Gene Summary

NAD kinase

IMPC Data Collections

IMPC Phenotype Summary

Not Significant
Not tested


The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
increased bone mineral content Nadkem2(IMPC)Bay HET Early adult 2.74×10-05
embryonic lethality prior to organogenesis Nadkem2(IMPC)Bay HOM   E9.5 0.00
increased lean body mass Nadkem2(IMPC)Bay HET Early adult 9.37×10-06
preweaning lethality, complete penetrance Nadkem2(IMPC)Bay HOM   Early adult 0.00
decreased total body fat amount Nadkem2(IMPC)Bay HET Early adult 2.06×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.


XRay Images Forepaw

11 Images

Eye Morphology

VIP of right eye

13 Images


XRay Images Skull Dorso Ventral Orientation

11 Images


XRay Images Whole Body Lateral Orientation

11 Images

Eye Morphology

VIP of left eye

14 Images

Eye Morphology

VIP of left fundus

12 Images

Eye Morphology

VIP of right fundus

14 Images


XRay Images Whole Body Dorso Ventral

11 Images


XRay Images Skull Lateral Orientation

11 Images

Human diseases caused by Nadk mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.
No human diseases associated to this gene by phenotypic similarity.


Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Nadk

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Nadk.

There are 8 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Molecular properties and regulation of NAD+ kinase (NADK). Redox biology (December 2022) Nadk  em2(IMPC)Bay  PMC9763689
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Nadk2tm1b(EUCOMM)Wtsi PMC7263671
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation. Nature immunology (December 2019) Nadk2tm1b(EUCOMM)Wtsi PMC7338221
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Nadk2tm1b(EUCOMM)Wtsi PMC6671969
Common and distinct transcriptional signatures of mammalian embryonic lethality. Nature communications (June 2019) Nadk2tm1b(EUCOMM)Wtsi Nadk2tm1a(EUCOMM)Wtsi PMC6594971
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Nadk2tm1b(EUCOMM)Wtsi PMC6459510
Deficiency of the Mitochondrial NAD Kinase Causes Stress-Induced Hepatic Steatosis in Mice. Gastroenterology (September 2017) Nadk2tm1a(EUCOMM)Wtsi 28923496
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Nadk2tm1b(EUCOMM)Wtsi PMC5827107

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MGI Allele Allele Type Produced
Nadkem1(IMPC)Bay Deletion Mice, Tissue
Nadktm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Nadkem2(IMPC)Bay Exon Deletion Mice, Tissue
Nadktm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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