Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
CD207 antigen
Synonyms:
Langerin

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Cd207 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Cd207 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Gamma-A-Globulin, Defect In Assembly Of
Decreased circulating IgA level OMIM:137050
Immune Deficiency, Familial Variable
Decreased circulating IgG level, Decreased circulating IgA level OMIM:146830
Immunodeficiency With Hyper-Igm, Type 3
Impaired memory B cell generation, Increased circulating IgM level, Decreased circulating IgE, Ab... OMIM:606843
B-Cell Expansion With Nfkb And T-Cell Anergy
Decreased circulating total IgM, Splenomegaly, Decreased circulating IgA level, Decreased specifi... OMIM:616452
Hemosiderosis, Pulmonary, With Deficiency Of Gamma-A Globulin
Decreased circulating IgA level OMIM:235500
Immunodeficiency With Hyper-Igm, Type 5
Increased circulating IgM level, Decreased circulating IgA level, Impaired Ig class switch recomb... OMIM:608106
Immunoglobulin M, Level Of
Decreased circulating total IgM OMIM:308250
Pa Polymorphism Of Alpha-2-Globulin
Abnormal immunoglobulin level OMIM:260100
Lymphoid System Deterioration, Progressive
Decreased circulating total IgM, Decreased circulating IgG level OMIM:247630
Immunodeficiency With Hyper-Igm, Type 2
Impaired Ig class switch recombination, Decreased circulating IgG level, Decreased circulating Ig... OMIM:605258
Immunodeficiency, Common Variable, 4
Decreased circulating total IgM, Complete or near-complete absence of specific antibody response ... OMIM:613494
Hepatic Venoocclusive Disease With Immunodeficiency
Absence of lymph node germinal center, Decreased circulating IgG level OMIM:235550
Retinal Telangiectasia And Hypogammaglobulinemia
Decreased circulating IgG level, Reduced delayed hypersensitivity OMIM:267900
Immunodeficiency 11
Decreased circulating antibody level OMIM:615206
Persistent Polyclonal B-Cell Lymphocytosis
Decreased circulating total IgM, Splenomegaly OMIM:606445
Immunodeficiency, Common Variable, 7
Reduced isohemagglutinin level, Decreased circulating total IgG, Decreased circulating IgA level,... OMIM:614699
Immunodeficiency 73C With Defective Neutrophil Chemotaxis And Hypogammaglobulinemia
Decreased circulating total IgM, Decreased circulating IgG level, Cervical lymphadenopathy OMIM:618987
Immunoglobulin A Deficiency 2
Decreased circulating IgA level OMIM:609529
Histiocytosis, Progressive Mucinous
Mucinous histiocytosis OMIM:142630
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome 4
Decreased circulating antibody level, Agammaglobulinemia OMIM:616911
Immunoerythromyeloid Hypoplasia
Decreased circulating IgG level OMIM:242880
Immunodeficiency, Common Variable, 3
Chronic decreased circulating total IgG, Decreased circulating total IgM, Decreased circulating I... OMIM:613493
Agammaglobulinemia 5, Autosomal Dominant
Agammaglobulinemia OMIM:613506
Caspase 8 Deficiency
Complete or near-complete absence of specific antibody response to unconjugated pneumococcus vacc... OMIM:607271
Immunodeficiency, Common Variable, 14
Defective B cell differentiation, Decreased specific antibody response to vaccination, Decreased ... OMIM:617765
Immunodeficiency Due To Defect In Mapbp-Interacting Protein
Decreased circulating total IgM OMIM:610798
Immunoglobulin A Deficiency 1
Decreased circulating IgA level OMIM:137100
Neutropenia-Monocytopenia-Deafness Syndrome
Abnormality of neutrophils, Abnormal macrophage morphology ORPHA:2690
Lymphoma, Hodgkin, Classic
Polyclonal elevation of IgM OMIM:236000
Immunodeficiency 33
Decreased circulating total IgM, Increased circulating IgA level OMIM:300636
Asthma, Short Stature, And Elevated Iga
Increased circulating IgA level OMIM:208600
Hyperimmunoglobulin G1(A1) Syndrome
Increased circulating IgG level, Increased circulating IgA level OMIM:144120
Transcobalamin Deficiency
Decreased circulating total IgM, Decreased circulating antibody level, Decreased circulating IgG ... ORPHA:859
Papular Xanthoma
Histiocytosis ORPHA:158008
Immunodeficiency, Partial Combined, With Absence Of Hla Determinants And Beta-2-Microglobulin From Lymphocytes
Decreased circulating IgG level OMIM:242870
Immunodeficiency 24
Partial absence of specific antibody response to tetanus vaccine, Defective T cell proliferation,... OMIM:615897
Agammaglobulinemia 2, Autosomal Recessive
Agammaglobulinemia OMIM:613500
Immunoglobulin Kappa Light Chain Deficiency
Abnormal immunoglobulin level OMIM:614102
Severe Combined Immunodeficiency, X-Linked
Decreased circulating IgE, Hypoplasia of the thymus, Agammaglobulinemia, Decreased circulating Ig... OMIM:300400
Agammaglobulinemia 7, Autosomal Recessive
Agammaglobulinemia OMIM:615214
Hyper-Ige Recurrent Infection Syndrome 5, Autosomal Recessive
Increased circulating interleukin 6, Decreased circulating IgG level, Increased circulating IgE l... OMIM:618944
Immunodeficiency, Common Variable, 5
Chronic decreased circulating total IgG OMIM:613495
Short-Limb Skeletal Dysplasia With Severe Combined Immunodeficiency
Hypoplasia of the thymus, Agammaglobulinemia OMIM:200900
Immunodeficiency 15B
Decreased circulating antibody level, Agammaglobulinemia OMIM:615592
Mental Retardation, X-Linked, Syndromic, Chudley-Schwartz Type
Decreased circulating total IgM, Decreased circulating IgG level, Decreased circulating IgA level OMIM:300861
Immunodeficiency, Developmental Delay, And Hypohomocysteinemia
Decreased circulating antibody level OMIM:617744
Macroglobulinemia, Waldenstrom, Susceptibility To, 1
Polyclonal elevation of IgM, Monoclonal immunoglobulin M proteinemia OMIM:153600
Immunodeficiency, Common Variable, 2
Partial absence of specific antibody response to unconjugated pneumococcus vaccine, Follicular hy... OMIM:240500
Immunodeficiency 48
Panhypogammaglobulinemia, Splenomegaly OMIM:269840
Immunodeficiency, Common Variable, 1
Impaired T cell function, Decreased circulating IgA level, Splenomegaly, Decreased circulating to... OMIM:607594
Undritz Anomaly
Hypersegmentation of neutrophil nuclei OMIM:191500
Hereditary Progressive Mucinous Histiocytosis
Mucinous histiocytosis ORPHA:158025
Agammaglobulinemia 8, Autosomal Dominant
Agammaglobulinemia OMIM:616941
Immunodeficiency 50
Decreased circulating antibody level OMIM:300988
Lymphoproliferative Syndrome 3
Partial absence of specific antibody response to tetanus vaccine, Decreased circulating antibody ... OMIM:618261
Immune Deficiency Disease
Decreased circulating total IgM OMIM:242850
Immunodeficiency 70
Decreased circulating total IgM, Decreased circulating antibody level, Decreased circulating tota... OMIM:618969
Immunodeficiency, Ovarian Dysgenesis, And Pulmonary Fibrosis
Decreased circulating total IgM, Decreased circulating IgG level, Decreased circulating IgA level OMIM:611926
Epilepsy-Telangiectasia Syndrome
Decreased circulating antibody level, Decreased circulating IgA level ORPHA:1951
Immunodeficiency 14B, Autosomal Recessive
Decreased circulating total IgM, Decreased circulating IgG level, Decreased circulating IgA level... OMIM:619281
Combined Cellular And Humoral Immune Defects With Granulomas
Decreased circulating IgG level OMIM:233650
Immunodeficiency 60
Decreased circulating IgE, Decreased circulating IgA level, Splenomegaly, Decreased circulating t... OMIM:618394
Benign Cephalic Histiocytosis
Histiocytosis ORPHA:157997
Histiocytosis, Familial Lipochrome
Increased circulating antibody level OMIM:235900
Autoinflammation, Antibody Deficiency, And Immune Dysregulation
Decreased circulating total IgM, Decreased circulating IgA level OMIM:614878
Spastic Ataxia-Corneal Dystrophy Syndrome
Decreased circulating antibody level ORPHA:2572
Polyneuropathy Associated With Igm Monoclonal Gammapathy With Anti-Mag
Monoclonal immunoglobulin M proteinemia ORPHA:639
Agammaglobulinemia 3, Autosomal Recessive
Agammaglobulinemia OMIM:613501
Immunodeficiency 14A, Autosomal Dominant
Increased circulating IgM level, Decreased circulating IgG2 level, Splenomegaly, Lymphadenopathy,... OMIM:615513
Microcephalic Primordial Dwarfism, Toriello Type
Decreased circulating total IgM, Decreased circulating IgG level ORPHA:2643
Thrombocytopenia With Elevated Serum Iga And Renal Disease
Increased circulating IgA level OMIM:314000
Autoimmune Lymphoproliferative Syndrome, Type V
Decreased circulating antibody level, Decreased circulating IgA level, Splenomegaly, Decreased ci... OMIM:616100
Immunodeficiency With Hyper-Igm, Type 1
Impaired memory B cell generation, Increased circulating IgM level, Decreased circulating IgE, De... OMIM:308230
Immunodeficiency 64
