Hectd1 | HECT domain E3 ubiquitin protein ligase 1

GeneMGI:2384768Synonyms: b2b327Clo, A630086P08Rik, +1 more

Physiological systems

17 / 24 physiological systems tested

5 Significantly impacted by the knock-out

 Homeostasis/metabolism Immune system Pigmentation Integument Hematopoietic system

12 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Viability data
Body weight measurements
Embryo imaging data
Gene metrics:5Significant phenotypes
0Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased basophil cell number2 supporting datasetsHectd1tm1b(EUCOMM)HmguheterozygoteEarly adult3.21x10-40 
increased eosinophil cell number2 supporting datasetsHectd1tm1b(EUCOMM)HmguheterozygoteEarly adult8.38x10-21 
decreased circulating alkaline phosphatase level1 supporting datasetHectd1tm1b(EUCOMM)HmguheterozygoteEarly adult5.75x10-5 
increased circulating calcium level1 supporting datasetHectd1tm1b(EUCOMM)HmguheterozygoteEarly adult5.15x10-10 
abnormal coat/hair pigmentation1 supporting datasetHectd1tm1b(EUCOMM)HmguheterozygoteEarly adult8.76x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
Download data as:  










* Does not have a P-value assigned because it was manually marked as significant.
Download data as:  

lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Hectd1tm1(NCOM)MfgcReporter-tagged deletion allele (with selection cassette)targeting vector
es cell
Hectd1tm1a(EUCOMM)HmguKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
mouse
Hectd1tm1b(EUCOMM)HmguReporter-tagged deletion allele (with selection cassette)mouse
Hectd1tm1e(EUCOMM)HmguTargeted, non-conditional allelees cell

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