Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Adrenal gland | Section images | heterozygote | 100% (2 of 2) |
Brain | Section images | heterozygote | 100% (2 of 2) |
Brainstem | Section images | heterozygote | 100% (2 of 2) |
Cerebellum | Section images | heterozygote | 100% (2 of 2) |
Cerebral cortex | Section images | heterozygote | 100% (2 of 2) |
Epididymis | Section images | heterozygote | 50% (1 of 2) |
Esophagus | Section images | heterozygote | 100% (2 of 2) |
Eye | Section images | heterozygote | 100% (2 of 2) |
Heart | Section images | heterozygote | 100% (2 of 2) |
Hippocampus | Section images | heterozygote | 100% (2 of 2) |
Hypothalamus | Section images | heterozygote | 100% (2 of 2) |
Kidney | Section images | heterozygote | 100% (2 of 2) |
Liver | Section images | heterozygote | 100% (2 of 2) |
Lung | Section images | heterozygote | 100% (2 of 2) |
Midbrain | Section images | heterozygote | 100% (2 of 2) |
Olfactory lobe | Section images | heterozygote | 100% (2 of 2) |
Ovary | Section images | heterozygote | 50% (1 of 2) |
Oviduct | Section images | heterozygote | 50% (1 of 2) |
Pancreas | Section images | heterozygote | 50% (1 of 2) |
Pituitary gland | Section images | heterozygote | 100% (2 of 2) |
Skeletal muscle | Section images | heterozygote | 100% (2 of 2) |
Small intestine | Section images | heterozygote | 100% (2 of 2) |
Spinal cord | Section images | heterozygote | 100% (2 of 2) |
Spleen | Section images | heterozygote | 50% (1 of 2) |
Stomach | Section images | heterozygote | 100% (2 of 2) |
Striatum | Section images | heterozygote | 100% (2 of 2) |
Submandibular gland | Section images | heterozygote | 100% (2 of 2) |
Testis | Section images | heterozygote | 50% (1 of 2) |
Thalamus | Section images | heterozygote | 100% (2 of 2) |
Thymus | Section images | heterozygote | 100% (2 of 2) |
Trachea | Section images | heterozygote | 100% (2 of 2) |
Uterus | Section images | heterozygote | 50% (1 of 2) |
Aorta | N/A | heterozygote | Not available |
Brown adipose tissue | N/A | heterozygote | 0.0% (0 of 2) |
Cartilage tissue | N/A | heterozygote | 0.0% (0 of 2) |
Large intestine | N/A | heterozygote | 0.0% (0 of 2) |
Lower urinary tract | N/A | heterozygote | Not available |
Lymph node | N/A | heterozygote | 0.0% (0 of 2) |
Mammary gland | N/A | heterozygote | 0.0% (0 of 2) |
Peripheral nervous system | N/A | heterozygote | 0.0% (0 of 2) |
Peyer's patch | N/A | heterozygote | 0.0% (0 of 2) |
Prostate gland | N/A | heterozygote | Not available |
Skin | N/A | heterozygote | 0.0% (0 of 2) |
Thyroid gland | N/A | heterozygote | 0.0% (0 of 2) |
Urinary bladder | N/A | heterozygote | 0.0% (0 of 2) |
Vascular system | N/A | heterozygote | 0.0% (0 of 2) |
Vesicular gland | N/A | heterozygote | Not available |
White adipose tissue | N/A | heterozygote | 0.0% (0 of 2) |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Embryo | N/A | heterozygote | 50% (1 of 2) |
Embryo | N/A | homozygote | Ambiguous |
Brain | N/A | heterozygote | 0.0% (0 of 2) |
Brain | N/A | homozygote | Ambiguous |
Dorsal root ganglion | N/A | heterozygote | 0.0% (0 of 2) |
N/A | Ambiguous | ||
Ear | N/A | heterozygote | 0.0% (0 of 2) |
Ear | N/A | homozygote | Ambiguous |
Eye | N/A | heterozygote | 0.0% (0 of 2) |
Eye | N/A | homozygote | Ambiguous |
Footplate | N/A | heterozygote | 0.0% (0 of 2) |
Footplate | N/A | homozygote | Ambiguous |
