Gene: Herc1

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Name
HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
MGI ID
MGI:2384589
Synonyms
D130015N03Rik 2810449H11Rik tbl
Viability
Embryo viewer
N/A
Other links
Expression & images (0) Disease models (0) Order (4)
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
increased total body fat amount Herc1em1(IMPC)Wtsi HOM Early adult 2.84×10-08
increased Ly6C high monocyte number Herc1em3(IMPC)Wtsi HOM Early adult 0.00
increased eosinophil cell number Herc1em3(IMPC)Wtsi HOM Early adult 0.00
abnormal lens morphology Herc1em2(IMPC)Wtsi HOM Early adult 9.78×10-08
increased hemoglobin content Herc1em3(IMPC)Wtsi HOM Early adult 1.59×10-05
decreased lean body mass Herc1em1(IMPC)Wtsi HOM Early adult 1.63×10-05
increased red blood cell distribution width Herc1em3(IMPC)Wtsi HOM Early adult 1.39×10-10
increased circulating alkaline phosphatase level Herc1em3(IMPC)Wtsi HOM Early adult 2.02×10-06
decreased heart weight Herc1em3(IMPC)Wtsi HOM   Early adult 9.77×10-06
increased circulating sodium level Herc1em3(IMPC)Wtsi HOM Early adult 1.10×10-13
cataract Herc1em2(IMPC)Wtsi HOM Early adult 9.78×10-08
decreased leukocyte cell number Herc1em2(IMPC)Wtsi HOM Early adult 2.23×10-06
increased hematocrit Herc1em3(IMPC)Wtsi HOM Early adult 9.00×10-10
decreased mean corpuscular hemoglobin Herc1em3(IMPC)Wtsi HOM   Early adult 3.07×10-05
increased monocyte cell number Herc1em3(IMPC)Wtsi HOM Early adult 0.00
increased Ly6C low monocyte number Herc1em3(IMPC)Wtsi HOM Early adult 0.00
increased total body fat amount Herc1em3(IMPC)Wtsi HOM   Early adult 9.05×10-15
increased leukocyte cell number Herc1em3(IMPC)Wtsi HOM Early adult 7.78×10-06
decreased circulating glucose level Herc1em1(IMPC)Wtsi HOM Early adult 1.99×10-05
thrombocytosis Herc1em3(IMPC)Wtsi HOM Early adult 7.96×10-11
decreased bone mineral density Herc1em3(IMPC)Wtsi HOM Early adult 1.79×10-25
decreased bone mineral content Herc1em1(IMPC)Wtsi HOM Early adult 2.14×10-05
decreased blood urea nitrogen level Herc1em2(IMPC)Wtsi HOM   Early adult 6.47×10-05
increased circulating chloride level Herc1em3(IMPC)Wtsi HOM Early adult 2.61×10-12
increased mean platelet volume Herc1em3(IMPC)Wtsi HOM Early adult 9.21×10-42
abnormal auditory brainstem response Herc1em3(IMPC)Wtsi HOM   Early adult 1.29×10-06
decreased lean body mass Herc1em3(IMPC)Wtsi HOM   Early adult 1.63×10-15
abnormal retina morphology Herc1em3(IMPC)Wtsi HOM Early adult 7.45×10-06
decreased bone mineral content Herc1em3(IMPC)Wtsi HOM Early adult 1.40×10-45

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 Expression

Expression data not available

 Associated Images

X-ray: XRay Images Whole Body Lateral Orientation
40 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
40 Images
X-ray: XRay Images Whole Body Dorso Ventral
42 Images
X-ray: XRay Images Skull Lateral Orientation
42 Images
X-ray: XRay Images Forepaw
41 Images
Eye Morphology: Images Ophthalmoscopy
21 Images
Eye Morphology: Images Slit Lamp
6 Images
Legacy Phenotype Associated Images

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 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Herc1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Herc1em1(IMPC)Wtsi Point Mutation Mice
Herc1em2(IMPC)Wtsi Point Mutation Mice
Herc1em3(IMPC)Wtsi Exon Deletion Mice

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