Gene: Eif4g1 MGI:2384784

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
eukaryotic translation initiation factor 4, gamma 1
Synonyms:
E030015G23Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Eif4g1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Eif4g1 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Hereditary Late-Onset Parkinson Disease
Apathy, Low frustration tolerance, Mental deterioration, Dementia ORPHA:411602
Parkinson Disease 18, Autosomal Dominant, Susceptibility To
OMIM:614251

The table below shows human diseases predicted to be associated to Eif4g1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Autism, Susceptibility To, 20
Impaired social interactions OMIM:618830
Intellectual Disability-Expressive Aphasia-Facial Dysmorphism Syndrome
Abnormal social behavior ORPHA:436151
Childhood Disintegrative Disorder
Impaired social interactions, Dementia, Abnormal emotion/affect behavior, Social and occupational... ORPHA:168782
Early-Onset Schizophrenia
Shyness, Abnormal emotion/affect behavior, Diminished motivation, Anhedonia, Emotional lability, ... ORPHA:96369
Dopa-Responsive Dystonia
Abnormal social behavior, Agoraphobia, Emotional lability, Panic attack, Fatigable weakness, Irri... ORPHA:255
Female Restricted Epilepsy With Intellectual Disability
Anxiety, Abnormal social behavior, Aggressive behavior ORPHA:101039
Early-Onset Autosomal Dominant Alzheimer Disease
Abnormal social behavior, Memory impairment, Semantic dementia, Dementia ORPHA:1020
Hsd10 Disease
Abnormal social behavior ORPHA:391417
11Q22.2Q22.3 Microdeletion Syndrome
Poor eye contact, Anxiety, Abnormal social behavior ORPHA:444002
Lamb-Shaffer Syndrome
Abnormal social behavior ORPHA:530983
Metachromatic Leukodystrophy, Juvenile Form
Abnormal social behavior, Progressive psychomotor deterioration, Emotional lability ORPHA:309263
Metachromatic Leukodystrophy, Adult Form
Dementia, Abnormal social behavior, Emotional lability, Progressive psychomotor deterioration, Me... ORPHA:309271
Childhood Absence Epilepsy
Abnormal social behavior, Anxiety ORPHA:64280
48,Xxxy Syndrome
Abnormal social behavior, Irritability, Anxiety, Abnormal aggressive, impulsive or violent behavior ORPHA:96263
Metachromatic Leukodystrophy, Late Infantile Form
Abnormal social behavior, Emotional lability ORPHA:309256
Prader-Willi Syndrome Due To Translocation
Impaired social interactions, Skin-picking, Abnormal social behavior, Head-banging, Anxiety, Happ... ORPHA:177907
Non-Progressive Cerebellar Ataxia With Intellectual Disability
Abnormal social behavior, Memory impairment, Aggressive behavior ORPHA:314647
Niemann-Pick Disease Type C
Progressive neurologic deterioration, Aggressive behavior, Dementia, Abnormal social behavior, Ap... ORPHA:646
Fg Syndrome Type 1
Abnormal social behavior ORPHA:93932
Dihydropyrimidine Dehydrogenase Deficiency
Abnormal social behavior, Irritability, Abnormal aggressive, impulsive or violent behavior ORPHA:1675
Mend Syndrome
Abnormal social behavior, Aggressive behavior ORPHA:401973
Tuberous Sclerosis Complex
Anxiety, Abnormal social behavior, Self-injurious behavior, Aggressive behavior ORPHA:805
Koolen-De Vries Syndrome Due To A Point Mutation
Abnormal social behavior, Anxiety, Overfriendliness ORPHA:363965
17Q21.31 Microdeletion Syndrome
Abnormal social behavior, Anxiety, Overfriendliness ORPHA:363958
Williams Syndrome
Abnormal social behavior, Anxiety, Overfriendliness ORPHA:904
Hereditary Late-Onset Parkinson Disease
Apathy, Low frustration tolerance, Mental deterioration, Dementia ORPHA:411602
Parkinson Disease 18, Autosomal Dominant, Susceptibility To
OMIM:614251

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Eif4g1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Eif4g1.

No publications found that use IMPC mice or data for Eif4g1.

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MGI Allele Allele Type Produced
Eif4g1em1(IMPC)Hmgu Exon Deletion Mice
Eif4g1tm43513(L1L2_Bact_P) Targeting vectors

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