Increased circulating IgM level, Defective T cell proliferation, Hepatosplenomegaly, Increased ci... OMIM:618534
Microcephalic Primordial Dwarfism, Toriello Type
Decreased circulating total IgM, Decreased circulating IgG level OMIM:251190
Axonal Polyneuropathy Associated With Igg/Igm/Iga Monoclonal Gammopathy
Monoclonal immunoglobulin M proteinemia, Cryoglobulinemia ORPHA:209004
Okur-Chung Neurodevelopmental Syndrome
Decreased circulating antibody level, Decreased circulating IgG level, Decreased circulating IgA ... OMIM:617062
Myeloma, Multiple
Paraproteinemia OMIM:254500
Immunodeficiency 61
Agammaglobulinemia OMIM:300310
Chondroitin-6-Sulfaturia, Defective Cellular Immunity, Nephrotic Syndrome
Decreased circulating IgA level OMIM:215250
Immunodeficiency 78 With Autoimmunity And Developmental Delay
Increased circulating IgM level, Increased circulating IgG level, Fluctuating splenomegaly, Lymph... OMIM:619220
Pulmonary Alveolar Proteinosis With Hypogammaglobulinemia
Decreased circulating antibody level OMIM:618042
Rosaï-Dorfman Disease
Dysgammaglobulinemia, Lymphadenopathy ORPHA:158014
Neurodegeneration, Infantile-Onset, Biotin-Responsive
Decreased circulating IgG level OMIM:618973
T-B+ Severe Combined Immunodeficiency Due To Cd3Delta/Cd3Epsilon/Cd3Zeta
Increased circulating antibody level, Decreased lymphocyte proliferation in response to mitogen, ... ORPHA:169160
Immunodeficiency 25
Increased circulating IgM level, Increased circulating IgE level, Decreased circulating IgG2 leve... OMIM:610163
Neutropenia, Chronic Familial
Increased circulating antibody level OMIM:162700
Agammaglobulinemia 4, Autosomal Recessive
Agammaglobulinemia OMIM:613502
Combined Immunodeficiency, X-Linked
Decreased circulating IgG level OMIM:312863
Lichtenstein Syndrome
Decreased circulating IgA level OMIM:246550
Sea-Blue Histiocyte Disease
Thrombocytopenia, Sea-blue histiocytosis, Splenomegaly OMIM:269600
Severe Combined Immunodeficiency Due To Complete Rag1/2 Deficiency
Decreased circulating total IgM, Decreased circulating antibody level, Lymphadenitis, Decreased l... ORPHA:331206
Immunodeficiency 37
Decreased circulating antibody level OMIM:616098
Immunodeficiency, Common Variable, 10
Decreased circulating total IgM, Decreased circulating IgG level, Decreased circulating IgA level OMIM:615577
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome 2
Decreased circulating antibody level OMIM:614069
Riddle Syndrome
Decreased circulating IgG level OMIM:611943
Transcobalamin Ii Deficiency
Decreased circulating total IgM, Decreased circulating IgG level, Decreased circulating IgA level OMIM:275350
Neuronal Intestinal Pseudoobstruction
Decreased circulating antibody level ORPHA:99811
Agammaglobulinemia 6, Autosomal Recessive
Agammaglobulinemia OMIM:612692
Immunodeficiency Due To Selective Anti-Polysaccharide Antibody Deficiency
Complete or near-complete absence of specific antibody response to unconjugated pneumococcus vacc... ORPHA:70593
Immunodeficiency 72 With Autoinflammation
Increased circulating IgG level, Increased circulating IgE level, Hepatosplenomegaly, Lymphadenop... OMIM:618982
Whim Syndrome 1
Decreased circulating antibody level, Decreased circulating IgG level OMIM:193670
Bone Marrow Failure Syndrome 5
Decreased circulating antibody level OMIM:618165
Xq28 (MECP2) duplication
Decreased circulating IgA level DECIPHER:45
Myotonic Dystrophy 2
Decreased circulating total IgM, Decreased circulating IgG level OMIM:602668
Immunoneurologic Disorder, X-Linked
Decreased circulating IgG2 level OMIM:300076
Immunodeficiency, Common Variable, 13
Decreased circulating antibody level OMIM:616873
Cirrhosis, Familial
Increased circulating antibody level OMIM:118900
Deafness, Neural, With Atypical Atopic Dermatitis
Increased circulating IgE level OMIM:221700
Severe Combined Immunodeficiency Due To Dclre1C Deficiency
Decreased circulating IgG level, Decreased circulating IgA level ORPHA:275
Immunodeficiency 47
Decreased circulating antibody level, Splenomegaly OMIM:300972
Hemophagocytic Lymphohistiocytosis, Familial, 5, With Or Without Microvillus Inclusion Disease
Abnormal natural killer cell physiology, Decreased circulating antibody level, Splenomegaly, Hepa... OMIM:613101
T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency
Lymph node hypoplasia, Increased circulating IgG level, Decreased lymphocyte proliferation in res... ORPHA:276
Kimura Disease
Increased circulating IgE level, Follicular hyperplasia, Lymphadenopathy ORPHA:482
Autoimmune Lymphoproliferative Syndrome
Increased circulating IgM level, Increased circulating IgA level, Chronic noninfectious lymphaden... OMIM:601859
Immunodeficiency, Common Variable, 11
Decreased circulating IgG level, Increased circulating IgE level OMIM:615767
Microcephaly With Chemotactic Defect And Transient Hypogammaglobulinemia
Transient hypogammaglobulinemia of infancy OMIM:251240
Neutropenia, Severe Congenital, 2, Autosomal Dominant
Monocytosis, B lymphocytopenia, Neutropenia OMIM:613107
Autoimmune Disease, Multisystem, Infantile-Onset, 2
Decreased specific pneumococcal antibody level OMIM:617006
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due To Adenosine Deaminase Deficiency
Aplasia of the thymus, Increased circulating IgE level, Decreased circulating IgG2 level, Absent ... OMIM:102700
Hemophagocytic Lymphohistiocytosis, Familial, 3
Hemophagocytosis, Hepatosplenomegaly, Granulocytopenia, Anemia OMIM:608898
Ectodermal Dysplasia And Immunodeficiency 1
Abnormal circulating IgG level, Increased circulating IgM level, Dysgammaglobulinemia, Increased ... OMIM:300291
Alpha-Heavy Chain Disease
Dysgammaglobulinemia, Lymphadenopathy, Splenomegaly ORPHA:100025
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome 1
Increased circulating IgM level, Decreased circulating IgA level OMIM:242860
Lung Disease, Immunodeficiency, And Chromosome Breakage Syndrome
Increased circulating IgM level, Increased circulating IgE level, Hypoplasia of the thymus, Reduc... OMIM:617241
Immunodeficiency 52
Decreased circulating antibody level, Lymphadenopathy, Splenomegaly OMIM:617514
X-Linked Immunoneurologic Disorder
Decreased circulating IgG2 level ORPHA:2571
Ige Responsiveness, Atopic
Increased circulating IgE level OMIM:147050
Lymphopenic Hypergammaglobulinemia, Antibody Deficiency, Autoimmune Hemolytic Anemia, And Glomerulonephritis
Increased circulating antibody level OMIM:247800
Immunodeficiency 41 With Lymphoproliferation And Autoimmunity
Increased circulating IgE level, Decreased specific anti-polysaccharide antibody level, Decreased... OMIM:606367
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome 3
Decreased circulating antibody level, Agammaglobulinemia OMIM:616910
T-B+ Severe Combined Immunodeficiency Due To Jak3 Deficiency
Partial IgA deficiency, Lack of T cell function, Decreased lymphocyte proliferation in response t... ORPHA:35078
Cernunnos-Xlf Deficiency
Decreased circulating antibody level ORPHA:169079
Ataxia-Pancytopenia Syndrome
Decreased circulating antibody level, Splenomegaly, Abnormal platelet function ORPHA:2585
Bone Marrow Failure Syndrome 4
Decreased circulating antibody level, Bone marrow hypocellularity OMIM:618116
Immunodeficiency, Common Variable, 8, With Autoimmunity
Decreased specific antibody response to vaccination, Generalized lymphadenopathy, Decreased circu... OMIM:614700
Lymphoproliferative Syndrome, X-Linked, 1
Increased circulating IgM level, Decreased circulating antibody level, Dysgammaglobulinemia, Sple... OMIM:308240
Macrocephaly/Autism Syndrome
Decreased circulating antibody level, Splenomegaly OMIM:605309
Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation
Lymph node hypoplasia, Aplasia of the thymus, Panhypogammaglobulinemia OMIM:602450
Rasmussen Subacute Encephalitis
Decreased circulating total IgA ORPHA:1929
Alopecia Antibody Deficiency
Decreased circulating antibody level ORPHA:1006
Immunodeficiency 46
Decreased circulating antibody level OMIM:616740
Bloom Syndrome
Decreased circulating total IgM, Decreased circulating IgG level, Decreased circulating IgA level OMIM:210900
Smith-Kingsmore Syndrome
Decreased circulating IgA level OMIM:616638
Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia
Decreased specific anti-polysaccharide antibody level, Lymphadenopathy, Decreased T cell activati... OMIM:300853
Lymphangiectasia, Intestinal
Decreased circulating IgG level OMIM:152800
Immunodeficiency 27A
Increased circulating IgM level, Increased circulating IgG level, Splenomegaly, Enlarged mesenter... OMIM:209950
Lambert Syndrome
Decreased circulating antibody level ORPHA:1296
