Gene: Rspo1

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Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased total retina thickness Rspo1tm2b(KOMP)Wtsi HOM Early adult 1.35×10-09
decreased circulating cholesterol level Rspo1tm1.1(KOMP)Vlcg HOM Early adult 8.36×10-05
abnormal testis morphology Rspo1tm1.1(KOMP)Vlcg HOM Early adult 0.00
abnormal seminal vesicle morphology Rspo1tm1.1(KOMP)Vlcg HOM Early adult 0.00
increased grip strength Rspo1tm1.1(KOMP)Vlcg HOM Early adult 9.90×10-05
increased leukocyte cell number Rspo1tm2b(KOMP)Wtsi HOM Early adult 6.52×10-06
decreased total body fat amount Rspo1tm1.1(KOMP)Vlcg HOM Early adult 3.12×10-10
abnormal kidney morphology Rspo1tm1.1(KOMP)Vlcg HOM Early adult 0.00
decreased circulating total protein level Rspo1tm1.1(KOMP)Vlcg HOM Early adult 2.19×10-06
female infertility Rspo1tm1.1(KOMP)Vlcg HOM Early adult 0.00
small testis Rspo1tm1.1(KOMP)Vlcg HOM Early adult 0.00
decreased circulating insulin level Rspo1tm1.1(KOMP)Vlcg HOM Early adult 3.56×10-11
decreased lymphocyte cell number Rspo1tm2b(KOMP)Wtsi HOM Early adult 6.39×10-05
increased lean body mass Rspo1tm1.1(KOMP)Vlcg HOM Early adult 5.89×10-08
decreased leukocyte cell number Rspo1tm2b(KOMP)Wtsi HOM Early adult 6.52×10-06
abnormal eye anterior chamber depth Rspo1tm2b(KOMP)Wtsi HOM Early adult 1.30×10-17
abnormal vitreous body morphology Rspo1tm2b(KOMP)Wtsi HOM Early adult 9.85×10-14
abnormal retinal outer nuclear layer morphology Rspo1tm2b(KOMP)Wtsi HOM Early adult 6.28×10-07
decreased circulating serum albumin level Rspo1tm1.1(KOMP)Vlcg HOM Early adult 5.07×10-06
increased lymphocyte cell number Rspo1tm2b(KOMP)Wtsi HOM Early adult 6.39×10-05

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No N/A
Blood 2 No N/A
Bone marrow 2 No N/A
Brain 2 No N/A
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cecum 2 No  (12/379) N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Chest bone 2 No N/A
Colon 2 No  (12/127) N/A
Diaphragm 2 No  (1/2)  Section images
Duodenum 2 No  (2/127) N/A
Epididymis 2 No  (18/134)  (1/2)  Section images
Esophagus 2 No  (7/415) N/A
Eye 2 No N/A
Gall bladder 2 No N/A
Gonadal fat pad 2 No N/A
Harderian gland 2 No N/A
Heart 2 No N/A
Hindlimb 2 No N/A
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Ileum 2 No  (14/127)  (1/2)  Section images
Jejunum 2 No  (6/127)  (1/2)  Section images
Kidney 2 No  (18/584) N/A
Large intestine 2 No  (10/584) N/A
Liver 2 No N/A
Lower urinary tract 2 No N/A
Lung 2 No  (1/2)  Section images
Lymph node 2 No N/A
Mammary gland 2 No N/A
Mesenteric adipose tissue 2 No  (1/2)  Section images
Mesenteric lymph node 2 No N/A
Midbrain 2 No N/A
Olfactory lobe 2 No N/A
Ovary 2 No  (1/584) N/A
Oviduct 2 No N/A
Pancreas 2 No  (5/584)  (1/2)  Section images
Parathyroid gland 2 No N/A
Parotid gland 2 No N/A
Penis 2 No  (1/2)  Section images
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584)  (1/2)  Section images
Quadriceps 2 No N/A
Sciatic nerve 2 No N/A
Skeletal muscle 2 No N/A
Skin 2 No  (2/2)  Section images
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No N/A
Spleen 2 No  (2/584)  (1/2)  Section images
Stomach 2 No  (12/584)  (1/2)  Section images
Stomach pyloric region 2 No N/A
Striatum 2 No N/A
Sublingual gland 2 No N/A
Submandibular gland 2 No  (2/132) N/A
Testis 2 No  (2/584) N/A
Thymus 2 No N/A
Thyroid gland 2 No  (15/584)  (1/2)  Section images
Tongue 2 No  (5/127)  (2/2)  Section images
Trachea 2 No  (1/2)  Section images
Trigeminal V nerve 2 No N/A
Urinary bladder 2 No N/A
Uterus 2 No N/A
Vagina 2 No N/A
Vas deferens 2 No  (15/388)  (1/2)  Section images
Vascular system 2 No N/A
Vesicular gland 2 No N/A
White adipose tissue 2 No N/A
No Embryo expression data was found for this gene.

 Associated Images

Adult LacZ: LacZ Images Section
34 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Rspo1tm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Rspo1tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, Targeting vectors, ES Cells
Rspo1tm2b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Rspo1tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice, Tissue

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