An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
| Anatomy | Images | Zygosity | Mutant Expr |
|---|---|---|---|
| Adrenal gland | Wholemount images | heterozygote | 100% (2 of 2) |
| Aorta | Wholemount images | heterozygote | 100% (2 of 2) |
| Bone | Wholemount images | heterozygote | Ambiguous |
| Brain | Wholemount images | heterozygote | 100% (2 of 2) |
| Brainstem | Wholemount images | heterozygote | 100% (2 of 2) |
| Brown adipose tissue | Wholemount images | heterozygote | 100% (2 of 2) |
| Cartilage tissue | Wholemount images | heterozygote | Ambiguous |
| Cerebellum | Wholemount images | heterozygote | 100% (2 of 2) |
| Heart | Wholemount images | heterozygote | 100% (2 of 2) |
| Hippocampus | Wholemount images | heterozygote | 100% (2 of 2) |
| Hypothalamus | Wholemount images | heterozygote | 100% (2 of 2) |
| Kidney | Wholemount images | heterozygote | 100% (2 of 2) |
| Large intestine | Wholemount images | heterozygote | 100% (2 of 2) |
| Lower urinary tract | Wholemount images | heterozygote | 100% (2 of 2) |
| Olfactory lobe | Wholemount images | heterozygote | Ambiguous |
| Oviduct | Wholemount images | heterozygote | 50% (1 of 2) |
| Parathyroid gland | Wholemount images | heterozygote | 100% (2 of 2) |
| Prostate gland | Wholemount images | heterozygote | 50% (1 of 2) |
| Skeletal muscle | Wholemount images | heterozygote | Ambiguous |
| Small intestine | Wholemount images | heterozygote | 100% (2 of 2) |
| Spinal cord | Wholemount images | heterozygote | 100% (2 of 2) |
| Striatum | Wholemount images | heterozygote | 100% (2 of 2) |
| Testis | Wholemount images | heterozygote | 50% (1 of 2) |
| Thyroid gland | Wholemount images | heterozygote | 100% (2 of 2) |
| Trachea | Wholemount images | heterozygote | 100% (2 of 2) |
| Uterus | Wholemount images | heterozygote | 50% (1 of 2) |
| Vas deferens | Wholemount images | heterozygote | 50% (1 of 2) |
| Vascular system | Wholemount images | heterozygote | 0.0% (0 of 2) |
| White adipose tissue | Wholemount images | heterozygote | 100% (2 of 2) |
| Cerebral cortex | N/A | heterozygote | 0.0% (0 of 2) |
| Esophagus | N/A | heterozygote | 0.0% (0 of 2) |
| Eye | N/A | heterozygote | Not available |
| Gall bladder | N/A | heterozygote | 0.0% (0 of 2) |
| Liver | N/A | heterozygote | 0.0% (0 of 2) |
| Lung | N/A | heterozygote | 100% (2 of 2) |
| Lymph node | N/A | heterozygote | 0.0% (0 of 2) |
| Mammary gland | N/A | heterozygote | 0.0% (0 of 2) |
| Mesenteric lymph node | N/A | heterozygote | 0.0% (0 of 2) |
| Oral epithelium | N/A | heterozygote | 0.0% (0 of 2) |
| Ovary | N/A | heterozygote | 0.0% (0 of 2) |
| Pancreas | N/A | heterozygote | 0.0% (0 of 2) |
| Peripheral nervous system | N/A | heterozygote | 0.0% (0 of 2) |
| Peyer's patch | N/A | heterozygote | 0.0% (0 of 2) |
| Pituitary gland | N/A | heterozygote | 0.0% (0 of 2) |
| Skin | N/A | heterozygote | 0.0% (0 of 2) |
| Spleen | N/A | heterozygote | 0.0% (0 of 2) |
| Stomach | N/A | heterozygote | 0.0% (0 of 2) |
| Thymus | N/A | heterozygote | 0.0% (0 of 2) |
| Trigeminal V nerve | N/A | heterozygote | 0.0% (0 of 2) |
| Urinary bladder | N/A | heterozygote | 100% (2 of 2) |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
| Anatomy | Images | Zygosity | Mutant Expr |
|---|---|---|---|
| Heart atrium | N/A | heterozygote | 100% (2 of 2) |
| Axial skeleton | N/A | heterozygote | 100% (2 of 2) |