Immunodeficiency, Common Variable, 6
Chronic decreased circulating total IgG, Complete or near-complete absence of specific antibody r... OMIM:613496
Osteopetrosis, Autosomal Recessive 7
Decreased circulating total IgM, Decreased circulating IgG level, Decreased circulating IgA level... OMIM:612301
Dyskeratosis Congenita, Autosomal Recessive 5
Decreased circulating antibody level, Bone marrow hypocellularity OMIM:615190
X-Linked Intellectual Disability-Hypogammaglobulinemia-Progressive Neurological Deterioration Syndrome
Decreased circulating antibody level ORPHA:85317
Cystic Fibrosis
Decreased circulating antibody level ORPHA:586
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Positive
Panhypogammaglobulinemia OMIM:601457
Immunodeficiency 43
Decreased circulating IgG level OMIM:241600
Congenital Disorder Of Glycosylation, Type Iir
Decreased circulating antibody level OMIM:301045
Ataxia-Telangiectasia
Defective B cell differentiation, Decreased circulating IgG2 level, Hypoplasia of the thymus, Dec... OMIM:208900
Schnitzler Syndrome
Increased circulating IgM level, Lymphadenopathy, Splenomegaly ORPHA:37748
Aplasia Cutis Congenita-Intestinal Lymphangiectasia Syndrome
Decreased circulating antibody level ORPHA:1116
Macrocephaly-Intellectual Disability-Neurodevelopmental Disorder-Small Thorax Syndrome
Decreased circulating IgA level ORPHA:457485
Erythema Elevatum Diutinum
Increased circulating antibody level ORPHA:90000
Immunodeficiency 36
Decreased circulating antibody level, Splenomegaly OMIM:616005
X-Linked Lymphoproliferative Disease
Increased proportion of CD25+ mast cells, Increased circulating IgM level, Decreased circulating ... ORPHA:2442
Agammaglobulinemia 1, Autosomal Recessive
Decreased circulating antibody level, Agammaglobulinemia OMIM:601495
X-Linked Severe Congenital Neutropenia
Monocytopenia, Neutropenia ORPHA:86788
Ataxia-Telangiectasia With Generalized Skin Pigmentation And Early Death
Decreased circulating IgA level OMIM:208910
Immunodeficiency, Common Variable, 12, With Autoimmunity
Decreased circulating antibody level OMIM:616576
T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency
Increased circulating IgE level, Increased circulating antibody level, Increased circulating IgG ... ORPHA:169154
Autoimmune Lymphoproliferative Syndrome, Type Iia
Increased circulating IgM level, Increased circulating IgA level, Chronic noninfectious lymphaden... OMIM:603909
Lymphoproliferative Syndrome 2
Decreased circulating antibody level, Decreased lymphocyte proliferation in response to mitogen, ... OMIM:615122
Lymphoproliferative Syndrome, X-Linked, 2
Decreased circulating antibody level, Splenomegaly OMIM:300635
Immunodeficiency 57 With Autoinflammation
Partial absence of specific antibody response to tetanus vaccine, Decreased circulating antibody ... OMIM:618108
Wiskott-Aldrich Syndrome, Autosomal Dominant
Increased circulating IgE level, Decreased specific anti-polysaccharide antibody level, Abnormal ... OMIM:600903
Autoimmune Disease, Multisystem, With Facial Dysmorphism
Decreased circulating IgA level, Hypersplenism, Splenomegaly OMIM:613385
Combined Immunodeficiency With Faciooculoskeletal Anomalies
Decreased circulating total IgM, Decreased specific antibody response to vaccination, Decreased c... ORPHA:221139
Lipodystrophy, Congenital Generalized, Type 4
Decreased circulating IgA level, Splenomegaly OMIM:613327
Enteropathy, Familial, With Villous Edema And Immunoglobulin G2 Deficiency
Decreased circulating IgG level OMIM:600351
Riddle Syndrome
Decreased circulating total IgM, Decreased circulating IgG level, Generalized lymphadenopathy, De... ORPHA:420741
Pulmonary Nodular Lymphoid Hyperplasia, Familial
Increased circulating antibody level OMIM:178610
Autoimmune Lymphoproliferative Syndrome, Type Iii
Decreased serum complement C3, Increased circulating antibody level, Decreased serum complement C... OMIM:615559
Reticular Dysgenesis
Decreased circulating antibody level ORPHA:33355
Boutonneuse Fever
Increased circulating IgG level, Increased circulating IgM level, Lymphadenopathy, Cervical lymph... ORPHA:83313
Thymic Tumor
Mediastinal lymphadenopathy, Dysgammaglobulinemia ORPHA:100100
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Negative
Cutaneous anergy, Absent peripheral lymph nodes in presence of infection, Panhypogammaglobulinemi... OMIM:600802
Autoinflammation, Panniculitis, And Dermatosis Syndrome
Increased circulating IgM level, Lymphadenopathy, Increased circulating IgA level OMIM:617099
Autoinflammation With Arthritis And Dyskeratosis
Splenomegaly, Increased circulating IgG level, Increased circulating IgA level OMIM:617388
Congenital Disorder Of Glycosylation, Type Ia
Decreased circulating IgG level, Decreased circulating IgA level OMIM:212065
Calcific Aortic Disease With Immunologic Abnormalities, Familial
Increased circulating antibody level OMIM:114065
Autoimmune Lymphoproliferative Syndrome
Increased circulating IgE level, Abnormal serum interleukin level, Decreased specific anti-polysa... ORPHA:3261
Combined Immunodeficiency And Megaloblastic Anemia With Or Without Hyperhomocysteinemia
Decreased circulating antibody level OMIM:617780
Adult Idiopathic Neutropenia
Increased circulating IgM level ORPHA:2688
Thrombocytopenia 1
Increased circulating IgE level, Increased circulating IgA level OMIM:313900
Lymphoproliferative Syndrome 1
Decreased circulating antibody level, Decreased circulating IgG level, Lymphadenopathy, Splenomegaly OMIM:613011
Celiac Disease, Susceptibility To, 1
Decreased circulating IgA level OMIM:212750
Roifman Syndrome
Decreased circulating antibody level, Hepatosplenomegaly, Lymphadenopathy ORPHA:353298
Maternal Uniparental Disomy Of Chromosome 1
Panhypogammaglobulinemia ORPHA:251009
Ring Chromosome 21 Syndrome
Decreased circulating antibody level ORPHA:1445
Iga Pemphigus
Increased circulating IgA level, Monoclonal elevation of circulating IgA ORPHA:555905
Selective Igm Deficiency
Lymphadenitis, Decreased specific antibody response to vaccination, Paraproteinemia, Decreased ci... ORPHA:331235
Bloom Syndrome
Decreased circulating total IgM, Decreased circulating antibody level, Decreased circulating IgG ... ORPHA:125
Hyperimmunoglobulinemia D With Periodic Fever
Lymphadenopathy, Increased circulating IgA level ORPHA:343
Intellectual Disability-Seizures-Hypophosphatasia-Ophthalmic-Skeletal Anomalies Syndrome
Decreased circulating total IgM, Decreased circulating IgA level ORPHA:369837
Angiostrongyliasis
Increased circulating IgG level, Increased circulating IgM level, Increased circulating specific ... ORPHA:74
Dubowitz Syndrome
Decreased circulating IgG level, Decreased circulating IgA level OMIM:223370
Immunodeficiency 73B With Defective Neutrophil Chemotaxis And Lymphopenia
Partial absence of specific antibody response to Haemophilus influenzae type b (Hib) vaccine, Lym... OMIM:618986
Skeletal Dysplasia-T-Cell Immunodeficiency-Developmental Delay Syndrome
Increased circulating IgE level, Decreased circulating antibody level, Decreased lymphocyte proli... ORPHA:508533
Griscelli Syndrome
Decreased circulating antibody level, Bone marrow hypocellularity, Lymphadenopathy, Splenomegaly ORPHA:381
Wolfram Syndrome 2
Decreased circulating antibody level, Impaired collagen-induced platelet aggregation OMIM:604928
Ataxia-Telangiectasia
Decreased circulating antibody level ORPHA:100
Wiskott-Aldrich Syndrome
Increased circulating IgE level, Decreased specific anti-polysaccharide antibody level, Abnormal ... OMIM:301000
Sting-Associated Vasculopathy, Infantile-Onset
Paratracheal lymphadenopathy, Increased circulating IgG level, Follicular hyperplasia, Increased ... OMIM:615934
Multiple Myeloma
Decreased circulating antibody level, Increased circulating IgA level, Increased circulating IgG ... ORPHA:29073
Bare Lymphocyte Syndrome, Type Ii
Cutaneous anergy, Panhypogammaglobulinemia, Agammaglobulinemia OMIM:209920
Monosomy 18Q
Decreased circulating IgA level ORPHA:1600
Trichothiodystrophy 5, Nonphotosensitive
Decreased circulating antibody level OMIM:300953
Autoimmune Disease, Multisystem, Infantile-Onset, 1
Decreased circulating antibody level, Hepatosplenomegaly OMIM:615952
Secondary Intestinal Lymphangiectasia
Decreased circulating antibody level ORPHA:90363
Hyper-Igd Syndrome
Lymphadenitis, Splenomegaly, Increased circulating IgA level, Hepatosplenomegaly, Increased circu... OMIM:260920
Congenital Disorder Of Glycosylation, Type Iib
Decreased circulating antibody level OMIM:606056
Netherton Syndrome
Decreased circulating IgG level, Increased circulating IgE level OMIM:256500
Familial Hemophagocytic Lymphohistiocytosis
Increased serum interferon-gamma level, Decreased circulating antibody level, Abnormality of seru... ORPHA:540
Good Syndrome
Mediastinal lymphadenopathy, Decreased circulating antibody level ORPHA:169105
Immunodeficiency By Defective Expression Of Mhc Class Ii
Abnormality of humoral immunity, Lack of T cell function, Decreased circulating antibody level, P... ORPHA:572
Icf Syndrome
Decreased circulating antibody level ORPHA:2268
Tempi Syndrome
Increased circulating IgG level ORPHA:284227
Hereditary Folate Malabsorption
Decreased circulating antibody level ORPHA:90045
Netherton Syndrome
Decreased circulating antibody level, Increased circulating IgE level ORPHA:634
Leukoencephalopathy, Arthritis, Colitis, And Hypogammaglobulinema
Decreased circulating IgG level OMIM:608809
Autosomal Agammaglobulinemia
Agammaglobulinemia ORPHA:33110
Vici Syndrome
Decreased circulating IgG level, Decreased circulating IgG2 level ORPHA:1493
Thymoma
Decreased circulating antibody level, Lymphadenopathy ORPHA:99867
Agammaglobulinemia, X-Linked
Lymph node hypoplasia, Agammaglobulinemia OMIM:300755
Sideroblastic Anemia With B-Cell Immunodeficiency, Periodic Fevers, And Developmental Delay
Decreased circulating antibody level, Splenomegaly OMIM:616084
Mohr-Tranebjaerg Syndrome
Agammaglobulinemia ORPHA:52368
Complement Hyperactivation, Angiopathic Thrombosis, And Protein-Losing Enteropathy
Decreased circulating antibody level OMIM:226300
Popov-Chang syndrome
Decreased circulating antibody level OMIM:618428
Common Variable Immunodeficiency
Decreased circulating antibody level, Lymphadenopathy, Splenomegaly ORPHA:1572
Pgm3-Cdg
Increased circulating IgE level, Increased circulating IgG level, Increased circulating IgA level... ORPHA:443811
X-Linked Agammaglobulinemia
Agammaglobulinemia ORPHA:47
Congenital Disorder Of Glycosylation, Type Ig
Decreased circulating antibody level OMIM:607143
Immunodeficiency 23
Increased circulating IgG level, Increased circulating IgE level, Increased circulating IgM level OMIM:615816
Immunoskeletal Dysplasia With Neurodevelopmental Abnormalities
Decreased circulating antibody level OMIM:617425
Distal Monosomy 19P13.3
Decreased circulating antibody level ORPHA:96129
Primary Biliary Cholangitis
Increased circulating IgM level, Increased circulating IgA level ORPHA:186
Short-Limb Skeletal Dysplasia With Severe Combined Immunodeficiency
Agammaglobulinemia ORPHA:935
Hepatic Veno-Occlusive Disease-Immunodeficiency Syndrome
Abnormal serum interleukin level, Panhypogammaglobulinemia, Abnormal serum interferon-gamma level... ORPHA:79124
Agammaglobulinemia-Microcephaly-Craniosynostosis-Severe Dermatitis Syndrome
Decreased circulating total IgM ORPHA:83617
Congenital Disorder Of Glycosylation, Type Iil
Impaired T cell function, Decreased specific anti-polysaccharide antibody level, Splenomegaly OMIM:614576
Zika Virus Disease
Increased circulating IgM level ORPHA:448237
Immunodeficiency 58
Decreased T cell activation, Decreased specific antibody response to vaccination, Decreased circu... OMIM:618131
Mannosidosis, Alpha B, Lysosomal
Decreased circulating antibody level, Splenomegaly OMIM:248500
Immunodeficiency 59 And Hypoglycemia
Decreased circulating antibody level OMIM:233600
Igg4-Related Submandibular Gland Disease
Increased circulating IgE level, Increased circulating antibody level, Increased circulating IgG4... ORPHA:449432
Mucopolysaccharidosis-Plus Syndrome
Increased circulating IgM level, Bone marrow hypocellularity, Splenomegaly OMIM:617303
Vici Syndrome
Decreased T cell activation, Decreased circulating IgG level, Decreased circulating IgG2 level, C... OMIM:242840
Isolated Growth Hormone Deficiency, Type Iii, With Agammaglobulinemia
Panhypogammaglobulinemia OMIM:307200
Autoimmune Hepatitis
Increased circulating antibody level, Increased circulating IgG level, Splenomegaly ORPHA:2137
Primary Intestinal Lymphangiectasia
Decreased circulating antibody level ORPHA:90362
Primary Biliary Cholangitis/Primary Sclerosing Cholangitis And Autoimmune Hepatitis Overlap Syndrome
Increased circulating IgG level, Increased circulating IgM level ORPHA:562639
Autoimmune Polyendocrinopathy Type 4
Decreased circulating antibody level, Aplasia/Hypoplasia of the spleen ORPHA:227990
Insulin-Resistance Syndrome Type B
