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Gene: Sectm1a MGI:2384805

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
secreted and transmembrane 1A
Synonyms:
N/A

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Sectm1a mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Sectm1a by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Immune-Mediated Necrotizing Myopathy
Myositis, Skin rash, Elevated circulating creatine kinase concentration, Raynaud phenomenon, Myoc... ORPHA:206569
Systemic-Onset Juvenile Idiopathic Arthritis
Anterior uveitis, Pericarditis, Skin rash, Elevated circulating C-reactive protein concentration,... ORPHA:85414
Polyarteritis Nodosa
Pericarditis, Elevated circulating C-reactive protein concentration, Raynaud phenomenon, Cardiomy... ORPHA:767
Drug-Induced Lupus Erythematosus
Pericarditis, Elevated circulating creatine kinase concentration, Elevated circulating C-reactive... ORPHA:231111
Adult-Onset Still Disease
Pericarditis, Skin rash, Elevated circulating C-reactive protein concentration, Myocarditis, Hepa... ORPHA:829
Sudden Cardiac Failure, Infantile
Sudden cardiac death, Myocarditis, Congestive heart failure, Bradycardia, Hypertrophic cardiomyop... OMIM:617222
Peripartum Cardiomyopathy
Tachycardia, Right ventricular failure, Myocarditis, Cardiogenic shock, Dilated cardiomyopathy, V... ORPHA:563
Antisynthetase Syndrome
Aortic regurgitation, Myositis, Skin rash, Elevated circulating creatine kinase concentration, Te... ORPHA:81
Bacterial Toxic-Shock Syndrome
Fasciitis, Sinusitis, Myositis, Elevated circulating creatine kinase concentration, Hypoalbuminem... ORPHA:36234
Immunodeficiency 22
Pericarditis, Capillary leak, Decreased circulating total IgM, Panniculitis, Decreased circulatin... OMIM:615758
Polymyositis
Gastrointestinal hemorrhage, Pericarditis, Elevated circulating creatine kinase concentration, My... ORPHA:732
Catastrophic Antiphospholipid Syndrome
Angina pectoris, Transient ischemic attack, Myocardial infarction, Pulmonary embolism, Arterial o... ORPHA:464343
Congenital Enterovirus Infection
Skin rash, Myocarditis, Hepatitis, Hyperammonemia, Cardiomyopathy, Hypoalbuminemia, Hypotension, ... ORPHA:292
Legionnaires Disease
Hyponatremia, Pericarditis, Myocarditis, Hepatitis, Endocarditis, Bone marrow hypocellularity, Hy... ORPHA:549
Simple Cryoglobulinemia
Gastrointestinal hemorrhage, Viral hepatitis, Pericarditis, Membranoproliferative glomerulonephri... ORPHA:91139
Systemic Lupus Erythematosus, Susceptibility To, 6
Arthritis, Pericarditis, Malar rash OMIM:609939
Loeffler Endocarditis
Aortic regurgitation, Pericarditis, Left ventricular diastolic dysfunction, Congestive heart fail... ORPHA:75566
American Trypanosomiasis
Skin rash, Myocarditis, Congestive heart failure, Cardiomyopathy, Arrhythmia, Achalasia, Infectio... ORPHA:3386
Juvenile Dermatomyositis
Calcinosis, Bundle branch block, Myositis, Pericarditis, Skin rash, Elevated circulating creatine... ORPHA:93672
Systemic Lupus Erythematosus
Pericarditis, Lupus nephritis, Arthritis, Malar rash, Nephritis OMIM:152700
Odontomatosis-Aortae Esophagus Stenosis Syndrome
Myocarditis ORPHA:2724
Microscopic Polyangiitis
Episcleritis, Increased inflammatory response, Pericarditis, Sinusitis, Skin rash, Gastrointestin... ORPHA:727
Malignant Atrophic Papulosis
Gastrointestinal hemorrhage, Constrictive pericarditis OMIM:602248
Eosinophilic Granulomatosis With Polyangiitis
Increased inflammatory response, Myositis, Sinusitis, Skin rash, Recurrent intrapulmonary hemorrh... ORPHA:183
Whipple Disease
Hyponatremia, Gastrointestinal hemorrhage, Myositis, Pericarditis, Myocardial infarction, Myocard... ORPHA:3452
Drug Reaction With Eosinophilia And Systemic Symptoms
