The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
|Phenotype||System||Allele||Zyg||Sex||Life Stage||P Value|
|abnormal coat appearance||Slc8b1em1(IMPC)J||HOM||Early adult||3.74×10-05|
|abnormal sleep behavior||Slc8b1em1(IMPC)J||HOM||Early adult||9.22×10-05|
|decreased exploration in new environment||Slc8b1em1(IMPC)J||HOM||Early adult||7.46×10-06|
|abnormal sinus arrhythmia||Slc8b1em1(IMPC)J||HOM||Early adult||7.39×10-05|
|impaired righting response||Slc8b1em1(IMPC)J||HOM||Early adult||1.65×10-07|
Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Slc8b1 by phenotypic similarity.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Slc8b1.
There are 4 publications which use IMPC produced mice or data.
|Title||Journal||IMPC Allele||PubMed ID|
|NCLX prevents cell death during adrenergic activation of the brown adipose tissue.||Nature communications (July 2020)||Slc8b1em1(IMPC)J||PMC7334226|
|Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer's disease.||Nature communications (August 2019)||Slc8b1tm1a(EUCOMM)Wtsi||PMC6715724|
|Spatial Separation of Mitochondrial Calcium Uptake and Extrusion for Energy-Efficient Mitochondrial Calcium Signaling in the Heart.||Cell reports (September 2018)||Slc8b1tm1c(EUCOMM)Wtsi||PMC6226263|
|The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability.||Nature (April 2017)||Slc8b1tm1a(EUCOMM)Wtsi||PMC5731245|
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|MGI Allele||Allele Type||Produced|
|Slc8b1tm1(KOMP)Vlcg||Reporter-tagged deletion allele (with selection cassette)||Targeting vectors, ES Cells|
|Slc8b1em1(IMPC)J||Indel causing a Frameshift Mutation||Mice|
|Slc8b1tm1a(EUCOMM)Wtsi||KO first allele (reporter-tagged insertion with conditional potential)||Targeting vectors, ES Cells|