Gene: Dicer1

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Name
dicer 1, ribonuclease type III
MGI ID
MGI:2177178
Synonyms
1110006F08Rik D12Ertd7e Dicer1
Viability
Embryo viewer
N/A
Other links
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, complete penetrance Dicer1tm1b(EUCOMM)Wtsi HOM   Early adult 0.00
decreased red blood cell distribution width Dicer1tm1b(EUCOMM)Wtsi HET Early adult 3.37×10-12
decreased neutrophil cell number Dicer1tm1b(EUCOMM)Wtsi HET Early adult 6.89×10-09
increased circulating cholesterol level Dicer1tm1b(EUCOMM)Wtsi HET   Early adult 4.22×10-05
embryonic lethality prior to tooth bud stage Dicer1tm1b(EUCOMM)Wtsi HOM   E12.5 0.00
abnormal retina morphology Dicer1tm1b(EUCOMM)Wtsi HET Early adult 5.33×10-07
absent spleen Dicer1tm1b(EUCOMM)Wtsi HET Early adult 0.00
increased circulating alkaline phosphatase level Dicer1tm1b(EUCOMM)Wtsi HET   Early adult 2.31×10-05
increased lymphocyte cell number Dicer1tm1b(EUCOMM)Wtsi HET Early adult 1.85×10-05
decreased spleen weight Dicer1tm1b(EUCOMM)Wtsi HET Early adult 3.97×10-09
embryonic lethality prior to organogenesis Dicer1tm1b(EUCOMM)Wtsi HOM   E9.5 0.00
increased circulating HDL cholesterol level Dicer1tm1b(EUCOMM)Wtsi HET   Early adult 6.06×10-05

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (4/583)  (2/2)  Wholemount images
Aorta 2 No  (1/583)  (2/2)  Wholemount images
Bone 2 No N/A
Brain 2 No  (4/583)  (2/2)  Wholemount images
Brainstem 2 No  (2/583)  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (1/583)  (2/2)  Wholemount images
Cerebellum 2 No  (3/583)  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/583)  (2/2)  Wholemount images
Esophagus 2 No  (7/407)  (2/2)  Wholemount images
Eye 2 No  (2/2)  Wholemount images
Gall bladder 2 No  (2/2)  Wholemount images
Heart 2 No  (2/583)  (2/2)  Wholemount images
Hippocampus 2 No  (3/583)  (2/2)  Wholemount images
Hypothalamus 2 No  (2/583)  (2/2)  Wholemount images
Kidney 2 No  (21/583)  (2/2)  Wholemount images
Large intestine 2 No  (10/583)  (2/2)  Wholemount images
Liver 2 No N/A
Lower urinary tract 2 No  (1/583)  (2/2)  Wholemount images
Lung 2 No  (2/583)  (2/2)  Wholemount images
Lymph node 2 No  (1/583) N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/583)  (2/2)  Wholemount images
Oral epithelium 2 No N/A
Ovary 2 No  (1/583)  (1/2)  Wholemount images
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/583)  (2/2)  Wholemount images
Parathyroid gland 2 No  (1/563)  (2/2)  Wholemount images
Peripheral nervous system 2 No  (2/583)  (2/2)  Wholemount images
Peyer's patch 2 No N/A
Pituitary gland 2 No  (1/583)  (2/2)  Wholemount images
Prostate gland 2 No  (12/583)  (1/2)  Wholemount images
Skeletal muscle 2 No N/A
Skin 2 No  (1/583)  (2/2)  Wholemount images
Small intestine 2 No  (9/583)  (2/2)  Wholemount images
Spinal cord 2 No  (3/583)  (2/2)  Wholemount images
Spleen 2 No  (3/583) N/A
Stomach 2 No  (13/583)  (2/2)  Wholemount images
Striatum 2 No  (3/583)  (2/2)  Wholemount images
Testis 2 No  (6/583)  (1/2)  Wholemount images
Thymus 2 No  (1/583) N/A
Thyroid gland 2 No  (17/583)  (2/2)  Wholemount images
Trachea 2 No  (3/583)  (2/2)  Wholemount images
Uterus 2 No  (1/2)  Wholemount images
Vascular system 2 No  (2/2)  Wholemount images
White adipose tissue 2 No N/A
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
2  (6/505)  (2/2) N/A
2  (1/505)  (1/2) N/A
2  (1/506)  (2/2) N/A
2  (1/505)  (2/2) N/A
2  (1/505)  (1/2) N/A
2  (1/505)  (2/2) N/A
2  (1/505)  (2/2) N/A
2  (1/505)  (1/2) N/A
2  (5/505)  (2/2) N/A
2  (1/505)  (1/2) N/A
2  (6/505)  (2/2) N/A
2  (1/505)  (2/2) N/A
2  (1/503)  (1/2) N/A
2  (1/503)  (1/2) N/A
2  (1/505)  (1/2) N/A
2  (1/505)  (1/2) N/A
2  (1/505)  (2/2) N/A
2  (1/503)  (1/2) N/A
2  (1/505)  (1/2) N/A
2  (1/505)  (2/2) N/A
2  (1/505)  (1/2) N/A

 Associated Images

Echo: M-Mode Images
32 Images
Adult LacZ: LacZ Images Wholemount
22 Images
X-ray: XRay Images Whole Body Lateral Orientation
10 Images
X-ray: XRay Images Whole Body Dorso Ventral
10 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
Embryo LacZ: LacZ images wholemount
4 Images
Immunophenotyping: Panel A FCS file(s)
8 Images
Immunophenotyping: Panel B FCS file(s)
8 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Dicer1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Dicer1tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice
Dicer1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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