Gene: Spns2

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Phenotype System Allele Zyg Sex Life Stage P Value
corneal opacity Spns2tm1b(KOMP)Wtsi HOM Early adult 5.05×10-11
abnormal eyelid aperture Spns2tm1a(KOMP)Wtsi HOM Early adult 7.27×10-06
absent pinna reflex Spns2tm1a(KOMP)Wtsi HOM Early adult 5.54×10-30
corneal opacity Spns2tm1a(KOMP)Wtsi HOM Early adult 1.34×10-21
increased mean corpuscular volume Spns2tm1b(KOMP)Wtsi HOM   Early adult 2.72×10-06
abnormal cornea morphology Spns2tm1b(KOMP)Wtsi HOM Early adult 9.77×10-11
increased bone mineral density Spns2tm1a(KOMP)Wtsi HOM Early adult 1.40×10-06
abnormal eye size Spns2tm1a(KOMP)Wtsi HOM Early adult 3.32×10-08
abnormal cornea morphology Spns2tm1a(KOMP)Wtsi HOM Early adult 1.24×10-20
narrow eye opening Spns2tm1b(KOMP)Wtsi HOM Early adult 8.60×10-09
decreased body weight Spns2tm1a(KOMP)Wtsi HOM   Early adult 6.29×10-05
decreased bone mineral content Spns2tm1b(KOMP)Wtsi HOM Early adult 3.36×10-05
increased circulating sodium level Spns2tm1b(KOMP)Wtsi HOM   Early adult 6.50×10-05
corneal vascularization Spns2tm1b(KOMP)Wtsi HOM Early adult 5.05×10-11
abnormal iris morphology Spns2tm1a(KOMP)Wtsi HOM Early adult 6.91×10-06
abnormal eye pigmentation Spns2tm1a(KOMP)Wtsi HOM Early adult 4.04×10-25
increased bone mineral content Spns2tm1a(KOMP)Wtsi HOM Early adult 4.28×10-06
decreased leukocyte cell number Spns2tm1b(KOMP)Wtsi HOM Early adult 4.08×10-39
decreased leukocyte cell number Spns2tm1a(KOMP)Wtsi HOM Early adult 1.23×10-23
abnormal rib morphology Spns2tm1a(KOMP)Wtsi HOM Early adult 3.83×10-05
corneal vascularization Spns2tm1a(KOMP)Wtsi HOM Early adult 4.21×10-21
excessive tearing Spns2tm1a(KOMP)Wtsi HOM Early adult 5.58×10-06
decreased circulating glucose level Spns2tm1a(KOMP)Wtsi HOM Early adult 7.13×10-05
abnormal eye morphology Spns2tm1a(KOMP)Wtsi HOM Early adult 6.79×10-09
abnormal iris morphology Spns2tm1b(KOMP)Wtsi HOM Early adult 9.70×10-05
abnormal behavior Spns2tm1a(KOMP)Wtsi HOM Early adult 9.80×10-05
trunk curl Spns2tm1b(KOMP)Wtsi HOM Early adult 8.60×10-09
abnormal pupil morphology Spns2tm1a(KOMP)Wtsi HOM   Early adult 1.75×10-05
absent pinna reflex Spns2tm1b(KOMP)Wtsi HOM Early adult 9.77×10-11
increased mean corpuscular hemoglobin Spns2tm1b(KOMP)Wtsi HOM Early adult 1.22×10-05

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
11 No  (4/583) N/A
11 No  (1/583) N/A
11 No N/A
11 No  (12/12) N/A
11 No  (4/583)  (12/12) N/A
11 No  (2/583) N/A
11 No N/A
11 No  (1/583) N/A
11 No  (3/583) N/A
11 No  (2/583) N/A
11 No  (10/12) N/A
11 No  (1/12) N/A
11 No  (2/583) N/A
11 No  (3/583) N/A
11 No  (2/583) N/A
11 No  (21/583)  (12/12) N/A
11 No  (10/583)  (1/12) N/A
11 No  (11/12) N/A
11 No  (1/583)  (11/12) N/A
11 No  (2/583)  (6/12) N/A
11 No  (1/583)  (12/12) N/A
11 No  (4/12) N/A
11 No  (12/12) N/A
11 No  (2/583) N/A
11 No  (1/583)  (3/12) N/A
11 No  (5/12) N/A
11 No  (5/583)  (6/12) N/A
11 No  (1/563) N/A
11 No  (2/583)  (7/12) N/A
11 No  (1/176)  (10/12) N/A
11 No  (1/583) N/A
11 No  (12/583) N/A
11 No N/A
11 No  (1/583)  (12/12) N/A
11 No  (9/583)  (2/12) N/A
11 No  (3/583)  (12/12) N/A
11 No  (3/583)  (7/12) N/A
11 No  (13/583)  (12/12) N/A
11 No  (3/583) N/A
11 No  (6/583)  (6/12) N/A
11 No  (1/583)  (3/12) N/A
11 No  (17/583)  (2/12) N/A
11 No  (3/583)  (2/12) N/A
11 No  (3/12) N/A
11 No N/A
LacZ Section Images

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View all 27 images

View all 8 images

View all 8 images

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View all 6 images

View all 6 images

No Embryo expression data was found for this gene.

 Associated Images

X-ray: XRay Images Forepaw
13 Images
Eye Morphology: Images Slit Lamp
27 Images
X-ray: XRay Images Skull Lateral Orientation
12 Images
X-ray: XRay Images Whole Body Dorso Ventral
15 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
13 Images
X-ray: XRay Images Whole Body Lateral Orientation
13 Images
Histopathology
6 Images
Legacy Phenotype Associated Images

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View all 58 images

View all 12 images

View all 8 images

View all 6 images

 Disease Models

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 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Eye with optic nerve - inflammation Spns2tm1a(KOMP)Wtsi HOM Early adult
Eye with optic nerve - developmental and structural abnormality Spns2tm1a(KOMP)Wtsi HOM Early adult

 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Spns2tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Spns2tm1c(KOMP)Wtsi Wild type floxed exon (post-Flp) Mice
Spns2tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells