Gene Summary

Name:
hexokinase domain containing 1
Synonyms:
N/A

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
increased total body fat amount Hkdc1em1(IMPC)Bay HOM Early adult 1.47×10-07
decreased bone mineral density Hkdc1em1(IMPC)Bay HOM Early adult 1.68×10-05
decreased lean body mass Hkdc1em1(IMPC)Bay HOM Early adult 5.99×10-07
decreased bone mineral content Hkdc1em1(IMPC)Bay HOM   Early adult 1.10×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Eye Morphology

VIP of left fundus

16 Images

Eye Morphology

VIP of left eye

16 Images

Eye Morphology

VIP of right eye

16 Images

Eye Morphology

VIP of right fundus

15 Images

Human diseases caused by Hkdc1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Hkdc1 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Retinitis Pigmentosa 92
Pigmentary retinopathy OMIM:619614

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Hkdc1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Hkdc1.

There are 3 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
The hexokinase "HKDC1" interaction with the mitochondria is essential for liver cancer progression. Cell death & disease (July 2022) Hkdc1tm1a(KOMP)Wtsi PMC9334634
Enterocyte HKDC1 Modulates Intestinal Glucose Absorption in Male Mice Fed a High-fat Diet. Endocrinology (June 2022) Hkdc1tm1a(KOMP)Wtsi PMC9078327
Hepatic hexokinase domain containing 1 (HKDC1) improves whole body glucose tolerance and insulin sensitivity in pregnant mice. Biochimica et biophysica acta. Molecular basis of disease (December 2018) Hkdc1tm1a(KOMP)Wtsi PMC6387585

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Hkdc1em1(IMPC)Bay Exon Deletion Mice
Hkdc1tm1(NCOM)Cmhd Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Hkdc1tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Hkdc1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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