Gene: Spns2

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Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal cornea morphology Spns2tm1b(KOMP)Wtsi HOM Early adult 9.77×10-11
increased mean corpuscular volume Spns2tm1b(KOMP)Wtsi HOM   Early adult 2.72×10-06
increased mean corpuscular hemoglobin Spns2tm1b(KOMP)Wtsi HOM Early adult 1.22×10-05
corneal opacity Spns2tm1b(KOMP)Wtsi HOM Early adult 5.05×10-11
increased circulating sodium level Spns2tm1b(KOMP)Wtsi HOM   Early adult 6.50×10-05
absent pinna reflex Spns2tm1b(KOMP)Wtsi HOM Early adult 9.77×10-11
narrow eye opening Spns2tm1b(KOMP)Wtsi HOM Early adult 8.60×10-09
corneal vascularization Spns2tm1b(KOMP)Wtsi HOM Early adult 5.05×10-11
decreased bone mineral content Spns2tm1b(KOMP)Wtsi HOM Early adult 3.36×10-05
abnormal iris morphology Spns2tm1b(KOMP)Wtsi HOM Early adult 9.70×10-05
trunk curl Spns2tm1b(KOMP)Wtsi HOM Early adult 8.60×10-09
decreased leukocyte cell number Spns2tm1b(KOMP)Wtsi HOM Early adult 4.08×10-39

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 11 No  (3/590) N/A
Aorta 11 No  (1/590) N/A
Blood vessel 11 No N/A
Bone 11 No  (12/12) N/A
Brain 11 No  (3/590)  (12/12) N/A
Brainstem 11 No  (2/590) N/A
Brown adipose tissue 11 No N/A
Cartilage tissue 11 No N/A
Cerebellum 11 No  (3/590) N/A
Cerebral cortex 11 No  (2/590) N/A
Eye 11 No  (10/12) N/A
Gall bladder 11 No  (1/12) N/A
Heart 11 No  (1/590) N/A
Hippocampus 11 No  (3/590) N/A
Hypothalamus 11 No  (2/590) N/A
Kidney 11 No  (20/590)  (12/12) N/A
Large intestine 11 No  (10/590)  (1/12) N/A
Liver 11 No  (11/12) N/A
Lower urinary tract 11 No  (1/590)  (11/12) N/A
Lung 11 No  (1/590)  (6/12) N/A
Lymph node 11 No  (12/12) N/A
Mammary gland 11 No  (4/12) N/A
Esophagus 11 No  (12/12) N/A
Olfactory lobe 11 No  (2/590) N/A
Ovary 11 No  (1/590)  (3/12) N/A
Oviduct 11 No  (5/12) N/A
Pancreas 11 No  (5/590)  (6/12) N/A
Parathyroid gland 11 No N/A
Peripheral nervous system 11 No  (1/590)  (7/12) N/A
Peyer's patch 11 No  (10/12) N/A
Pituitary gland 11 No  (1/590) N/A
Prostate gland 11 No  (12/590) N/A
Skeletal muscle tissue 11 No N/A
Skin 11 No  (12/12) N/A
Small intestine 11 No  (9/590)  (2/12) N/A
Spinal cord 11 No  (2/590)  (12/12) N/A
Spleen 11 No  (2/590)  (7/12) N/A
Stomach 11 No  (13/590)  (12/12) N/A
Striatum 11 No  (3/590) N/A
Testis 11 No  (5/590)  (6/12) N/A
Thymus 11 No  (3/12) N/A
Thyroid gland 11 No  (16/590)  (2/12) N/A
Trachea 11 No  (2/590)  (2/12) N/A
Uterus 11 No  (3/12) N/A
White adipose tissue 11 No N/A
LacZ Section Images

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No Embryo expression data was found for this gene.

 Associated Images

X-ray: XRay Images Skull Dorso Ventral Orientation
13 Images
Eye Morphology: Images Slit Lamp
27 Images
X-ray: XRay Images Skull Lateral Orientation
12 Images
X-ray: XRay Images Whole Body Dorso Ventral
15 Images
X-ray: XRay Images Forepaw
13 Images
X-ray: XRay Images Whole Body Lateral Orientation
13 Images
Legacy Phenotype Associated Images

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 Disease Models

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MGI Allele Allele Type Produced
Spns2tm1c(KOMP)Wtsi Wild type floxed exon (post-Flp) Mice
Spns2tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Spns2tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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