| Brain | N/A | heterozygote | 100% (2 of 2) |
| Central nervous system ganglion | N/A | heterozygote | 100% (2 of 2) |
| Cranium | N/A | heterozygote | 100% (2 of 2) |
| Dorsal root ganglion | N/A | heterozygote | 100% (2 of 2) |
| Ear | N/A | heterozygote | 100% (2 of 2) |
| Embryo | N/A | heterozygote | 100% (2 of 2) |
| Outer ear | N/A | heterozygote | 100% (2 of 2) |
| Eye | N/A | heterozygote | 100% (2 of 2) |
| Femur pre-cartilage condensation | N/A | heterozygote | 100% (2 of 2) |
| Footplate | N/A | heterozygote | 100% (2 of 2) |
| Forearm | N/A | heterozygote | 100% (2 of 2) |
| Forebrain | N/A | heterozygote | 100% (2 of 2) |
| Forelimb | N/A | heterozygote | 100% (2 of 2) |
| Fronto-nasal process | N/A | heterozygote | 100% (2 of 2) |
| Gut | N/A | heterozygote | 100% (2 of 2) |
| Handplate | N/A | heterozygote | 100% (2 of 2) |
| Head mesenchyme | N/A | heterozygote | 100% (2 of 2) |
| Head | N/A | heterozygote | 100% (2 of 2) |
| Heart ventricle | N/A | heterozygote | 100% (2 of 2) |
| Heart | N/A | heterozygote | 100% (2 of 2) |
| Hindbrain | N/A | heterozygote | 100% (2 of 2) |
| Hindlimb | N/A | heterozygote | 100% (2 of 2) |
| Humerus pre-cartilage condensation | N/A | heterozygote | 100% (2 of 2) |
| Inner ear | N/A | heterozygote | 100% (2 of 2) |
| Intestine | N/A | heterozygote | 100% (2 of 2) |
| Liver | N/A | heterozygote | 100% (2 of 2) |
| Lower leg | N/A | heterozygote | 100% (2 of 2) |
| Lung | N/A | heterozygote | 100% (2 of 2) |
| Mandibular process | N/A | heterozygote | 100% (2 of 2) |
| Maxillary process | N/A | heterozygote | 100% (2 of 2) |
| Mesonephros of female | N/A | heterozygote | 50% (1 of 2) |
| Mesonephros of male | N/A | heterozygote | 50% (1 of 2) |
| Metanephros | N/A | heterozygote | 100% (2 of 2) |
| Midbrain | N/A | heterozygote | 100% (2 of 2) |
| Nasal septum | N/A | heterozygote | 100% (2 of 2) |
| Nose | N/A | heterozygote | 100% (2 of 2) |
| Notochord | N/A | heterozygote | 100% (2 of 2) |
| Oral cavity | N/A | heterozygote | 100% (2 of 2) |
| Outflow tract | N/A | heterozygote | 100% (2 of 2) |
| Pancreas | N/A | heterozygote | 100% (2 of 2) |
| N/A | heterozygote | 100% (2 of 2) | |
| Pharynx | N/A | heterozygote | 100% (2 of 2) |
| Radius-ulna pre-cartilage condensation | N/A | heterozygote | 100% (2 of 2) |
| Rib pre-cartilage condensation | N/A | heterozygote | 100% (2 of 2) |
| Skeleton | N/A | heterozygote | 100% (2 of 2) |
| Skin | N/A | heterozygote | 100% (2 of 2) |
| Spinal cord | N/A | heterozygote | 100% (2 of 2) |
| Stomach | N/A | heterozygote | 100% (2 of 2) |
| Tail somite | N/A | heterozygote | 100% (2 of 2) |
| Tail | N/A | heterozygote | 100% (2 of 2) |
| Thoracic vertebral cartilage condensation | N/A | heterozygote | 100% (2 of 2) |
| Tongue | N/A | heterozygote | 100% (2 of 2) |
| Trachea | N/A | heterozygote | 100% (2 of 2) |
| Trunk mesenchyme | N/A | heterozygote | 100% (2 of 2) |
| Umbilical artery embryonic part | N/A | heterozygote | 100% (2 of 2) |
| Umbilical vein embryonic part | N/A | heterozygote | 100% (2 of 2) |
| Upper arm | N/A | heterozygote | 100% (2 of 2) |
| Upper leg | N/A | heterozygote | 100% (2 of 2) |
| Urinary system | N/A | heterozygote | 100% (2 of 2) |
| Vibrissa | N/A | heterozygote | 100% (2 of 2) |
Background staining occurs in wild type mice and embryos at an incidental rate.
