Gene: Spns2

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Phenotype System Allele Zyg Sex Life Stage P Value
decreased bone mineral content Spns2tm1b(KOMP)Wtsi HOM Early adult 3.36×10-05
corneal opacity Spns2tm1a(KOMP)Wtsi HOM Early adult 1.36×10-21
abnormal cornea morphology Spns2tm1a(KOMP)Wtsi HOM Early adult 1.26×10-20
increased bone mineral density Spns2tm1a(KOMP)Wtsi HOM Early adult 3.98×10-05
absent pinna reflex Spns2tm1a(KOMP)Wtsi HOM Early adult 5.65×10-30
increased thermal nociceptive threshold Spns2tm1a(KOMP)Wtsi HOM Early adult 7.57×10-05
trunk curl Spns2tm1b(KOMP)Wtsi HOM Early adult 8.60×10-09
narrow eye opening Spns2tm1b(KOMP)Wtsi HOM Early adult 8.60×10-09
increased mean corpuscular hemoglobin Spns2tm1b(KOMP)Wtsi HOM Early adult 1.22×10-05
corneal opacity Spns2tm1b(KOMP)Wtsi HOM Early adult 5.05×10-11
absent pinna reflex Spns2tm1b(KOMP)Wtsi HOM Early adult 9.77×10-11
abnormal pupil morphology Spns2tm1a(KOMP)Wtsi HOM   Early adult 1.76×10-05
abnormal iris morphology Spns2tm1b(KOMP)Wtsi HOM Early adult 9.70×10-05
abnormal iris morphology Spns2tm1a(KOMP)Wtsi HOM Early adult 5.32×10-05
abnormal rib morphology Spns2tm1a(KOMP)Wtsi HOM Early adult 3.83×10-05
decreased leukocyte cell number Spns2tm1a(KOMP)Wtsi HOM Early adult 1.91×10-17
decreased leukocyte cell number Spns2tm1b(KOMP)Wtsi HOM Early adult 4.08×10-39
corneal vascularization Spns2tm1a(KOMP)Wtsi HOM Early adult 4.26×10-21
abnormal eye morphology Spns2tm1a(KOMP)Wtsi HOM Early adult 6.47×10-09
excessive tearing Spns2tm1a(KOMP)Wtsi HOM Early adult 5.60×10-06
corneal vascularization Spns2tm1b(KOMP)Wtsi HOM Early adult 5.05×10-11
abnormal cornea morphology Spns2tm1b(KOMP)Wtsi HOM Early adult 9.77×10-11
abnormal eyelid aperture Spns2tm1a(KOMP)Wtsi HOM Early adult 2.10×10-06
abnormal eye size Spns2tm1a(KOMP)Wtsi HOM Early adult 7.17×10-07
abnormal eye pigmentation Spns2tm1a(KOMP)Wtsi HOM Early adult 4.12×10-25

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
11 No  (4/584) N/A
11 No  (1/584) N/A
11 No N/A
11 No  (12/12) N/A
11 No  (4/584)  (12/12) N/A
11 No  (2/584) N/A
11 No N/A
11 No  (1/584) N/A
11 No  (3/584) N/A
11 No  (2/584) N/A
11 No  (10/12) N/A
11 No  (1/12) N/A
11 No  (2/584) N/A
11 No  (3/584) N/A
11 No  (2/584) N/A
11 No  (21/584)  (12/12) N/A
11 No  (10/584)  (1/12) N/A
11 No  (11/12) N/A
11 No  (1/584)  (11/12) N/A
11 No  (2/584)  (6/12) N/A
11 No  (1/584)  (12/12) N/A
11 No  (4/12) N/A
11 No  (12/12) N/A
11 No  (2/584) N/A
11 No  (1/584)  (3/12) N/A
11 No  (5/12) N/A
11 No  (5/584)  (6/12) N/A
11 No  (1/562) N/A
11 No  (2/584)  (7/12) N/A
11 No  (1/176)  (10/12) N/A
11 No  (1/584) N/A
11 No  (12/584) N/A
11 No N/A
11 No  (1/584)  (12/12) N/A
11 No  (9/584)  (2/12) N/A
11 No  (3/584)  (12/12) N/A
11 No  (3/584)  (7/12) N/A
11 No  (12/584)  (12/12) N/A
11 No  (3/584) N/A
11 No  (6/584)  (6/12) N/A
11 No  (1/584)  (3/12) N/A
11 No  (16/584)  (2/12) N/A
11 No  (3/584)  (2/12) N/A
11 No  (3/12) N/A
11 No N/A
LacZ Section Images

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View all 27 images

View all 8 images

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View all 6 images

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No Embryo expression data was found for this gene.

 Associated Images

X-ray: XRay Images Skull Lateral Orientation
12 Images
Eye Morphology: Images Slit Lamp
27 Images
X-ray: XRay Images Whole Body Lateral Orientation
13 Images
X-ray: XRay Images Forepaw
13 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
13 Images
X-ray: XRay Images Whole Body Dorso Ventral
15 Images
Histopathology
6 Images
Legacy Phenotype Associated Images

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View all 12 images

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View all 6 images

 Disease Models

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 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Eye with optic nerve - developmental and structural abnormality Spns2tm1a(KOMP)Wtsi HOM Early adult
Eye with optic nerve - inflammation Spns2tm1a(KOMP)Wtsi HOM Early adult

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MGI Allele Allele Type Produced
Spns2tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Spns2tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Spns2tm1c(KOMP)Wtsi Wild type floxed exon (post-Flp) Mice