Forebrain | N/A | heterozygote | 0.0% (0 of 2) |
Forebrain | N/A | homozygote | Ambiguous |
Forelimb | N/A | heterozygote | 0.0% (0 of 2) |
Forelimb | N/A | homozygote | Ambiguous |
Fronto-nasal process | N/A | heterozygote | 0.0% (0 of 2) |
N/A | Ambiguous | ||
Handplate | N/A | heterozygote | 0.0% (0 of 2) |
Handplate | N/A | homozygote | Ambiguous |
Head | N/A | heterozygote | 0.0% (0 of 2) |
Head | N/A | homozygote | Ambiguous |
Heart | N/A | heterozygote | 0.0% (0 of 2) |
Heart | N/A | homozygote | Ambiguous |
Hindbrain | N/A | heterozygote | 0.0% (0 of 2) |
Hindbrain | N/A | homozygote | Ambiguous |
Hindlimb | N/A | heterozygote | 0.0% (0 of 2) |
Hindlimb | N/A | homozygote | Ambiguous |
Liver | N/A | heterozygote | 0.0% (0 of 2) |
Liver | N/A | homozygote | Ambiguous |
Lung | N/A | heterozygote | 0.0% (0 of 2) |
Lung | N/A | homozygote | Ambiguous |
Mandibular process | N/A | heterozygote | 0.0% (0 of 2) |
Mandibular process | N/A | homozygote | Ambiguous |
Maxillary process | N/A | heterozygote | 0.0% (0 of 2) |
Maxillary process | N/A | homozygote | Ambiguous |
Metanephros | N/A | heterozygote | 100% (1 of 1) |
N/A | Ambiguous | ||
Midbrain | N/A | heterozygote | 0.0% (0 of 2) |
Midbrain | N/A | homozygote | Ambiguous |
Nose | N/A | heterozygote | 0.0% (0 of 2) |
N/A | Ambiguous | ||
Oral cavity | N/A | heterozygote | 0.0% (0 of 2) |
Oral cavity | N/A | homozygote | Ambiguous |
Skin | N/A | heterozygote | 0.0% (0 of 2) |
Skin | N/A | homozygote | Ambiguous |
Spinal cord | N/A | heterozygote | 0.0% (0 of 2) |
N/A | Ambiguous | ||
Tail somite | N/A | heterozygote | 0.0% (0 of 2) |
Tail somite | N/A | homozygote | Ambiguous |
Tail | N/A | heterozygote | 0.0% (0 of 2) |
Tail | N/A | homozygote | Ambiguous |
Background staining occurs in wild type mice and embryos at an incidental rate.
Anatomy | Background staining in controls (WT) |
---|---|
adrenal gland | 0.67% (4 of 598) |
aorta | 0.17% (1 of 598) |
brain | 0.84% (5 of 598) |
brainstem | 0.33% (2 of 598) |
brown adipose tissue | 0.0% |
cartilage tissue | 0.17% (1 of 598) |
cerebellum | 0.5% (3 of 598) |
cerebral cortex | 0.33% (2 of 598) |
epididymis | 14.29% (21 of 147) |
esophagus | 1.66% (7 of 422) |
eye | 0.0% |
heart | 0.33% (2 of 598) |
hippocampus | 0.5% (3 of 598) |
hypothalamus | 0.33% (2 of 598) |
kidney | 4.52% (27 of 598) |
large intestine | 5.35% (32 of 598) |
liver | 0.0% |
lower urinary tract | 0.17% (1 of 598) |
lung | 0.33% (2 of 598) |
lymph node | 0.17% (1 of 598) |
mammary gland | 0.0% |
midbrain | 0.0% |
olfactory lobe | 0.33% (2 of 598) |
ovary | 0.17% (1 of 598) |
oviduct | 0.0% |
pancreas | 0.84% (5 of 598) |
peripheral nervous system | 0.33% (2 of 598) |
peyers patch | 0.0% |
pituitary gland | 0.17% (1 of 598) |
prostate gland | 2.17% (13 of 598) |
skeletal muscle | 0.0% |
skin | 0.17% (1 of 598) |
small intestine | 5.35% (32 of 598) |
spinal cord | 0.5% (3 of 598) |
spleen | 0.5% (3 of 598) |
stomach | 3.68% (22 of 598) |
striatum | 0.5% (3 of 598) |
submandibular gland | 1.38% (2 of 145) |
testis | 1% (6 of 598) |
thalamus | 0.0% |
thymus | 0.17% (1 of 598) |
thyroid gland | 3.01% (18 of 598) |
trachea | 0.5% (3 of 598) |
urinary bladder | 0.0% |
uterus | 0.33% (2 of 598) |
vascular system | 0.0% |
vesicular gland | 0.0% |
white adipose tissue | 0.0% |
Background staining occurs in wild type mice and embryos at an incidental rate.