| Anatomy | Background staining in controls (WT) |
|---|---|
| adrenal gland | 0.67% (4 of 598) |
| aorta | 0.17% (1 of 598) |
| bone | 0.0% |
| brain | 0.84% (5 of 598) |
| brainstem | 0.33% (2 of 598) |
| brown adipose tissue | 0.0% |
| cartilage tissue | 0.17% (1 of 598) |
| cerebellum | 0.5% (3 of 598) |
| cerebral cortex | 0.33% (2 of 598) |
| esophagus | 1.66% (7 of 422) |
| eye | 0.0% |
| gall bladder | 0.0% |
| heart | 0.33% (2 of 598) |
| hippocampus | 0.5% (3 of 598) |
| hypothalamus | 0.33% (2 of 598) |
| kidney | 4.52% (27 of 598) |
| large intestine | 5.35% (32 of 598) |
| liver | 0.0% |
| lower urinary tract | 0.17% (1 of 598) |
| lung | 0.33% (2 of 598) |
| lymph node | 0.17% (1 of 598) |
| mammary gland | 0.0% |
| mesenteric lymph node | 0.31% (1 of 323) |
| olfactory lobe | 0.33% (2 of 598) |
| oral epithelium | 0.0% |
| ovary | 0.17% (1 of 598) |
| oviduct | 0.0% |
| pancreas | 0.84% (5 of 598) |
| parathyroid gland | 0.17% (1 of 576) |
| peripheral nervous system | 0.33% (2 of 598) |
| peyers patch | 0.0% |
| pituitary gland | 0.17% (1 of 598) |
| prostate gland | 2.17% (13 of 598) |
| skeletal muscle | 0.0% |
| skin | 0.17% (1 of 598) |
| small intestine | 5.35% (32 of 598) |
| spinal cord | 0.5% (3 of 598) |
| spleen | 0.5% (3 of 598) |
| stomach | 3.68% (22 of 598) |
| striatum | 0.5% (3 of 598) |
| testis | 1% (6 of 598) |
| thymus | 0.17% (1 of 598) |
| thyroid gland | 3.01% (18 of 598) |
| trachea | 0.5% (3 of 598) |
| trigeminal v nerve | 0.0% |
| urinary bladder | 0.0% |
| uterus | 0.33% (2 of 598) |
| vas deferens | 4.56% (18 of 395) |
| vascular system | 0.0% |
| white adipose tissue | 0.0% |
Background staining occurs in wild type mice and embryos at an incidental rate.
