KOMP)Wtsi HOM Early adult 9.77×10-11
increased mean corpuscular hemoglobin Spns2tm1b(KOMP)Wtsi HOM Early adult 1.22×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
11 No  (4/583) N/A
11 No  (1/583) N/A
11 No N/A
11 No  (12/12) N/A
11 No  (4/583)  (12/12) N/A
11 No  (2/583) N/A
11 No N/A
11 No  (1/583) N/A
11 No  (3/583) N/A
11 No  (2/583) N/A
11 No  (10/12) N/A
11 No  (1/12) N/A
11 No  (2/583) N/A
11 No  (3/583) N/A
11 No  (2/583) N/A
11 No  (21/583)  (12/12) N/A
11 No  (10/583)  (1/12) N/A
11 No  (11/12) N/A
11 No  (1/583)  (11/12) N/A
11 No  (2/583)  (6/12) N/A
11 No  (1/583)  (12/12) N/A
11 No  (4/12) N/A
11 No  (12/12) N/A
11 No  (2/583) N/A
11 No  (1/583)  (3/12) N/A
11 No  (5/12) N/A
11 No  (5/583)  (6/12) N/A
11 No  (1/563) N/A
11 No  (2/583)  (7/12) N/A
11 No  (1/176)  (10/12) N/A
11 No  (1/583) N/A
11 No  (12/583) N/A
11 No N/A
11 No  (1/583)  (12/12) N/A
11 No  (9/583)  (2/12) N/A
11 No  (3/583)  (12/12) N/A
11 No  (3/583)  (7/12) N/A
11 No  (13/583)  (12/12) N/A
11 No  (3/583) N/A
11 No  (6/583)  (6/12) N/A
11 No  (1/583)  (3/12) N/A
11 No  (17/583)  (2/12) N/A
11 No  (3/583)  (2/12) N/A
11 No  (3/12) N/A
11 No N/A
LacZ Wholemount Images
LacZ Section Images
LacZ Section Images
Spns2tm1b(KOMP)Wtsi
thymus, HET, Female, WTSI
Spns2tm1a(KOMP)Wtsi
inguinal lymph node, lymph node, HET, Female, WTSI
Spns2tm1a(KOMP)Wtsi
kidney, HET, Female, WTSI
Spns2tm1a(KOMP)Wtsi
brain, HET, Female, WTSI
Spns2tm1a(KOMP)Wtsi
brain, HET, Female, WTSI

View all 46 images

Spns2tm1b(KOMP)Wtsi
thymus, HET, Female, WTSI
Spns2tm1a(KOMP)Wtsi
kidney, HET, Female, WTSI
Spns2tm1a(KOMP)Wtsi
spinal cord, HET, Female, WTSI
Spns2tm1a(KOMP)Wtsi
spleen, HET, Male, WTSI
Spns2tm1b(KOMP)Wtsi
oviduct, ovary, uterus, HET, Female, WTSI

View all 27 images

Spns2tm1b(KOMP)Wtsi
large intestine, HET, Female, WTSI
Spns2tm1a(KOMP)Wtsi
peyer's patch, HET, Female, WTSI
Spns2tm1a(KOMP)Wtsi
oesophagus, HET, Female, WTSI
Spns2tm1b(KOMP)Wtsi
gall bladder, HOM, Female, WTSI
Spns2tm1b(KOMP)Wtsi
oesophagus, HET, Female, WTSI

View all 8 images

Spns2tm1b(KOMP)Wtsi
thymus, HET, Female, WTSI
Spns2tm1a(KOMP)Wtsi
inguinal lymph node, lymph node, HET, Female, WTSI
Spns2tm1a(KOMP)Wtsi
spleen, HET, Male, WTSI
Spns2tm1a(KOMP)Wtsi
peyer's patch, HET, Female, WTSI
Spns2tm1a(KOMP)Wtsi
lymph node, inguinal lymph node, HET, Female, WTSI

View all 8 images

Spns2tm1a(KOMP)Wtsi
brain, HET, Female, WTSI
Spns2tm1a(KOMP)Wtsi
brain, HET, Female, WTSI
Spns2tm1a(KOMP)Wtsi
spinal cord, HET, Female, WTSI
Spns2tm1a(KOMP)Wtsi
brain, HET, Female, WTSI
Spns2tm1a(KOMP)Wtsi
brain, HET, Female, WTSI

View all 8 images

Spns2tm1b(KOMP)Wtsi
oviduct, ovary, uterus, HET, Female, WTSI
Spns2tm1a(KOMP)Wtsi
testis, HET, Male, WTSI
Spns2tm1b(KOMP)Wtsi
prostate gland, HET, Male, WTSI
Spns2tm1a(KOMP)Wtsi
oviduct, HET, Female, WTSI
Spns2tm1a(KOMP)Wtsi
testis, HET, Male, WTSI

View all 6 images

Spns2tm1a(KOMP)Wtsi
kidney, HET, Female, WTSI
Spns2tm1a(KOMP)Wtsi
urinary bladder, lower urinary tract, HET, Male, WTSI
Spns2tm1a(KOMP)Wtsi
kidney, HET, Female, WTSI
Spns2tm1b(KOMP)Wtsi
kidney, HET, Male, WTSI
Spns2tm1a(KOMP)Wtsi
urinary bladder, lower urinary tract, HET, Female, WTSI