Background staining occurs in wild type embryos at a measurable rate.
Anatomy | Background staining in controls(WT) |
---|---|
brain | 1.17% (6 of 511) |
dorsal root ganglion | 1.67% (1 of 60) |
ear | 0.2% (1 of 511) |
embryo | 0.39% (2 of 512) |
eye | 0.2% (1 of 511) |
footplate | 0.2% (1 of 511) |
forebrain | 0.2% (1 of 511) |
forelimb | 0.2% (1 of 511) |
fronto-nasal process | 1.64% (1 of 61) |
handplate | 0.2% (1 of 511) |
head | 0.98% (5 of 511) |
heart | 0.2% (1 of 511) |
hindbrain | 1.17% (6 of 511) |
hindlimb | 0.2% (1 of 511) |
liver | 0.2% (1 of 506) |
lung | 0.2% (1 of 506) |
mandibular process | 0.2% (1 of 511) |
maxillary process | 0.2% (1 of 511) |
metanephros | 1.82% (1 of 55) |
midbrain | 0.2% (1 of 511) |
nose | 1.28% (1 of 78) |
oral cavity | 0.2% (1 of 506) |
skin | 0.2% (1 of 511) |
spinal cord | 1.39% (1 of 72) |
tail | 0.2% (1 of 511) |
tail somite group | 0.2% (1 of 511) |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Dnajc28 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Attention Deficit-Hyperactivity Disorder | Hyperactivity, Attention deficit hyperactivity disorder | OMIM:143465 | |
Attention Deficit-Hyperactivity Disorder 8 | Attention deficit hyperactivity disorder | OMIM:619957 | |
Schizophrenia 15 | Hyperactivity | OMIM:613950 | |
Potocki-Lupski syndrome (17p11.2 duplication syndrome) | Hyperactivity | DECIPHER:19 | |
Autism, Susceptibility To, 20 | Attention deficit hyperactivity disorder | OMIM:618830 | |
Attention Deficit-Hyperactivity Disorder, Susceptibility To, 7 | Attention deficit hyperactivity disorder | OMIM:613003 | |
22q13 deletion syndrome (Phelan-Mcdermid syndrome) | Hyperactivity | DECIPHER:20 | |
Intellectual Developmental Disorder, Autosomal Recessive 3 | Hyperactivity | OMIM:608443 | |
Intellectual Developmental Disorder, X-Linked 72 | Hyperactivity | OMIM:300271 | |
Intellectual Developmental Disorder, X-Linked 77 | Hyperactivity | OMIM:300454 | |
Intellectual Developmental Disorder, Autosomal Dominant 33 | Hyperactivity | OMIM:616311 | |
Intellectual Disability-Expressive Aphasia-Facial Dysmorphism Syndrome | Hyperactivity | ORPHA:436151 | |
Smith-Magenis syndrome | Hyperactivity | DECIPHER:8 | |
Intellectual Developmental Disorder, Autosomal Recessive 37 | Hyperactivity | OMIM:615493 | |
Ank3-Related Intellectual Disability-Sleep Disturbance Syndrome | Hyperactivity | ORPHA:356996 | |
Intellectual Developmental Disorder, X-Linked, Syndromic, Houge Type | Impulsivity, Hyperactivity, Attention deficit hyperactivity disorder | OMIM:301008 | |
Developmental And Epileptic Encephalopathy 43 | Impulsivity, Hyperactivity, Attention deficit hyperactivity disorder, Ataxia | OMIM:617113 | |
Microcephaly, Seizures, And Developmental Delay | Hyperactivity, Ataxia | OMIM:613402 | |
Hartnup Disorder | Hyperactivity, Attention deficit hyperactivity disorder, Episodic ataxia | OMIM:234500 | |
Hyperlysinemia, Type I | Hyperactivity | OMIM:238700 | |
Intellectual Developmental Disorder, X-Linked, Syndromic, Pilorge Type | Hyperactivity | OMIM:301076 | |
Developmental And Epileptic Encephalopathy 104 | Hyperactivity, Agitation | OMIM:619970 | |
8p23.1 deletion syndrome | Hyperactivity | DECIPHER:39 | |
Intellectual Developmental Disorder, X-Linked 101 | Hyperactivity | OMIM:300928 | |
Intellectual Developmental Disorder, X-Linked 109 | Impulsivity, Hyperactivity, Agitation | OMIM:309548 | |
Fraxe Intellectual Disability | Hyperactivity, Impulsivity, Agitation | ORPHA:100973 | |
Hyperprolinemia, Type I | Hyperactivity, Ataxia | OMIM:239500 | |
Intellectual Developmental Disorder With Epilepsy, Behavioral Abnormalities, And Coarse Facies | Hyperactivity | OMIM:619031 | |
Glycine Encephalopathy | Impulsivity, Hyperactivity, Restlessness | OMIM:605899 | |
Neurodevelopmental Disorder With Epilepsy And Hypoplasia Of The Corpus Callosum | Gait ataxia, Hyperactivity, Inability to walk, Gait disturbance, Dysmetria | OMIM:618090 | |
Mannosidosis, Beta A, Lysosomal | Hyperactivity | OMIM:248510 | |
Histidinemia | Hyperactivity | ORPHA:2157 | |
Language Delay And Attention Deficit-Hyperactivity Disorder/Cognitive Impairment With Or Without Cardiac Arrhythmia | Hyperactivity, Attention deficit hyperactivity disorder | OMIM:617182 | |
Encephalopathy, Progressive, With Or Without Lipodystrophy | Hyperactivity, Ataxia | OMIM:615924 | |
Intellectual Developmental Disorder, Autosomal Dominant 67 | Hyperactivity, Attention deficit hyperactivity disorder | OMIM:619927 | |
Intellectual Developmental Disorder, Autosomal Recessive 74 | Hyperactivity | OMIM:617169 | |
Lennox-Gastaut Syndrome | Hyperactivity, Falls | ORPHA:2382 | |
Guanidinoacetate Methyltransferase Deficiency | Hyperactivity, Athetosis, Ataxia | ORPHA:382 | |
Juvenile Huntington Disease | Gait ataxia, Hyperactivity, Ataxia, Progressive cerebellar ataxia, Broad-based gait | ORPHA:248111 | |
Dystonia, Dopa-Responsive, Due To Sepiapterin Reductase Deficiency | Hyperactivity, Choreoathetosis, Ataxia | OMIM:612716 | |
Angelman Syndrome Due To Imprinting Defect In 15Q11-Q13 | Hyperactivity, Polyphagia, Broad-based gait, Ataxia | ORPHA:411515 | |
Childhood-Onset Motor And Cognitive Regression Syndrome With Extrapyramidal Movement Disorder | Gait ataxia, Hyperactivity, Inability to walk, Impulsivity, Dysphagia | ORPHA:500180 | |
Intellectual Developmental Disorder, X-Linked 21 | Impulsivity, Hyperactivity | OMIM:300143 | |
Female Restricted Epilepsy With Intellectual Disability | Impulsivity, Hyperactivity, Abnormal eating behavior | ORPHA:101039 | |
Intellectual Developmental Disorder, X-Linked 107 | Hyperactivity, Attention deficit hyperactivity disorder | OMIM:301013 | |
Graves Disease, Susceptibility To, 1 | Hyperactivity, Polyphagia | OMIM:275000 | |
X-Linked Intellectual Disability-Acromegaly-Hyperactivity Syndrome | Hyperactivity | ORPHA:85327 | |
Hypomagnesemia, Seizures, And Impaired Intellectual Development 2 | Hyperactivity | OMIM:618314 | |
Neurodegeneration With Brain Iron Accumulation 2B | Gait ataxia, Hyperactivity, Dysdiadochokinesis, Impulsivity, Dysmetria, Dysphagia | OMIM:610217 | |
Familial Gestational Hyperthyroidism | Hyperactivity, Agitation | ORPHA:99819 | |
Familial Hyperthyroidism Due To Mutations In Tsh Receptor | Hyperactivity, Agitation | ORPHA:424 | |
Microcephaly 29, Primary, Autosomal Recessive | Hyperactivity, Ataxia | OMIM:620047 |
Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.
There is no histopathology data for Dnajc28
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MGI Allele | Allele Type | Produced |
---|---|---|
Dnajc28tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | Mice |
Dnajc28tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | Mice, ES Cells |
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