Skin rash, Cardiac arrest, Pustule, Myocarditis, Hepatitis, Thyroiditis, Tubulointerstitial nephr... ORPHA:139402
Q Fever
Pericarditis, Osteomyelitis, Maculopapular exanthema, Pneumonia, Myocarditis, Vasculitis, Hepatit... ORPHA:781
Rat-Bite Fever
Pericarditis, Maculopapular exanthema, Skin rash, Erythema nodosum, Lymphadenitis, Pustule, Myoca... ORPHA:31205
Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome
Arthritis, Constrictive pericarditis OMIM:208250
Colchicine Poisoning
Hyponatremia, Myocarditis, Congestive heart failure, Hypovolemia, Abnormal blood ion concentratio... ORPHA:31824
Rheumatic Fever
Pericarditis, Sinusitis, Epistaxis, Myocarditis, Endocarditis, Arthritis, Arrhythmia ORPHA:3099
Systemic Capillary Leak Syndrome
Pericarditis, Myocarditis, Hypotension, Arrhythmia, Pancreatitis ORPHA:188
Yao Syndrome
Inflammatory abnormality of the skin, Pericarditis, Skin rash, Arthritis, Keratoconjunctivitis sicca OMIM:617321
Scrub Typhus
Anterior uveitis, Skin rash, Myocarditis, Hypotension, Infectious encephalitis ORPHA:83317
Tumor Necrosis Factor Receptor 1 Associated Periodic Syndrome
Fasciitis, Myositis, Pericarditis, Skin rash, Elevated circulating C-reactive protein concentrati... ORPHA:32960
Felty Syndrome
Episcleritis, Pericarditis, Sinusitis, Recurrent pneumonia, Synovitis, Arthritis, Rhinitis, Bone ... ORPHA:47612
Systemic Sclerosis
Pericarditis, Osteomyelitis, Recurrent skin infections, Glomerulonephritis, Elevated circulating ... ORPHA:90291
Congenital Gerbode Defect
Elevated right atrial pressure, Tricuspid regurgitation, Left-to-right shunt, Right ventricular f... ORPHA:99095
Brucellosis
Anterior uveitis, Pericarditis, Osteomyelitis, Transient ischemic attack, Pneumonia, Elevated cir... ORPHA:1304
Camptodactyly-Arthropathy-Coxa-Vara-Pericarditis Syndrome
Increased inflammatory response, Pericarditis, Knee osteoarthritis, Mitral regurgitation, Osteoar... ORPHA:2848
Familial Mediterranean Fever
Pericarditis, Elevated circulating C-reactive protein concentration, Orchitis, Peritonitis, Arthr... OMIM:249100
Lujo Hemorrhagic Fever
Shock, Skin rash, Maculopapular exanthema, Elevated circulating C-reactive protein concentration,... ORPHA:319213
Hb Bart'S Hydrops Fetalis
Congestive heart failure, Pericarditis ORPHA:163596
Crimean-Congo Hemorrhagic Fever
Bundle branch block, Elevated circulating creatine kinase concentration, Abnormal left ventricula... ORPHA:99827
Scedosporiosis
Pericarditis, Osteomyelitis, Arthralgia/arthritis, Sinusitis, Pneumonia, Endocarditis, Septic art... ORPHA:449280
Mixed Connective Tissue Disease
Gastrointestinal hemorrhage, Myositis, Pericarditis, Skin rash, Gastritis, Myocarditis, Arthritis... ORPHA:809
Secondary Intestinal Lymphangiectasia
Decreased circulating IgG1 level, Right ventricular failure, Reduced circulating transferrin conc... ORPHA:90363
Granulomatosis With Polyangiitis
Gastrointestinal hemorrhage, Increased inflammatory response, Pericarditis, Sinusitis, Skin rash,... ORPHA:900
Amoebiasis Due To Entamoeba Histolytica
Constrictive pericarditis, Hypoalbuminemia, Congestive heart failure, Acute colitis ORPHA:67
Shigellosis
Hyponatremia, Pneumonia, Myocarditis, Peritonitis, Abnormal blood ion concentration, Uveitis, Ulc... ORPHA:810
Scorpion Envenomation
Bundle branch block, Acute pancreatitis, Increased circulating NT-proBNP concentration, Tachycard... ORPHA:466677
Aicardi-Goutieres Syndrome 9
Acute pancreatitis, Pericarditis, Chilblains, Portal hypertension, Hypertension, Hypoalbuminemia,... OMIM:619487
Igg4-Related Kidney Disease
Elevated circulating C-reactive protein concentration, Lymphadenitis, Decreased retinol-binding p... ORPHA:449395
Infection-Related Hemolytic Uremic Syndrome
Hyponatremia, Increased circulating interleukin 6 concentration, Hypertensive crisis, Pneumonia, ... ORPHA:544482
Microsporidiosis