View all 6 images

Spns2tm1a(KOMP)Wtsi
skin, HET, Female, WTSI
Spns2tm1b(KOMP)Wtsi
mammary gland, HET, Female, WTSI
Spns2tm1b(KOMP)Wtsi
skin, HET, Female, WTSI
Spns2tm1a(KOMP)Wtsi
bone, HET, Female, WTSI
Spns2tm1b(KOMP)Wtsi
bone, HET, Female, WTSI
Spns2tm1b(KOMP)Wtsi
bone, peripheral nervous system, HET, Female, WTSI
Spns2tm1a(KOMP)Wtsi
eye, retina, HET, Male, WTSI
Spns2tm1b(KOMP)Wtsi
eye, HET, Female, WTSI
Spns2tm1a(KOMP)Wtsi
eye, HET, Male, WTSI
Spns2tm1b(KOMP)Wtsi
prostate gland, HET, Male, WTSI
Spns2tm1b(KOMP)Wtsi
mammary gland, HET, Female, WTSI
Spns2tm1b(KOMP)Wtsi
thyroid gland, HET, Male, WTSI
Spns2tm1b(KOMP)Wtsi
lung, HET, Female, WTSI
No Embryo expression data was found for this gene.

 Associated Images

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X-ray: XRay Images Forepaw
13 Images
thumbnail
Eye Morphology: Images Slit Lamp
27 Images
thumbnail
X-ray: XRay Images Skull Lateral Orientation
12 Images
thumbnail
X-ray: XRay Images Whole Body Dorso Ventral
15 Images
thumbnail
X-ray: XRay Images Skull Dorso Ventral Orientation
13 Images
thumbnail
X-ray: XRay Images Whole Body Lateral Orientation
13 Images
thumbnail
Histopathology
6 Images
Legacy Phenotype Associated Images
Spns2tm1a(KOMP)Wtsi
forearm, WT, Female, WTSI
Spns2tm1a(KOMP)Wtsi
body, WT, Male, WTSI
Spns2tm1a(KOMP)Wtsi
head, WT, Male, WTSI
Spns2tm1a(KOMP)Wtsi
head, WT, Male, WTSI
Spns2tm1a(KOMP)Wtsi
forearm, WT, Male, WTSI

View all 207 images

Spns2tm1a(KOMP)Wtsi
eye, corneal opacity, cornea/lens fusion, HOM, Female, WTSI
Spns2tm1a(KOMP)Wtsi
eye, corneal opacity, cornea/lens fusion, cataracts, corneal vascularization, HOM, Female, WTSI
Spns2tm1a(KOMP)Wtsi
eye, corneal ulcer, corneal opacity, corneal vascularization, HOM, Female, WTSI
Spns2tm1a(KOMP)Wtsi
eye, narrow eye opening, corneal vascularization, corneal opacity, HOM, Male, WTSI
Spns2tm1a(KOMP)Wtsi
eye, corneal opacity, abnormal pupil morphology, corneal vascularization, HOM, Male, WTSI

View all 58 images

Spns2tm1b(KOMP)Wtsi
increased NK cell number, decreased T cell number, HOM, Female, WTSI
Spns2tm1b(KOMP)Wtsi
decreased B cell number, HOM, Female, WTSI
Spns2tm1b(KOMP)Wtsi
decreased CD4-positive T cell number, HOM, Female, WTSI
Spns2tm1b(KOMP)Wtsi
decreased CD8-positive T cell number, HOM, Female, WTSI
Spns2tm1b(KOMP)Wtsi
increased monocyte cell number, increased granulocyte number, HOM, Female, WTSI

View all 12 images

Spns2tm1b(KOMP)Wtsi
HOM, Male, WTSI
Spns2tm1b(KOMP)Wtsi
HOM, Male, WTSI
Spns2tm1b(KOMP)Wtsi
HOM, Male, WTSI
Spns2tm1b(KOMP)Wtsi
HOM, Female, WTSI
Spns2tm1b(KOMP)Wtsi
HOM, Female, WTSI

View all 8 images

Spns2tm1b(KOMP)Wtsi
decreased corpus callosum size, corpus callosum, HOM, Male, WTSI
Spns2tm1b(KOMP)Wtsi
corpus callosum, decreased corpus callosum size, HOM, Male, WTSI
Spns2tm1b(KOMP)Wtsi
HOM, Male, WTSI
Spns2tm1b(KOMP)Wtsi
HOM, Male, WTSI
Spns2tm1b(KOMP)Wtsi
lateral ventricle, enlarged lateral ventricles, HOM, Male, WTSI

View all 6 images

Spns2tm1a(KOMP)Wtsi
back skin, HOM, Female, WTSI
Spns2tm1a(KOMP)Wtsi
back skin, HOM, Female, WTSI
Spns2tm1a(KOMP)Wtsi
back skin, HOM, Female, WTSI
Spns2tm1b(KOMP)Wtsi
back skin, HOM, Female, WTSI
Spns2tm1b(KOMP)Wtsi
back skin, HOM, Female, WTSI

 Disease Models

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 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Eye with optic nerve - inflammation Spns2tm1a(KOMP)Wtsi HOM Early adult
Eye with optic nerve - developmental and structural abnormality Spns2tm1a(KOMP)Wtsi HOM Early adult

 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Spns2tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Spns2tm1c(KOMP)Wtsi Wild type floxed exon (post-Flp) Mice
Spns2tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells