Genes Phenotypes

Gene: Dicer1

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Name
dicer 1, ribonuclease type III
MGI ID
MGI:2177178
Synonyms
1110006F08Rik D12Ertd7e Dicer1
Viability
Homozygous - Lethal
Embryo viewer
N/A
Other links
MGI   Ensembl  
Significant phenotypes (11) Measurements chart (232) All data table (445)
Expression & images (67) Disease models (0) Order (3)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
embryonic lethality prior to tooth bud stage Dicer1tm1b(EUCOMM)Wtsi HOM E12.5 0.00
increased lymphocyte cell number Dicer1tm1b(EUCOMM)Wtsi HET Early adult 1.89×10-05
decreased red blood cell distribution width Dicer1tm1b(EUCOMM)Wtsi HET Early adult 3.39×10-12
decreased spleen weight Dicer1tm1b(EUCOMM)Wtsi HET Early adult 2.17×10-08
embryonic lethality prior to organogenesis Dicer1tm1b(EUCOMM)Wtsi HOM E9.5 0.00
absent spleen Dicer1tm1b(EUCOMM)Wtsi HET Early adult 0.00
decreased neutrophil cell number Dicer1tm1b(EUCOMM)Wtsi HET Early adult 7.37×10-09
preweaning lethality, complete penetrance Dicer1tm1b(EUCOMM)Wtsi HOM Early adult 0.00
abnormal retina morphology Dicer1tm1b(EUCOMM)Wtsi HET Early adult 5.92×10-07
abnormal circulating HDL cholesterol level Dicer1tm1b(EUCOMM)Wtsi HET Early adult 5.27×10-05
abnormal circulating cholesterol level Dicer1tm1b(EUCOMM)Wtsi HET Early adult 3.78×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (3/589)  (2/2)  Wholemount images
Aorta 2 No  (1/589)  (2/2)  Wholemount images
Bone 2 No N/A
Brain 2 No  (3/589)  (2/2)  Wholemount images
Brainstem 2 No  (2/589)  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (2/2)  Wholemount images
Cerebellum 2 No  (3/589)  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/589)  (2/2)  Wholemount images
Esophagus 2 No  (7/415)  (2/2)  Wholemount images
Eye 2 No  (2/2)  Wholemount images
Gall bladder 2 No  (2/2)  Wholemount images
Heart 2 No  (1/589)  (2/2)  Wholemount images
Hippocampus 2 No  (3/589)  (2/2)  Wholemount images
Hypothalamus 2 No  (2/589)  (2/2)  Wholemount images
Kidney 2 No  (20/589)  (2/2)  Wholemount images
Large intestine 2 No  (10/589)  (2/2)  Wholemount images
Liver 2 No N/A
Lower urinary tract 2 No  (1/589)  (2/2)  Wholemount images
Lung 2 No  (1/589)  (2/2)  Wholemount images
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/589)  (2/2)  Wholemount images
Oral epithelium 2 No N/A
Ovary 2 No  (1/589)  (1/2)  Wholemount images
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/589)  (2/2)  Wholemount images
Parathyroid gland 2 No  (2/2)  Wholemount images
Peripheral nervous system 2 No  (1/589)  (2/2)  Wholemount images
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/589)  (2/2)  Wholemount images
Prostate gland 2 No  (12/589)  (1/2)  Wholemount images
Skeletal muscle 2 No N/A
Skin 2 No  (2/2)  Wholemount images
Small intestine 2 No  (9/589)  (2/2)  Wholemount images
Spinal cord 2 No  (2/589)  (2/2)  Wholemount images
Spleen 2 No  (2/589) N/A
Stomach 2 No  (13/589)  (2/2)  Wholemount images
Striatum 2 No  (3/589)  (2/2)  Wholemount images
Testis 2 No  (5/589)  (1/2)  Wholemount images
Thymus 2 No N/A
Thyroid gland 2 No  (16/589)  (2/2)  Wholemount images
Trachea 2 No  (2/589)  (2/2)  Wholemount images
Uterus 2 No  (1/2)  Wholemount images
Vascular system 2 No  (2/2)  Wholemount images
White adipose tissue 2 No N/A
LacZ Wholemount Images
Unassigned Top Level MA (37)
Esophagus expression
Stomach
cardiovascular system (1)
Vascular System expression
MA:0002718
digestive system (3)
Gall Bladder expression
MA:0000356
endocrine system (1)
Adrenal gland expression
MA:0000116
integumental system (1)
Skin expression
MA:0000151
nervous system (1)
Spinal cord expression
MA:0000216
postnatal mouse (12)
Adrenal gland expression
MA:0000116
reproductive system (1)
Testis expression
MA:0000411
respiratory system (1)
Lung expression
MA:0000415
sensory organ (1)
Eye expression
MA:0000261
trunk (9)
Adrenal gland expression
MA:0000116
urinary system (1)
Kidney expression
MA:0000368
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/506)  (2/2) N/A
Ear 2  (1/506)  (1/2) N/A
Embryo 2  (1/507)  (2/2) N/A
Eye 2  (1/506)  (2/2) N/A
Foot 2  (1/506)  (1/2) N/A
Forebrain 2  (1/506)  (2/2) N/A
Forelimb 2  (1/506)  (2/2) N/A
Hand 2  (1/505)  (1/2) N/A
Head 2  (5/506)  (2/2) N/A
Heart 2  (1/506)  (1/2) N/A
Hindbrain 2  (6/506)  (2/2) N/A
Hindlimb 2  (1/505)  (2/2) N/A
Liver 2  (1/506)  (1/2) N/A
Lung 2  (1/502)  (1/2) N/A
Mandibular process 2  (1/506)  (1/2) N/A
Maxillary process 2  (1/506)  (1/2) N/A
Midbrain 2  (1/506)  (2/2) N/A
Oral cavity 2  (1/506)  (1/2) N/A
Skin 2  (1/506)  (1/2) N/A
Tail 2  (1/506)  (2/2) N/A
Tail somite 2  (1/506)  (1/2) N/A

 Associated Images

Adult LacZ: LacZ Images Wholemount
49 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
9 Images
Echo: M-Mode Images
32 Images
X-ray: XRay Images Whole Body Dorso Ventral
10 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images
Immunophenotyping: Panel A FCS file(s)
8 Images
Immunophenotyping: Panel B FCS file(s)
8 Images
X-ray: XRay Images Whole Body Lateral Orientation
10 Images
Embryo LacZ: LacZ images wholemount
4 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Dicer1tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Dicer1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Dicer1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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