Myositis, Sinusitis, Osteomyelitis, Cholangitis, Pneumonia, Keratitis, Lymphadenitis, Prostatitis... ORPHA:2552
Marburg Hemorrhagic Fever
Elevated circulating creatine kinase concentration, Uveitis, Hypoalbuminemia, Internal hemorrhage... ORPHA:99826
Relapsing Polychondritis
Episcleritis, Pericarditis, Chondritis of pinna, Keratitis, Myocarditis, Hepatitis, Uveitis, Larg... ORPHA:728
Congenital Disorder Of Glycosylation, Type Ia
Pericarditis, Cardiomyopathy, Hypoalbuminemia, Hypocholesterolemia, Decreased circulating IgG lev... OMIM:212065
Coccidioidomycosis
Pericarditis, Osteomyelitis, Skin rash, Pneumonia, Erythema nodosum, Peritonitis, Vasculitis, Inc... ORPHA:228123
Zygomycosis
Gastrointestinal hemorrhage, Fasciitis, Sinusitis, Pericarditis, Gastritis, Epistaxis, Pustule, M... ORPHA:73263
Blau Syndrome
Nongranulomatous uveitis, Pericarditis, Eczema, Erythema nodosum, Synovitis, Uveitis, Arthritis, ... OMIM:186580
Listeriosis
Pericarditis, Osteomyelitis, Pneumonia, Pustule, Myocarditis, Peritonitis, Congestive heart failu... ORPHA:533
Behçet Disease
Aortic regurgitation, Increased inflammatory response, Myositis, Pericarditis, Acne, Gastrointest... ORPHA:117
Kawasaki Disease
Pericarditis, Skin rash, Myocarditis, Congestive heart failure, Vasculitis, Hepatitis, Cheilitis,... ORPHA:2331
Leptospirosis
Pericarditis, Skin rash, First degree atrioventricular block, Hepatitis, Uveitis, Retinal hemorrh... ORPHA:509
Arterial Tortuosity Syndrome
Telangiectasia of the skin, Cardiac arrest, Myocardial infarction, Myocarditis, Congestive heart ... ORPHA:3342
Reactive Arthritis
Aortic regurgitation, Pericarditis, Osteomyelitis, Pustule, Enthesitis, Arthritis, Inflammation o... ORPHA:29207
Giant Cell Arteritis
Pericarditis, Epistaxis, Sudden cardiac death, Vasculitis, Arthritis, Cerebral ischemia, Arrhythmia ORPHA:397
Familial Mediterranean Fever
Pericarditis, Skin rash, Myocardial infarction, Orchitis, Osteoarthritis, Peritonitis, Vasculitis... ORPHA:342
Kikuchi-Fujimoto Disease
Skin rash, Elevated circulating C-reactive protein concentration, Pustule, Myocarditis, Vasculiti... ORPHA:50918
Dermatomyositis
Pericarditis, Telangiectasia of the skin, Myocardial infarction, Myocarditis, Vasculitis, Arthrit... ORPHA:221
Nocardiosis
Pericarditis, Osteomyelitis, Pneumonia, Keratitis, Lymphadenitis, Peritonitis, Thyroiditis, Endoc... ORPHA:31204
Von Hippel-Lindau Disease
Myocardial infarction, Myocarditis, Abnormal left ventricular function, Hypertension, Cardiomyopa... ORPHA:892
Spondylometaphyseal Dysplasia, Sedaghatian Type
Myocarditis, Arrhythmia, Atrioventricular block ORPHA:93317
Blau Syndrome
Pericarditis, Skin rash, Keratitis, Retrobulbar optic neuritis, Erythema nodosum, Iridocyclitis, ... ORPHA:90340
African Trypanosomiasis
Abnormal EKG, Pericarditis, Keratitis, Myocarditis, Congestive heart failure, Second degree atrio... ORPHA:3385
Aymé-Gripp Syndrome
Pericarditis ORPHA:1272
Spondylometaphyseal Dysplasia, Sedaghatian Type
Myocarditis, Arrhythmia OMIM:250220
Ayme-Gripp Syndrome
Pericarditis OMIM:601088
Tetrasomy 9P
Myositis, Pericarditis, Raynaud phenomenon, Arthritis, Pulmonary arterial hypertension ORPHA:3310
Pmm2-Cdg
Pericarditis, Angina pectoris, Reduced thyroxin-binding globulin, Intracranial hemorrhage, Hypoal... ORPHA:79318

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Sectm1a

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Sectm1a.

No publications found that use IMPC mice or data for Sectm1a.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Sectm1atm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Sectm1atm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Sectm1atm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, ES Cells

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