Ndrg4 | N-myc downstream regulated gene 4

GeneMGI:2384590Synonyms: D8Bwg1337e, Ndr4, +2 more

Physiological systems

19 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Homeostasis/metabolism Muscle Behavior/neurological Cardiovascular system

15 No significant impact

5 Not tested

Gene metrics:6Significant phenotypes
0Associated diseases
Expression examined in:46Adult tissues
42Embryo tissues

Phenotypes

hyperactivity8 supporting datasetsNdrg4tm1b(KOMP)WtsihomozygoteEarly adult1.2x10-18 
decreased cardiac muscle contractility1 supporting datasetNdrg4tm1b(KOMP)WtsihomozygoteEarly adult4.36x10-5 
increased blood urea nitrogen level1 supporting datasetNdrg4tm1b(KOMP)WtsihomozygoteEarly adult6.87x10-8 
limb grasping1 supporting datasetNdrg4tm1b(KOMP)WtsihomozygoteEarly adult9.41x10-7 
increased circulating creatinine level1 supporting datasetNdrg4tm1b(KOMP)WtsihomozygoteEarly adult1.53x10-6 
abnormal gait1 supporting datasetNdrg4tm1b(KOMP)WtsihomozygoteEarly adult6.29x10-10 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoten/a100% (2/2)0.7% (4/570)
aortaheterozygoten/a0% (0/2)0.19% (1/533)
boneheterozygoten/a50% (1/2)0% (0/394)
brainheterozygoten/a100% (2/2)0.86% (5/579)
brainstemheterozygoten/a100% (2/2)0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/2)0% (0/588)
cartilage tissueheterozygoten/a0% (0/2)0.22% (1/454)
cerebellumheterozygoten/a100% (2/2)0.56% (3/532)
cerebral cortexheterozygoten/a100% (2/2)0.41% (2/491)
esophagusheterozygoten/a100% (2/2)1.67% (7/419)
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Histopathology

IMPC related publications

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Ndrg4tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
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Ndrg4tm1b(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)mouse
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