Gene: Rspo1

Name
R-spondin 1
MGI ID
MGI:2183426
Synonyms
R-spondin Rspondin
Viability
Homozygous - Viable
Other links
View data by physiological system
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal retinal outer nuclear layer morphology Rspo1tm2b(KOMP)Wtsi HOM postnatal 6.20×10-07
abnormal vibrissa morphology Rspo1tm1.1(KOMP)Vlcg HOM postnatal 1.14×10-05
small testis Rspo1tm1.1(KOMP)Vlcg HOM postnatal 0.00
abnormal kidney morphology Rspo1tm1.1(KOMP)Vlcg HOM postnatal 0.00
decreased circulating insulin level Rspo1tm1.1(KOMP)Vlcg HOM postnatal 3.68×10-11
decreased circulating serum albumin level Rspo1tm1.1(KOMP)Vlcg HOM postnatal 4.91×10-06
decreased lymphocyte cell number Rspo1tm2b(KOMP)Wtsi HOM postnatal 5.74×10-05
decreased total body fat amount Rspo1tm1.1(KOMP)Vlcg HOM postnatal 3.23×10-10
increased leukocyte cell number Rspo1tm2b(KOMP)Wtsi HOM postnatal 7.97×10-06
abnormal testis morphology Rspo1tm1.1(KOMP)Vlcg HOM postnatal 0.00
decreased circulating total protein level Rspo1tm1.1(KOMP)Vlcg HOM postnatal 2.07×10-06
abnormal vitreous body morphology Rspo1tm2b(KOMP)Wtsi HOM postnatal 1.20×10-13
decreased total retina thickness Rspo1tm2b(KOMP)Wtsi HOM postnatal 1.31×10-09
increased lymphocyte cell number Rspo1tm2b(KOMP)Wtsi HOM postnatal 5.74×10-05
decreased leukocyte cell number Rspo1tm2b(KOMP)Wtsi HOM postnatal 7.97×10-06
increased lean body mass Rspo1tm1.1(KOMP)Vlcg HOM postnatal 6.17×10-08
decreased circulating cholesterol level Rspo1tm1.1(KOMP)Vlcg HOM postnatal 8.31×10-05
abnormal eye anterior chamber depth Rspo1tm2b(KOMP)Wtsi HOM postnatal 1.56×10-17
increased grip strength Rspo1tm1.1(KOMP)Vlcg HOM postnatal 9.73×10-05
female infertility Rspo1tm1.1(KOMP)Vlcg HOM postpartum stage 0.00
abnormal seminal vesicle morphology Rspo1tm1.1(KOMP)Vlcg HOM postnatal 0.00

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Filtered by: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No N/A
Blood 2 No N/A
Bone marrow 2 No N/A
Brain 2 No N/A
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cecum 2 No  (12/383) N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Chest bone 2 No N/A
Colon 2 No  (12/127) N/A
Diaphragm 2 No  (1/2) N/A
Duodenum 2 No  (2/127) N/A
Epididymis 2 No  (18/134)  (1/2) N/A
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Gonadal fat pad 2 No N/A
Harderian gland 2 No N/A
Heart 2 No N/A
Hindlimb 2 No N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Ileum 2 No  (14/127)  (1/2) N/A
Jejunum 2 No  (6/127)  (1/2) N/A
Kidney 2 No  (18/584) N/A
Large intestine 2 No  (10/584) N/A
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No  (1/2) N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Mesenteric adipose tissue 2 No  (1/2) N/A
Mesenteric lymph node 2 No N/A
Midbrain 2 No N/A
Olfactory lobe 2 No N/A
Ovary 2 No  (1/584) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584)  (1/2) N/A
Parathyroid gland 2 No N/A
Parotid gland 2 No N/A
Penis 2 No  (1/2) N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584)  (1/2) N/A
Quadriceps 2 No N/A
Sciatic nerve 2 No N/A
Skeletal muscle 2 No N/A
Skin 2 No  (2/2) N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No N/A
Spleen 2 No  (2/584)  (1/2) N/A
Stomach 2 No  (12/584)  (1/2) N/A
Stomach pyloric region 2 No N/A
Striatum 2 No N/A
Sublingual gland 2 No N/A
Submandibular gland 2 No  (2/132) N/A
Testis 2 No  (2/584) N/A
Thymus 2 No N/A
Thyroid gland 2 No  (15/584)  (1/2) N/A
Tongue 2 No  (5/127)  (2/2) N/A
Trachea 2 No  (1/2) N/A
Trigeminal V nerve 2 No N/A
Urinary bladder 2 No N/A
Uterus 2 No N/A
Vagina 2 No N/A
Vas deferens 2 No  (15/388)  (1/2) N/A
Vascular system 2 No N/A
Vesicular gland 2 No N/A
White adipose tissue 2 No N/A
No Embryo expression data was found for this gene.

 Associated Images

X-ray: XRay Images Lateral Orientation
10 Images
X-ray: XRay Images Dorso Ventral
10 Images

 Disease Models

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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Rspo1tm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Rspo1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells
Rspo1tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice, Tissue
Rspo1tm2b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice

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