Decreased serum complement factor B, Increased circulating IgG level, Increased circulating IgA l... ORPHA:2298
Deficiency In Anterior Pituitary Function-Variable Immunodeficiency Syndrome
Decreased circulating antibody level ORPHA:293978
Diarrhea 10, Protein-Losing Enteropathy Type
Decreased circulating antibody level OMIM:618183
Cowden Syndrome 1
Decreased circulating antibody level OMIM:158350
Say-Barber-Miller Syndrome
Decreased circulating antibody level, Decreased circulating IgG level, Impaired neutrophil chemot... ORPHA:3132
Whim Syndrome
Lymphadenitis, Decreased circulating antibody level ORPHA:51636
Mucopolysaccharidosis-Like Syndrome With Congenital Heart Defects And Hematopoietic Disorders
Hepatosplenomegaly, Increased circulating IgM level, Bone marrow hypocellularity, Decreased circu... ORPHA:505248
Proteasome-Associated Autoinflammatory Syndrome 1
Increased serum interferon-gamma level, Increased circulating antibody level, Increased circulati... OMIM:256040
Autoimmune Polyendocrinopathy Type 3
Decreased circulating antibody level, Aplasia/Hypoplasia of the spleen ORPHA:227982
Vasculitis, Autoinflammation, Immunodeficiency, And Hematologic Defects Syndrome
Decreased circulating antibody level, Splenomegaly, Hepatosplenomegaly, Bone marrow hypocellulari... OMIM:615688
Trichothiodystrophy 1, Photosensitive
Decreased circulating IgG level OMIM:601675
Tick-Borne Encephalitis
Increased circulating IgG level, Abnormality of serum cytokine level, Increased circulating IgM l... ORPHA:297
Autosomal Dominant Generalized Epidermolysis Bullosa Simplex, Severe Form
Decreased circulating antibody level ORPHA:79396
Inflammatory Bowel Disease, Immunodeficiency, And Encephalopathy
Decreased T cell activation, Increased circulating IgG level, Increased circulating IgE level, De... OMIM:618213
Japanese Encephalitis
Increased circulating antibody level, Increased circulating IgM level ORPHA:79139
Nijmegen Breakage Syndrome
Dysgammaglobulinemia OMIM:251260
Coccidioidomycosis
Increased circulating IgM level, Increased circulating IgG level, Mediastinal lymphadenopathy, Ab... ORPHA:228123
Hennekam Syndrome
Decreased circulating antibody level, Lymphadenopathy, Splenomegaly ORPHA:2136
Thrombocytopenia-Absent Radius Syndrome
Decreased circulating antibody level, Hepatosplenomegaly OMIM:274000
Primary Sjögren Syndrome
Cryoglobulinemia, Decreased circulating antibody level, Increased circulating antibody level, Dec... ORPHA:289390
Syndromic Diarrhea
Hypoplasia of the thymus, Panhypogammaglobulinemia, Splenomegaly ORPHA:84064
Spondyloepimetaphyseal Dysplasia, Sponastrime Type
Decreased circulating IgG level OMIM:271510
Cartilage-Hair Hypoplasia
Decreased circulating antibody level ORPHA:175
Neonatal Intrahepatic Cholestasis Due To Citrin Deficiency
Decreased circulating antibody level, Hepatosplenomegaly ORPHA:247598
Trichothiodystrophy
Panhypogammaglobulinemia ORPHA:33364
Lysinuric Protein Intolerance
Abnormality of humoral immunity, Decreased circulating antibody level, Increased circulating anti... ORPHA:470
Brucellosis
Increased circulating IgM level, Increased circulating IgG level, Hypersplenism, Splenomegaly, Ly... ORPHA:1304
Primary Sclerosing Cholangitis
Polyclonal elevation of IgM, Hepatosplenomegaly, Splenomegaly ORPHA:171
Leukocyte Adhesion Deficiency Type Ii
Abnormal isohemagglutinin level ORPHA:99843
Sponastrime Dysplasia
Decreased circulating antibody level ORPHA:93357
Brain Malformations-Musculoskeletal Abnormalities-Facial Dysmorphism-Intellectual Disability Syndrome
Secretory IgA deficiency, Decreased circulating IgG level ORPHA:500150
Mowat-Wilson Syndrome Due To Monosomy 2Q22
Decreased circulating antibody level, Asplenia ORPHA:261537
Mowat-Wilson Syndrome
Decreased circulating antibody level, Asplenia ORPHA:2152
Mowat-Wilson Syndrome Due To A Zeb2 Point Mutation
Decreased circulating antibody level, Asplenia ORPHA:261552

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cd207

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cd207.

No publications found that use IMPC mice or data for Cd207.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Cd207tm189369(L1L2_Pgk_P) Targeting vectors
Cd207tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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