Background staining occurs in wild type embryos at a measurable rate.
| Anatomy | Background staining in controls(WT) |
|---|---|
| atrium | 1.67% (1 of 60) |
| axial skeleton | 1.56% (1 of 64) |
| brain | 1.17% (6 of 511) |
| central nervous system ganglion | 1.37% (1 of 73) |
| cranium | 1.56% (1 of 64) |
| dorsal root ganglion | 1.67% (1 of 60) |
| ear | 0.2% (1 of 511) |
| embryo | 0.39% (2 of 512) |
| external ear | 1.35% (1 of 74) |
| eye | 0.2% (1 of 511) |
| femur pre-cartilage condensation | 1.82% (1 of 55) |
| footplate | 0.2% (1 of 511) |
| forearm | 0.33% (1 of 305) |
| forebrain | 0.2% (1 of 511) |
| forelimb | 0.2% (1 of 511) |
| fronto-nasal process | 1.64% (1 of 61) |
| gut | 1.69% (1 of 59) |
| handplate | 0.2% (1 of 511) |
| head | 0.98% (5 of 511) |
| head mesenchyme | 1.67% (1 of 60) |
| heart | 0.2% (1 of 511) |
| heart ventricle | 1.67% (1 of 60) |
| hindbrain | 1.17% (6 of 511) |
| hindlimb | 0.2% (1 of 511) |
| humerus pre-cartilage condensation | 1.56% (1 of 64) |
| inner ear | 1.56% (1 of 64) |
| intestine | 1.72% (1 of 58) |
| liver | 0.2% (1 of 506) |
| lower leg | 0.33% (1 of 305) |
| lung | 0.2% (1 of 506) |
| mandibular process | 0.2% (1 of 511) |
| maxillary process | 0.2% (1 of 511) |
| mesonephros of female | 1.82% (1 of 55) |
| mesonephros of male | 1.82% (1 of 55) |
| metanephros | 1.82% (1 of 55) |
| midbrain | 0.2% (1 of 511) |
| nasal septum | 1.67% (1 of 60) |
| nose | 1.28% (1 of 78) |
| notochord | 1.67% (1 of 60) |
| oral cavity | 0.2% (1 of 506) |
| outflow tract | 1.67% (1 of 60) |
| pancreas | 1.82% (1 of 55) |
| pericardium | 1.82% (1 of 55) |
| pharynx | 1.79% (1 of 56) |
| radius-ulna pre cartilage condensation | 1.56% (1 of 64) |
| rib pre-cartilage condensation | 1.75% (1 of 57) |
| skeleton | 1.28% (1 of 78) |
| skin | 0.2% (1 of 511) |
| spinal cord | 1.39% (1 of 72) |
| stomach | 1.82% (1 of 55) |
| tail | 0.2% (1 of 511) |
| tail somite group | 0.2% (1 of 511) |
| thoracic vertebral cartilage condensation | 1.82% (1 of 55) |
| tongue | 1.82% (1 of 55) |
| trachea | 1.69% (1 of 59) |
| trunk mesenchyme | 1.67% (1 of 60) |
| umbilical artery embryonic part | 1.67% (1 of 60) |
| umbilical vein embryonic part | 1.67% (1 of 60) |
| upper arm | 0.33% (1 of 305) |
| upper leg | 0.33% (1 of 305) |
| urinary system | 1.69% (1 of 59) |
| vibrissa | 1.35% (1 of 74) |
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
XRay Images Skull Dorso Ventral Orientation
18 Images
XRay Images Whole Body Dorso Ventral
18 Images
LacZ Images Wholemount
17 Images
XRay Images Whole Body Lateral Orientation
18 Images
XRay Images Skull Lateral Orientation
18 Images
XRay Images Forepaw
18 Images
LacZ images wholemount
4 Images
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Chpt1.
There are 1 publication which use IMPC produced mice or data.
| Title | Journal | IMPC Allele | PubMed ID |
|---|---|---|---|
| Spatiotemporal gene expression patterns reveal molecular relatedness between retinal laminae. | The Journal of comparative neurology (October 2019) | Chpt1tm1b(EUCOMM)Wtsi | 31609468 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
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| MGI Allele | Allele Type | Produced |
|---|---|---|
| Chpt1tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | Mice, Tissue |
| Chpt1tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
| Chpt1tm1e(EUCOMM)Wtsi | Targeted, non-conditional allele | ES Cells |
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